triptolide (BioDeep_00000398763)

Main id: BioDeep_00000000516

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


triptolide

化学式: C20H24O6 (360.1573)
中文名称: 雷公藤甲素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
InChI: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 0.848
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D000988 - Antispermatogenic Agents
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.842
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.835
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

同义名列表

3 个代谢物同义名

triptolide; PG490; Triptolide



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ANG, BCL2, BDNF, CASP3, JAK2, MAPK14, MAPK8, NOS2, POLR2A, PTGS2, STAT1, VEGFA, VIM
Peripheral membrane protein 3 CYP1B1, JAK2, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP1B1, PTGS2
Nucleus 11 ANG, BCL2, CASP3, ERCC3, JAK2, MAPK14, MAPK8, NOS2, POLR2A, STAT1, VEGFA
cytosol 9 ANG, BCL2, CASP3, JAK2, MAPK14, MAPK8, NOS2, STAT1, VIM
dendrite 2 BDNF, STAT1
phagocytic vesicle 1 VIM
nucleoplasm 8 CASP3, ERCC3, JAK2, MAPK14, MAPK8, NOS2, POLR2A, STAT1
RNA polymerase II transcription regulator complex 1 STAT1
Cell membrane 2 ABCB1, VIM
Multi-pass membrane protein 1 ABCB1
Synapse 1 MAPK8
cell surface 2 ABCB1, VEGFA
glutamatergic synapse 3 CASP3, JAK2, MAPK14
Golgi apparatus 1 VEGFA
growth cone 1 ANG
neuronal cell body 2 ANG, CASP3
postsynapse 1 JAK2
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NOS2
plasma membrane 5 ABCB1, IFNLR1, JAK2, NOS2, VIM
Membrane 7 ABCB1, BCL2, BDNF, CYP1B1, IFNLR1, JAK2, VEGFA
apical plasma membrane 1 ABCB1
axon 4 BDNF, MAPK8, STAT1, VIM
caveola 2 JAK2, PTGS2
extracellular exosome 2 ABCB1, VIM
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 6 ANG, BDNF, CXCL8, IL10, IL4, VEGFA
perinuclear region of cytoplasm 3 BDNF, NOS2, STAT1
adherens junction 1 VEGFA
mitochondrion 3 BCL2, CYP1B1, MAPK14
protein-containing complex 3 BCL2, PTGS2, STAT1
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IFNLR1
Secreted 6 ANG, BDNF, CXCL8, IL10, IL4, VEGFA
extracellular region 7 ANG, BDNF, CXCL8, IL10, IL4, MAPK14, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 2 ANG, STAT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 JAK2
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 2 JAK2, VIM
extracellular matrix 1 VEGFA
Peroxisome 2 NOS2, VIM
basement membrane 1 ANG
peroxisomal matrix 1 NOS2
secretory granule 1 VEGFA
intermediate filament 1 VIM
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS2, VIM
chromatin 1 STAT1
cell leading edge 1 VIM
Chromosome 2 ANG, POLR2A
cytoskeleton 2 JAK2, VIM
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
microtubule organizing center 1 VIM
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 2 JAK2, POLR2A
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 BDNF, PTGS2
nuclear matrix 1 VIM
transcription factor TFIID complex 1 ERCC3
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
Nucleus matrix 1 VIM
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
RNA polymerase II, core complex 1 POLR2A
death-inducing signaling complex 1 CASP3
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
transcription preinitiation complex 1 ERCC3
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
transcription factor TFIIH core complex 1 ERCC3
transcription factor TFIIH holo complex 1 ERCC3
nucleotide-excision repair factor 3 complex 1 ERCC3
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ISGF3 complex 1 STAT1
interleukin-28 receptor complex 1 IFNLR1
nuclear lumen 1 POLR2A
DNA-directed RNA polymerase complex 1 POLR2A


文献列表

  • Yiwen Zhang, Feng Lu. Molecular mechanism of triptolide in myocardial fibrosis through the Wnt/β-catenin signaling pathway. Scandinavian cardiovascular journal : SCJ. 2024 Dec; 58(1):2295785. doi: 10.1080/14017431.2023.2295785. [PMID: 38164796]
  • Haoran Zhang, Qianhui Tang, Yingying Miao, Jie Wang, Zihang Yuan, Xinliang Huang, Ying Zhu, Cheng Nong, Guoqing Li, Ruyu Cui, Xin Huang, Luyong Zhang, Qinwei Yu, Zhenzhou Jiang. Group 1 innate lymphoid cell activation via recognition of NKG2D and liver resident macrophage MULT-1: Collaborated roles in triptolide induced hepatic immunotoxicity in mice. Ecotoxicology and environmental safety. 2024 Mar; 272(?):116072. doi: 10.1016/j.ecoenv.2024.116072. [PMID: 38342011]
  • Bingtao Mu, Minfang Guo, Jingwen Yu, Huiyu Zhang. [Triptolide reduces neuronal damage in cerebral ischemia-reperfusion rats by promoting microglial M2 polarization]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2024 Mar; 40(3):222-228. doi: ". [PMID: 38512032]
  • Yuan Mei, Xinyu Li, Chao He, Yiying Zhang, Weichao Kong, Rufeng Xue, Xin Huang, Yaxiang Shi, Gang Tao, Mengtao Xing, Xinzhi Wang. Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury. Chemical research in toxicology. 2024 Jan; 37(1):42-56. doi: 10.1021/acs.chemrestox.3c00250. [PMID: 38091573]
  • Yan Jin, Deng Di-Si, Wu Ke-Ming. XinJiaCongRongTuSiZiWan protects triptolide-induced rats from oxidative stress injury via mitophagy mediated PINK1/Parkin signaling pathway. Acta cirurgica brasileira. 2024; 39(?):e391424. doi: 10.1590/acb391424. [PMID: 38511762]
  • Yu Huang, Shuyang Wu, Jingjing Li, Chenglin He, Yanfen Cheng, Nan Li, Yitao Wang, Yihan Wu, Jinming Zhang. Self-Amplified pH/ROS Dual-Responsive Co-Delivery Nano-System with Chemo-Photodynamic Combination Therapy in Hepatic Carcinoma Treatment. International journal of nanomedicine. 2024; 19(?):3737-3751. doi: 10.2147/ijn.s453199. [PMID: 38699684]
  • Manlan Guo, Minyi He, Yi Zhang, Weiwen Liu, Min Qi, Zhifeng Liu, Guozhong Yi, Shengze Deng, Yaomin Li, Xuegang Sun, Liang Zhao, Tengxiang Chen, Yawei Liu. Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy. Cancer biology & therapy. 2023 12; 24(1):2246203. doi: 10.1080/15384047.2023.2246203. [PMID: 37599448]
  • Hang Chen, Xinyu Wang, Mengmeng Liu, Jiefen Yang, Yanting Kuang, Ruting Wei, Zongguang Tai, Quangang Zhu, Zhongjian Chen, Jianming Chen, Xin Wu. Synergism and attenuation of triptolide through prodrug engineering combined with liposomal scaffold strategy to enhance inhibition in pancreatic cancer. International journal of pharmaceutics. 2023 Dec; 648(?):123623. doi: 10.1016/j.ijpharm.2023.123623. [PMID: 37989402]
  • Tingyun Xu, Yiwei Zhu, Shuaishuai Ge, Song-Bai Liu. The roles of TPL in hematological malignancies. Hematology (Amsterdam, Netherlands). 2023 Dec; 28(1):2231765. doi: 10.1080/16078454.2023.2231765. [PMID: 37403451]
  • Wei-Zheng Zhang, Xiao-Ming Qi, Yu-Qin Zuo, Qing-Shan Li. [Protective effect and mechanism of Astragalus membranaceus and Angelica sinensis compatibility against triptolide-induced hepatotoxicity by regulating Keap1/Nrf2/PGC-1α]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(23):6378-6386. doi: 10.19540/j.cnki.cjcmm.20231008.301. [PMID: 38211994]
  • Shiyuan Jiang, Jing Feng, Yanling Jiang, Zhihao Lu, Jingwei Kong, Xueming Li, Hui Lian, Fang Zhang, Yu Li, Jian Li. Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice. International immunopharmacology. 2023 Nov; 125(Pt B):111206. doi: 10.1016/j.intimp.2023.111206. [PMID: 37956491]
  • Xue Fan, Yangping Zhu, Shuang Peng, Yingying Miao, Qian Lu, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP. Toxicology letters. 2023 Nov; ?(?):. doi: 10.1016/j.toxlet.2023.11.001. [PMID: 37944651]
  • Weiji Lin, Yaqin Song, Tingting Li, Jiahui Yan, Ruiyuan Zhang, Liang Han, Xin Ba, Yao Huang, Kai Qin, Zhe Chen, Yu Wang, Shenghao Tu, Ying Huang. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct; 166(?):115394. doi: 10.1016/j.biopha.2023.115394. [PMID: 37660647]
  • Lei Wan, Jian Liu, Chuanbing Huang, Kun Wang, Ziheng Zhu, Fangze Li. A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis. The Journal of pharmacy and pharmacology. 2023 Sep; ?(?):. doi: 10.1093/jpp/rgad078. [PMID: 37738207]
  • Baowei Ji, Junchao Liu, Ye Yin, Hong Xu, Qian Shen, Jian Yu. Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis. Cell death & disease. 2023 Sep; 14(9):601. doi: 10.1038/s41419-023-06124-0. [PMID: 37689694]
  • Manyun Dai, Wan Peng, Lisha Lin, Zhanxuan E Wu, Ting Zhang, Qi Zhao, Yan Cheng, Qiuxia Lin, Binbin Zhang, Aiming Liu, Qianru Rao, Jianfeng Huang, Jinhua Zhao, Frank J Gonzalez, Fei Li. Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155054. doi: 10.1016/j.phymed.2023.155054. [PMID: 37738906]
  • Ziyi Xu, Yu Huang, Yihan Wu, Jiamei Chen, Sai-Wang Seto, George Pak-Heng Leung, Yin Cai, Jingjing Li, Jinming Zhang. Glycyrrhizic Acid-Lipid Framework Nanovehicle Loading Triptolide for Combined Immunochemotherapy. ACS applied materials & interfaces. 2023 Aug; ?(?):. doi: 10.1021/acsami.3c08003. [PMID: 37615350]
  • Jie Gao, Lin Ma, Yuan Liu, Lichan Tu, Xiaoyi Wu, Jian Wang, Dan Li, Xianan Zhang, Wei Gao, Yifeng Zhang, Changli Liu. CYP72D19 from Tripterygium wilfordii catalyzes C-2 hydroxylation of abietane-type diterpenoids. Plant cell reports. 2023 Aug; ?(?):. doi: 10.1007/s00299-023-03059-w. [PMID: 37615706]
  • Peng Chen, Pengcheng Zhao, Mingliang Hu, Lili Wang, Tong Lei, Bin Liu, Li Li, Jianyu Shi, Cheng Lu. HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 117(?):154929. doi: 10.1016/j.phymed.2023.154929. [PMID: 37329754]
  • Dongxiao Cui, Dingqiao Xu, Shijun Yue, Chaoqun Yan, Wenjuan Liu, Ruijia Fu, Wenfu Ma, Yuping Tang. Recent advances in the pharmacological applications and liver toxicity of triptolide. Chemico-biological interactions. 2023 Jul; 382(?):110651. doi: 10.1016/j.cbi.2023.110651. [PMID: 37516378]
  • QinWei Huang, ChunMei Tan, Cheng Zheng, Hong Meng, ZhengNan Wang, Guo-Qiang Lin, WenTing Zhang, BiLian Chen, Qing-Li He. DCTPP1, a reliable Q-biomarker for comprehensive evaluation of the quality of tripterygium glycoside tablets based on chemical references. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 119(?):154972. doi: 10.1016/j.phymed.2023.154972. [PMID: 37531903]
  • Kang Fang, Yanting Sun, Jingxian Yang, Xiaochun Hu, Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, Chunyan Dong, Shuo Shi. A Dual Stimuli-Responsive Nanoplatform Loaded PtIV -Triptolide Prodrug for Achieving Synergistic Therapy toward Breast Cancer. Advanced healthcare materials. 2023 Jul; ?(?):e2301328. doi: 10.1002/adhm.202301328. [PMID: 37392128]
  • Jing Song, Guan-Nan He, Long Dai. A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114705. doi: 10.1016/j.biopha.2023.114705. [PMID: 37062220]
  • Qinhang Wu, Xuelin Ma, Zhuolin Jin, Ruijun Ni, Yang Pan, Guangming Yang. Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK. Journal of ethnopharmacology. 2023 May; ?(?):116644. doi: 10.1016/j.jep.2023.116644. [PMID: 37196814]
  • Yao Huang, Xin Ba, Hui Wang, Pan Shen, Liang Han, Weiji Lin, Jiahui Yan, Zhe Chen, Shenghao Tu. Triptolide alleviates collagen-induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN-STAT3 pathway. Basic & clinical pharmacology & toxicology. 2023 Apr; ?(?):. doi: 10.1111/bcpt.13880. [PMID: 37186366]
  • Baowei Ji, Junchao Liu, Yanli Ma, Ye Yin, Hong Xu, Qian Shen, Jian Yu. Minnelide Markedly Reduces Proteinuria in Mice with Adriamycin Nephropathy by Protecting Against Podocyte Injury. Applied biochemistry and biotechnology. 2023 Mar; ?(?):. doi: 10.1007/s12010-023-04333-z. [PMID: 37000351]
  • Xiaohui Wu, Junming Wang, Bingyin Li, Mingzhu Gong, Can Cao, Lingling Song, Lingyu Qin, Yanmei Wang, Yueyue Zhang, Yamin Li. Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis. Toxicology and applied pharmacology. 2023 Mar; 467(?):116479. doi: 10.1016/j.taap.2023.116479. [PMID: 36963520]
  • Shiyuan Jiang, Feng Wan, Hui Lian, Zhihao Lu, Xueming Li, Dan Cao, Yangyu Jiang, Jian Li. Friend or foe? The dual role of triptolide in the liver, kidney, and heart. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 161(?):114470. doi: 10.1016/j.biopha.2023.114470. [PMID: 36868013]
  • Yifeng Zhang, Jie Gao, Lin Ma, Lichan Tu, Tianyuan Hu, Xiaoyi Wu, Ping Su, Yujun Zhao, Yuan Liu, Dan Li, Jiawei Zhou, Yan Yin, Yuru Tong, Huan Zhao, Yun Lu, Jiadian Wang, Wei Gao, Luqi Huang. Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae. Nature communications. 2023 02; 14(1):875. doi: 10.1038/s41467-023-36353-y. [PMID: 36797237]
  • Jia Xin Li, Meng Jiao Zhang, Jin Feng Shi, Sheng Peng Wang, Xue Mei Zhong, Yi Han Wu, Yan Qu, Hui Le Gao, Jin Ming Zhang. pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide. International journal of pharmaceutics. 2023 Feb; 632(?):122572. doi: 10.1016/j.ijpharm.2022.122572. [PMID: 36592894]
  • Guoyao Tan, Zhiyan Qin, Shiqin Jiang, Lei Zhang, Gengyi Zhang, Min Huang, Zhiying Huang, Jing Jin. MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Feb; 86(?):105487. doi: 10.1016/j.tiv.2022.105487. [PMID: 36272531]
  • Baowei Ji, Junchao Liu, Yanli Ma, Ye Yin, Hong Xu, Qian Shen, Jian Yu. Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways. International immunopharmacology. 2023 Feb; 115(?):109656. doi: 10.1016/j.intimp.2022.109656. [PMID: 36608441]
  • Dongliang Shi, Yan Li, Xiaomei Shi, Meihong Yao, Dan Wu, Yuhui Zheng, Qing Lin, Yinghong Yang. Transcriptional expression of CXCL10 and STAT1 in lupus nephritis and the intervention effect of triptolide. Clinical rheumatology. 2023 Feb; 42(2):539-548. doi: 10.1007/s10067-022-06400-y. [PMID: 36374433]
  • Meng Li, Qiong Luo, Xi Chen, Furong Qiu, Yanyan Tao, Xin Sun, Chenghai Liu. Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns. BMC complementary medicine and therapies. 2023 Jan; 23(1):9. doi: 10.1186/s12906-023-03836-w. [PMID: 36627617]
  • Meng Yang, Jianxia Meng, Lu Han, Xiaoyan Yu, Zhimin Fan, Yongfang Yuan. Pharmacokinetic Study of Triptolide Nanocarrier in Transdermal Drug Delivery System-Combination of Experiment and Mathematical Modeling. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020553. [PMID: 36677610]
  • Haoran Zhang, Zihang Yuan, Jie Wang, Qianhui Tang, Yingying Miao, Ziqiao Yuan, Xinliang Huang, Ying Zhu, Cheng Nong, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154621. doi: 10.1016/j.phymed.2022.154621. [PMID: 36610139]
  • Xiao-Ming Qi, Yuan-Biao Qiao, Yuan-Lin Zhang, Ai-Cheng Wang, Jin-Hong Ren, Hui-Zhi Wei, Qing-Shan Li. PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113513. doi: 10.1016/j.fct.2022.113513. [PMID: 36436616]
  • Li Li, Chuting Wang, Zhenpeng Qiu, Dongjie Deng, Xin Chen, Qi Wang, Yan Meng, Baohui Zhang, Guohua Zheng, Junjie Hu. Triptolide inhibits intrahepatic cholangiocarcinoma growth by suppressing glycolysis via the AKT/mTOR pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154575. doi: 10.1016/j.phymed.2022.154575. [PMID: 36610163]
  • Qian-Qian Hao, Zhi-Ran Xu, Han Nie, Feng-Xin Qiao, Ming-Xin Sun, Yue-Cen Liu, Hai-Long Wang, Zhong-Quan Qi, Chang-Long Xu, Yu Liu. Triptolide exposure induces oxidative stress and decreases oocyte quality in mouse. Toxicon : official journal of the International Society on Toxinology. 2023 Jan; 221(?):106964. doi: 10.1016/j.toxicon.2022.106964. [PMID: 36372154]
  • Xia Wu, Shangqing Chen, Kechu Huang, Gongping Lin. Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin. Molecular medicine reports. 2023 Jan; 27(1):. doi: 10.3892/mmr.2022.12904. [PMID: 36453238]
  • Yafang Zhang, Junqiang Wei, Lingwei Kong, Mingze Song, Yange Zhang, Xiangyu Xiao, Haiying Cao, Yu Jin. Network pharmacology, molecular docking and bioinformatics reveal the mechanism of Tripterygii Wilfordii against Osteosarcoma. Medicine. 2022 Dec; 101(52):e32389. doi: 10.1097/md.0000000000032389. [PMID: 36595977]
  • Yang Feng, Rui An, Yajun Zhang, Mingjun Chen, Li Wang, Yunyou Duan, Changyang Xing. AHNAK-modified microbubbles for the intracranial delivery of triptolide: In-vitro and in-vivo investigations. International journal of pharmaceutics. 2022 Dec; 629(?):122351. doi: 10.1016/j.ijpharm.2022.122351. [PMID: 36404486]
  • Che-Chia Hsu, Chin-Chuan Tsai, Po-Yen Ko, Ting-Hsien Kwan, Ming-Yie Liu, Po-Ting Wu, I-Ming Jou. Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model. International journal of environmental research and public health. 2022 12; 19(24):. doi: 10.3390/ijerph192416685. [PMID: 36554566]
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