Tetracain (BioDeep_00000402575)
Main id: BioDeep_00000398464
代谢物信息卡片
tetracaine
化学式: C15H24N2O2 (264.1838)
中文名称: 丁卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C
InChI: InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
描述信息
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AB - Anesthetics for topical use
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AD - Local anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BA - Esters of aminobenzoic acid
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
CONFIDENCE standard compound; INTERNAL_ID 8620
同义名列表
4 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:9468
- KEGG: C07526
- KEGGdrug: D00551
- PubChem: 5411
- DrugBank: DB09085
- ChEMBL: CHEMBL698
- MeSH: Tetracaine
- CAS: 100311-22-6
- CAS: 94-24-6
- MoNA: SM862001
- PubChem: 9729
- PDB-CCD: TE4
- NIKKAJI: J3.945D
- KNApSAcK: 9468
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R Pérez-Isidoro, F J Guevara-Pantoja, C Ventura-Hunter, C Guerrero-Sánchez, J C Ruiz-Suárez, U S Schubert, E Saldívar-Guerra. Fluidized or not fluidized? Biophysical characterization of biohybrid lipid/protein/polymer liposomes and their interaction with tetracaine.
Biochimica et biophysica acta. General subjects.
2023 02; 1867(2):130287. doi:
10.1016/j.bbagen.2022.130287. [PMID: 36460234] - Simone R Castro, Lígia N M Ribeiro, Márcia C Breitkreitz, Viviane A Guilherme, Gustavo H Rodrigues da Silva, Hery Mitsutake, Ana C S Alcântara, Fabiano Yokaichiya, Margareth K K D Franco, Daniel Clemens, Ben Kent, Marcelo Lancellotti, Daniele R de Araújo, Eneida de Paula. A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.
Scientific reports.
2021 11; 11(1):21463. doi:
10.1038/s41598-021-99743-6. [PMID: 34728779] - Robin Wijngaard, Marina Parra-Robert, Lourdes Marés, Anna Escalante, Emilio Salgado, Bernardino González-de-la-Presa, Jordi To-Figueras, Mercè Brunet. Tetracaine from urethral ointment causes false positive amphetamine results by immunoassay.
Clinical toxicology (Philadelphia, Pa.).
2021 06; 59(6):500-505. doi:
10.1080/15563650.2020.1834114. [PMID: 33112680] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - W Q Liu, R Bai, C L Ma, F Yu, B Xie, M Dong, J Ha, D Wen. Metabolomics Changes of Serum and Tissues in Mice Died of Acute Tetracaine Poisoning.
Fa yi xue za zhi.
2021 Apr; 37(2):166-174. doi:
10.12116/j.issn.1004-5619.2020.401006. [PMID: 34142476] - Carol S Velez-Saboyá, Eric Oropeza-Guzman, Francisco J Sierra-Valdez, Jesús C Ruiz-Suárez. Ca2+-mediated enhancement of anesthetic diffusion across phospholipid multilamellar systems.
Biochimica et biophysica acta. Biomembranes.
2021 02; 1863(2):183509. doi:
10.1016/j.bbamem.2020.183509. [PMID: 33189718] - Shipeng Hu, Tao Zhao, Hewen Li, Danling Cheng, Zhihua Sun. Effect of tetracaine on dynamic reorganization of lipid membranes.
Biochimica et biophysica acta. Biomembranes.
2020 09; 1862(9):183351. doi:
10.1016/j.bbamem.2020.183351. [PMID: 32416192] - Mahmud Arif Pavel, Hae-Won Chung, E Nicholas Petersen, Scott B Hansen. Polymodal Mechanism for TWIK-Related K+ Channel Inhibition by Local Anesthetic.
Anesthesia and analgesia.
2019 10; 129(4):973-982. doi:
10.1213/ane.0000000000004216. [PMID: 31124840] - Xiaoli Liu, Qianqian Zhao. Long-term anesthetic analgesic effects: Comparison of tetracaine loaded polymeric nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers in vitro and in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Sep; 117(?):109057. doi:
10.1016/j.biopha.2019.109057. [PMID: 31203133] - Zhiyi Yu, David C Chiara, Pavel Y Savechenkov, Karol S Bruzik, Jonathan B Cohen. A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
The Journal of biological chemistry.
2019 05; 294(19):7892-7903. doi:
10.1074/jbc.ra118.007172. [PMID: 30923128] - Zhan Song, Ting-Jun Fan. Tetracaine induces apoptosis through a mitochondrion-dependent pathway in human corneal stromal cells in vitro.
Cutaneous and ocular toxicology.
2018 Dec; 37(4):350-358. doi:
10.1080/15569527.2018.1468342. [PMID: 29742927] - Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova. Lipid-mediated mode of action of local anesthetics on lipid pores induced by polyenes, peptides and lipopeptides.
Colloids and surfaces. B, Biointerfaces.
2018 Jun; 166(?):1-8. doi:
10.1016/j.colsurfb.2018.02.051. [PMID: 29525621] - Seifollah Jalili, Marzieh Saeedi. Study of procaine and tetracaine in the lipid bilayer using molecular dynamics simulation.
European biophysics journal : EBJ.
2017 Apr; 46(3):265-282. doi:
10.1007/s00249-016-1164-8. [PMID: 27557558] - Anthony T Cacek, Jogarao V S Gobburu, Mathangi Gopalakrishnan. Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers.
Journal of clinical pharmacology.
2017 02; 57(2):247-254. doi:
10.1002/jcph.799. [PMID: 27436060] - Dan Liu, Jingdong Peng, Shaopu Liu, Mingqiong Zhou, Jing Zhang, Aiping Li. Resonance Rayleigh scattering technique as a detection method for the RP-HPLC determination of local anaesthetics in human urine.
Luminescence : the journal of biological and chemical luminescence.
2017 Feb; 32(1):4-10. doi:
10.1002/bio.3140. [PMID: 27145989] - Rosendo Pérez-Isidoro, J C Ruiz-Suárez. Calcium and protons affect the interaction of neurotransmitters and anesthetics with anionic lipid membranes.
Biochimica et biophysica acta.
2016 09; 1858(9):2215-2222. doi:
10.1016/j.bbamem.2016.06.017. [PMID: 27362370] - Qinqin Xu, Tao Zhao, Zhihua Sun. Monitoring drug-lipid membrane interactions via a molecular rotor probe.
The Analyst.
2016 Aug; 141(15):4676-84. doi:
10.1039/c6an00721j. [PMID: 27243370] - Anikó Lajtai, Mátyás Mayer, Ágnes Lakatos, Zoltán Porpáczy, Attila Miseta. Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse?.
Journal of forensic sciences.
2016 Mar; 61(2):573-575. doi:
10.1111/1556-4029.13010. [PMID: 27404634] - María del Mar LópezGuerrero, Maykel Hernández-Mesa, Carmen Cruces-Blanco, Ana M García-Campaña. On-line preconcentration strategy for the simultaneous quantification of three local anesthetics in human urine using CZE.
Electrophoresis.
2015 Dec; 36(23):2961-7. doi:
10.1002/elps.201500081. [PMID: 26436521] - Raquel S Teixeira, Tânia F G G Cova, Sérgio M C Silva, Rita Oliveira, M Luísa C do Vale, Eduardo F Marques, Alberto A C C Pais, Francisco J B Veiga. Novel serine-based gemini surfactants as chemical permeation enhancers of local anesthetics: A comprehensive study on structure-activity relationships, molecular dynamics and dermal delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Jun; 93(?):205-13. doi:
10.1016/j.ejpb.2015.02.024. [PMID: 25748796] - Raquel S Teixeira, Tânia F G G Cova, Sérgio M C Silva, Rita Oliveira, Maria J Araújo, Eduardo F Marques, Alberto A C C Pais, Francisco J B Veiga. Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics.
International journal of pharmaceutics.
2014 Oct; 474(1-2):212-22. doi:
10.1016/j.ijpharm.2014.08.002. [PMID: 25108047] - Lotta Salmela, Clive Washington. A continuous flow method for estimation of drug release rates from emulsion formulations.
International journal of pharmaceutics.
2014 Sep; 472(1-2):276-81. doi:
10.1016/j.ijpharm.2014.06.024. [PMID: 24945139] - Patricio A Zapata-Morin, F J Sierra-Valdez, J C Ruiz-Suárez. The interaction of local anesthetics with lipid membranes.
Journal of molecular graphics & modelling.
2014 Sep; 53(?):200-205. doi:
10.1016/j.jmgm.2014.08.001. [PMID: 25181454] - A P Serro, R Galante, A Kozica, P Paradiso, A M P S Gonçalves da Silva, K V Luzyanin, A C Fernandes, B Saramago. Effect of tetracaine on DMPC and DMPC+cholesterol biomembrane models: liposomes and monolayers.
Colloids and surfaces. B, Biointerfaces.
2014 Apr; 116(?):63-71. doi:
10.1016/j.colsurfb.2013.12.042. [PMID: 24448175] - Alicia R Sanderson, Edward C Wu, Lih-Huei L Liaw, Rohit Garg, Richard A Gangnes. The effect of topical anesthetic hydration on the depth of thermal injury from the plasma skin regeneration device.
Lasers in surgery and medicine.
2014 Feb; 46(2):127-31. doi:
10.1002/lsm.22210. [PMID: 24375476] - Da Huang, Tao Zhao, Wei Xu, Tinglu Yang, Paul S Cremer. Sensing small molecule interactions with lipid membranes by local pH modulation.
Analytical chemistry.
2013 Nov; 85(21):10240-8. doi:
10.1021/ac401955t. [PMID: 24152205] - Joel L Cohen. Pain management with a topical lidocaine and tetracaine 7\%/7\% cream with laser dermatologic procedures.
Journal of drugs in dermatology : JDD.
2013 Sep; 12(9):986-9. doi:
. [PMID: 24002144] - Georgette Oni, Yvonne Rasko, Jeffrey Kenkel. Topical lidocaine enhanced by laser pretreatment: a safe and effective method of analgesia for facial rejuvenation.
Aesthetic surgery journal.
2013 Aug; 33(6):854-61. doi:
10.1177/1090820x13496248. [PMID: 23908302] - Frank Musshoff, Katrin M Kirschbaum, Burkhard Madea. Another suicide using the veterinary drug T61 and distribution of drugs in the body.
Journal of analytical toxicology.
2013 Apr; 37(3):186. doi:
10.1093/jat/bks140. [PMID: 23358154] - Cátia Bandeiras, Ana Paula Serro, Konstantin Luzyanin, Anabela Fernandes, Benilde Saramago. Anesthetics interacting with lipid rafts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2013 Jan; 48(1-2):153-65. doi:
10.1016/j.ejps.2012.10.023. [PMID: 23142844] - Francisco J Sierra-Valdez, Linda S Forero-Quintero, Patricio A Zapata-Morin, Miguel Costas, Arturo Chavez-Reyes, Jesús C Ruiz-Suárez. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers.
PloS one.
2013; 8(4):e59364. doi:
10.1371/journal.pone.0059364. [PMID: 23565149] - Patrick E McCleskey, Seema M Patel, Katherine A Mansalis, Amanda L Elam, Tina R Kinsley. Serum lidocaine levels and cutaneous side effects after application of 23\% lidocaine 7\% tetracaine ointment to the face.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].
2013 Jan; 39(1 Pt 1):82-91. doi:
10.1111/dsu.12064. [PMID: 23278914] - Jarin Paphangkorakit, Chaichan Sangsirinakagul, Aroonsri Priprem. Relief of palatal injection pain by liposome-encapsulated 2\% lignocaine prepared by ultrasonic dental scaler.
The British journal of oral & maxillofacial surgery.
2012 Dec; 50(8):784-7. doi:
10.1016/j.bjoms.2011.12.009. [PMID: 22277697] - Nicole Weizenmann, Daniel Huster, Holger A Scheidt. Interaction of local anesthetics with lipid bilayers investigated by ¹H MAS NMR spectroscopy.
Biochimica et biophysica acta.
2012 Dec; 1818(12):3010-8. doi:
10.1016/j.bbamem.2012.07.014. [PMID: 22842001] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - K Ruetzler, B Sima, L Mayer, A Golescu, D Dunkler, W Jaeger, M Hoeferl, J You, D I Sessler, G Grubhofer, D Hutschala. Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial access: a double-blind, randomized trial.
British journal of anaesthesia.
2012 Nov; 109(5):790-6. doi:
10.1093/bja/aes254. [PMID: 22831890] - Thomas B Marriott, Martha R Charney, Stephanie Stanworth. Effects of application durations and heat on the pharmacokinetic properties of drug delivered by a lidocaine/tetracaine patch: a randomized, open-label, controlled study in healthy volunteers.
Clinical therapeutics.
2012 Oct; 34(10):2174-83. doi:
10.1016/j.clinthera.2012.08.008. [PMID: 22943969] - Helen Giannakopoulos, Lawrence M Levin, Joli C Chou, Anthony T Cacek, Matthew Hutcheson, Stacey A Secreto, Paul A Moore, Elliot V Hersh. The cardiovascular effects and pharmacokinetics of intranasal tetracaine plus oxymetazoline: preliminary findings.
Journal of the American Dental Association (1939).
2012 Aug; 143(8):872-80. doi:
10.14219/jada.archive.2012.0291. [PMID: 22855901] - Niels Voigt, Na Li, Qiongling Wang, Wei Wang, Andrew W Trafford, Issam Abu-Taha, Qiang Sun, Thomas Wieland, Ursula Ravens, Stanley Nattel, Xander H T Wehrens, Dobromir Dobrev. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.
Circulation.
2012 May; 125(17):2059-70. doi:
10.1161/circulationaha.111.067306. [PMID: 22456474] - Georgette Oni, Spencer Brown, Jeffrey Kenkel. Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX).
Aesthetic surgery journal.
2012 May; 32(4):495-503. doi:
10.1177/1090820x12442672. [PMID: 22452841] - Xiaojuan Gan, Shaopu Liu, Zhongfang Liu, Xiaoli Hu. Determination of tetracaine hydrochloride by fluorescence quenching method with some aromatic amino acids as probes.
Journal of fluorescence.
2012 Jan; 22(1):129-35. doi:
10.1007/s10895-011-0938-8. [PMID: 21822580] - Catherine E Morris, Pierre-Alexandre Boucher, Béla Joós. Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists?.
Frontiers in pharmacology.
2012; 3(?):19. doi:
10.3389/fphar.2012.00019. [PMID: 22375118] - Norbert Kummerfeld, Marko Legler, Peter Wohlsein, Maren Kummerfeld. [Morphological studies in different avian species on artefacts induced by euthanasia with T 61 " or Pentobarbital (Narcoren)].
Berliner und Munchener tierarztliche Wochenschrift.
2012 Jan; 125(1-2):27-31. doi:
. [PMID: 22372321] - Elena Galfré, Samantha J Pitt, Elisa Venturi, Mano Sitsapesan, Nathan R Zaccai, Krasimira Tsaneva-Atanasova, Stephen O'Neill, Rebecca Sitsapesan. FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
PloS one.
2012; 7(2):e31956. doi:
10.1371/journal.pone.0031956. [PMID: 22363773] - Roberta Aline Franco de Lima, Marcelo Bispo de Jesus, Cíntia Maria Saia Cereda, Giovana Radomille Tofoli, Luis Fernando Cabeça, Irineu Mazzaro, Leonardo Fernandes Fraceto, Eneida de Paula. Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins.
Journal of drug targeting.
2012 Jan; 20(1):85-96. doi:
10.3109/1061186x.2011.622400. [PMID: 22047178] - Solmon Yang, Tserendorj Uugangerel, In-Ki Jang, Hyung-Chul Lee, Jong Min Kim, Byeong-Cheol Kang, Chong Soo Kim, Kook-Hyun Lee. Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse.
Anesthesiology research and practice.
2012; 2012(?):878764. doi:
10.1155/2012/878764. [PMID: 22567005] - Klaara Kannisto, Lasse Murtomäki, Tapani Viitala. An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers.
Colloids and surfaces. B, Biointerfaces.
2011 Sep; 86(2):298-304. doi:
10.1016/j.colsurfb.2011.04.012. [PMID: 21549577] - Derek R Laver, Dirk F van Helden. Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels.
Journal of molecular and cellular cardiology.
2011 Sep; 51(3):357-69. doi:
10.1016/j.yjmcc.2011.05.009. [PMID: 21624373] - Trang T Nguyen, John C Conboy. High-throughput screening of drug-lipid membrane interactions via counter-propagating second harmonic generation imaging.
Analytical chemistry.
2011 Aug; 83(15):5979-88. doi:
10.1021/ac2009614. [PMID: 21696170] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Adriana L Andrade, Kenneth Melich, G Gregory Whatley, Sarah R Kirk, Jeffrey W Karpen. Cyclic nucleotide-gated channel block by hydrolysis-resistant tetracaine derivatives.
Journal of medicinal chemistry.
2011 Jul; 54(13):4904-12. doi:
10.1021/jm200495g. [PMID: 21634421] - Katrin M Kirschbaum, Wolfgang Grellner, Gertrud Rochholz, Frank Musshoff, Burkhard Madea. Liquid chromatography-tandem mass spectrometry detection of the quaternary ammonium compound mebezonium as an active ingredient in t61.
Journal of analytical toxicology.
2011 Mar; 35(2):124-8. doi:
10.1093/anatox/35.2.124. [PMID: 21396233] - Martin Maenz, Mourice Morcos, Thomas Ritter. A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model.
Molecular vision.
2011 Feb; 17(?):420-9. doi:
NULL. [PMID: 21321672] - Minghua Lu, Qin Li, Yongquan Lai, Lan Zhang, Bin Qiu, Guonan Chen, Zongwei Cai. Determination of stimulants and narcotics as well as their in vitro metabolites by online CE-ESI-MS.
Electrophoresis.
2011 Feb; 32(3-4):472-8. doi:
10.1002/elps.201000453. [PMID: 21254133] - Murali Mohan Yallapu, Mara C Ebeling, Neeraj Chauhan, Meena Jaggi, Subhash C Chauhan. Interaction of curcumin nanoformulations with human plasma proteins and erythrocytes.
International journal of nanomedicine.
2011; 6(?):2779-90. doi:
10.2147/ijn.s25534. [PMID: 22128249] - Antonio Raudino, Maria Grazia Sarpietro, Martina Pannuzzo. The thermodynamics of simple biomembrane mimetic systems.
Journal of pharmacy & bioallied sciences.
2011 Jan; 3(1):15-38. doi:
10.4103/0975-7406.76462. [PMID: 21430953] - Liliana L Jorge, Caroline C Feres, Vitor Ep Teles. Topical preparations for pain relief: efficacy and patient adherence.
Journal of pain research.
2010 Dec; 4(?):11-24. doi:
10.2147/jpr.s9492. [PMID: 21386951] - Beyazit Zencirci. Sertraline-induced pseudocholinesterase enzyme deficiency.
International journal of general medicine.
2010 Nov; 3(?):375-8. doi:
10.2147/ijgm.s14365. [PMID: 21189834] - Sunil K Parapuram, Radu I Cojocaru, Jessica R Chang, Ritu Khanna, Matthew Brooks, Mohammad Othman, Sepideh Zareparsi, Naheed W Khan, Norimoto Gotoh, Tiziana Cogliati, Anand Swaroop. Distinct signature of altered homeostasis in aging rod photoreceptors: implications for retinal diseases.
PloS one.
2010 Nov; 5(11):e13885. doi:
10.1371/journal.pone.0013885. [PMID: 21079736] - Joel S Goldberg. Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions.
Perspectives in medicinal chemistry.
2010 Aug; 4(?):23-31. doi:
10.4137/pmc.s5490. [PMID: 20703328] - Jae Myeong Lee, Jung Kook Suh, Ji Seon Jeong, Sang Yun Cho, Dong Won Kim. Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta.
Korean journal of anesthesiology.
2010 Aug; 59(2):104-10. doi:
10.4097/kjae.2010.59.2.104. [PMID: 20740215] - Philippe Hantson, Antoine Villa, Anne-Cécile Galloy, Sara Negri, Giulia Esabon, Fabien Lambiotte, Vincent Haufroid, Robert Garnier. Dimethylformamide metabolism following self-harm using a veterinary euthanasia product.
Clinical toxicology (Philadelphia, Pa.).
2010 Aug; 48(7):725-9. doi:
10.3109/15563650.2010.498790. [PMID: 20849330] - Wei-Wei Qin, Zheng Jiao, Ming-Kang Zhong, Xiao-Jin Shi, Jun Zhang, Zhong-Dong Li, Xue-Yan Cui. Simultaneous determination of procaine, lidocaine, ropivacaine, tetracaine and bupivacaine in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 May; 878(15-16):1185-9. doi:
10.1016/j.jchromb.2010.03.003. [PMID: 20356808] - Fredrick A Hilliard, Derek S Steele, Derek Laver, Zhaokang Yang, Sylvain J Le Marchand, Nagesh Chopra, David W Piston, Sabine Huke, Björn C Knollmann. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.
Journal of molecular and cellular cardiology.
2010 Feb; 48(2):293-301. doi:
10.1016/j.yjmcc.2009.10.005. [PMID: 19835880] - Richard T Addo, Aladin Siddig, Rodney Siwale, Neil J Patel, Janet Akande, Akm N Uddin, Martin J D'Souza. Formulation, characterization and testing of tetracaine hydrochloride-loaded albumin-chitosan microparticles for ocular drug delivery.
Journal of microencapsulation.
2010; 27(2):95-104. doi:
10.3109/02652040903010638. [PMID: 20055748] - Hanwen Sun, Ming Su, Liqing Li. Simultaneous determination of tetracaine, proline, and enoxacin in human urine by CE with ECL detection.
Journal of chromatographic science.
2010 Jan; 48(1):49-54. doi:
10.1093/chromsci/48.1.49. [PMID: 20056036] - Koichi Takeda, Hiroko Okuno, Takashi Hata, Makoto Nishimoto, Hitoshi Matsuki, Shoji Kaneshina. Interdigitation and vesicle-to-micelle transformation induced by a local anesthetic tetracaine in phospholipids bilayers.
Colloids and surfaces. B, Biointerfaces.
2009 Aug; 72(1):135-40. doi:
10.1016/j.colsurfb.2009.03.026. [PMID: 19403276] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - Trang T Nguyen, Kelvin Rembert, John C Conboy. Label-free detection of drug-membrane association using ultraviolet-visible sum-frequency generation.
Journal of the American Chemical Society.
2009 Feb; 131(4):1401-3. doi:
10.1021/ja8070607. [PMID: 19140762] - H T Syyong, H H C Yang, G Trinh, C Cheung, K H Kuo, C van Breemen. Mechanism of asynchronous Ca(2+) waves underlying agonist-induced contraction in the rat basilar artery.
British journal of pharmacology.
2009 Feb; 156(4):587-600. doi:
10.1111/j.1476-5381.2008.00063.x. [PMID: 19154440] - Mingyou Qin, Shaopu Liu, Zhongfang Liu, Xiaoli Hu. Resonance Rayleigh scattering spectra, non-linear scattering spectra of tetracaine hydrochloride-erythrosin system and its analytical application.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2009 Jan; 71(5):2063-8. doi:
10.1016/j.saa.2008.08.003. [PMID: 18976950] - Shanmugam Sivabalan, Shanmugam Renuka, Venugopal P Menon. Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar rats.
International archives of medicine.
2008 May; 1(1):7. doi:
10.1186/1755-7682-1-7. [PMID: 18500989] - Penny Y T Wang, Liora Caspi, Carol K L Lam, Madhu Chari, Xiaosong Li, Peter E Light, Roger Gutierrez-Juarez, Michelle Ang, Gary J Schwartz, Tony K T Lam. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.
Nature.
2008 Apr; 452(7190):1012-6. doi:
10.1038/nature06852. [PMID: 18401341] - John E Baenziger, Stephen E Ryan, Michael M Goodreid, Ngoc Q Vuong, Raymond M Sturgeon, Corrie J B daCosta. Lipid composition alters drug action at the nicotinic acetylcholine receptor.
Molecular pharmacology.
2008 Mar; 73(3):880-90. doi:
10.1124/mol.107.039008. [PMID: 18055762] - Ming-You Qin, Shao-Pu Liu, Zhong-Fang Liu, Xiao-Li Hu. [Fluorescence quenching reaction of tetracaine hydrochloride with erythrosine and their analytical applications].
Guang pu xue yu guang pu fen xi = Guang pu.
2008 Feb; 28(2):389-93. doi:
NULL. [PMID: 18479029] - Tim M Curtis, James Tumelty, Michael T Stewart, A Rakha Arora, F Anthony Lai, Mary K McGahon, C Norman Scholfield, J Graham McGeown. Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.
Cell calcium.
2008 Feb; 43(2):142-54. doi:
10.1016/j.ceca.2007.04.016. [PMID: 17574671] - Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura. Local anesthetic failure associated with inflammation: verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite.
Journal of inflammation research.
2008; 1(?):41-8. doi:
10.2147/jir.s3982. [PMID: 22096346] - Lazarre Ogden, Georgette Love, Susan Basta. Systemic exposure to lidocaine and tetracaine is low after an application of a lidocaine 7\%-tetracaine 7\% peel in adults.
International journal of dermatology.
2008 Jan; 47(1):87-90. doi:
10.1111/j.1365-4632.2007.03331.x. [PMID: 18173612] - Yu-An Zhang, Richard A Tuft, Lawrence M Lifshitz, Kevin E Fogarty, Joshua J Singer, Hui Zou. Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance.
American journal of physiology. Heart and circulatory physiology.
2007 Oct; 293(4):H2448-61. doi:
10.1152/ajpheart.00032.2007. [PMID: 17483243] - Virgilio L Lew, Nuala Daw, Zipora Etzion, Teresa Tiffert, Adaeze Muoma, Laura Vanagas, Robert M Bookchin. Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells.
Blood.
2007 Aug; 110(4):1334-42. doi:
10.1182/blood-2006-11-057232. [PMID: 17456724] - Jingzhong Zhang, Theresa Hadlock, Alison Gent, Gary R Strichartz. Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization.
Biophysical journal.
2007 Jun; 92(11):3988-4001. doi:
10.1529/biophysj.106.102434. [PMID: 17351014] - Varaporn Buraphacheep Junyaprasert, Prapaporn Boonme, Sarunyoo Songkro, Karen Krauel, Thomas Rades. Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2007; 10(3):288-98. doi:
". [PMID: 17727792] - Sven O Hagge, Malte U Hammer, Andre Wiese, Ulrich Seydel, Thomas Gutsmann. Calcium adsorption and displacement: characterization of lipid monolayers and their interaction with membrane-active peptides/proteins.
BMC biochemistry.
2006 May; 7(?):15. doi:
10.1186/1471-2091-7-15. [PMID: 16672047] - Mohammad Changez, Jagdish Chander, Amit Kumar Dinda. Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: in vivo.
Colloids and surfaces. B, Biointerfaces.
2006 Mar; 48(1):58-66. doi:
10.1016/j.colsurfb.2006.01.007. [PMID: 16497490] - Ilaria Guidi, Daniela Galimberti, Silvia Lonati, Cristina Novembrino, Fabrizia Bamonti, Marco Tiriticco, Chiara Fenoglio, Eliana Venturelli, Pierluigi Baron, Nereo Bresolin, Elio Scarpini. Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease.
Neurobiology of aging.
2006 Feb; 27(2):262-9. doi:
10.1016/j.neurobiolaging.2005.01.001. [PMID: 16399211] - Ming Ma, Shaoying Kang, Qian Zhao, Bo Chen, Shouzhuo Yao. Liquid-phase microextraction combined with high-performance liquid chromatography for the determination of local anaesthetics in human urine.
Journal of pharmaceutical and biomedical analysis.
2006 Jan; 40(1):128-35. doi:
10.1016/j.jpba.2005.06.023. [PMID: 16076540] - Amelie Lupp, Elke Karge, Johannes Wange, Claudia Eisentraut, Tobias Zwenizner, Herbert Oelschläger, Christian Fleck. In vitro interactions with the Cytochrome P450 system, toxicity, and local anaesthetic effects of Fomocaine Alkylmorpholine derivatives in rats.
Arzneimittel-Forschung.
2006; 56(1):1-11. doi:
10.1055/s-0031-1296694. [PMID: 16477999] - Akio Jinnouchi, Yoshitomi Aida, Kohji Nozoe, Katsumasa Maeda, Michael J Pabst. Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms.
Journal of leukocyte biology.
2005 Dec; 78(6):1356-65. doi:
10.1189/jlb.0305169. [PMID: 16204644] - Tomoyuki Araki, Yukifumi Uesono, Tomoko Oguchi, Akio Toh-E. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast.
Genes & genetic systems.
2005 Oct; 80(5):325-43. doi:
10.1266/ggs.80.325. [PMID: 16394584] - Yanming F Wang, Judith K Gwathmey, Guorong Zhang, Sulpicio G Soriano, Shunli He, Yanguang Wang. Cerebrospinal fluid may mediate CNS ischemic injury.
Cerebrospinal fluid research.
2005 Sep; 2(?):7. doi:
10.1186/1743-8454-2-7. [PMID: 16174300] - A P Galenko-Yaroshevskii, P N Fistunenko, A S Dukhanin. Kinetics of interaction of local anesthetics with human serum albumin.
Bulletin of experimental biology and medicine.
2005 Sep; 140(3):315-6. doi:
10.1007/s10517-005-0477-x. [PMID: 16307046] - Chiara Pincin, Loretta Ferrera, Oscar Moran. Minimal sodium channel pore consisting of S5-P-S6 segments preserves intracellular pharmacology.
Biochemical and biophysical research communications.
2005 Aug; 334(1):140-4. doi:
10.1016/j.bbrc.2005.06.068. [PMID: 15992775] - A Shibata, K Maeda, H Ikema, S Ueno, Y Suezaki, S Liu, Y Baba, I Ueda. Local anesthetics facilitate ion transport across lipid planar bilayer membranes under an electric field: dependence on type of lipid bilayer.
Colloids and surfaces. B, Biointerfaces.
2005 May; 42(3-4):197-203. doi:
10.1016/j.colsurfb.2005.02.006. [PMID: 15893219] - Dali Luo, Hongli Sun, Xiaomei Lan, RuiPing Xiao, Qide Han. Direct coupling between arachidonic acid-induced Ca2+ release and Ca2+ entry in HEK293 cells.
Prostaglandins & other lipid mediators.
2005 Jan; 75(1-4):141-51. doi:
10.1016/j.prostaglandins.2004.11.004. [PMID: 15789621] - Vittorio Luzzati, Evelyne Benoit, Gilles Charpentier, Patrice Vachette. X-ray scattering study of pike olfactory nerve: elastic, thermodynamic and physiological properties of the axonal membrane.
Journal of molecular biology.
2004 Oct; 343(1):199-212. doi:
10.1016/j.jmb.2004.08.029. [PMID: 15381430] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - H Thomas Lee, Igor E Krichevsky, Hua Xu, Ayuko Ota-Setlik, Vivette D D'Agati, Charles W Emala. Local anesthetics worsen renal function after ischemia-reperfusion injury in rats.
American journal of physiology. Renal physiology.
2004 Jan; 286(1):F111-9. doi:
10.1152/ajprenal.00108.2003. [PMID: 14519592] - S B Mantipragada, L I Horváth, H R Arias, G Schwarzmann, K Sandhoff, F J Barrantes, D Marsh. Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ.
Biochemistry.
2003 Aug; 42(30):9167-75. doi:
10.1021/bi034485q. [PMID: 12885251] - H Thomas Lee, Hua Xu, Cory D Siegel, Igor E Krichevsky. Local anesthetics induce human renal cell apoptosis.
American journal of nephrology.
2003 May; 23(3):129-39. doi:
10.1159/000069304. [PMID: 12586958]
