diphenhydramine (BioDeep_00000398396)

Main id: BioDeep_00000001461

 


代谢物信息卡片


diphenhydramine

化学式: C17H21NO (255.1623056)
中文名称: 苯海拉明
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2671
CONFIDENCE standard compound; INTERNAL_ID 8588
CONFIDENCE standard compound; INTERNAL_ID 4116
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3].

同义名列表

1 个代谢物同义名

diphenhydramine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dongqi Zhou, Ting Zhou, Shiyun Tang, Qing Li, Wen Li, Gaofeng Gan, Mingqiao Li, Qiu Chen. Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy. Frontiers in endocrinology. 2024; 15(?):1354950. doi: 10.3389/fendo.2024.1354950. [PMID: 38332893]
  • Angela Barreto, Joana Santos, Lara Almeida, Vítor Tavares, Edgar Pinto, Maria Celeiro, Carmen Garcia-Jares, Vera L Maria. First approach to assess the effects of nanoplastics on the soil species Folsomia candida: A mixture design with bisphenol A and diphenhydramine. NanoImpact. 2023 01; 29(?):100450. doi: 10.1016/j.impact.2023.100450. [PMID: 36610661]
  • Tuyen Van Nguyen, Adam Bořík, Josef Velíšek, Antonín Kouba, Vladimír Žlábek, Anna Koubová. Integrated biomarker response in signal crayfish Pacifastacus leniusculus exposed to diphenhydramine. Chemosphere. 2022 Dec; 308(Pt 2):136382. doi: 10.1016/j.chemosphere.2022.136382. [PMID: 36088977]
  • Joseph Clemons, Arvinder Jandu, Brandon Stein, Michael Chary. Authors' reply to comment on 'Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion'. Clinical toxicology (Philadelphia, Pa.). 2022 08; 60(8):993-994. doi: 10.1080/15563650.2022.2066543. [PMID: 35475765]
  • Ju-Tae Sohn. Comment on 'Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports'. Clinical toxicology (Philadelphia, Pa.). 2022 08; 60(8):992-993. doi: 10.1080/15563650.2022.2057324. [PMID: 35343867]
  • Sigal Klainbart, Meital Grabarnik, Efrat Kelmer, Orit Chai, Olga Cuneah, Gilad Segev, Itamar Aroch. Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 39 cats. The Veterinary record. 2022 07; 191(1):e1633. doi: 10.1002/vetr.1633. [PMID: 35437770]
  • Jiao Guan, Liming Wang, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu. UHPLC-MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):458-464. doi: 10.1093/chromsci/bmab116. [PMID: 34734235]
  • Angela Barreto, Joana Santos, Ana Capitão, Rodrigo Eusébio, Évila Pinheiro Damasceno, Ana Luísa Machado, Luciana S Rocha, Vânia Calisto, Mónica J B Amorim, Vera L Maria. Assessment of diphenhydramine toxicity - Is its mode of action conserved between human and zebrafish?. Environment international. 2022 06; 164(?):107263. doi: 10.1016/j.envint.2022.107263. [PMID: 35504231]
  • Joseph Clemons, Arvinder Jandu, Brandon Stein, Michael Chary. Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports. Clinical toxicology (Philadelphia, Pa.). 2022 May; 60(5):550-558. doi: 10.1080/15563650.2022.2038187. [PMID: 35171053]
  • Jeremy S Redmond, Bernadette V Stang, John W Schlipf, John M Christensen. Pharmacokinetics of diphenhydramine following single-dose intravenous and oral administration in non-fasted adult horses. Journal of veterinary pharmacology and therapeutics. 2022 Mar; 45(2):188-195. doi: 10.1111/jvp.13041. [PMID: 34921427]
  • Tara Carney, Jennifer A Rooney, Nandi Niemand, Bronwyn Myers, Danie Theron, Robin Wood, Laura F White, Christina S Meade, Novel N Chegou, Elizabeth Ragan, Gerhard Walzl, Robert Horsburgh, Robin M Warren, Karen R Jacobson. Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. PloS one. 2022; 17(2):e0262440. doi: 10.1371/journal.pone.0262440. [PMID: 35167586]
  • Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada, Masahiro Iwaki. Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis. Brain research. 2021 10; 1768(?):147581. doi: 10.1016/j.brainres.2021.147581. [PMID: 34280372]
  • Sherin F Hammad, Basma Z El-Khateeb, Samah F El-Malla. Micelle-enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets. Luminescence : the journal of biological and chemical luminescence. 2021 May; 36(3):733-741. doi: 10.1002/bio.3996. [PMID: 33332700]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hirofumi Hamano, Masayuki Chuma, Kenshi Takechi, Yasumasa Ikeda. The authors reply. Kidney international. 2021 04; 99(4):1026. doi: 10.1016/j.kint.2021.01.009. [PMID: 33745535]
  • Shruti Gupta, David E Leaf. Diphenhydramine for the prevention of cisplatin-associated acute kidney injury. Kidney international. 2021 04; 99(4):1025-1026. doi: 10.1016/j.kint.2021.01.007. [PMID: 33745534]
  • Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-Ichi Aihara, Koichiro Tsuchiya. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney international. 2021 04; 99(4):885-899. doi: 10.1016/j.kint.2020.10.041. [PMID: 33307103]
  • Timothy Nguyen, Beatrice Polyakova, John Cerenzio, Josh Renzo Ramilo. Diphenhydramine Use in End-Stage Kidney Disease. American journal of therapeutics. 2021 Mar; 28(2):e232-e237. doi: 10.1097/mjt.0000000000001057. [PMID: 31513022]
  • Donghwa Kim, Maria Castaño, Lauren K Lujan, Jung A Woo, Stephen B Liggett. The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14. The Journal of biological chemistry. 2021 Jan; 296(?):100216. doi: 10.1074/jbc.ra120.016056. [PMID: 33465377]
  • Maja D Nešić, Tanja Dučić, Xinyue Liang, Manuel Algarra, Lan Mi, Lela Korićanac, Jelena Žakula, Tatjana J Kop, Mira S Bjelaković, Aleksandra Mitrović, Gordana D Gojgić Cvijović, Milutin Stepić, Marijana Petković. SR-FTIR spectro-microscopic interaction study of biochemical changes in HeLa cells induced by Levan-C60, Pullulan-C60, and their cholesterol-derivatives. International journal of biological macromolecules. 2020 Dec; 165(Pt B):2541-2549. doi: 10.1016/j.ijbiomac.2020.10.141. [PMID: 33736274]
  • Ekjot Grewal, Bayu Sutarjono, Ibbad Mohammed. Angioedema, ACE inhibitor and COVID-19. BMJ case reports. 2020 Sep; 13(9):. doi: 10.1136/bcr-2020-237888. [PMID: 32912894]
  • Frane Banovic, Tara Denley, Amanda Blubaugh, Ileia Scheibe, Niksa Lemo, Mark G Papich. Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study. Veterinary dermatology. 2020 Aug; 31(4):256-e58. doi: 10.1111/vde.12840. [PMID: 31899570]
  • Shashidhar N Manchegowda, Reine Zbeidy, Fouad G Souki. Transient phlebitis: an unusual effect of intravenous diphenhydramine. BMJ case reports. 2020 Jul; 13(7):. doi: 10.1136/bcr-2020-237273. [PMID: 32675136]
  • Corie A Ellison, Shengde Wu. Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation. Regulatory toxicology and pharmacology : RTP. 2020 Jul; 114(?):104667. doi: 10.1016/j.yrtph.2020.104667. [PMID: 32387187]
  • Narjes Akbari, Neda Asadimehr, Zahra Kiani. The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. Complementary therapies in medicine. 2020 May; 50(?):102401. doi: 10.1016/j.ctim.2020.102401. [PMID: 32444056]
  • Amit Dahal, Rabin Neupane, Sai Hs Boddu, Jwala Renukuntla, Rahul Khupse, Richard Dudley. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. International journal of pharmaceutical compounding. 2020 Mar; 24(2):168-175. doi: NULL. [PMID: 32196480]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • W Casan Scott, Samuel P Haddad, Gavin N Saari, C Kevin Chambliss, Jeremy L Conkle, Cole W Matson, Bryan W Brooks. Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis. Chemosphere. 2019 Aug; 229(?):434-442. doi: 10.1016/j.chemosphere.2019.04.188. [PMID: 31082711]
  • Alan K Jarmusch, Emmanuel O Elijah, Fernando Vargas, Amina Bouslimani, Ricardo R da Silva, Madeleine Ernst, Mingxun Wang, Krizia K Del Rosario, Pieter C Dorrestein, Shirley M Tsunoda. Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin. Analytical chemistry. 2019 07; 91(13):8062-8069. doi: 10.1021/acs.analchem.8b05854. [PMID: 31074958]
  • Takahiro Tsuji, Koji Mochizuki, Kotaro Okada, Yoshihiro Hayashi, Yasuko Obata, Kozo Takayama, Yoshinori Onuki. Time-temperature superposition principle for the kinetic analysis of destabilization of pharmaceutical emulsions. International journal of pharmaceutics. 2019 May; 563(?):406-412. doi: 10.1016/j.ijpharm.2019.04.020. [PMID: 30978488]
  • Sundar V Cherukuri, Alan W Purvis, Sebastian T Tosto, Arash Velayati. IV Lipid Emulsion Infusion in the Treatment of Severe Diphenhydramine Overdose. The American journal of case reports. 2019 May; 20(?):758-763. doi: 10.12659/ajcr.912523. [PMID: 31138776]
  • Sarah Ehling, Wolfgang Bäumer, Mark G Papich. Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Veterinary dermatology. 2019 Apr; 30(2):91-e24. doi: 10.1111/vde.12727. [PMID: 30779257]
  • Nadezhda M Zakharova, Yury S Tarahovsky, Irina S Fadeeva, Natalia P Komelina, Maxim O Khrenov, Olga V Glushkova, Dmitry A Prokhorov, Viktor P Kutyshenko, Anatoly L Kovtun. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats. Life sciences. 2019 Feb; 219(?):190-198. doi: 10.1016/j.lfs.2019.01.023. [PMID: 30658098]
  • Mayyada Wazaify, Eman Elayeh, Razan Tubeileh, Eman A Hammad. Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach. PloS one. 2019; 14(12):e0226076. doi: 10.1371/journal.pone.0226076. [PMID: 31834888]
  • Yang Hu, Pieter J Gaillard, Jaap Rip, Elizabeth C M de Lange, Margareta Hammarlund-Udenaes. In Vivo Quantitative Understanding of PEGylated Liposome's Influence on Brain Delivery of Diphenhydramine. Molecular pharmaceutics. 2018 12; 15(12):5493-5500. doi: 10.1021/acs.molpharmaceut.8b00611. [PMID: 30376346]
  • Bin Wu, Justin K Murray, Kristin L Andrews, Kelvin Sham, Jason Long, Jennifer Aral, Joseph Ligutti, Shanti Amagasu, Dong Liu, Anruo Zou, Xiaoshan Min, Zhulun Wang, Christopher P Ilch, Thomas J Kornecook, Min-Hwa Jasmine Lin, Xuhai Be, Les P Miranda, Bryan D Moyer, Kaustav Biswas. Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis. Journal of medicinal chemistry. 2018 11; 61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. [PMID: 30346167]
  • Ji Li, Lingli Zhang, Xianliang Cheng, Lei Zhang, Baochun Shen, Chen Qing, Guorong Fan. Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking. Journal of pharmaceutical and biomedical analysis. 2018 Jul; 156(?):263-271. doi: 10.1016/j.jpba.2018.04.040. [PMID: 29729640]
  • Sarah J Wolfson, Abigail W Porter, Thomas S Villani, James E Simon, Lily Y Young. The antihistamine diphenhydramine is demethylated by anaerobic wastewater microorganisms. Chemosphere. 2018 Jul; 202(?):460-466. doi: 10.1016/j.chemosphere.2018.03.093. [PMID: 29579680]
  • Joris Meurs, Morgan R Alexander, Pavel A Levkin, Simon Widmaier, Josephine Bunch, David A Barrett, Dong-Hyun Kim. Improved Extraction Repeatability and Spectral Reproducibility for Liquid Extraction Surface Analysis-Mass Spectrometry Using Superhydrophobic-Superhydrophilic Patterning. Analytical chemistry. 2018 05; 90(10):6001-6005. doi: 10.1021/acs.analchem.8b00973. [PMID: 29701986]
  • Cathy K Gelotte, Brenda A Zimmerman, Gary A Thompson. Single-Dose Pharmacokinetic Study of Diphenhydramine HCl in Children and Adolescents. Clinical pharmacology in drug development. 2018 05; 7(4):400-407. doi: 10.1002/cpdd.391. [PMID: 28967696]
  • Muhammad Afzal, Shakir Saleem, Nalini Singh, Imran Kazmi, Ruqaiyah Khan, Mohammed Shahid Nadeem, Mazin A Zamzami, Fahad A Al-Abbasi, Firoz Anwar. Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus in Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):652-655. doi: 10.1016/j.biopha.2017.10.085. [PMID: 29101809]
  • Ju-Tae Sohn. Lipid emulsion therapy for diphenhydramine toxicity. Journal of the Formosan Medical Association = Taiwan yi zhi. 2017 11; 116(11):912-913. doi: 10.1016/j.jfma.2017.08.012. [PMID: 28927556]
  • Jiun-Hao Yu. Response to a Letter to the Editor titled, 'Lipid emulsion therapy for diphenhydramine toxicity'. Journal of the Formosan Medical Association = Taiwan yi zhi. 2017 11; 116(11):914. doi: 10.1016/j.jfma.2017.09.005. [PMID: 28947135]
  • Andrea Sanchez, Alexander Valverde, Melissa Sinclair, Cornelia Mosley, Ameet Singh, Anthony J Mutsaers, Brad Hanna, Ron Johnson, Yu Gu, Michelle Beaudoin-Kimble. Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors. Journal of the American Veterinary Medical Association. 2017 Oct; 251(7):804-813. doi: 10.2460/javma.251.7.804. [PMID: 28967819]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Sylvain Auvity, Hélène Chapy, Sébastien Goutal, Fabien Caillé, Benoit Hosten, Maria Smirnova, Xavier Declèves, Nicolas Tournier, Salvatore Cisternino. Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 Jun; 37(6):2185-2195. doi: 10.1177/0271678x16662042. [PMID: 27488910]
  • Hina Rehman, Syed Adnan Ali, Safila Naveed, Khan Usmanghani. An interquartile relationship between polyherbal extract based lozenges linkus a phase IV comparative randomised control trial. Pakistan journal of pharmaceutical sciences. 2017 May; 30(3(Suppl.)):961-966. doi: ". [PMID: 28655692]
  • Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara. Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data. Drug metabolism and pharmacokinetics. 2017 Apr; 32(2):135-144. doi: 10.1016/j.dmpk.2016.11.007. [PMID: 28190755]
  • Sophie Gosselin, Lotte C G Hoegberg, Robert S Hoffman, Andis Graudins, Christine M Stork, Simon H L Thomas, Samuel J Stellpflug, Bryan D Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F Turgeon, Benoit Bailey, Diane P Calello, Ryan Chuang, Theodore C Bania, Bruno Mégarbane, Ashish Bhalla, Valéry Lavergne. Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clinical toxicology (Philadelphia, Pa.). 2016 Dec; 54(10):899-923. doi: 10.1080/15563650.2016.1214275. [PMID: 27608281]
  • Jiun-Hao Yu, Dong-Yi Chen, Hsien-Yi Chen, Kuo-Hua Lee. Intravenous lipid-emulsion therapy in a patient with cardiac arrest after overdose of diphenhydramine. Journal of the Formosan Medical Association = Taiwan yi zhi. 2016 Nov; 115(11):1017-1018. doi: 10.1016/j.jfma.2016.06.005. [PMID: 27421174]
  • A Sanchez, A Valverde, M Sinclair, C Mosley, A Singh, A J Mutsaers, B Hanna, Y Gu, R Johnson. The pharmacokinetics of DPH after the administration of a single intravenous or intramuscular dose in healthy dogs. Journal of veterinary pharmacology and therapeutics. 2016 Oct; 39(5):452-9. doi: 10.1111/jvp.12293. [PMID: 26813802]
  • Lesley Pahs, Chris Droege, Hilary Kneale, Arthur Pancioli. A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator Administration. Annals of emergency medicine. 2016 09; 68(3):345-8. doi: 10.1016/j.annemergmed.2016.02.019. [PMID: 27174372]
  • Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model. Cardiovascular toxicology. 2016 Apr; 16(2):138-46. doi: 10.1007/s12012-015-9322-2. [PMID: 25822712]
  • Kelly Ann Scanlon, Robert Stoppacher, Lee M Blum, Samantha J Starkey. Comprehensive Duloxetine Analysis in a Fatal Overdose. Journal of analytical toxicology. 2016 Mar; 40(2):167-70. doi: 10.1093/jat/bkv134. [PMID: 26662354]
  • Shawn M Varney, Vikhyat S Bebarta, Susan M Boudreau, Toni E Vargas, Maria Castaneda, Lee A Zarzabal. Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. Annals of emergency medicine. 2016 Feb; 67(2):196-205.e3. doi: 10.1016/j.annemergmed.2015.05.028. [PMID: 26164644]
  • Zhenwei Qin, Qiuli Fu, Lifang Zhang, Houfa Yin, Xiuming Jin, Qiaomei Tang, Danni Lyu, Ke Yao. Proliferative Effects of Histamine on Primary Human Pterygium Fibroblasts. Mediators of inflammation. 2016; 2016(?):9862496. doi: 10.1155/2016/9862496. [PMID: 27872516]
  • Yoshinori Onuki, Masamitsu Yokokawa, Shunichi Utsumi, Yasuko Obata, Yoshiaki Machida, Chieko Seike, Yoshihiro Hayashi, Kozo Takayama. Effect of Surfactants and Thickeners on the Stability of Menthol-Diphenhydramine Cream Identified by Magnetic Resonance Imaging. Chemical & pharmaceutical bulletin. 2016; 64(11):1616-1621. doi: 10.1248/cpb.c16-00562. [PMID: 27803472]
  • Lauren A Kristofco, Luis Colon Cruz, Samuel P Haddad, Martine L Behra, C Kevin Chambliss, Bryan W Brooks. Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine. Aquatic toxicology (Amsterdam, Netherlands). 2016 Jan; 170(?):344-354. doi: 10.1016/j.aquatox.2015.09.011. [PMID: 26431593]
  • Hyun-moon Back, Jong-Hwa Lee, Jung-woo Chae, Byungjeong Song, Joung-Wook Seo, Hwi-yeol Yun, Kwang-il Kwon. A novel HPLC-MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):121-6. doi: 10.1016/j.jpba.2015.04.036. [PMID: 26037160]
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