Peoniflorin (BioDeep_00000398518)

Main id: BioDeep_00000409317

 

natural product PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


Paeoniflorin

化学式: C23H28O11 (480.16315380000003)
中文名称: 芍药苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CC3(C4CC1(C4(C(O2)O3)COC(=O)C5=CC=CC=C5)OC6C(C(C(C(O6)CO)O)O)O)O
InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Annotation level-1
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].

同义名列表

2 个代谢物同义名

Peoniflorin; Paeoniflorin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cuicui Xu, Xinke Wang, Jinlong Han, Zhengwei Gu, Qingmei Guo. LMD and LC-MS-based chemical constituents and pharmacological effects assessment for two different processing methods of the root of Paeonia lactiflora Pall. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116184. doi: 10.1016/j.jpba.2024.116184. [PMID: 38692214]
  • Tian Li, Na Mao, Zihao Xie, Jianing Wang, Fuyu Jin, Yaqian Li, Shupeng Liu, Wenchen Cai, Xuemin Gao, Zhongqiu Wei, Fang Yang, Hong Xu, Heliang Liu, Haibo Zhang, Dingjie Xu. Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155616. doi: 10.1016/j.phymed.2024.155616. [PMID: 38669965]
  • Jialing Sun, Mengqing Ma, Xin Zhong, Jing Li, Jinyu Yi, Renjie Zhang, Xingning Liu, Lanfen Peng, Xinfeng Sun, Wenxing Feng, Rui Hu, Qi Huang, Minling Lv, Kongli Fan, Xiaozhou Zhou. Investigating the molecular mechanism of Qizhu anticancer prescription in inhibiting hepatocellular carcinoma based on high-resolution mass spectrometry and network pharmacology. Journal of ethnopharmacology. 2024 Jun; 328(?):117985. doi: 10.1016/j.jep.2024.117985. [PMID: 38417600]
  • Qiu-Yue Wang, Shu-Yu Liu, Dong-Hua Yu, Ping-Ping Chen, Yu Wang, Fang Lu, Shu-Min Liu. Evaluation of drug interactions of Saposhnikoviae Radix and its major components with astragaloside IV and paeoniflorin using in vitro and in vivo experiments. Journal of chromatography. A. 2024 May; 1723(?):464716. doi: 10.1016/j.chroma.2024.464716. [PMID: 38640881]
  • Tiantai Wu, Huan Zhang, Yang Jin, Ming Zhang, Qing Zhao, Herong Li, Shouli Wang, Yuan Lu, Shuaishuai Chen, Huakang Du, Ting Liu, Weiyu Guo, Wen Liu. The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: An integrated metabolomics, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 326(?):117901. doi: 10.1016/j.jep.2024.117901. [PMID: 38341112]
  • Shi-Yi Xu, Hui-Yan Cao, Rui-Hong Yang, Rong-Xue Xu, Xing-Yu Zhu, Wei Ma, Xiu-Bo Liu, Xue-Ying Yan, Peng Fu. Genus Paeonia monoterpene glycosides: A systematic review on their pharmacological activities and molecular mechanisms. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155483. doi: 10.1016/j.phymed.2024.155483. [PMID: 38432036]
  • Zixia Zhu, Cong Li, Xiaofan Gu, Xiaoting Wang, Gang Zhang, Meng Fan, Yun Zhao, Xuan Liu, Xiongwen Zhang. Paeoniflorin alleviated muscle atrophy in cancer cachexia through inhibiting TLR4/NF-κB signaling and activating AKT/mTOR signaling. Toxicology and applied pharmacology. 2024 Mar; 484(?):116846. doi: 10.1016/j.taap.2024.116846. [PMID: 38331105]
  • Hongxiao Xie, Zhiqiang Xie, Fei Luan, Jiuseng Zeng, Xiumeng Zhang, Li Chen, Nan Zeng, Rong Liu. Potential therapeutic effects of Chinese herbal medicine in postpartum depression: Mechanisms and future directions. Journal of ethnopharmacology. 2024 Jan; 324(?):117785. doi: 10.1016/j.jep.2024.117785. [PMID: 38262525]
  • Haowei Wu, Peipei Zhang, Jiedong Zhou, Songqing Hu, Jinjin Hao, Zuoquan Zhong, Haiju Yu, Juntao Yang, Hangyuan Guo, Jufang Chi. Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy. American journal of physiology. Cell physiology. 2024 Jan; ?(?):. doi: 10.1152/ajpcell.00565.2023. [PMID: 38223927]
  • Dan Liang, Lu Liu, Yulin Qi, Feng Nan, Ju Huang, Shiyun Tang, Jianyuan Tang, Nianzhi Chen. Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II. Journal of ethnopharmacology. 2024 Jan; 324(?):117745. doi: 10.1016/j.jep.2024.117745. [PMID: 38228231]
  • Yaoyao Xiao, Lele Zhou, Wenkang Tao, Xuan Yang, Junying Li, Rulin Wang, Yanan Zhao, Can Peng, Caiyun Zhang. Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jan; 192(?):106664. doi: 10.1016/j.ejps.2023.106664. [PMID: 38061662]
  • Yong Jiang, Liu Xu, Nina Wei, Rui Chen, Yutong Wang, Li Wu, Weidong Li, Zheng Yan, Linwei Chen, Zhipeng Chen. Comparative pharmacokinetics of 11 major bioactive components between two dosage forms of Qixue Shuangbu Prescription in rats by ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of separation science. 2024 Jan; 47(1):e2300677. doi: 10.1002/jssc.202300677. [PMID: 37994256]
  • Qingchang Wu, Miao Chen, Yao Li, Xiangyun Zhao, Cailian Fan, Yi Dai. Paeoniflorin Alleviates Cisplatin-Induced Diminished Ovarian Reserve by Restoring the Function of Ovarian Granulosa Cells via Activating FSHR/cAMP/PKA/CREB Signaling Pathway. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28248123. [PMID: 38138611]
  • Shasha Liu, Ying Li, Caojie Wu. Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway. Pharmaceutical biology. 2023 Dec; 61(1):1454-1461. doi: 10.1080/13880209.2023.2220360. [PMID: 37674320]
  • Ruo Man Wu, Chun Yan Wang, Jie Wang, Xiao Le Xu. Promoting reverse cholesterol transport contributes to the amelioration of atherosclerosis by paeoniflorin. European journal of pharmacology. 2023 Nov; 961(?):176137. doi: 10.1016/j.ejphar.2023.176137. [PMID: 37939989]
  • Li-Ling Si, Lu Niu, Xiao-Yan Wang, Hui Zhang, Ming-Liang Zhang, Shuang Xu, Xian-Qing Ren, Jin-Fa Tang, Wei-Xia Li. [Comparison of distribution of eight components from Liangxue Tuizi Mixture between normal and Henoch-Schonlein purpura rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(21):5915-5931. doi: 10.19540/j.cnki.cjcmm.20230618.202. [PMID: 38114188]
  • Di Xing, Yihua Ma, Miaomiao Lu, Wenlin Liu, Hongli Zhou. Paeoniflorin alleviates hypoxia/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1/Nrf2/HO-1 pathway. BMC nephrology. 2023 10; 24(1):314. doi: 10.1186/s12882-023-03366-0. [PMID: 37884904]
  • Lin-Feng Tang, Hao Chang, Dan-Dan Wang, Zhu-Qing Liu, Lan Han, Dai-Yin Peng. [Active components and potential mechanism of Taohong Siwu Decoction in regulating ischemic stroke based on target cell trapping combined with network pharmacology, molecular docking, and experimental validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(17):4761-4773. doi: 10.19540/j.cnki.cjcmm.20230423.403. [PMID: 37802815]
  • Meng Gao, Dongjian Zhang, Cuihua Jiang, Qiaomei Jin, Jian Zhang. Paeoniflorin inhibits hepatocellular carcinoma growth by reducing PD-L1 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115317. doi: 10.1016/j.biopha.2023.115317. [PMID: 37597322]
  • Shijie Bi, Yanan Liu, Tianyi Lv, Yue Ren, Kaiyang Liu, Chaoqun Liu, Yanling Zhang. Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example. Journal of ethnopharmacology. 2023 Aug; 312(?):116539. doi: 10.1016/j.jep.2023.116539. [PMID: 37088240]
  • Zhao Su, Beier Hu, Jing Li, Zhichun Zeng, Hu Chen, Yuhang Guo, Yun Mao, Wen Cao. Paeoniflorin inhibits colorectal cancer cell stemness through the miR-3194-5p/catenin beta-interacting protein 1 axis. The Kaohsiung journal of medical sciences. 2023 Aug; ?(?):. doi: 10.1002/kjm2.12736. [PMID: 37530655]
  • Liping Zhai, Hongyan Pei, Heping Shen, Yi Yang, Chenyang Han, Qiaobing Guan. Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice. Phytotherapy research : PTR. 2023 Jul; ?(?):. doi: 10.1002/ptr.7946. [PMID: 37448137]
  • Yuzhuo Dong, Kazufumi Toume, Shu Zhu, Yanhong Shi, Takayuki Tamura, Kayo Yoshimatsu, Katsuko Komatsu. Metabolomics analysis of peony root using NMR spectroscopy and impact of the preprocessing method for NMR data in multivariate analysis. Journal of natural medicines. 2023 Jul; ?(?):. doi: 10.1007/s11418-023-01721-x. [PMID: 37432536]
  • Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
  • Yang Liu, Chun-Yu He, Xue-Mei Yang, Wei-Cong Chen, Ming-Jia Zhang, Xiao-Dan Zhong, Wei-Guang Chen, Bing-Lian Zhong, Song-Qi He, Hai-Tao Sun. Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-[Formula: see text]B/HIF-1α Pathway in CCl4-Induced Liver Fibrosis. The American journal of Chinese medicine. 2023 Jun; ?(?):1-19. doi: 10.1142/s0192415x2350057x. [PMID: 37317554]
  • Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang. Identification of paeoniflorin from Paeonia lactiflora pall. As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice. Journal of ethnopharmacology. 2023 Jun; ?(?):116714. doi: 10.1016/j.jep.2023.116714. [PMID: 37315645]
  • Kangchen Li, Xinguang Liu, Runsu Hou, Hulei Zhao, Peng Zhao, Yange Tian, Jiansheng Li. Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis. Ecotoxicology and environmental safety. 2023 May; 260(?):115082. doi: 10.1016/j.ecoenv.2023.115082. [PMID: 37257350]
  • Fengyan Zhao, Caiwang Peng, Hengli Li, Haodong Chen, Yantao Yang, Qidi Ai, Naihong Chen, Fang Liu. Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway. Journal of ethnopharmacology. 2023 May; ?(?):116567. doi: 10.1016/j.jep.2023.116567. [PMID: 37172921]
  • Fu-Guang Wang, Yi Sun, Juan Cao, Xu-Ri Shen, Fu-Wang Liu, Shuang-Shuang Song, Xue-Qin Hou, Lei Yin. Effects of Danggui-Shaoyao-San on central neuroendocrine and pharmacokinetics in female ovariectomized rats. Journal of ethnopharmacology. 2023 May; ?(?):116609. doi: 10.1016/j.jep.2023.116609. [PMID: 37150422]
  • Lei Wang, Jinyan Lei, Zeyu Zhao, Jianwei Jia, Li Wang. Therapeutic effects of paeoniflorin on irritable bowel syndrome in rats. Journal of veterinary science. 2023 May; 24(3):e23. doi: 10.4142/jvs.22083. [PMID: 37271501]
  • Siqi Liu, Pengmin Ding, Mengjiao Wu, Zhihao Zhu, Jiayue Tao, Jing Wang, Zhe Xue, Rufeng Wang. Screening quality markers (Q-markers) of Xiaoer Chaige Tuire Oral Liquid by in vitro sequential metabolism and in vivo biopharmaceutical analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 116(?):154844. doi: 10.1016/j.phymed.2023.154844. [PMID: 37163902]
  • Wei-Chun Chen, Xiao-Yi Liang, Li-Yuan Xie, Ming-An Wu, Qi Shen, Li-Mei Yao, Wei Zhao, Shi-Jie Zhang, Qi Wang, Yong Liang, Wei-Rong Li. Comparative Study on the Pharmacokinetics of Paeoniflorin, White Peony Root Water Extract, and Taohong Siwu Decoction After Oral Administration in Rats. European journal of drug metabolism and pharmacokinetics. 2023 Apr; ?(?):. doi: 10.1007/s13318-023-00825-9. [PMID: 37079249]
  • Qi Wang, Huaqiang Li, Jinling You, Binjun Yan, Weifeng Jin, Menglan Shen, Yunjie Sheng, Bingqian He, Xinrui Wang, Xiongyu Meng, Luping Qin. An integrated strategy of spectrum-effect relationship and near-infrared spectroscopy rapid evaluation based on back propagation neural network for quality control of Paeoniae Radix Alba. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023 Apr; ?(?):. doi: 10.1007/s44211-023-00334-4. [PMID: 37037970]
  • Weilan Yu, Xiaolin Liu, Dake Cai, Juntao Zheng, Biaochang Lao, Min Huang, Guoping Zhong. Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co-administered with quercetin and paeoniflorin. Biopharmaceutics & drug disposition. 2023 Apr; 44(2):183-191. doi: 10.1002/bdd.2346. [PMID: 36638836]
  • Vithleem Klontza, Konstantia Graikou, Antigoni Cheilari, Vasilios Kasapis, Christos Ganos, Nektarios Aligiannis, Ioanna Chinou. Phytochemical Study on Seeds of Paeonia clusii subsp. rhodia-Antioxidant and Anti-Tyrosinase Properties. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054935. [PMID: 36902364]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Lin Peng, Zhe Ma, Wenhui Chu, Peisi Jiang, Yongqian Fu, Pan Wang. Identification and hepatoprotective activity of total glycosides of paeony with high content of paeoniflorin extracted from Paeonia lactiflora Pall. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Mar; 173(?):113624. doi: 10.1016/j.fct.2023.113624. [PMID: 36681265]
  • Lijuan Ma, Xueqi Liu, Mengya Zhang, Lang Zhou, Ling Jiang, Li Gao, Xian Wang, Yuebo Huang, Hanxu Zeng, Yonggui Wu. Paeoniflorin alleviates ischemia/reperfusion induced acute kidney injury by inhibiting Slc7a11-mediated ferroptosis. International immunopharmacology. 2023 Mar; 116(?):109754. doi: 10.1016/j.intimp.2023.109754. [PMID: 36753983]
  • Shuang Yang, Qian-Qian DU, Qian-Xia Yue, Ye-Fen Sun, Chuan-Shan Jin, Wei Zhang, Lei Ma, Cong-Bin Liu, Dong-Mei Xie. [Analysis and evaluation on Paeoniae Radix Alba from different cultivars by UPLC-Q-TOF-MS and HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Feb; 48(3):715-724. doi: 10.19540/j.cnki.cjcmm.20220618.201. [PMID: 36872235]
  • Xia'nan Sang, Xuedong Wan, Han Zhang, Jialiang Ying, Lu Wang, Qiao Yang, Qiyuan Shan, Min Hao, Minjing Qin, Qitong Zheng, Quan Chen, Xin Han, Gang Cao. The most bioactive fraction of stir-fried Radix Paeoniae Alba regulating IL-6/STAT3 signaling pathway in allergic asthma mouse. Journal of ethnopharmacology. 2023 Jan; 301(?):115821. doi: 10.1016/j.jep.2022.115821. [PMID: 36220510]
  • Fanchen Yan, Huang Ding, Zhengji Sun, Jingze Liu, Junxi Li, Dan Zhou, Wei Zhang. Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jan; ?(?):. doi: 10.1007/s00210-023-02389-6. [PMID: 36692827]
  • Rui-Xin Li, Cai-Lian Fan, Wan-Yi Xu, Wen Wei, Xiao-Xing Wang, Zi-Ting Li, Peng-Cheng Zhao, Zhi-Jian Su, Xi-Yang Tang, Zhi-Hong Yao, Yi Dai. Simultaneous determination of multiple constituents of Qi-Lin pill by UPLC-MS/MS: Applications to pharmacokinetics and testicular tissue distribution in rats. Journal of pharmaceutical and biomedical analysis. 2023 Jan; 223(?):115157. doi: 10.1016/j.jpba.2022.115157. [PMID: 36379101]
  • Xue-Er Zhang, Yao-Bin Pang, Qu Bo, Shuang-Yuan Hu, Ju-Yi Xiang, Zheng-Ru Yang, Xiao-Mei Zhang, An-Jing Chen, Jin-Hao Zeng, Xiao Ma, Jing Guo. Protective effect of paeoniflorin in diabetic nephropathy: A preclinical systematic review revealing the mechanism of action. PloS one. 2023; 18(9):e0282275. doi: 10.1371/journal.pone.0282275. [PMID: 37733659]
  • Xiao-Xiao Zhang, Jia-Qi Zuo, Yi-Ting Wang, Hui-Yun Duan, Ming-Hui Zhou, Hao-Jie Li, Yong-Hong Hu, Jun-Hui Yuan. PoDPBT, a BAHD acyltransferase, catalyses the benzoylation in paeoniflorin biosynthesis in Paeonia ostii. Plant biotechnology journal. 2023 01; 21(1):14-16. doi: 10.1111/pbi.13947. [PMID: 36221906]
  • Qian Zhang, Yuzhuo Wu, Maoxu Ge, Guiyang Xia, Huan Xia, Lingyan Wang, Xiaohong Wei, Hongwei He, Sheng Lin. Paeoniflorin-free subfraction of Paeonia lactiflora Pall. shows the potential of anti-hepatic fibrosis: an integrated analysis of network pharmacology and experimental validation. Journal of ethnopharmacology. 2022 Dec; 299(?):115678. doi: 10.1016/j.jep.2022.115678. [PMID: 36058476]
  • Xinyu Deng, Yubing Li, Xing Li, Zhenpeng Zhang, Shu Dai, Hefei Wu, Fangling Zhang, Qichao Hu, Yuan Chen, Jinhao Zeng, Xiao Ma. Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway. Molecules (Basel, Switzerland). 2022 Dec; 27(23):. doi: 10.3390/molecules27238534. [PMID: 36500627]
  • Bin Bao, Yonglin Zhao, Huan Gong, Songshan Shi, Huijun Wang, Shunchun Wang. Quantification of Paeoniflorin by Fully Validated LC-MS/MS Method: Its Application to Pharmacokinetic Interaction between Paeoniflorin and Verapamil. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238337. [PMID: 36500431]
  • Jiawei Wang, Jianxia Wen, Xiao Ma, Ju Yang, Zhao Zhang, Shuying Xie, Shizhang Wei, Manyi Jing, Haotian Li, Liwei Lang, Xuelin Zhou, Yanling Zhao. Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics. European journal of pharmacology. 2022 Nov; 935(?):175331. doi: 10.1016/j.ejphar.2022.175331. [PMID: 36273619]
  • Xiao-Li Si, Yan Wang, Bo-Ni Song, Yan Zhang, Qing-Xia Yang, Zhi Li, Yan-Ping Luo, Yong-Qiang Duan, Xing-Ming Ma, Yan-Ying Zhang. Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment. Chemistry & biodiversity. 2022 Aug; 19(8):e202200295. doi: 10.1002/cbdv.202200295. [PMID: 35841592]
  • X F Hong, L Li, Z X Yang, J Yan. [Paeoniflorin improves myocardial injury via inhibition of Src/VE-cadherin pathway in septic rats]. Zhonghua nei ke za zhi. 2022 Jun; 61(6):652-658. doi: 10.3760/cma.j.cn112138-20210811-00545. [PMID: 35673745]
  • Di Zhang, Shiquan Chang, Xin Li, Huimei Shi, Bei Jing, Zhenni Chen, Yi Lin, Yachun Zheng, Guoqiang Qian, Yuwei Pan, Guoping Zhao. Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis. Phytotherapy research : PTR. 2022 Jun; 36(6):2572-2582. doi: 10.1002/ptr.7472. [PMID: 35499270]
  • Xiao-Le Wang, Ya-Ting Wang, Zhen-Yu Guo, Ning-Ning Zhang, Yuan-Yuan Wang, Die Hu, Zhen-Zhen Wang, Yi Zhang. Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies. Journal of ethnopharmacology. 2022 May; 290(?):115067. doi: 10.1016/j.jep.2022.115067. [PMID: 35143936]
  • Xue Zhen Wang, Lei Xia, Xiao Yu Zhang, Qian Chen, Xiao Li, Yue Mou, Tong Wang, Ya Nan Zhang. The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112800. doi: 10.1016/j.biopha.2022.112800. [PMID: 35279012]
  • Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou. Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway. Bioengineered. 2022 05; 13(5):13622-13631. doi: 10.1080/21655979.2022.2081755. [PMID: 35653799]
  • Zhu-Qing He, Peng-Fei Huan, Li Wang, Jian-Cheng He. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metabolic brain disease. 2022 04; 37(4):1057-1070. doi: 10.1007/s11011-022-00937-2. [PMID: 35230626]
  • Lili Zhang, Lin Han, Jiang Ma, Tingchao Wu, Yu Wei, Linhua Zhao, Xiaolin Tong. Exploring the synergistic and complementary effects of berberine and paeoniflorin in the treatment of type 2 diabetes mellitus by network pharmacology. European journal of pharmacology. 2022 Mar; 919(?):174769. doi: 10.1016/j.ejphar.2022.174769. [PMID: 35151646]
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