L-Homocysteine (BioDeep_00000402827)

Main id: BioDeep_00000001340

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


DL-Homocysteine

化学式: C4H9NO2S (135.0354)
中文名称: L-高半胱氨酸, 高半胱氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CS)C(C(=O)O)N
InChI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)

描述信息

A homocysteine that has L configuration.
L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].

同义名列表

3 个代谢物同义名

DL-Homocysteine; L-Homocysteine; L-Homocysteine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(10)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AHCY, CTH, GNMT, MARS1, MTR
Endosome membrane 1 TF
Endoplasmic reticulum membrane 3 PEMT, PON1, PROS1
Mitochondrion membrane 1 PEMT
Nucleus 1 AHCY
cytosol 7 AHCY, COMT, CTH, GNMT, MARS1, MTR, PEMT
dendrite 1 COMT
mitochondrial membrane 1 PEMT
Cell membrane 3 COMT, SELE, SELP
Multi-pass membrane protein 1 PEMT
Synapse 1 COMT
cell surface 4 F3, PLG, TF, THBD
glutamatergic synapse 1 PLG
Golgi membrane 1 PROS1
Cytoplasm, cytosol 1 MARS1
plasma membrane 12 COMT, CTH, F2, F3, F7, PLG, PROS1, SELE, SELP, SERPINC1, TF, THBD
Membrane 5 COMT, CTH, F3, MARS1, PEMT
apical plasma membrane 1 TF
axon 1 COMT
caveola 1 SELE
extracellular exosome 12 AHCY, COMT, CTH, F2, MARS1, PLG, PON1, PROS1, SELP, SERPINC1, TF, VWF
endoplasmic reticulum 4 AHCY, PEMT, PROS1, VWF
extracellular space 13 CCL2, F2, F3, F7, PLG, PON1, PROS1, SELE, SELP, SERPINC1, TF, THBD, VWF
perinuclear region of cytoplasm 2 SELE, TF
Schaffer collateral - CA1 synapse 1 PLG
apicolateral plasma membrane 1 THBD
mitochondrion 1 PEMT
intracellular membrane-bounded organelle 2 COMT, PEMT
Single-pass type I membrane protein 4 CTH, F3, SELE, SELP
Secreted 8 CCL2, F2, F7, PLG, PROS1, SELP, TF, VWF
extracellular region 10 CCL2, F2, F7, PLG, PON1, PROS1, SELP, SERPINC1, TF, VWF
basal part of cell 1 TF
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
Extracellular side 1 COMT
external side of plasma membrane 5 F3, PLG, SELE, SELP, THBD
Secreted, extracellular space, extracellular matrix 1 VWF
high-density lipoprotein particle 1 PON1
cytoplasmic vesicle 1 TF
nucleolus 1 MARS1
Early endosome 1 TF
clathrin-coated pit 2 SELE, TF
recycling endosome 1 TF
Single-pass type II membrane protein 1 COMT
vesicle 2 F7, TF
Membrane raft 1 SELE
extracellular matrix 1 VWF
collagen-containing extracellular matrix 6 F2, F3, F7, PLG, SERPINC1, VWF
Late endosome 1 TF
Secreted, extracellular space 1 SERPINC1
Nucleus, nucleolus 1 MARS1
blood microparticle 6 F2, PLG, PON1, PROS1, SERPINC1, TF
[Isoform 1]: Endoplasmic reticulum membrane 1 PEMT
Melanosome 1 AHCY
basal plasma membrane 1 TF
platelet alpha granule 1 VWF
platelet dense granule membrane 1 SELP
secretory granule lumen 1 TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 3 F2, F7, PROS1
endoplasmic reticulum lumen 4 F2, F7, SERPINC1, TF
platelet alpha granule lumen 3 PLG, PROS1, VWF
endocytic vesicle 1 TF
serine-type endopeptidase complex 1 THBD
clathrin-coated endocytic vesicle membrane 1 TF
aminoacyl-tRNA synthetase multienzyme complex 1 MARS1
[Isoform 2]: Endoplasmic reticulum membrane 1 PEMT
platelet alpha granule membrane 1 SELP
vesicle coat 1 TF
spherical high-density lipoprotein particle 1 PON1
cortical cytoskeleton 1 SELE
platelet dense granule lumen 1 SELP
Weibel-Palade body 1 VWF
vacuolar membrane 1 THBD
serine-type peptidase complex 2 F3, F7
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
dense body 1 TF


文献列表

  • Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu. The relationship between thiamin, folic acid and cognitive function in a rat model of uremia. Renal failure. 2024 Dec; 46(1):2329257. doi: 10.1080/0886022x.2024.2329257. [PMID: 38482596]
  • Qi Sun, Ting Zhang, Yuchen Ren, Yuan Qiu, Xiaogang Luo, Jingfang Yang, Genyan Liu. A two-photon fluorescent probe for highly selective detection of Cys over GSH and Hcy based on the Michael addition and transcyclization mechanism and its application in bioimaging and protein straining in SDS-PAGE. Analytica chimica acta. 2024 Jun; 1309(?):342687. doi: 10.1016/j.aca.2024.342687. [PMID: 38772659]
  • Tatjana Đurašinović, Zorana Lopandić, Isidora Protić-Rosić, Andrijana Nešić, Jovana Trbojević-Ivić, Uta Jappe, Marija Gavrović-Jankulović. Identification of S-adenosyl-l-homocysteine hydrolase from banana fruit as a novel plant panallergen. Food chemistry. 2024 Mar; 437(Pt 1):137782. doi: 10.1016/j.foodchem.2023.137782. [PMID: 37871426]
  • Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, Rima Rozen. Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner. Molecular nutrition & food research. 2024 Mar; 68(5):e2300355. doi: 10.1002/mnfr.202300355. [PMID: 38327171]
  • Chaoyi Xia, Xiyue Xing, Wenxia Zhang, Yang Wang, Xin Jin, Yang Wang, Meihong Tian, Xueqing Ba, Fengqi Hao. Cysteine and homocysteine can be exploited by GPX4 in ferroptosis inhibition independent of GSH synthesis. Redox biology. 2024 Feb; 69(?):102999. doi: 10.1016/j.redox.2023.102999. [PMID: 38150992]
  • Stephen G Andrews, Anthony M Koehle, Devendra Paudel, Thomas Neuberger, A Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro. Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030330. [PMID: 38337615]
  • Chi Zhang, Qiu-Ping Xin, Yun-Bo Xie, Xiang-Yu Guo, En-Hong Xing, Zhi-Jie Dou, Cui Zhao. Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension. BMC cardiovascular disorders. 2024 Jan; 24(1):55. doi: 10.1186/s12872-024-03704-6. [PMID: 38238653]
  • Jinshuai Lan, Li Liu, Zhe Li, Ruifeng Zeng, Lixia Chen, Yitian He, Hai Wei, Yue Ding, Tong Zhang. A multi-signal mitochondria-targeted fluorescent probe for simultaneously distinguishing biothiols and realtime visualizing its metabolism in cancer cells and tumor models. Talanta. 2024 Jan; 267(?):125104. doi: 10.1016/j.talanta.2023.125104. [PMID: 37703779]
  • Meryem Al Fatly, Monique T Mulder, Jeanine Roeters van Lennep, Henk J Blom, Kirsten A C Berk. The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes. Nutrition journal. 2024 Jan; 23(1):2. doi: 10.1186/s12937-023-00908-y. [PMID: 38167024]
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  • Zhengqin Zuo, Zhigang Xu, Chunxia Cheng, Shiyan Yang, Mingxing Li. Predictive Value of Carotid Plaque Contrast-Enhanced Ultrasound Score and Homocysteine in Senile Metabolic Syndrome Complicated by Cerebral Infarction. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2023 Oct; 33(10):1100-1105. doi: 10.29271/jcpsp.2023.10.1100. [PMID: 37804013]
  • Minji Wi, Yumin Kim, Cheol-Hyun Kim, Sangkwan Lee, Gi-Sang Bae, Jungtae Leem, Hongmin Chu. Effectiveness and Safety of Fufang Danshen Dripping Pill (Cardiotonic Pill) on Blood Viscosity and Hemorheological Factors for Cardiovascular Event Prevention in Patients with Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis. Medicina (Kaunas, Lithuania). 2023 Sep; 59(10):. doi: 10.3390/medicina59101730. [PMID: 37893448]
  • Kinga Ilona Nyulas, Mariana Cornelia Tilinca, Sándor Pál, Erzsébet Májai Fogarasi, Mircea Dumitru Croitoru, Robert Gabriel Tripon, Zoltán Preg, Márta Germán-Salló, Zsuzsánna Simon-Szabó, Enikő Nemes-Nagy. Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients. Pakistan journal of pharmaceutical sciences. 2023 Sep; 36(5):1399-1405. doi: ". [PMID: 37869915]
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  • Liang Ren, Jing Guo, Weibo Zhao, Ruijing Zuo, Shuang Guo, Chaoguo Jia, Wei Gao. Serum homocysteine relates to elevated lipid level, inflammation and major adverse cardiac event risk in acute myocardial infarction patients. Biomarkers in medicine. 2023 Jun; ?(?):. doi: 10.2217/bmm-2023-0096. [PMID: 37284746]
  • Qing-Heng Wu, Peng-Chao Li, Fang-Hua Zhang, Zhong Hua, Xing-Hua Zhang, Zi-Xue Sun. [To evaluate the efficacy of Yishen Tongluo decoction combined with low-dose tadalafil in the treatment of diabetic erectile dysfunction with kidney deficiency and blood stasis syndrome]. Zhonghua nan ke xue = National journal of andrology. 2023 Jun; 29(6):527-532. doi: ". [PMID: 38602726]
  • Wei Jia, Xixuan Wu, Ning Liu, Zengrun Xia, Lin Shi. Quantitative fusion omics reveals that refrigeration drives methionine degradation through perturbing 5-methyltetrahydropteroyltriglutamate-homocysteine activity. Food chemistry. 2023 May; 409(?):135322. doi: 10.1016/j.foodchem.2022.135322. [PMID: 36584532]
  • Wenzhi Xie, Jinyu Jiang, Dunji Shu, Yanjun Zhang, Sheng Yang, Kai Zhang. Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104252. [PMID: 37241992]
  • Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen DA Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study. The Journal of nutrition. 2023 May; ?(?):. doi: 10.1016/j.tjnut.2023.05.008. [PMID: 37164267]
  • Abolfazl Akbari, Muhammad Islampanah, Hadise Arhaminiya, Mohammad Mahdi Alvandi Fard, Tannaz Jamialahmadi, Amirhossein Sahebkar. Impact of Statin or Fibrate Therapy on Homocysteine Concentrations: A Systematic Review and Meta-Analysis. Current medicinal chemistry. 2023 Apr; ?(?):. doi: 10.2174/0929867330666230413090416. [PMID: 37069715]
  • Seyedeh Fatemeh Hoseinlar, Masoud Nikanfar, Delara Laghousi, Masoud Darabi, Behrouz Shademan, Alireza Nourazarian. Diagnostic Value of ATG5, Apo-Lipoprotein B-48, Thyroid Hormones, and Homocysteine in Patients with Alzheimer's Disease. Clinical laboratory. 2023 Mar; 69(3):. doi: 10.7754/clin.lab.2022.220614. [PMID: 36912305]
  • Juliana Dias Gonçalves Dos Santos, Fabíola Isabel Suano de Souza, João Carlos Pina Faria, Luciana Satiko Sawamura, Anelise Del Vecchio Gessullo, Roseli Oselka Saccardo Sarni. Homocysteine concentrations in overweight children and adolescents. Revista da Associacao Medica Brasileira (1992). 2023; 69(2):285-290. doi: 10.1590/1806-9282.20220991. [PMID: 36722654]
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  • Wenwen Yuan, Yan Shao, Dong Zhao, Bin Zhang. Correlation analysis of lipid accumulation index, triglyceride-glucose index and H-type hypertension and coronary artery disease. PeerJ. 2023; 11(?):e16069. doi: 10.7717/peerj.16069. [PMID: 37727694]
  • Dusan Todorovic, Marija Stojanovic, Kristina Gopcevic, Ana Medic, Sanja Stankovic, Boba Kotlica, Milica Labudovic Borovic, Dragan Djuric. Effects of four weeks lasting aerobic physical activity on cardiovascular biomarkers, oxidative stress and histomorphometric changes of heart and aorta in rats with experimentally induced hyperhomocysteinemia. Molecular and cellular biochemistry. 2023 Jan; 478(1):161-172. doi: 10.1007/s11010-022-04503-3. [PMID: 35759142]
  • Shanshan Li, Yunchao Wang, Lulu Yu, Yuan Gao, Yinghao Yang, Hanghang Zhu, Lu An, Wenxin Yuan, Jinghao Wu, Ce Zong, Yuming Xu, Yusheng Li. Association of Blood Lipid Profile Components with White Matter Hyperintensity Burden in Cerebral Small Vessel Disease. Current neurovascular research. 2023; 20(2):175-182. doi: 10.2174/1567202620666230524155702. [PMID: 37226782]
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  • Zilong Shen, Zhengmei Zhang, Wenjing Zhao. Relationship between plasma homocysteine and chronic kidney disease in US patients with type 2 diabetes mellitus: a cross-sectional study. BMC nephrology. 2022 12; 23(1):419. doi: 10.1186/s12882-022-03045-6. [PMID: 36587192]
  • Qian-Nan Guo, Ling Wang, Zheng-Yan Liu, Hong-Dan Wang, Li Wang, Jian-Gang Long, Shi-Xiu Liao. Different effects of maternal homocysteine concentration, MTHFR and MTRR genetic polymorphisms on the occurrence of fetal aneuploidy. Reproductive biomedicine online. 2022 12; 45(6):1207-1215. doi: 10.1016/j.rbmo.2022.06.024. [PMID: 36210274]
  • Jasna Čerkez Habek, Mirna Vuković Bobić, Dubravko Habek, Sandra Jerković Gulin, Dario Gulin. CARDIOVASCULAR RISK IN WOMEN WITH PREECLAMPSIA. Acta clinica Croatica. 2022 Dec; 61(4):574-580. doi: 10.20471/acc.2022.61.04.02. [PMID: 37868169]
  • Farnaz Pouriayevali, Marziyeh Tavalaee, Taghi Taktaz-Hafshejani, Maurizio Dattilio, Mohammad H Nasr-Esfahani. Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations. Andrologia. 2022 Dec; 54(11):e14592. doi: 10.1111/and.14592. [PMID: 36123798]
  • Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatric research. 2022 12; 92(6):1606-1612. doi: 10.1038/s41390-022-02132-6. [PMID: 35688962]
  • Ayşe Çakır Gündoğdu, Fatih Kar, Cansu Özbayer. Investigation of the Gastroprotective Effect of Betaine-Homocysteine Homeostasis on Oxidative Stress, Inflammation and Apoptosis in Ethanol-Induced Ulcer Model. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022 Nov; 35(11-12):1806-1817. doi: 10.1080/08941939.2022.2126566. [PMID: 36154440]
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  • Akihiro Nakajima, Peter Libby, Satoru Mitomo, Haruhito Yuki, Makoto Araki, Lena Marie Seegers, Iris McNulty, Hang Lee, Midori Ishibashi, Kazuna Kobayashi, Jouke Dijkstra, Toru Ouchi, Hirokazu Onishi, Hiroto Yabushita, Satoshi Matsuoka, Hiroyoshi Kawamoto, Yusuke Watanabe, Kentaro Tanaka, Shengpu Chou, Tomohiko Sato, Toru Naganuma, Masaaki Okutsu, Satoko Tahara, Naoyuki Kurita, Shotaro Nakamura, David J Kuter, Sunao Nakamura, Ik-Kyung Jang. Biomarkers associated with coronary high-risk plaques. Journal of thrombosis and thrombolysis. 2022 Nov; 54(4):647-659. doi: 10.1007/s11239-022-02709-2. [PMID: 36205839]
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