betaxolol (BioDeep_00000398417)
Main id: BioDeep_00000001908
代谢物信息卡片
betaxolol
化学式: C18H29NO3 (307.2147324)
中文名称: 倍他洛尔
谱图信息:
最多检出来源 Homo sapiens(urine) 6.45%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
InChI: InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01ED - Beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.
同义名列表
1 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:3082
- KEGG: C75987
- KEGG: C06849
- KEGGdrug: D07526
- PubChem: 2369
- DrugBank: DB00195
- ChEMBL: CHEMBL423
- MeSH: Betaxolol
- CAS: 108008-51-1
- CAS: 63659-18-7
- MoNA: WA001972
- MoNA: WA001971
- MoNA: WA001970
- MoNA: WA001969
- MoNA: WA001968
- MoNA: FiehnHILIC001795
- MoNA: FiehnHILIC000222
- MoNA: CO000080
- MoNA: CO000079
- MoNA: CO000078
- MoNA: CO000077
- MoNA: CO000076
- PubChem: 9067
- NIKKAJI: J19.271F
- medchemexpress: HY-B0381
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou. Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode.
Drug delivery.
2023 Dec; 30(1):2184312. doi:
10.1080/10717544.2023.2184312. [PMID: 36866574] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Majed J Al-Wadei, Ahmed H Bakheit, Alaa A-M Abdel-Aziz, Tanveer A Wani. Betaxolol: A comprehensive profile.
Profiles of drug substances, excipients, and related methodology.
2021; 46(?):91-136. doi:
10.1016/bs.podrm.2020.07.002. [PMID: 33461701] - Shuo Liu, Xinyue Han, Hanyu Liu, Yawen Zhao, Huamei Li, Ilva D Rupenthal, Zhufen Lv, Yanzhong Chen, Fan Yang, Qineng Ping, Yufang Pan, Dongzhi Hou. Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment.
Drug delivery.
2020 Dec; 27(1):652-661. doi:
10.1080/10717544.2020.1756984. [PMID: 32347126] - Yidan Wei, Conghao Li, Qiang Zhu, Xin Zhang, Jian Guan, Shirui Mao. Comparison of thermosensitive in situ gels and drug-resin complex for ocular drug delivery: In vitro drug release and in vivo tissue distribution.
International journal of pharmaceutics.
2020 Mar; 578(?):119184. doi:
10.1016/j.ijpharm.2020.119184. [PMID: 32112932] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jia Wu, Xue Xiao, Zhenqun Li, Li Jia. Enantioseparation of chiral β-blockers using polynorepinephrine-coated nanoparticles and chiral capillary electrophoresis.
Analytical and bioanalytical chemistry.
2019 Apr; 411(10):2121-2129. doi:
10.1007/s00216-019-01641-4. [PMID: 30734853] - Ivana Šrámková, Petr Chocholouš, Hana Sklenářová, Dalibor Šatínský. On-line coupling of Micro-Extraction by Packed Sorbent with Sequential Injection Chromatography system for direct extraction and determination of betaxolol in human urine.
Talanta.
2015 Oct; 143(?):132-137. doi:
10.1016/j.talanta.2015.05.048. [PMID: 26078140] - Asma Khoobi, Sayed Mehdi Ghoreishi, Saeed Masoum, Mohsen Behpour. Multivariate curve resolution-alternating least squares assisted by voltammetry for simultaneous determination of betaxolol and atenolol using carbon nanotube paste electrode.
Bioelectrochemistry (Amsterdam, Netherlands).
2013 Dec; 94(?):100-7. doi:
10.1016/j.bioelechem.2013.04.002. [PMID: 23632433] - Leila Arjomandi-Behzad, Yadollah Yamini, Maryam Rezazadeh. Pulsed electromembrane method for simultaneous extraction of drugs with different properties.
Analytical biochemistry.
2013 Jul; 438(2):136-43. doi:
10.1016/j.ab.2013.03.027. [PMID: 23562379] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Bonpei Takase, Yasuchika Takeishi, Tadakazu Hirai, Jong-Dae Lee, Hiroyasu Uzui, Shoichi Senda, Kunihisa Miwa, Yuji Hiraoka, Toru Kinugawa, Ryohei Hosokawa, Masatoshi Fujita. Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension.
Circulation journal : official journal of the Japanese Circulation Society.
2008 May; 72(5):764-9. doi:
10.1253/circj.72.764. [PMID: 18441457] - Claudio Babiloni, Rosanna Squitti, Claudio Del Percio, Emanuele Cassetta, Maria Carla Ventriglia, Florinda Ferreri, Mario Tombini, Giovanni Frisoni, Giuliano Binetti, Mariella Gurzi, Serenella Salinari, Filippo Zappasodi, Paolo M Rossini. Free copper and resting temporal EEG rhythms correlate across healthy, mild cognitive impairment, and Alzheimer's disease subjects.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.
2007 Jun; 118(6):1244-60. doi:
10.1016/j.clinph.2007.03.016. [PMID: 17462944] - Pascal Bilbault, Sophie Pynn, Cyrille Mathien, Jean P Mazzucotelli, Francis Schneider, A Jaeger. Near-fatal betaxolol self-poisoning treated with percutaneous extracorporeal life support.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine.
2007 Apr; 14(2):120-2. doi:
10.1097/mej.0b013e328013f87c. [PMID: 17496693] - Hans R Figulla, Maria Krzeminska-Pakula, Krzystof Wrabec, Jiri Chochola, Claudia Kalmbach, P Fridl. Betaxolol is equivalent to carvedilol in patients with heart failure NYHA II or III: result of a randomized multicenter trial (BETACAR Trial).
International journal of cardiology.
2006 Nov; 113(2):153-60. doi:
10.1016/j.ijcard.2005.06.067. [PMID: 16157399] - Gábor Holló, Jess T Whitson, Robert Faulkner, Bette McCue, Michael Curtis, Helga Wieland, James Chastain, Mark Sanders, Louis DeSantis, Johan Przydryga, David C Dahlin. Concentrations of betaxolol in ocular tissues of patients with glaucoma and normal monkeys after 1 month of topical ocular administration.
Investigative ophthalmology & visual science.
2006 Jan; 47(1):235-40. doi:
10.1167/iovs.05-0945. [PMID: 16384968] - D V Dupliakov, V L Glukhova, Z I Vozhdaeva, G A Golovina. [Cardioselective beta-adrenoblockers in patients with stable angina pectoris. Comparison of efficacy and safety].
Terapevticheskii arkhiv.
2006; 78(9):43-8. doi:
. [PMID: 17076224] - S Ma, D A Morilak. Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress.
Journal of neuroendocrinology.
2005 Jan; 17(1):22-8. doi:
10.1111/j.1365-2826.2005.01279.x. [PMID: 15720472] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - Andrzej Gebka, Barbara Iwaszkiewicz-Bilikiewicz, Krystyna Raczyńska, Magdalena Homziuk, Cezary Ciechanowski. [Serum lipid profile in non-exudative AMD patients treated with locally administrated beta-blockers].
Klinika oczna.
2004; 106(3 Suppl):407-8. doi:
NULL. [PMID: 15636216] - Catherine Blondin, Pascale Hamard, Béatrice Cholley, Nicole Haeffner-Cavaillon, Christophe Baudouin. In vitro effects of preserved or preservative-free antiglaucoma medications on human complement system.
Current eye research.
2003 Oct; 27(4):253-9. doi:
10.1076/ceyr.27.4.253.16603. [PMID: 14562177] - Eric A Stone, Gary L Grunewald, Yan Lin, Rashedul Ahsan, Helen Rosengarten, H Kenneth Kramer, David Quartermain. Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice.
Synapse (New York, N.Y.).
2003 Jul; 49(1):67-76. doi:
10.1002/syn.10212. [PMID: 12710017] - A N Korzh. [Clinical and metabolic effects of betaxolol (lokren) in treatment of patients with chronic cardiac insufficiency].
Likars'ka sprava.
2003 Jul; ?(5-6):90-2. doi:
. [PMID: 14618815] - Kiyoshi Ishii, Hiroshi Matsuo, Yasuhiro Fukaya, Sumiyoshi Tanaka, Hideyuki Sakaki, Mitsunori Waki, Makoto Araie. Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation.
Investigative ophthalmology & visual science.
2003 Mar; 44(3):1169-77. doi:
10.1167/iovs.02-0482. [PMID: 12601046] - Kenichi Watanabe, Wen Juan, Gurusamy Narasimman, Meilei Ma, Mikio Inoue, Yuki Saito, Mir I I Wahed, Mikio Nakazawa, Go Hasegawa, Makoto Naito, Hitoshi Tachikawa, Naohito Tanabe, Makoto Kodama, Yoshifusa Aizawa, Tadashi Yamamoto, Kenichi Yamaguchi, Toshihiro Takahashi. Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure.
Journal of cardiovascular pharmacology.
2003 Jan; 41 Suppl 1(?):S99-103. doi:
. [PMID: 12693380] - E Vainio-Jylhä, M L Vuori, K Pyykkö, R Huupponen. Plasma concentration of topically applied betaxolol in elderly glaucoma patients.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2001 Jun; 17(3):207-13. doi:
10.1089/108076801750295245. [PMID: 11436941] - A J McLean, G Milligan. Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors.
British journal of pharmacology.
2000 Aug; 130(8):1825-32. doi:
10.1038/sj.bjp.0703506. [PMID: 10952671] - R Braakman, P van der Linden, P Sipkema. Effects of topical beta-blockers on the diameter of the isolated porcine short posterior ciliary artery.
Investigative ophthalmology & visual science.
1999 Feb; 40(2):370-7. doi:
NULL. [PMID: 9950595] - M M Bystrova, A N Britov, V M Gorbunov, A V Lebedev, N A Eliseeva, V A Metel'skaia. [Betaxolol treatment of hypertension in postmenopausal women].
Terapevticheskii arkhiv.
1999; 71(6):67-9. doi:
. [PMID: 10420462] - F Berthault, P Kintz, A Tracqui, P Mangin. A fatal case of betaxolol poisoning.
Journal of analytical toxicology.
1997 May; 21(3):228-31. doi:
10.1093/jat/21.3.228. [PMID: 9171209] - K Saku, B Zhang, T Okamoto, Y Takeda, K Liu, S Jimi, K Arakawa. Medium-term effects of betaxolol monotherapy and combination therapy with nitrendipine on lipoprotein and apolipoprotein metabolism in patients with mild to moderate essential hypertension.
Journal of human hypertension.
1996 Apr; 10(4):263-8. doi:
NULL. [PMID: 8736459] - H Yoshida, M Suzukawa, T Ishikawa, H Shige, E Nishio, H Hosoai, M Ayaori, H Nakamura. Effects of beta-blockers on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts.
Cardiovascular drugs and therapy.
1996 Mar; 10(1):67-74. doi:
10.1007/bf00051132. [PMID: 8723172] - M D Johns, C D Ponte. Acute pulmonary edema associated with ocular metipranolol use.
The Annals of pharmacotherapy.
1995 Apr; 29(4):370-3. doi:
10.1177/106002809502900405. [PMID: 7633013] - A Harris, V Malinovsky, B Martin. Correlates of acute exercise-induced ocular hypotension.
Investigative ophthalmology & visual science.
1994 Oct; 35(11):3852-7. doi:
NULL. [PMID: 7928182] - M L Vuori, T Ali-Melkkilä, T Kaila, E Iisalo, K M Saari. Beta 1- and beta 2-antagonist activity of topically applied betaxolol and timolol in the systemic circulation.
Acta ophthalmologica.
1993 Oct; 71(5):682-5. doi:
10.1111/j.1755-3768.1993.tb04661.x. [PMID: 7906474] - Y H Lee, U B Kompella, V H Lee. Systemic absorption pathways of topically applied beta adrenergic antagonists in the pigmented rabbit.
Experimental eye research.
1993 Sep; 57(3):341-9. doi:
10.1006/exer.1993.1133. [PMID: 7901046] - M L Vuori, T Ali-Melkkilä, T Kaila, E Iisalo, K M Saari. Plasma and aqueous humour concentrations and systemic effects of topical betaxolol and timolol in man.
Acta ophthalmologica.
1993 Apr; 71(2):201-6. doi:
10.1111/j.1755-3768.1993.tb04991.x. [PMID: 8333266] - T Shoji, Y Aki, K Horiuchi, T Tamaki, H He, A Nishiyama, H Kiyomoto, Y Fujisawa, H Iwao, Y Abe. Regional hemodynamic effects of betaxolol, a new selective beta 1-blocker, and atenolol in conscious spontaneously hypertensive rats.
Japanese journal of pharmacology.
1992 Nov; 60(3):253-9. doi:
10.1254/jjp.60.253. [PMID: 1491514] - J J Benn, P M Brown, L J Beckwith, M Farebrother, P H Sönksen. Glucose turnover in type I diabetic subjects during exercise. Effect of selective and nonselective beta-blockade and insulin withdrawal.
Diabetes care.
1992 Nov; 15(11):1721-6. doi:
10.2337/diacare.15.11.1721. [PMID: 1468307] - P Judlin, M J Boutroy, J P Mallie. Rat neonates renal function after beta-receptors and adrenoceptors blockade during pregnancy.
Archives internationales de physiologie, de biochimie et de biophysique.
1992 Sep; 100(5):355-9. doi:
10.3109/13813459209000726. [PMID: 1282389] - J M McLenachan, I N Findlay, J T Wilson, H J Dargie. Twenty-four-hour beta-blockade in stable angina pectoris: a study of atenolol and betaxolol.
Journal of cardiovascular pharmacology.
1992 Aug; 20(2):311-5. doi:
10.1097/00005344-199208000-00018. [PMID: 1381024] - J S van Os, P van Brummelen, A J Woittiez. Betaxolol in obese hypertensive patients. Long-term effects on blood pressure and serum lipids.
The Netherlands journal of medicine.
1992 Jun; 40(5-6):227-31. doi:
NULL. [PMID: 1436258] - M Hollenbeck, J Plum, P Heering, B Kutkuhn, B Grabensee. Influence of betaxolol on renal function and atrial natriuretic peptide in essential hypertension.
Journal of hypertension.
1991 Sep; 9(9):819-24. doi:
NULL. [PMID: 1663983] - D R Whikehart, B Montgomery, D H Sorna, J D Wells. Beta-blocking agents inhibit Na+K+ATPase in cultured corneal endothelial and epithelial cells.
Journal of ocular pharmacology.
1991; 7(3):195-200. doi:
10.1089/jop.1991.7.195. [PMID: 1664444] - B J Lipworth, N A Irvine, D G McDevitt. The effects of chronic dosing on the beta 1 and beta 2-adrenoceptor antagonism of betaxolol and atenolol.
European journal of clinical pharmacology.
1991; 40(5):467-71. doi:
10.1007/bf00315224. [PMID: 1653143] - Y W Wong, T M Ludden. Determination of betaxolol and its metabolites in blood and urine by high-performance liquid chromatography with fluorimetric detection.
Journal of chromatography.
1990 Dec; 534(?):161-72. doi:
10.1016/s0378-4347(00)82158-1. [PMID: 2094703] - A J Sinclair, I B Davies, S J Warrington. Betaxolol and glucose-insulin relationships: studies in normal subjects taking glibenclamide or metformin.
British journal of clinical pharmacology.
1990 Nov; 30(5):699-702. doi:
10.1111/j.1365-2125.1990.tb03838.x. [PMID: 2125460] - S Uchida, M Itoh, M Fujimoto, K Yamashita, M Niwa, I Sekine, M Ozaki. [Antihypertensive effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, in stroke-prone spontaneously hypertensive rats (SHRSP)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1990 Aug; 96(2):49-63. doi:
10.1254/fpj.96.2_49. [PMID: 1977670] - W H Frishman, D Tepper, E J Lazar, D Behrman. Betaxolol: a new long-acting beta 1-selective adrenergic blocker.
Journal of clinical pharmacology.
1990 Aug; 30(8):686-92. doi:
10.1002/j.1552-4604.1990.tb03627.x. [PMID: 2205635] - J Plum, M Hollenbeck, P Heering, B Grabensee. [Effect of a beta 1-receptor blocker on the plasma level of atrial natriuretic peptide in patients with essential hypertension in the exercise test].
Klinische Wochenschrift.
1990 May; 68(9):476-84. doi:
10.1007/bf01648904. [PMID: 2162449] - M A Alpert, V Mukerji, D Villarreal, A Singh, G C Flaker, J F Sanfelippo, C L Beach, R J Morgan. Efficacy of betaxolol in the treatment of stable exertional angina pectoris: a dose-ranging study.
Angiology.
1990 May; 41(5):365-76. doi:
10.1177/000331979004100503. [PMID: 2162638] - F Chaouloff, V Baudrie, D Laude. Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat.
Naunyn-Schmiedeberg's archives of pharmacology.
1990 Apr; 341(4):381-4. doi:
10.1007/bf00180665. [PMID: 1970616] - K P Lesch, K Söhnle, B Poten, G Schoellnhammer, R Rupprecht, H M Schulte. Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists.
The Journal of clinical endocrinology and metabolism.
1990 Mar; 70(3):670-4. doi:
10.1210/jcem-70-3-670. [PMID: 1968468] - P Heering, M Hollenbeck, J Plum, B Grabensee. [Effect of betaxolol on atrial natriuretic peptide regulation in patients with essential hypertension].
Zeitschrift fur Kardiologie.
1990 Feb; 79(2):134-8. doi:
NULL. [PMID: 2138833] - D J Edwards, D A Sorisio, S Knopf. Effects of the beta 2-adrenoceptor agonist clenbuterol on tyrosine and tryptophan in plasma and brain of the rat.
Biochemical pharmacology.
1989 Sep; 38(18):2957-65. doi:
10.1016/0006-2952(89)90003-8. [PMID: 2551300] - R L Kunka, Y Y Wong, R L Andersen, D G Haack. Steady-state fluctuation and variability of betaxolol and atenolol plasma levels.
Therapeutic drug monitoring.
1989 Sep; 11(5):523-7. doi:
NULL. [PMID: 2573178] - G P Reams, J H Bauer. The effect of triple drug therapy on renal function in patients with essential hypertension.
Journal of clinical pharmacology.
1989 Sep; 29(9):803-8. doi:
10.1002/j.1552-4604.1989.tb03423.x. [PMID: 2572610] - H U Janka, A G Ziegler, V Larrat, H Mehnert. [The effect of the beta 1 selective beta blocker, betaxolol, on metabolism in type II diabetics].
Arzneimittel-Forschung.
1989 May; 39(5):615-7. doi:
. [PMID: 2569309] - P R Sundaresan, S L Kelvie. Beta-adrenergic receptor coupled adenylate cyclase in rat kidney. Differential coupling in glomeruli and tubules.
Biochemical pharmacology.
1988 Dec; 37(23):4513-22. doi:
10.1016/0006-2952(88)90667-3. [PMID: 2849448] - C R Lee, A C Coste, J Allen. Determination of the beta-blocker betaxolol and labelled analogues by gas chromatography/mass spectrometry with selected ion monitoring of the alpha-cleavage fragment (m/z 72).
Biomedical & environmental mass spectrometry.
1988 Oct; 16(1-12):387-92. doi:
10.1002/bms.1200160176. [PMID: 2907410] - T M Ludden, D A Boyle, D Gieseker, G T Kennedy, M H Crawford, L K Ludden, W A Clementi. Absolute bioavailability and dose proportionality of betaxolol in normal healthy subjects.
Journal of pharmaceutical sciences.
1988 Sep; 77(9):779-83. doi:
10.1002/jps.2600770913. [PMID: 2906367] - V Kühlkamp, O Ickrath, R Haasis, L Seipel. [Electrophysiologic effects of betaxolol on conduction properties of the antegrade and retrograde pathway in patients with typical atrioventricular node reentry tachycardia following intravenous and oral administration].
Zeitschrift fur Kardiologie.
1988 Aug; 77(8):527-33. doi:
. [PMID: 3176596] - J A Nathanson. Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process.
The Journal of pharmacology and experimental therapeutics.
1988 Apr; 245(1):94-101. doi:
. [PMID: 2896241] - O Madonna, M Labeeuw, N Pozet, A H Aissa, P Zech. Influence of treatment by betaxolol on the renal response to postural changes in moderate hypertension.
International journal of clinical pharmacology, therapy, and toxicology.
1988 Mar; 26(3):133-7. doi:
. [PMID: 3410595] - G E Trope, G S Liu, P K Basu. Toxic effects of topically administered Betagan, Betoptic, and Timoptic on regenerating corneal epithelium.
Journal of ocular pharmacology.
1988; 4(4):359-66. doi:
10.1089/jop.1988.4.359. [PMID: 3246571] - D Herpin, P Boutaud, M A Ciber, A Amiel, J Demange. [Comparative pharmacoclinical study of 2 beta-blockers: atenolol and betaxolol in slight-to-moderate arterial hypertension].
Annales de cardiologie et d'angeiologie.
1987 Nov; 36(9):487-93. doi:
NULL. [PMID: 2892458] - J Ganansia, G Bianchetti, J P Thénot. Correlation between reversed-phase high-performance liquid chromatography and plasma protein binding.
Journal of chromatography.
1987 Oct; 421(1):83-90. doi:
10.1016/0378-4347(87)80381-x. [PMID: 2892848] - J H Bauer, G P Reams, A Lau. A comparison of betaxolol and nadolol on renal function in essential hypertension.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1987 Aug; 10(2):109-12. doi:
10.1016/s0272-6386(87)80041-0. [PMID: 3300292] - R K Bhamra, A E Ward, D W Holt. Column liquid chromatographic measurement of betaxolol in plasma or serum.
Journal of chromatography.
1987 Jun; 417(1):229-32. doi:
10.1016/0378-4347(87)80113-5. [PMID: 2887581] - P M Manoury, J L Binet, J Rousseau, F Lefèvre-Borg, I G Cavero. Synthesis of a series of compounds related to betaxolol, a new beta 1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases.
Journal of medicinal chemistry.
1987 Jun; 30(6):1003-11. doi:
10.1021/jm00389a008. [PMID: 2884312] - A S Iskandrian, P F Nestico, A H Hakki, J Heo, M Fernandes, R Fiorentini, C Schenk. Effects of beta blockade on systolic and diastolic left ventricular function at rest and during exercise in patients with chronic stable angina pectoris.
American heart journal.
1987 Mar; 113(3):791-8. doi:
10.1016/0002-8703(87)90721-6. [PMID: 2881478] - G P Reams, J H Bauer, A Lau. The acute and chronic effects of betaxolol on blood pressure, renin-aldosterone, and renal function in essential hypertension.
Journal of clinical pharmacology.
1987 Feb; 27(2):118-21. doi:
10.1002/j.1552-4604.1987.tb02171.x. [PMID: 2890665] - H Mitsuhashi, K Akiyama, K Hashimoto. Effects of betaxolol, a new beta 1 selective blocker, on canine ventricular arrhythmias.
Japanese journal of pharmacology.
1987 Feb; 43(2):179-85. doi:
10.1254/jjp.43.179. [PMID: 2883336] - A Wellstein, D Palm, G G Belz. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 11(?):S36-40. doi:
10.1097/00005344-198511001-00006. [PMID: 2439796] - R Beresford, R C Heel. Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension.
Drugs.
1986 Jan; 31(1):6-28. doi:
10.2165/00003495-198631010-00002. [PMID: 2866947] - D P Healy, P A Münzel, P A Insel. Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography.
Circulation research.
1985 Aug; 57(2):278-84. doi:
10.1161/01.res.57.2.278. [PMID: 2990758] - M Canal, B Flouvat. Determination of betaxolol in plasma by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1985 Jul; 342(1):212-5. doi:
10.1016/s0378-4347(00)84506-5. [PMID: 2864353] - M Pathe, J Schwartz. [Changes in hemodynamics and renal function during the oral administration of betaxolol].
Therapie.
1985 Jul; 40(4):209-12. doi:
NULL. [PMID: 2862715] - R Lew, R J Summers. Autoradiographic localization of beta-adrenoceptor subtypes in guinea-pig kidney.
British journal of pharmacology.
1985 Jun; 85(2):341-8. doi:
10.1111/j.1476-5381.1985.tb08867.x. [PMID: 2992660] - D Bojanic, J D Jansen, S R Nahorski, J Zaagsma. Atypical characteristics of the beta-adrenoceptor mediating cyclic AMP generation and lipolysis in the rat adipocyte.
British journal of pharmacology.
1985 Jan; 84(1):131-7. doi:
NULL. [PMID: 2983800] - H Caqueret, G Bianchetti. Simple method for routine determination of betaxolol in blood and urine by automated high-performance liquid chromatography with fluorimetric detection.
Journal of chromatography.
1984 Nov; 311(1):199-205. doi:
10.1016/s0378-4347(00)84710-6. [PMID: 6151567] - R Palminteri, B M Assael, G Bianchetti, R Gomeni, A Claris-Appiani, A Edefonti, P L Morselli. Betaxolol kinetics in hypertensive children with normal and abnormal renal function.
Clinical pharmacology and therapeutics.
1984 Feb; 35(2):141-7. doi:
10.1038/clpt.1984.19. [PMID: 6692644] - J Ganansia, G Gillet, P Padovani, G Bianchetti. Improved determination of betaxolol in biological samples by capillary column gas chromatography.
Journal of chromatography.
1983 Jun; 275(1):183-8. doi:
10.1016/s0378-4347(00)84359-5. [PMID: 6135703] - F Weber, O E Brodde, M Anlauf, K D Bock. Subclassification of human beta-adrenergic receptors mediating renin release.
Clinical and experimental hypertension. Part A, Theory and practice.
1983; 5(2):225-38. doi:
10.3109/10641968309048823. [PMID: 6131758] - J Saunders, S A Prestwich, A J Avery, J R Kilborn, P L Morselli, P H Sönksen. The effect of non-selective and selective beta-1-blockade on the plasma potassium response to hypoglycaemia.
Diabete & metabolisme.
1981 Dec; 7(4):239-42. doi:
. [PMID: 6120859] - K Balnave, J D Neill, C J Russell, D W Harron, W J Leahey, R Wilson, R G Shanks. Observation on the efficacy and pharmacokinetics of betaxolol (SL 75212), a cardioselective beta-adrenoceptor blocking drug.
British journal of clinical pharmacology.
1981 Feb; 11(2):171-80. doi:
10.1111/j.1365-2125.1981.tb01121.x. [PMID: 6111331] - J F Giudicelli, M Chauvin, C Thuillez, C Richer, G Bianchetti, R Gomeni, P L Morselli. Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man.
British journal of clinical pharmacology.
1980 Jul; 10(1):41-9. doi:
10.1111/j.1365-2125.1980.tb00500.x. [PMID: 6104973] - P J Cadigan, D R London, B L Pentecost, G Bianchetti, R Gomeni, J R Kilborn, P L Morselli. Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers.
British journal of clinical pharmacology.
1980 Jun; 9(6):569-75. doi:
10.1111/j.1365-2125.1980.tb01082.x. [PMID: 6104498] - G Bianchetti, J Ganansia, P L Morselli. Sensitive gas chromatographic method for the determination in blood and urine of SL 75212 [4-(2-cyclopropylmethoxyethyl)-1-phenoxy-3-isopropylaminopropan-2-ol], a new beta 1 adrenoceptor blocking agent.
Journal of chromatography.
1979 Aug; 176(1):134-9. doi:
10.1016/s0021-9673(00)92096-x. [PMID: 44712]