Norethindrone (BioDeep_00000399166)
Main id: BioDeep_00000003060
natural product
代谢物信息卡片
Norethindrone (Norethisterone)
化学式: C20H26O2 (298.1932696)
中文名称: 炔诺酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#C[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)O
InChI: InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DC - Estren derivatives
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 8723
同义名列表
2 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:7627
- KEGG: C76161
- KEGG: C05028
- KEGGdrug: D00182
- PubChem: 6230
- DrugBank: DB00717
- ChEMBL: CHEMBL1162
- MeSH: Norethindrone
- CAS: 68-22-4
- MoNA: SM872301
- MoNA: CCMSLIB00000078634
- PubChem: 7499
- LipidMAPS: LMST02030097
- PDB-CCD: NDR
- 3DMET: B01805
- NIKKAJI: J1.416H
- RefMet: Norethindrone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ishani Landry, Jagadeesh Aluri, Nancy Hall, Gleb Filippov, Satish Dayal, Margaret Moline, Larisa Reyderman. Effects of Lemborexant on the Pharmacokinetics of Oral Contraceptives: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Females.
Clinical pharmacology in drug development.
2021 09; 10(9):1089-1098. doi:
10.1002/cpdd.953. [PMID: 34107159] - Refilwe P Molatlhegi, Samkelisiwe Ngcobo, Lenine J P Liebenberg, Sinaye Ngcapu, Amanda Mabhula, Alasdair Leslie, Nobuhle Mchunu, Mthobisi M Zondi, John H Adamson, Katya Govender, Natasha Samsunder, Salim S Abdool Karim, Quarraisha Abdool Karim, Jo-Ann S Passmore, Aida Sivro, Lyle R McKinnon. Genital and systemic immune effects of the injectable, contraceptive norethisterone enanthate (NET-EN), in South African women.
American journal of reproductive immunology (New York, N.Y. : 1989).
2021 08; 86(2):e13411. doi:
10.1111/aji.13411. [PMID: 33641222] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Smritee Dabee, Ramla F Tanko, Bryan P Brown, Rubina Bunjun, Christina Balle, Colin Feng, Iyaloo N Konstantinus, Shameem Z Jaumdally, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Katherine Gill, Jared M Baeten, Linda-Gail Bekker, Jo-Ann S Passmore, Renee Heffron, Heather B Jaspan, Anna-Ursula Happel. Comparison of Female Genital Tract Cytokine and Microbiota Signatures Induced by Initiation of Intramuscular DMPA and NET-EN Hormonal Contraceptives - a Prospective Cohort Analysis.
Frontiers in immunology.
2021; 12(?):760504. doi:
10.3389/fimmu.2021.760504. [PMID: 34956191] - Liping Hou, Shanduo Chen, Wenjun Shi, Hongxing Chen, Yanqiu Liang, Xiaolan Wang, Jiefeng Tan, Yifan Wang, Xikai Deng, Manjun Zhan, Jianzhao Long, Guowei Cai, Shaowen Luo, Cuiping Zhang, Juan Liu, Jonathan Y S Leung, Lingtian Xie. Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio).
Ecotoxicology and environmental safety.
2020 Jun; 195(?):110496. doi:
10.1016/j.ecoenv.2020.110496. [PMID: 32213369] - Bob Gray, Lisa Tuckley, Charlotte Cutler, Simon Biddle, Simon Hudson, Simon Gower, Lynn Vanhaecke. Investigations into the analysis of intact drug conjugates in animal sport doping control - Development and assessment of a rapid and economical approach for screening greyhound urine.
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2020 Jun; 12(6):731-742. doi:
10.1002/dta.2779. [PMID: 32052913] - Payal Trupti Kotecha, Ian F Godsland, David Crook, John C Stevenson. Effects of tibolone or continuous combined oestradiol and norethisterone acetate on lipids, high-density lipoprotein subfractions and apolipoproteins in postmenopausal women in a two-year, randomized, double-blind, placebo-controlled trial.
Clinical endocrinology.
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Menopause (New York, N.Y.).
2016 05; 23(5):511-7. doi:
10.1097/gme.0000000000000585. [PMID: 26836244] - Mary Abraham, Jennifer Mitchell, Debra Simsovits, James Gasperino. Hypertriglyceridemic Pancreatitis Caused by the Oral Contraceptive Agent Estrostep.
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2015 02; 70(2):107-13. doi:
10.6061/clinics/2015(02)07. [PMID: 25789519] - Eva Lundström, Peter Conner, Sabine Naessén, Lars Löfgren, Kjell Carlström, Gunnar Söderqvist. Estrone - a partial estradiol antagonist in the normal breast.
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10.3109/09513590.2015.1062866. [PMID: 26190536] - Barent N DuBois, Jessica Atrio, Frank Z Stanczyk, Ganesh Cherala. Increased exposure of norethindrone in HIV+ women treated with ritonavir-boosted atazanavir therapy.
Contraception.
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Annals of clinical biochemistry.
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10.1177/0004563213512800. [PMID: 24265092] - Herta M Crauwels, Rolf P G van Heeswijk, Annemie Buelens, Marita Stevens, Richard M W Hoetelmans. Lack of an effect of rilpivirine on the pharmacokinetics of ethinylestradiol and norethindrone in healthy volunteers.
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PloS one.
2012; 7(1):e30635. doi:
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PloS one.
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ZooKeys.
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International journal of andrology.
2011 Dec; 34(6 Pt 1):548-55. doi:
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Maturitas.
2011 Dec; 70(4):361-4. doi:
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Climacteric : the journal of the International Menopause Society.
2011 Dec; 14(6):683-8. doi:
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Molecular imaging and biology.
2011 Oct; 13(5):930-9. doi:
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Planta.
2011 Sep; 234(3):609-21. doi:
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PLoS neglected tropical diseases.
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Journal of clinical pharmacology.
2011 Sep; 51(9):1319-25. doi:
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Diagnostic pathology.
2011 Aug; 6(?):75. doi:
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Lipids in health and disease.
2011 Jul; 10(?):126. doi:
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Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
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PLoS neglected tropical diseases.
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Steroids.
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Veterinary research.
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PloS one.
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BMC medical genomics.
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PloS one.
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Biomedical optics express.
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Ginekologia polska.
2011 Mar; 82(3):200-4. doi:
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BMC complementary and alternative medicine.
2011 Jan; 11(?):8. doi:
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International journal of women's health.
2011 Jan; 3(?):19-24. doi:
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Proteome science.
2011 Jan; 9(1):1. doi:
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Clinical proteomics.
2011 Jan; 8(1):2. doi:
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Genome biology and evolution.
2011; 3(?):762-81. doi:
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International journal of molecular sciences.
2011; 12(7):4661-77. doi:
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Evidence-based complementary and alternative medicine : eCAM.
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International journal of molecular sciences.
2011; 12(9):6116-34. doi:
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2011 Jan; 22(1):179-84. doi:
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PloS one.
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Evidence-based complementary and alternative medicine : eCAM.
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International journal of biological sciences.
2011; 7(6):715-28. doi:
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International journal of nanomedicine.
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BMC genomics.
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