Xanthosine (BioDeep_00000398755)
Main id: BioDeep_00000001710
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
化学式: C10H12N4O6 (284.07568119999996)
中文名称: 黄嘌呤核苷, 黄嘌呤
谱图信息:
最多检出来源 Homo sapiens(blood) 0.04%
分子结构信息
SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c2[nH]c(=O)[nH]c3=O)O1)O)O)O
InChI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1
描述信息
A purine nucleoside in which xanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
COVID info from COVID-19 Disease Map
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relative retention time with respect to 9-anthracene Carboxylic Acid is 0.057
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.056
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].
同义名列表
3 个代谢物同义名
数据库引用编号
53 个数据库交叉引用编号
- ChEBI: CHEBI:18107
- KEGG: C01762
- PubChem: 64959
- ChEMBL: CHEMBL402439
- CAS: 146-80-5
- MoNA: CCMSLIB00000578196
- MoNA: CCMSLIB00005464318
- MoNA: CCMSLIB00005464391
- MoNA: CCMSLIB00005720400
- MoNA: CCMSLIB00005720693
- MoNA: MoNA038533
- MoNA: MoNA037840
- MoNA: MoNA037136
- MoNA: MoNA035977
- MoNA: MoNA035973
- MoNA: MoNA035972
- MoNA: MoNA033944
- MoNA: MoNA033943
- MoNA: MoNA033940
- MoNA: MoNA032033
- MoNA: MoNA032031
- MoNA: MoNA032030
- MoNA: MoNA024252
- MoNA: MoNA024200
- MoNA: EMBL-MCF_spec115496
- MoNA: EMBL-MCF_spec43942
- MoNA: MoNA016931
- MoNA: MoNA016817
- MoNA: MoNA001829
- MoNA: MoNA001828
- MoNA: MoNA001826
- MoNA: FiehnHILIC003055
- MoNA: FiehnHILIC001581
- MoNA: FiehnHILIC000861
- MoNA: HMDB0000299_ms_ms_508
- MoNA: HMDB0000299_ms_ms_509
- MoNA: HMDB0000299_ms_ms_507
- MoNA: PT209940
- MoNA: PT206450
- MoNA: BML82353
- MoNA: BML82351
- MoNA: BML82350
- MetaboLights: MTBLC18107
- PubChem: 4895
- KNApSAcK: C00007222
- PDB-CCD: 4UO
- 3DMET: B01495
- NIKKAJI: J9.367J
- RefMet: Xanthosine
- medchemexpress: HY-W011527
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-162
- KNApSAcK: 18107
- LOTUS: LTS0192214
分类词条
相关代谢途径
Reactome(0)
BioCyc(6)
PlantCyc(7)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
75 个相关的物种来源信息
- 7458 - Apidae: LTS0192214
- 7459 - Apis: LTS0192214
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 - Apis cerana: LTS0192214
- 3701 - Arabidopsis: LTS0192214
- 3702 - Arabidopsis thaliana:
- 3702 - Arabidopsis thaliana: 10.1074/JBC.RA118.003351
- 3702 - Arabidopsis thaliana: LTS0192214
- 6656 - Arthropoda: LTS0192214
- 4890 - Ascomycota: LTS0192214
- 40552 - Asparagaceae: LTS0192214
- 2 - Bacteria: LTS0192214
- 3700 - Brassicaceae: LTS0192214
- 4441 - Camellia: 10.1093/PCP/PCQ175
- 4441 - Camellia: LTS0192214
- 319931 - Camellia ptilophylla: 10.1093/PCP/PCQ175
- 319931 - Camellia ptilophylla: LTS0192214
- 4442 - Camellia sinensis: 10.1093/PCP/PCQ175
- 4442 - Camellia sinensis: LTS0192214
- 261999 - Camellia sinensis var. assamica: 10.1093/PCP/PCQ175
- 261999 - Camellia sinensis var. assamica: LTS0192214
- 182317 - Camellia taliensis: 10.1093/PCP/PCQ175
- 182317 - Camellia taliensis: LTS0192214
- 7711 - Chordata: LTS0192214
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
- 543 - Enterobacteriaceae: LTS0192214
- 561 - Escherichia: LTS0192214
- 562 - Escherichia coli: LTS0192214
- 33682 - Euglenozoa: LTS0192214
- 2759 - Eukaryota: LTS0192214
- 4751 - Fungi: LTS0192214
- 1236 - Gammaproteobacteria: LTS0192214
- 9604 - Hominidae: LTS0192214
- 9605 - Homo: LTS0192214
- 9606 - Homo sapiens:
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0192214
- 44985 - Hyacinthaceae: LTS0192214
- 81757 - Hyacinthoides: LTS0192214
- 81762 - Hyacinthoides non-scripta: 10.1038/S41598-019-38940-W
- 81762 - Hyacinthoides non-scripta: LTS0192214
- 50557 - Insecta: LTS0192214
- 5653 - Kinetoplastea: LTS0192214
- 4447 - Liliopsida: LTS0192214
- 3398 - Magnoliopsida: LTS0192214
- 40674 - Mammalia: LTS0192214
- 33208 - Metazoa: LTS0192214
- 31969 - Mollicutes: LTS0192214
- 10066 - Muridae: LTS0192214
- 10088 - Mus: LTS0192214
- 10090 - Mus musculus: LTS0192214
- 10090 - Mus musculus: NA
- 2093 - Mycoplasma: LTS0192214
- 28903 - Mycoplasma bovis: 10.1128/MSYSTEMS.00055-17
- 2096 - Mycoplasma gallisepticum: 10.1128/MSYSTEMS.00055-17
- 2092 - Mycoplasmataceae: LTS0192214
- 2767358 - Mycoplasmopsis: LTS0192214
- 474995 - Ophiocordyceps: LTS0192214
- 72228 - Ophiocordyceps sinensis: 10.1016/J.JEP.2013.10.064
- 72228 - Ophiocordyceps sinensis: LTS0192214
- 474942 - Ophiocordycipitaceae: LTS0192214
- 147550 - Sordariomycetes: LTS0192214
- 35493 - Streptophyta: LTS0192214
- 27065 - Theaceae: LTS0192214
- 58023 - Tracheophyta: LTS0192214
- 66647 - Tribulus: LTS0192214
- 210369 - Tribulus terrestris: 10.1016/S0031-9422(97)01086-8
- 210369 - Tribulus terrestris: LTS0192214
- 5690 - Trypanosoma: LTS0192214
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
- 5691 - Trypanosoma brucei: LTS0192214
- 5654 - Trypanosomatidae: LTS0192214
- 33090 - Viridiplantae: LTS0192214
- 43873 - Zygophyllaceae: LTS0192214
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 08; 78(2):226-235.e1. doi:
10.1053/j.ajkd.2020.12.005
. [PMID: 33421453] - Ke Wang, Leila R Zelnick, Yan Chen, Andrew N Hoofnagle, Terry Watnick, Stephen Seliger, Bryan Kestenbaum. Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease.
Clinical journal of the American Society of Nephrology : CJASN.
2020 01; 15(1):80-88. doi:
10.2215/cjn.05610519
. [PMID: 31628117] - Chiara Baccolini, Claus-Peter Witte. AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex.
The Plant cell.
2019 03; 31(3):734-751. doi:
10.1105/tpc.18.00899
. [PMID: 30787180] - Chao-Jung Chen, Wen-Ling Liao, Chiz-Tzung Chang, Yu-Ning Lin, Fuu-Jen Tsai. Identification of Urinary Metabolite Biomarkers of Type 2 Diabetes Nephropathy Using an Untargeted Metabolomic Approach.
Journal of proteome research.
2018 11; 17(11):3997-4007. doi:
10.1021/acs.jproteome.8b00644
. [PMID: 30265543] - Philipp Opitz, Olf Herbarth, Annerose Seidel, Andreas Boehm, Milos Fischer, Christian Mozet, Andreas Dietz, Gunnar Wichmann. Modified Nucleosides - Molecular Markers Suitable for Small-volume Cancer?.
Anticancer research.
2018 Nov; 38(11):6113-6119. doi:
10.21873/anticanres.12962
. [PMID: 30396926] - Ratan K Choudhary, Shanti Choudhary, Ramneek Verma. In vivo response of xanthosine on mammary gene expression of lactating Beetal goat.
Molecular biology reports.
2018 Aug; 45(4):581-590. doi:
10.1007/s11033-018-4196-6
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Nature communications.
2016 07; 7(?):12360. doi:
10.1038/ncomms12360
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Journal of proteome research.
2014 Jun; 13(6):3088-99. doi:
10.1021/pr5003142
. [PMID: 24796210] - Kathleen Dahncke, Claus-Peter Witte. Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis.
The Plant cell.
2013 Oct; 25(10):4101-9. doi:
10.1105/tpc.113.117184
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PloS one.
2013; 8(9):e74584. doi:
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Molecular bioSystems.
2012 Nov; 8(11):2956-63. doi:
10.1039/c2mb25227a
. [PMID: 22932763] - C A Bourke. Motor neurone disease in molybdenum-deficient sheep fed the endogenous purine xanthosine: possible mechanism for Tribulus staggers.
Australian veterinary journal.
2012 Jul; 90(7):272-4. doi:
10.1111/j.1751-0813.2012.00947.x
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Journal of proteome research.
2012 Apr; 11(4):2551-8. doi:
10.1021/pr201263q
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Journal of separation science.
2012 Mar; 35(5-6):625-32. doi:
10.1002/jssc.201100992
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Chemical research in toxicology.
2012 Feb; 25(2):454-61. doi:
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PloS one.
2012; 7(4):e34157. doi:
10.1371/journal.pone.0034157
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Journal of experimental botany.
2011 Nov; 62(15):5623-32. doi:
10.1093/jxb/err251
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The New phytologist.
2011 Jul; 191(2):349-359. doi:
10.1111/j.1469-8137.2011.03711.x
. [PMID: 21599668] - Benjamin Jung, Christiane Hoffmann, Torsten Möhlmann. Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines.
The Plant journal : for cell and molecular biology.
2011 Mar; 65(5):703-11. doi:
10.1111/j.1365-313x.2010.04455.x
. [PMID: 21235647] - Cheng-Ying Shi, Hua Yang, Chao-Ling Wei, Oliver Yu, Zheng-Zhu Zhang, Chang-Jun Jiang, Jun Sun, Ye-Yun Li, Qi Chen, Tao Xia, Xiao-Chun Wan. Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds.
BMC genomics.
2011 Feb; 12(?):131. doi:
10.1186/1471-2164-12-131
. [PMID: 21356090] - Hiroshi Ashihara, Misako Kato, Alan Crozier. Distribution, biosynthesis and catabolism of methylxanthines in plants.
Handbook of experimental pharmacology.
2011; ?(200):11-31. doi:
10.1007/978-3-642-13443-2_2
. [PMID: 20859792] - Wei-Wei Deng, Hiroshi Ashihara. Profiles of purine metabolism in leaves and roots of Camellia sinensis seedlings.
Plant & cell physiology.
2010 Dec; 51(12):2105-18. doi:
10.1093/pcp/pcq175
. [PMID: 21071429] - Luis González-Candelas, Santiago Alamar, Paloma Sánchez-Torres, Lorenzo Zacarías, Jose F Marcos. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection.
BMC plant biology.
2010 Aug; 10(?):194. doi:
10.1186/1471-2229-10-194
. [PMID: 20807411] - Ning Ma, Mikio Sasoh, Shosuke Kawanishi, Hiromichi Sugiura, Fengyuan Piao. Protection effect of taurine on nitrosative stress in the mice brain with chronic exposure to arsenic.
Journal of biomedical science.
2010 Aug; 17 Suppl 1(?):S7. doi:
10.1186/1423-0127-17-s1-s7
. [PMID: 20804627] - Sudha Rana, Raj Kumar, Sarwat Sultana, Rakesh Kumar Sharma. Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses.
Journal of pharmacy & bioallied sciences.
2010 Jul; 2(3):189-96. doi:
10.4103/0975-7406.68500
. [PMID: 21829314] - Jeffrey K Yao, George G Dougherty, Ravinder D Reddy, Matcheri S Keshavan, Debra M Montrose, Wayne R Matson, Joseph McEvoy, Rima Kaddurah-Daouk. Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia.
PloS one.
2010 Mar; 5(3):e9508. doi:
10.1371/journal.pone.0009508
. [PMID: 20209081] - Misako Kato, Naoko Kitao, Mariko Ishida, Hanayo Morimoto, Fumi Irino, Kouichi Mizuno. Expression for caffeine biosynthesis and related enzymes in Camellia sinensis.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2010 Mar; 65(3-4):245-56. doi:
10.1515/znc-2010-3-413
. [PMID: 20469645] - Rahul C Deo, Luke Hunter, Gregory D Lewis, Guillaume Pare, Ramachandran S Vasan, Daniel Chasman, Thomas J Wang, Robert E Gerszten, Frederick P Roth. Interpreting metabolomic profiles using unbiased pathway models.
PLoS computational biology.
2010 Feb; 6(2):e1000692. doi:
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. [PMID: 20195502] - T Maiguma, T Yosida, K Otsubo, Y Okabe, A Sugitani, M Tanaka, R Oishi, D Teshima. Evaluation of inosin-5'-monophosphate dehydrogenase activity during maintenance therapy with tacrolimus.
Journal of clinical pharmacy and therapeutics.
2010 Feb; 35(1):79-85. doi:
10.1111/j.1365-2710.2009.01072.x
. [PMID: 20175815] - Paolo Mannelli, Ashwin Patkar, Steve Rozen, Wayne Matson, Ranga Krishnan, Rima Kaddurah-Daouk. Opioid use affects antioxidant activity and purine metabolism: preliminary results.
Human psychopharmacology.
2009 Dec; 24(8):666-75. doi:
10.1002/hup.1068
. [PMID: 19760630] - Ashwin A Patkar, Steve Rozen, Paolo Mannelli, Wayne Matson, Chi-Un Pae, K Ranga Krishnan, Rima Kaddurah-Daouk. Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study.
Psychopharmacology.
2009 Oct; 206(3):479-89. doi:
10.1007/s00213-009-1625-1
. [PMID: 19649617] - Yongqing Jiang, Yinfa Ma. A fast capillary electrophoresis method for separation and quantification of modified nucleosides in urinary samples.
Analytical chemistry.
2009 Aug; 81(15):6474-80. doi:
10.1021/ac901216n
. [PMID: 19552424] - John B Tyburski, Andrew D Patterson, Kristopher W Krausz, Josef Slavík, Albert J Fornace, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.
Radiation research.
2009 Jul; 172(1):42-57. doi:
10.1667/rr1703.1
. [PMID: 19580506] - Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell, Bernd Kammerer. Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.
BMC cancer.
2009 Apr; 9(?):104. doi:
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. [PMID: 19344524] - M Sharaf. Chemical constituents from the seeds of Trifolium alexandrinum.
Natural product research.
2008 Dec; 22(18):1620-3. doi:
10.1080/14786410701869226
. [PMID: 19085418] - Yeyun Li, Shinjiro Ogita, Chaman Ara Keya, Hiroshi Ashihara. Expression of caffeine biosynthesis genes in tea (Camellia sinensis).
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2008 Mar; 63(3-4):267-70. doi:
10.1515/znc-2008-3-417
. [PMID: 18533472] - Michael G Cornelius, Heinz H Schmeiser. RNA analysis by MEKC with LIF detection.
Electrophoresis.
2007 Nov; 28(21):3901-7. doi:
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. [PMID: 17922502] - Andrew A McCarthy, James G McCarthy. The structure of two N-methyltransferases from the caffeine biosynthetic pathway.
Plant physiology.
2007 Jun; 144(2):879-89. doi:
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Antiviral research.
2007 Mar; 73(3):206-11. doi:
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Transgenic research.
2006 Dec; 15(6):667-72. doi:
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. [PMID: 17091387] - Nils Tore Vethe, Stein Bergan. Determination of inosine monophosphate dehydrogenase activity in human CD4+ cells isolated from whole blood during mycophenolic acid therapy.
Therapeutic drug monitoring.
2006 Oct; 28(5):608-13. doi:
10.1097/01.ftd.0000245680.38143.ca
. [PMID: 17038874] - Robin Tuytten, Filip Lemière, Eddy L Esmans, Wouter A Herrebout, Benjamin J van der Veken, Ed Dudley, Russell P Newton, Erwin Witters. In-source CID of guanosine: gas phase ion-molecule reactions.
Journal of the American Society for Mass Spectrometry.
2006 Aug; 17(8):1050-1062. doi:
10.1016/j.jasms.2006.03.012
. [PMID: 16750381] - Maciej Szuwart, Elzbieta Starzyńska, Małgorzata Pietrowska-Borek, Andrzej Guranowski. Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus).
Phytochemistry.
2006 Jul; 67(14):1476-85. doi:
10.1016/j.phytochem.2006.05.021
. [PMID: 16820181] - I M Rusina, A F Makarchikov, E A Makar, V L Kubyshin. [Nucleoside-5'-triphosphate hydrolysis in the liver and kidney of rats with chronic alloxan diabetes].
Biomeditsinskaia khimiia.
2006 Jul; 52(4):364-9. doi:
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. [PMID: 17044594] - A Seidel, S Brunner, P Seidel, G I Fritz, O Herbarth. Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control.
British journal of cancer.
2006 Jun; 94(11):1726-33. doi:
10.1038/sj.bjc.6603164
. [PMID: 16685264] - Barbara Tavazzi, Giuseppe Lazzarino, Paola Leone, Angela Maria Amorini, Francesco Bellia, Christopher G Janson, Valentina Di Pietro, Lia Ceccarelli, Sonia Donzelli, Jeremy S Francis, Bruno Giardina. Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.
Clinical biochemistry.
2005 Nov; 38(11):997-1008. doi:
10.1016/j.clinbiochem.2005.08.002
. [PMID: 16139832] - K V Satyanarayana, Vinod Kumar, A Chandrashekar, G A Ravishankar. Isolation of promoter for N-methyltransferase gene associated with caffeine biosynthesis in Coffea canephora.
Journal of biotechnology.
2005 Sep; 119(1):20-5. doi:
10.1016/j.jbiotec.2005.06.008
. [PMID: 16043251] - Hirotaka Uefuji, Yuko Tatsumi, Masayuki Morimoto, Pulla Kaothien-Nakayama, Shinjiro Ogita, Hiroshi Sano. Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltrasferases and its potential as a pest repellant.
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