diphenhydramine (BioDeep_00000398396)

Main id: BioDeep_00000001461

 


代谢物信息卡片


diphenhydramine

化学式: C17H21NO (255.1623)
中文名称: 苯海拉明
谱图信息: 最多检出来源 Homo sapiens(blood) 38%

分子结构信息

SMILES: CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2671
CONFIDENCE standard compound; INTERNAL_ID 8588
CONFIDENCE standard compound; INTERNAL_ID 4116
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3].

同义名列表

3 个代谢物同义名

diphenhydramine; Diphenhydramine; Benadryl



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, ALKBH1, AXIN2, CAT, CYP2D6, HDC, SLC9A1
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 CYP2D6
Nucleus 5 ACHE, ALB, ALKBH1, AXIN2, HDC
cytosol 4 ALB, AXIN2, CAT, HDC
centrosome 2 ALB, AXIN2
nucleoplasm 3 ALKBH1, SCNN1G, SLC9A1
Cell membrane 5 ABCB1, ACHE, SLC47A1, SLC9A1, TNF
lamellipodium 1 SLC9A1
Multi-pass membrane protein 5 ABCB1, CACNA1I, SCNN1G, SLC47A1, SLC9A1
Synapse 2 ACHE, TAC1
cell surface 4 ABCB1, ACHE, SLC9A1, TNF
Golgi apparatus 2 ACHE, ALB
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 2 TAC1, TNF
Cytoplasmic vesicle, secretory vesicle 1 NTS
plasma membrane 11 ABCB1, ACHE, AXIN2, BCHE, CACNA1I, IGHE, KNG1, SCNN1G, SLC47A1, SLC9A1, TNF
Membrane 8 ABCB1, ACHE, CACNA1I, CAT, CYP2D6, HDC, SLC47A1, SLC9A1
apical plasma membrane 4 ABCB1, SCNN1G, SLC47A1, SLC9A1
axon 1 TAC1
basolateral plasma membrane 2 SLC47A1, SLC9A1
extracellular exosome 6 ABCB1, ALB, CAT, KNG1, SCNN1G, SLC9A1
endoplasmic reticulum 3 ALB, ALKBH1, CYP2D6
extracellular space 9 ACHE, ALB, BCHE, CXCL8, IGHE, INS, KNG1, TAC1, TNF
perinuclear region of cytoplasm 2 ACHE, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 4 ALKBH1, CAT, CYP2D6, SLC9A1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 CAT, CYP2D6, NTS
Microsome membrane 1 CYP2D6
Single-pass type I membrane protein 1 IGHE
Secreted 6 ACHE, ALB, BCHE, CXCL8, INS, NTS
extracellular region 11 ACHE, ALB, BCHE, CAT, CXCL8, IGHE, INS, KNG1, NTS, TAC1, TNF
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
external side of plasma membrane 2 SCNN1G, TNF
T-tubule 1 SLC9A1
beta-catenin destruction complex 1 AXIN2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 3 ABCB1, SCNN1G, SLC47A1
Membrane raft 2 SLC9A1, TNF
focal adhesion 2 CAT, SLC9A1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 KNG1
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, KNG1
Basolateral cell membrane 1 SLC9A1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
sodium channel complex 1 SCNN1G
euchromatin 1 ALKBH1
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
axon terminus 1 NTS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 INS, NTS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
cation-transporting ATPase complex 1 SLC9A1
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dongqi Zhou, Ting Zhou, Shiyun Tang, Qing Li, Wen Li, Gaofeng Gan, Mingqiao Li, Qiu Chen. Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy. Frontiers in endocrinology. 2024; 15(?):1354950. doi: 10.3389/fendo.2024.1354950. [PMID: 38332893]
  • Angela Barreto, Joana Santos, Lara Almeida, Vítor Tavares, Edgar Pinto, Maria Celeiro, Carmen Garcia-Jares, Vera L Maria. First approach to assess the effects of nanoplastics on the soil species Folsomia candida: A mixture design with bisphenol A and diphenhydramine. NanoImpact. 2023 01; 29(?):100450. doi: 10.1016/j.impact.2023.100450. [PMID: 36610661]
  • Tuyen Van Nguyen, Adam Bořík, Josef Velíšek, Antonín Kouba, Vladimír Žlábek, Anna Koubová. Integrated biomarker response in signal crayfish Pacifastacus leniusculus exposed to diphenhydramine. Chemosphere. 2022 Dec; 308(Pt 2):136382. doi: 10.1016/j.chemosphere.2022.136382. [PMID: 36088977]
  • Joseph Clemons, Arvinder Jandu, Brandon Stein, Michael Chary. Authors' reply to comment on 'Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion'. Clinical toxicology (Philadelphia, Pa.). 2022 08; 60(8):993-994. doi: 10.1080/15563650.2022.2066543. [PMID: 35475765]
  • Ju-Tae Sohn. Comment on 'Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports'. Clinical toxicology (Philadelphia, Pa.). 2022 08; 60(8):992-993. doi: 10.1080/15563650.2022.2057324. [PMID: 35343867]
  • Sigal Klainbart, Meital Grabarnik, Efrat Kelmer, Orit Chai, Olga Cuneah, Gilad Segev, Itamar Aroch. Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 39 cats. The Veterinary record. 2022 07; 191(1):e1633. doi: 10.1002/vetr.1633. [PMID: 35437770]
  • Jiao Guan, Liming Wang, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu. UHPLC-MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):458-464. doi: 10.1093/chromsci/bmab116. [PMID: 34734235]
  • Angela Barreto, Joana Santos, Ana Capitão, Rodrigo Eusébio, Évila Pinheiro Damasceno, Ana Luísa Machado, Luciana S Rocha, Vânia Calisto, Mónica J B Amorim, Vera L Maria. Assessment of diphenhydramine toxicity - Is its mode of action conserved between human and zebrafish?. Environment international. 2022 06; 164(?):107263. doi: 10.1016/j.envint.2022.107263. [PMID: 35504231]
  • Joseph Clemons, Arvinder Jandu, Brandon Stein, Michael Chary. Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports. Clinical toxicology (Philadelphia, Pa.). 2022 May; 60(5):550-558. doi: 10.1080/15563650.2022.2038187. [PMID: 35171053]
  • Jeremy S Redmond, Bernadette V Stang, John W Schlipf, John M Christensen. Pharmacokinetics of diphenhydramine following single-dose intravenous and oral administration in non-fasted adult horses. Journal of veterinary pharmacology and therapeutics. 2022 Mar; 45(2):188-195. doi: 10.1111/jvp.13041. [PMID: 34921427]
  • Tara Carney, Jennifer A Rooney, Nandi Niemand, Bronwyn Myers, Danie Theron, Robin Wood, Laura F White, Christina S Meade, Novel N Chegou, Elizabeth Ragan, Gerhard Walzl, Robert Horsburgh, Robin M Warren, Karen R Jacobson. Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. PloS one. 2022; 17(2):e0262440. doi: 10.1371/journal.pone.0262440. [PMID: 35167586]
  • Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada, Masahiro Iwaki. Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis. Brain research. 2021 10; 1768(?):147581. doi: 10.1016/j.brainres.2021.147581. [PMID: 34280372]
  • Sherin F Hammad, Basma Z El-Khateeb, Samah F El-Malla. Micelle-enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets. Luminescence : the journal of biological and chemical luminescence. 2021 May; 36(3):733-741. doi: 10.1002/bio.3996. [PMID: 33332700]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hirofumi Hamano, Masayuki Chuma, Kenshi Takechi, Yasumasa Ikeda. The authors reply. Kidney international. 2021 04; 99(4):1026. doi: 10.1016/j.kint.2021.01.009. [PMID: 33745535]
  • Shruti Gupta, David E Leaf. Diphenhydramine for the prevention of cisplatin-associated acute kidney injury. Kidney international. 2021 04; 99(4):1025-1026. doi: 10.1016/j.kint.2021.01.007. [PMID: 33745534]
  • Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-Ichi Aihara, Koichiro Tsuchiya. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney international. 2021 04; 99(4):885-899. doi: 10.1016/j.kint.2020.10.041. [PMID: 33307103]
  • Timothy Nguyen, Beatrice Polyakova, John Cerenzio, Josh Renzo Ramilo. Diphenhydramine Use in End-Stage Kidney Disease. American journal of therapeutics. 2021 Mar; 28(2):e232-e237. doi: 10.1097/mjt.0000000000001057. [PMID: 31513022]
  • Donghwa Kim, Maria Castaño, Lauren K Lujan, Jung A Woo, Stephen B Liggett. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14. The Journal of biological chemistry. 2021 Jan; 296(?):100216. doi: 10.1074/jbc.ra120.016056. [PMID: 33465377]
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  • Frane Banovic, Tara Denley, Amanda Blubaugh, Ileia Scheibe, Niksa Lemo, Mark G Papich. Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study. Veterinary dermatology. 2020 Aug; 31(4):256-e58. doi: 10.1111/vde.12840. [PMID: 31899570]
  • Shashidhar N Manchegowda, Reine Zbeidy, Fouad G Souki. Transient phlebitis: an unusual effect of intravenous diphenhydramine. BMJ case reports. 2020 Jul; 13(7):. doi: 10.1136/bcr-2020-237273. [PMID: 32675136]
  • Corie A Ellison, Shengde Wu. Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation. Regulatory toxicology and pharmacology : RTP. 2020 Jul; 114(?):104667. doi: 10.1016/j.yrtph.2020.104667. [PMID: 32387187]
  • Narjes Akbari, Neda Asadimehr, Zahra Kiani. The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. Complementary therapies in medicine. 2020 May; 50(?):102401. doi: 10.1016/j.ctim.2020.102401. [PMID: 32444056]
  • Amit Dahal, Rabin Neupane, Sai Hs Boddu, Jwala Renukuntla, Rahul Khupse, Richard Dudley. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. International journal of pharmaceutical compounding. 2020 Mar; 24(2):168-175. doi: NULL. [PMID: 32196480]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • W Casan Scott, Samuel P Haddad, Gavin N Saari, C Kevin Chambliss, Jeremy L Conkle, Cole W Matson, Bryan W Brooks. Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere. 2019 Aug; 229(?):434-442. doi: 10.1016/j.chemosphere.2019.04.188. [PMID: 31082711]
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