2-pyridone (BioDeep_00000399997)

Main id: BioDeep_00000003077

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


2-HYDROXYPYRIDINE

化学式: C5H5NO (95.0371)
中文名称: 2-羟基吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=O)NC=C1
InChI: InChI=1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)

描述信息

α-Pyridone is an endogenous metabolite.

同义名列表

6 个代谢物同义名

2-HYDROXYPYRIDINE; 2-Pyridinol; 2-pyridone; α-Pyridone; 2-Hydroxypyridine; 2-Hydroxypyridine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 BCL2, CASP3, CNR1, CNR2, EGFR, FPR2, MAPK8, MT4, PMP2, PSMA1, PTGS2, SH2D1A, SNCA
Peripheral membrane protein 2 CYP1B1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, EGFR, PTGS2
Nucleus 8 BCL2, CASP3, EGFR, MAPK8, MT4, PMP2, PSMA1, SNCA
cytosol 8 BCL2, CASP3, IL2RG, MAPK8, PMP2, PSMA1, SH2D1A, SNCA
dendrite 1 CNR2
centrosome 1 PSMA1
nucleoplasm 4 CASP3, IL2RG, MAPK8, PSMA1
Cell membrane 7 APLNR, CNR1, EGFR, FPR2, IL2RG, PROKR2, TNF
ruffle membrane 1 EGFR
Cell projection, axon 2 CNR1, SNCA
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 CNR1, FPR2, PROKR2
Synapse 2 MAPK8, SNCA
cell cortex 1 SNCA
cell junction 1 EGFR
cell surface 3 EGFR, IL2RG, TNF
glutamatergic synapse 3 CASP3, CNR1, EGFR
Golgi membrane 1 EGFR
growth cone 2 CNR1, SNCA
neuronal cell body 3 CASP3, SNCA, TNF
postsynapse 1 SNCA
presynaptic membrane 1 CNR1
Lysosome 1 SNCA
Presynapse 1 CNR1
endosome 2 EGFR, IL2RG
plasma membrane 10 APLNR, CNR1, CNR2, EGFR, F2, FPR2, IL2RG, PROKR2, SNCA, TNF
synaptic vesicle membrane 1 SNCA
Membrane 6 BCL2, CYP1B1, EGFR, FPR2, IL2RG, SNCA
apical plasma membrane 1 EGFR
axon 3 CNR1, MAPK8, SNCA
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 3 F2, PMP2, PSMA1
endoplasmic reticulum 4 BCL2, CNR2, IL2RG, PTGS2
extracellular space 5 EGFR, F2, IL6, SNCA, TNF
perinuclear region of cytoplasm 2 EGFR, SNCA
mitochondrion 3 BCL2, CYP1B1, SNCA
protein-containing complex 4 BCL2, EGFR, PTGS2, SNCA
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, IL2RG
Secreted 3 F2, IL6, SNCA
extracellular region 4 F2, IL6, SNCA, TNF
Mitochondrion outer membrane 2 BCL2, CNR1
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CNR1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 IL2RG, TNF
actin cytoskeleton 2 CNR1, SNCA
perikaryon 1 CNR2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CNR2
Membrane raft 3 CNR1, EGFR, TNF
pore complex 1 BCL2
focal adhesion 1 EGFR
GABA-ergic synapse 1 CNR1
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 F2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 EGFR, IL2RG
neuron projection 1 PTGS2
phagocytic cup 1 TNF
supramolecular fiber 1 SNCA
blood microparticle 1 F2
Cell projection, dendrite 1 CNR2
specific granule membrane 1 FPR2
tertiary granule membrane 1 FPR2
myelin sheath 2 BCL2, PMP2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
proteasome complex 1 PSMA1
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
axon terminus 1 SNCA
proteasome core complex 1 PSMA1
proteasome core complex, alpha-subunit complex 1 PSMA1
clathrin-coated endocytic vesicle membrane 1 EGFR
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
ficolin-1-rich granule membrane 1 FPR2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 SNCA
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Rotchana Klaram, Tida Dethoup, Fátima P Machado, Luís Gales, Decha Kumla, Salar Hafez Ghoran, Emília Sousa, Sharad Mistry, Artur M S Silva, Anake Kijjoa. Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732. Marine drugs. 2023 Jun; 21(6):. doi: 10.3390/md21060344. [PMID: 37367669]
  • Yaojie Guo, Fabiano J Contesini, Xinhui Wang, Simone Ghidinelli, Ditte S Tornby, Thomas E Andersen, Uffe H Mortensen, Thomas O Larsen. Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in Aspergillus californicus. Organic letters. 2022 01; 24(3):804-808. doi: 10.1021/acs.orglett.1c03792. [PMID: 35045257]
  • Bo Chen, Yanlei Sun, Shiqin Li, Ying Yin, Chengshu Wang. Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches. mBio. 2021 12; 12(6):e0327921. doi: 10.1128/mbio.03279-21. [PMID: 34903054]
  • Ishaat M Khan, Sonam Shakya, Roushan Akhtar, Kehkashan Alam, Maidul Islam, Nisat Alam. Exploring interaction dynamics of designed organic cocrystal charge transfer complex of 2-hydroxypyridine and oxalic acid with human serum albumin: Single crystal, spectrophotometric, theoretical and antimicrobial studies. Bioorganic chemistry. 2020 07; 100(?):103872. doi: 10.1016/j.bioorg.2020.103872. [PMID: 32348934]
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