Xanthine (BioDeep_00000400028)

Main id: BioDeep_00000001096

Secondary id: BioDeep_00000229633, BioDeep_00000868735

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Xanthine

化学式: C5H4N4O2 (152.0334)
中文名称: 黄嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 36.42%

分子结构信息

SMILES: C1=NC2=C(N1)C(=O)NC(=O)N2
InChI: InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)

描述信息

COVID info from COVID-19 Disease Map, PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; LRFVTYWOQMYALW_STSL_0180_Xanthine_0500fmol_180506_S2_LC02_MS02_265; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation[1][2][3].
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation[1][2][3].
Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation[1][2][3].

同义名列表

3 个代谢物同义名

Xanthine; Xanthine; Xanthine



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(20)

PlantCyc(11)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ADA, ALB, APRT, BCL2, CASP3, CAT, EMP2, PNP, PRKX, XDH
Peripheral membrane protein 2 ADA, HSD17B6
Endoplasmic reticulum membrane 1 BCL2
Nucleus 5 ALB, BCL2, CASP3, EMP2, PRKX
cytosol 10 ADA, ALB, APRT, BCL2, CASP3, CAT, GDA, GPT, PNP, XDH
dendrite 2 ADORA1, ADORA2A
centrosome 1 ALB
nucleoplasm 3 APRT, CASP3, PRKX
Cell membrane 6 ADA, ADORA1, ADORA2A, DPP4, EMP2, TNF
lamellipodium 1 DPP4
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 ADORA1, ADORA2A, EMP2, GDA
Golgi apparatus membrane 1 EMP2
Synapse 1 ADORA1
cell junction 2 ADA, DPP4
cell surface 4 ADA, DPP4, EMP2, TNF
glutamatergic synapse 3 ADORA2A, ADORA2B, CASP3
Golgi apparatus 2 ALB, EMP2
Golgi membrane 2 EMP2, INS
lysosomal membrane 1 DPP4
mitochondrial inner membrane 1 GDA
neuronal cell body 4 ADORA1, ADORA2A, CASP3, TNF
presynaptic membrane 2 ADORA1, ADORA2A
Lysosome 1 ADA
Presynapse 1 ADORA2B
plasma membrane 7 ADA, ADORA1, ADORA2A, ADORA2B, DPP4, EMP2, TNF
presynaptic active zone 2 ADORA1, ADORA2A
terminal bouton 1 ADORA1
Membrane 7 ADA, ADORA2A, ADORA2B, BCL2, CAT, DPP4, EMP2
apical plasma membrane 2 DPP4, EMP2
basolateral plasma membrane 1 ADORA1
extracellular exosome 6 ALB, APRT, CAT, DPP4, GPT, PNP
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 ALB, BCL2, HSD17B6
extracellular space 6 ALB, IL6, INS, PNP, TNF, XDH
perinuclear region of cytoplasm 1 EMP2
Schaffer collateral - CA1 synapse 1 ADORA2B
intercellular canaliculus 1 DPP4
mitochondrion 3 BCL2, CAT, GDA
protein-containing complex 3 ALB, BCL2, CAT
intracellular membrane-bounded organelle 2 CAT, HSD17B6
Microsome membrane 1 HSD17B6
postsynaptic density 1 CASP3
Secreted 5 ALB, DPP4, IL6, INS, PNP
extracellular region 8 ALB, APRT, CAT, DPP4, IL6, INS, PNP, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, DPP4
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 3 ADA, ALB, DPP4
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ADA, TNF
dendritic spine 1 ADORA1
cytoplasmic vesicle 1 EMP2
apical part of cell 1 EMP2
recycling endosome 1 TNF
Single-pass type II membrane protein 2 DPP4, TNF
postsynaptic membrane 2 ADORA1, ADORA2A
Apical cell membrane 2 DPP4, EMP2
Cytoplasm, perinuclear region 1 EMP2
Mitochondrion inner membrane 1 GDA
Membrane raft 3 DPP4, EMP2, TNF
pore complex 1 BCL2
focal adhesion 2 CAT, DPP4
axolemma 2 ADORA1, ADORA2A
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
intermediate filament 1 ADORA2A
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 1 DPP4
endosome lumen 1 INS
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, PNP
secretory granule lumen 4 APRT, CAT, INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 DPP4
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calyx of Held 1 ADORA1
death-inducing signaling complex 1 CASP3
lamellipodium membrane 1 DPP4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
Cell projection, lamellipodium membrane 1 DPP4
interleukin-6 receptor complex 1 IL6
Cell projection, invadopodium membrane 1 DPP4
asymmetric synapse 2 ADORA1, ADORA2A
BAD-BCL-2 complex 1 BCL2
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yanfen Zheng, Xuwen Cao, Yanan Zhou, Siqi Ma, Youqiang Wang, Zhe Li, Donglin Zhao, Yanzhe Yang, Han Zhang, Chen Meng, Zhihong Xie, Xiaona Sui, Kangwen Xu, Yiqiang Li, Cheng-Sheng Zhang. Purines enrich root-associated Pseudomonas and improve wild soybean growth under salt stress. Nature communications. 2024 Apr; 15(1):3520. doi: 10.1038/s41467-024-47773-9. [PMID: 38664402]
  • Ningxia Xu, Meng Xiao, Zipei Yu, Baohui Jin, Mengsu Yang, Changqing Yi. On-site quantitation of xanthine in fish and serum using a smartphone-based spectrophotometer integrated with a dual-readout nanosensing assay. Food chemistry. 2024 Jan; 431(?):137107. doi: 10.1016/j.foodchem.2023.137107. [PMID: 37562333]
  • Monika Kubacka, Szczepan Mogilski, Marek Bednarski, Krzysztof Pociecha, Artur Świerczek, Noemi Nicosia, Jakub Schabikowski, Michał Załuski, Grażyna Chłoń-Rzepa, Jörg Hockemeyer, Christa E Müller, Katarzyna Kieć-Kononowicz, Magdalena Kotańska. Antiplatelet Effects of Selected Xanthine-Based Adenosine A2A and A2B Receptor Antagonists Determined in Rat Blood. International journal of molecular sciences. 2023 Aug; 24(17):. doi: 10.3390/ijms241713378. [PMID: 37686188]
  • Xiaoyan Feng, Hongkun Ma, Lina Zou, Yingyao Wang, Yannan Zhang, Yan Wang, Jiaxin Chen, Hongzhi Pan, Shengzhong Rong. Determination of purines in prepackaged food using optimum acid hydrolysis followed by high performance liquid chromatography. Food chemistry. 2023 Aug; 417(?):135813. doi: 10.1016/j.foodchem.2023.135813. [PMID: 36913870]
  • Ahlam Majid Azeez, Mahmoud Hussain Hadwan. Simple assay for quantifying xanthine oxidase activity. Analytical biochemistry. 2023 May; 673(?):115192. doi: 10.1016/j.ab.2023.115192. [PMID: 37225068]
  • Mihaya Kotajima, Jae-Hoon Choi, Tomohiro Suzuki, Jing Wu, Hirofumi Hirai, David C Nelson, Hitoshi Ouchi, Makoto Inai, Hideo Dohra, Hirokazu Kawagishi. The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida. Bioscience, biotechnology, and biochemistry. 2023 Jan; ?(?):. doi: 10.1093/bbb/zbad005. [PMID: 36756780]
  • Peiyu Wang, Yuyao Yuan, Mantang Qiu. Identification of Plasma Metabolites Associated with Lung Cancer Survival. Methods in molecular biology (Clifton, N.J.). 2023; 2695(?):181-193. doi: 10.1007/978-1-0716-3346-5_12. [PMID: 37450119]
  • Shuyun Zhang, Lei Wang, Hang Liu, Na Yang, Shujing Yu, Baolei Wang. Synthesis, Crystal Structures, and Biological Activity Evaluation of Novel Xanthine Derivatives Containing a Pyrethroid Moiety. Journal of agricultural and food chemistry. 2022 Oct; 70(39):12330-12340. doi: 10.1021/acs.jafc.2c03876. [PMID: 36148494]
  • Stefano Fornasaro, Alessandro Esposito, Fiorella Florian, Alberto Pallavicini, Luigina De Leo, Tarcisio Not, Cristina Lagatolla, Marica Mezzarobba, Alessia Di Silvestre, Valter Sergo, Alois Bonifacio. Spectroscopic investigation of faeces with surface-enhanced Raman scattering: a case study with coeliac patients on gluten-free diet. Analytical and bioanalytical chemistry. 2022 May; 414(11):3517-3527. doi: 10.1007/s00216-022-03975-y. [PMID: 35258650]
  • Zhi Luo, Hetao Wang, Simin Lin, Lili Liao, Lishan Cai, Xiaoxu Zhang, Yangying Tan, Mei Shen. Study on the levels of N-nitrosamine compounds and untargeted metabolomics in patients with colorectal cancer. Analytical and bioanalytical chemistry. 2022 May; 414(11):3483-3496. doi: 10.1007/s00216-022-03969-w. [PMID: 35174409]
  • Xuanxuan An, Qin Tan, Shuang Pan, Shujun Zhen, Yongmei Hu, Xiaoli Hu. Determination of xanthine using a ratiometric fluorescence probe based on boron-doped carbon quantum dots and gold nanoclusters. Mikrochimica acta. 2022 03; 189(4):148. doi: 10.1007/s00604-021-05139-8. [PMID: 35299262]
  • Masahiro Ohira, Shou Tanaka, Yasuhiro Watanabe, Shoko Nakamura, Rena Oka, Takashi Yamaguchi, Noriko Ban, Atsuhito Saiki, Noriko Ishihara, Takeyoshi Murano, Takayo Murase, Takashi Nakamura, Ichiro Tatsuno. Association of Plasma Xanthine Oxidoreductase with Arterial Stiffness in Type 2 Diabetes with Liver Dysfunction. The American journal of the medical sciences. 2022 03; 363(3):242-250. doi: 10.1016/j.amjms.2021.09.011. [PMID: 34619144]
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  • Dmitri Svistounov, Marit D Solbu, Trond G Jenssen, Ulla Dorte Mathisen, Terkel Hansen, Katja Benedikte Prestø Elgstøen, Svetlana N Zykova. Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry. Scandinavian journal of clinical and laboratory investigation. 2022 02; 82(1):37-49. doi: 10.1080/00365513.2021.2015799. [PMID: 35048747]
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  • Lingyu Ruan, Lei Jiang, Wenlong Zhao, Huihui Meng, Qi Zheng, Junsong Wang. Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by 1H-NMR metabolomics profiling. Toxicology and applied pharmacology. 2021 11; 431(?):115734. doi: 10.1016/j.taap.2021.115734. [PMID: 34606778]
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  • Liang Yue, Nan Jiang, Anguo Wu, Wenqiao Qiu, Xin Shen, Dalian Qin, Hong Li, Jing Lin, Sicheng Liang, Jianming Wu. Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies. BMC pharmacology & toxicology. 2021 07; 22(1):45. doi: 10.1186/s40360-021-00511-z. [PMID: 34274011]
  • So Young Yi, Myungjin Lee, Jana Jeevan Rameneni, Lu Lu, Chetan Kaur, Yong Pyo Lim. Xanthine-derived metabolites enhance chlorophyll degradation in cotyledons and seedling growth during nitrogen deficient condition in Brassica rapa. Plant signaling & behavior. 2021 06; 16(6):1913309. doi: 10.1080/15592324.2021.1913309. [PMID: 33955825]
  • Smitha Sivapragasam, Arpita Ghosh, Sanjay Kumar, Danté T Johnson, Anne Grove. Similar solutions to a common challenge: regulation of genes encoding Ralstonia solanacearum xanthine dehydrogenase. FEMS microbiology letters. 2021 03; 368(4):. doi: 10.1093/femsle/fnab022. [PMID: 33620442]
  • Lu Kang, Ju Liu, Hongyang Zhang, Min Jiang, Yidian Jin, Min Zhang, Ping Hu. Improved ultra-high performance liquid chromatographic method for simultaneous determination of five gout-related metabolites in human serum. Journal of separation science. 2021 Mar; 44(5):954-962. doi: 10.1002/jssc.202000974. [PMID: 33348445]
  • Tomoko Okuyama, Jun Shirakawa, Takashi Nakamura, Takayo Murase, Daisuke Miyashita, Ryota Inoue, Mayu Kyohara, Yu Togashi, Yasuo Terauchi. Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes. Scientific reports. 2021 02; 11(1):3768. doi: 10.1038/s41598-021-83234-9. [PMID: 33580173]
  • Bin Wei, Sijia Wang, Yakun Wang, Songze Ke, Weihua Jin, Jianwei Chen, Huawei Zhang, Jiadong Sun, Susanne M Henning, Jian Wang, Hong Wang. Gut microbiota-mediated xanthine metabolism is associated with resistance to high-fat diet-induced obesity. The Journal of nutritional biochemistry. 2021 02; 88(?):108533. doi: 10.1016/j.jnutbio.2020.108533. [PMID: 33250443]
  • Dan Li, Fangfang Chen, Na Li, Xiwen Ye, Ying Sun, Pinyi Ma, Daqian Song, Xinghua Wang. Sensitive ratiometric fluorescence assay for detecting xanthine in serum based on the inner filter effect of enzyme-catalyzed oxidation products to silicon nanoparticles. Analytical and bioanalytical chemistry. 2021 Feb; 413(5):1405-1415. doi: 10.1007/s00216-020-03104-7. [PMID: 33388845]
  • Tingting Sun, Tingting Pei, Lulu Yang, Zhijun Zhang, Mingjun Li, Yuerong Liu, Fengwang Ma, Changhai Liu. Exogenous application of xanthine and uric acid and nucleobase-ascorbate transporter MdNAT7 expression regulate salinity tolerance in apple. BMC plant biology. 2021 Jan; 21(1):52. doi: 10.1186/s12870-021-02831-y. [PMID: 33468049]
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  • Hung-Cheng Hsu, Pei-Wen Liao, Hsiang-Tzu Lee, Wei-Chen Liu, Mei-Lin Ho. Silver Nanoplates for Colorimetric Determination of Xanthine in Human Plasma and in Fish Meat via Etching/Aggregation/Fusion Steps. Sensors (Basel, Switzerland). 2020 Oct; 20(20):. doi: 10.3390/s20205739. [PMID: 33050252]
  • Ying Cui, Junhua Li, Mengqin Liu, Haixia Tong, Zeng Liu, Jiawen Hu, Dong Qian. Convenient synthesis of three-dimensional hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide for non-enzymatic electrochemical sensing of xanthine. Mikrochimica acta. 2020 10; 187(11):589. doi: 10.1007/s00604-020-04570-7. [PMID: 33033940]
  • Yiran Wang, Hongbin Zhao, Huixian Song, Junping Dong, Jiaqiang Xu. Monodispersed gold nanoparticles entrapped in ordered mesoporous carbon/silica nanocomposites as xanthine oxidase mimic for electrochemical sensing of xanthine. Mikrochimica acta. 2020 09; 187(10):543. doi: 10.1007/s00604-020-04494-2. [PMID: 32880716]
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