mefenamic acid (BioDeep_00000399178)
Main id: BioDeep_00000001546
natural product
代谢物信息卡片
mefenamic acid
化学式: C15H15NO2 (241.1103)
中文名称: 甲芬那酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1C(=CC=CC=1)NC2C(=C(C=CC=2)C)C)(=O)O
InChI: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:6717
- KEGG: C02168
- KEGGdrug: D00151
- PubChem: 4044
- DrugBank: DB00784
- ChEMBL: CHEMBL686
- MeSH: Mefenamic Acid
- CAS: 61-68-7
- MoNA: WA001185
- MoNA: WA001184
- MoNA: WA001183
- MoNA: WA001182
- MoNA: WA001181
- MoNA: WA001180
- MoNA: WA001179
- MoNA: CCMSLIB00000078649
- ChEBI: CHEBI:174348
- PubChem: 5243
- PDB-CCD: ID8
- NIKKAJI: J2.344B
- RefMet: Mefenamic acid
- KNApSAcK: 174348
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jose Guzman-Esquivel, Hector R Galvan-Salazar, Hannah P Guzman-Solorzano, Andrea C Cuevas-Velazquez, Jose A Guzman-Solorzano, Karen A Mokay-Ramirez, Brenda A Paz-Michel, Efren Murillo-Zamora, Josuel Delgado-Enciso, Valery Melnikov, Osiris G Delgado-Enciso, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Fabian Rojas-Larios, Mireya Walle-Guillen, Citlaly B Cardenas-Aguilar, Oscar Beas-Guzman, Daniel Chaviano-Conesa, Hossana S Garcia-Garcia, Ivan Delgado-Enciso. Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized double‑blind placebo‑controlled trial.
International journal of molecular medicine.
2022 Mar; 49(3):. doi:
10.3892/ijmm.2022.5084. [PMID: 35029292] - Dounia Sid, Milad Baitiche, Zineb Elbahri, Ferhat Djerboua, Mokhtar Boutahala, Zouhair Bouaziz, Marc Le Borgne. Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):605-617. doi:
10.1080/14756366.2020.1869225. [PMID: 33557644] - Yan Rong, Tony K L Kiang. Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification.
Toxicology and applied pharmacology.
2021 08; 425(?):115553. doi:
10.1016/j.taap.2021.115553. [PMID: 33915121] - Rami Ayoub, Qais Jarrar, Dalia Ali, Said Moshawih, Yazun Jarrar, Muhammad Hakim, Zainul Zakaria. Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA, Opioid and Glutamate Receptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Aug; 163(?):105865. doi:
10.1016/j.ejps.2021.105865. [PMID: 33979659] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Fatemeh Darvishnejad, Jahan Bakhsh Raoof, Milad Ghani. In-situ synthesis of nanocubic cobalt oxide @ graphene oxide nanocomposite reinforced hollow fiber-solid phase microextraction for enrichment of non-steroidal anti-inflammatory drugs from human urine prior to their quantification via high-performance liquid chromatography-ultraviolet detection.
Journal of chromatography. A.
2021 Mar; 1641(?):461984. doi:
10.1016/j.chroma.2021.461984. [PMID: 33611121] - Ernesto Callegari, Jian Lin, Susanna Tse, Theunis C Goosen, Vaishali Sahasrabudhe. Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.
CPT: pharmacometrics & systems pharmacology.
2021 02; 10(2):127-136. doi:
10.1002/psp4.12581. [PMID: 33314761] - Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D E Sewell, Mahmoud Rafieian-Kopaei. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis.
Journal of complementary & integrative medicine.
2021 Jan; 18(2):261-269. doi:
10.1515/jcim-2019-0212. [PMID: 34187122] - Zahra Jafari, Mohammad Reza Hadjmohammadi. A banana peel/silicon glue coated stir bar for extraction of aspirin, diclofenac, ibuprofen and mefenamic acid followed by high performance liquid chromatography-UV detection.
Analytical methods : advancing methods and applications.
2020 09; 12(36):4429-4437. doi:
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Journal of medicinal chemistry.
2020 08; 63(15):8314-8324. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1142(?):122039. doi:
10.1016/j.jchromb.2020.122039. [PMID: 32163902] - Qais Bashir Jarrar, Muhammad Nazrul Hakim, Zainul Amiruddin Zakaria, Manraj Singh Cheema, Said Moshawih. Renal ultrastructural alterations induced by various preparations of mefenamic acid.
Ultrastructural pathology.
2020 Jan; 44(1):130-140. doi:
10.1080/01913123.2020.1717705. [PMID: 31967489] - Hmed Ben-Nasr, Kamilia Ksouda, Bahira Harrabi, Serria Turki Hammami, Khaled Zeghal, Hanen Affes. Pediatric liver failure following mefenamic acid associated to herbal auto-medication: A case report.
Therapie.
2019 12; 74(6):677-680. doi:
10.1016/j.therap.2019.04.001. [PMID: 31635831] - Tianlang Zhang, Junlang Qiu, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. Uptake of pharmaceuticals acts as an abiotic stress and triggers variation of jasmonates in Malabar spinach (Basella alba. L).
Chemosphere.
2019 Dec; 236(?):124711. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram. Application of hydrophobic deep eutectic solvent as the carrier for ferrofluid: A novel strategy for pre-concentration and determination of mefenamic acid in human urine samples by high performance liquid chromatography under experimental design optimization.
Talanta.
2019 Sep; 202(?):526-530. doi:
10.1016/j.talanta.2019.05.027. [PMID: 31171217] - Yang Li, Yingmin Liao, Youfang Huang, Ziwen Ye, Xiaojia Huang. Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples.
Talanta.
2019 Aug; 201(?):496-502. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Aug; 1122-1123(?):49-57. doi:
10.1016/j.jchromb.2019.05.023. [PMID: 31153131] - Z Raisi Dehkordi, M Rafieian-Kopaei, F S Hosseini-Baharanchi. A double-blind controlled crossover study to investigate the efficacy of salix extract on primary dysmenorrhea.
Complementary therapies in medicine.
2019 Jun; 44(?):102-109. doi:
10.1016/j.ctim.2019.04.002. [PMID: 31126541] - Shahram Seidi, Sasan Eshghi Sanàti. Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV.
Mikrochimica acta.
2019 04; 186(5):297. doi:
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Analytica chimica acta.
2019 Mar; 1051(?):58-72. doi:
10.1016/j.aca.2018.11.041. [PMID: 30661620] - Alketa Tarushi, George D Geromichalos, Dimitris P Kessissoglou, George Psomas. Manganese coordination compounds of mefenamic acid: In vitro screening and in silico prediction of biological activity.
Journal of inorganic biochemistry.
2019 01; 190(?):1-14. doi:
10.1016/j.jinorgbio.2018.09.017. [PMID: 30312777] - Mukesh Kumar, Dilpreet Singh, Neena Bedi. Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile.
Therapeutic delivery.
2019 01; 10(1):21-36. doi:
10.4155/tde-2018-0053. [PMID: 30730824] - Ian Cook, Ting Wang, Thomas S Leyh. Isoform-specific therapeutic control of sulfonation in humans.
Biochemical pharmacology.
2019 01; 159(?):25-31. doi:
10.1016/j.bcp.2018.11.010. [PMID: 30423313] - Yazun Jarrar, Qais Jarrar, Mohammad Abu-Shalhoob, Abdulqader Abed, Esra'a Sha'ban. Relative Expression of Mouse Udp-glucuronosyl Transferase 2b1 Gene in the Livers, Kidneys, and Hearts: The Influence of Nonsteroidal Anti-inflammatory Drug Treatment.
Current drug metabolism.
2019; 20(11):918-923. doi:
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Talanta.
2018 Aug; 185(?):80-88. doi:
10.1016/j.talanta.2018.03.058. [PMID: 29759253] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
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Journal of biochemical and molecular toxicology.
2018 Apr; 32(4):e22043. doi:
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2018 Jan; 997(?):67-79. doi:
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Cancer chemotherapy and pharmacology.
2016 10; 78(4):709-18. doi:
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2016 Sep; 73(5):1287-1297. doi:
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Journal of inorganic biochemistry.
2016 07; 160(?):125-39. doi:
10.1016/j.jinorgbio.2015.12.015. [PMID: 26775611] - Hussin A Rothan, Hirbod Bahrani, Ammar Y Abdulrahman, Zulqarnain Mohamed, Teow Chong Teoh, Shatrah Othman, Nurshamimi Nor Rashid, Noorsaadah A Rahman, Rohana Yusof. Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo.
Antiviral research.
2016 Mar; 127(?):50-6. doi:
10.1016/j.antiviral.2016.01.006. [PMID: 26794398] - Panagiotis Theodosis-Nobelos, Malamati Kourti, Antonios Gavalas, Eleni A Rekka. Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Bioorganic & medicinal chemistry letters.
2016 Feb; 26(3):910-913. doi:
10.1016/j.bmcl.2015.12.063. [PMID: 26750253] - Khadige Abadian, Zohreh Keshavarz, Faraz Mojab, Hamid Alavi Majd, Nazari Mohamad Abbasi. Comparison the effect of mefenamic acid and Teucrium polium on the severity and systemic symptoms of dysmenorrhea.
Complementary therapies in clinical practice.
2016 Feb; 22(?):12-5. doi:
10.1016/j.ctcp.2015.09.003. [PMID: 26850798] - Asif Husain, Priyanka Ahuja, Aftab Ahmad, Shah A Khan. Synthesis, Biological Evaluation and Pharmacokinetic Studies of Mefenamic Acid - N-Hydroxymethylsuccinimide Ester Prodrug as Safer NSAID.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2016; 12(6):585-91. doi:
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Bioorganic & medicinal chemistry letters.
2015 Nov; 25(22):5028-31. doi:
10.1016/j.bmcl.2015.10.036. [PMID: 26494261] - Sophia Yui Kau Fong, Yufeng Zhang, Yin Cheong Wong, Limin Zhou, Quanbin Han, Zhong Zuo. Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo.
Biopharmaceutics & drug disposition.
2015 Nov; 36(8):529-51. doi:
10.1002/bdd.1964. [PMID: 26109199] - Valentina Manzo, Karla Ulisse, Inés Rodríguez, Eduardo Pereira, Pablo Richter. A molecularly imprinted polymer as the sorptive phase immobilized in a rotating disk extraction device for the determination of diclofenac and mefenamic acid in wastewater.
Analytica chimica acta.
2015 Aug; 889(?):130-7. doi:
10.1016/j.aca.2015.07.038. [PMID: 26343435] - Sophia Yui Kau Fong, Yin Cheong Wong, Chen Xie, Zhong Zuo. Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats.
Journal of ethnopharmacology.
2015 Jul; 170(?):106-16. doi:
10.1016/j.jep.2015.04.036. [PMID: 25980420] - Marjan Ahmad Shirvani, Narges Motahari-Tabari, Abbas Alipour. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial.
Archives of gynecology and obstetrics.
2015 Jun; 291(6):1277-81. doi:
10.1007/s00404-014-3548-2. [PMID: 25399316] - Hamid Abedi, Homeira Ebrahimzadeh. Electromembrane-surrounded solid-phase microextraction coupled to ion mobility spectrometry for the determination of nonsteroidal anti-inflammatory drugs: A rapid screening method in complicated matrices.
Journal of separation science.
2015 May; 38(8):1358-64. doi:
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Journal of inorganic biochemistry.
2015 Apr; 145(?):79-93. doi:
10.1016/j.jinorgbio.2015.01.009. [PMID: 25660964] - Eva Kupetz, Heike Bunjes. Lipid nanoparticles: drug localization is substance-specific and achievable load depends on the size and physical state of the particles.
Journal of controlled release : official journal of the Controlled Release Society.
2014 Sep; 189(?):54-64. doi:
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Iranian journal of kidney diseases.
2014 May; 8(3):240-2. doi:
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Pharmaceutical biology.
2014 Mar; 52(3):291-7. doi:
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Complementary therapies in clinical practice.
2014 Feb; 20(1):81-8. doi:
10.1016/j.ctcp.2013.09.002. [PMID: 24439651] - Asadollah Beiraghi, Kamyar Pourghazi, Mitra Amoli-Diva, Akbar Razmara. Magnetic solid phase extraction of mefenamic acid from biological samples based on the formation of mixed hemimicelle aggregates on Fe(3)O(4) nanoparticles prior to its HPLC-UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Journal of inorganic biochemistry.
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Pediatric emergency care.
2013 Nov; 29(11):1220-2. doi:
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Acta poloniae pharmaceutica.
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Diabetes, obesity & metabolism.
2013 Mar; 15(3):280-3. doi:
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Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2013; 48(13):1655-62. doi:
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Journal of fluorescence.
2012 Nov; 22(6):1483-92. doi:
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Biomedical chromatography : BMC.
2012 Oct; 26(10):1137-42. doi:
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Pharmaceutical research.
2012 Oct; 29(10):2777-91. doi:
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Drug and chemical toxicology.
2012 Oct; 35(4):393-8. doi:
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Environmental science & technology.
2012 Aug; 46(16):9080-8. doi:
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Free radical research.
2012 Jun; 46(6):726-39. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 May; 40(5):1051-65. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Apr; 45(5):624-31. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Apr; 40(4):772-8. doi:
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Environmental technology.
2012 Apr; 33(7-9):1041-7. doi:
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Pharmacognosy magazine.
2012 Apr; 8(30):103-6. doi:
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Histochemistry and cell biology.
2012 Mar; 137(3):355-66. doi:
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Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2012; 21(3):223-7. doi:
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Environmental monitoring and assessment.
2012 Jan; 184(2):1049-62. doi:
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Food & nutrition research.
2012; 56(?):. doi:
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PloS one.
2012; 7(3):e34187. doi:
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Dalton transactions (Cambridge, England : 2003).
2011 Sep; 40(34):8555-68. doi:
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Journal of agricultural and food chemistry.
2011 May; 59(9):5125-32. doi:
10.1021/jf200364w. [PMID: 21469656] - Sungwook Choi, Jeffery W Kelly. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
Bioorganic & medicinal chemistry.
2011 Feb; 19(4):1505-14. doi:
10.1016/j.bmc.2010.12.050. [PMID: 21273081] - E Benítez-Rangel, L García, M C Namorado, J L Reyes, A Guerrero-Hernández. Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration.
Cell death & disease.
2011 Jan; 2(?):e113. doi:
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Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2011 Jan; 60(1):79-86. doi:
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Journal of biomedicine & biotechnology.
2011; 2011(?):238474. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):543216. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Jan; 39(1):54-60. doi:
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Journal of medicinal chemistry.
2010 Dec; 53(24):8727-33. doi:
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PloS one.
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The Korean journal of pain.
2010 Dec; 23(4):266-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Dec; 878(31):3249-54. doi:
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Journal of enzyme inhibition and medicinal chemistry.
2010 Dec; 25(6):804-11. doi:
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Journal of agricultural and food chemistry.
2010 Nov; 58(22):11600-5. doi:
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Journal of pain research.
2010 Nov; 3(?):235-40. doi:
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Indian journal of pharmaceutical sciences.
2010 Sep; 72(5):546-56. doi:
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Toxins.
2010 08; 2(8):2055-82. doi:
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The Science of the total environment.
2010 Jul; 408(16):3139-47. doi:
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Environmental toxicology and chemistry.
2010 Jun; 29(6):1377-84. doi:
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Dalton transactions (Cambridge, England : 2003).
2010 May; 39(19):4517-28. doi:
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Journal of food science.
2010 Apr; 75(3):C286-90. doi:
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Water research.
2010 Jan; 44(2):578-88. doi:
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Bioinorganic chemistry and applications.
2010; ?(?):. doi:
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Biological & pharmaceutical bulletin.
2010; 33(5):886-90. doi:
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BMC complementary and alternative medicine.
2009 Dec; 9(?):53. doi:
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Zeitschrift fur Naturforschung. C, Journal of biosciences.
2009 Nov; 64(11-12):809-12. doi:
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Neurochemical research.
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British journal of clinical pharmacology.
2009 Sep; 68(3):402-12. doi:
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Biomedical chromatography : BMC.
2009 Sep; 23(9):922-8. doi:
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Journal of midwifery & women's health.
2009 Sep; 54(5):401-404. doi:
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