Trimethioprim (BioDeep_00000398393)
Main id: BioDeep_00000001590
natural product
代谢物信息卡片
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
化学式: C14H18N4O3 (290.1378838)
中文名称: 甲氧苄氨嘧啶
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-07-09.
Cite this Page
Trimethioprim. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/trimethioprim (retrieved
2024-11-05) (BioDeep RN: BioDeep_00000398393). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1(N=C(C(=CN=1)CC2C=C(C(=C(C=2)OC)OC)OC)N)N
InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
描述信息
Trimethoprim. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=738-70-5 (retrieved 2024-07-09) (CAS RN: 738-70-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
1 个代谢物同义名
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:45924
- KEGG: C01965
- KEGGdrug: D00145
- PubChem: 5578
- DrugBank: DB00440
- ChEMBL: CHEMBL22
- MeSH: Trimethoprim
- CAS: 738-70-5
- MoNA: AU266606
- MoNA: AU266605
- MoNA: AU266604
- MoNA: AU266603
- MoNA: AU266602
- MoNA: AU266601
- MoNA: WA000866
- MoNA: WA000865
- MoNA: WA000864
- MoNA: WA000863
- MoNA: WA000862
- MoNA: WA000861
- MoNA: CCMSLIB00000078580
- MoNA: UF410604
- MoNA: UF410603
- MoNA: UF410602
- MoNA: UF410601
- PDB-CCD: TOP
- PDB-CCD: TRR
- NIKKAJI: J9.454D
- RefMet: Trimethoprim
- CAS: 56585-33-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(5)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Science of the total environment.
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Environmental pollution (Barking, Essex : 1987).
2023 Dec; 339(?):122670. doi:
10.1016/j.envpol.2023.122670. [PMID: 37813143] - Taiwo J Erinle, Martine Boulianne, Deborah Adewole. Red osier dogwood extract vs. trimethoprim-sulfadiazine (Part 2). Pharmacodynamic effects on ileal and cecal microbiota of broiler chickens challenged orally with Salmonella Enteritidis.
Poultry science.
2023 Feb; 102(4):102550. doi:
10.1016/j.psj.2023.102550. [PMID: 36854216] - Junge Xu, Ziwei Zhang, Junxian Hong, Dong Wang, Gongduan Fan, Jian Zhou, Yingmu Wang. Co-doped Fe3O4/α-FeOOH for highly efficient peroxymonosulfate activation to degrade trimethoprim: Occurrence of hybrid non-radical and radical pathways.
Journal of environmental management.
2023 Jan; 325(Pt A):116459. doi:
10.1016/j.jenvman.2022.116459. [PMID: 36244291] - Vincenzo Cunsolo, Antonella Di Francesco, Maria Gaetana Giovanna Pittalà, Rosaria Saletti, Salvatore Foti. The TriMet_DB: A Manually Curated Database of the Metabolic Proteins of Triticum aestivum.
Nutrients.
2022 Dec; 14(24):. doi:
10.3390/nu14245377. [PMID: 36558536] - Klaudia Stando, Aleksandra Czyż, Magdalena Gajda, Ewa Felis, Sylwia Bajkacz. Study of the Phytoextraction and Phytodegradation of Sulfamethoxazole and Trimethoprim from Water by Limnobium laevigatum.
International journal of environmental research and public health.
2022 12; 19(24):. doi:
10.3390/ijerph192416994. [PMID: 36554877] - Mariana N Miranda, Ana R Lado Ribeiro, Adrián M T Silva, M Fernando R Pereira. Can aged microplastics be transport vectors for organic micropollutants? - Sorption and phytotoxicity tests.
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Journal of hazardous materials.
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Chemosphere.
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Veterinary medicine and science.
2022 05; 8(3):1065-1071. doi:
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Analytical and bioanalytical chemistry.
2022 Apr; 414(9):3121-3135. doi:
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Poultry science.
2022 Jan; 101(1):101538. doi:
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2022 Jan; 45(1):133-145. doi:
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Tropical animal health and production.
2021 Dec; 54(1):25. doi:
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The Analyst.
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ACS chemical biology.
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Minerva medica.
2021 Aug; 112(4):500-505. doi:
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The Journal of chemical physics.
2021 Jul; 155(4):045101. doi:
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Chemosphere.
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Chemosphere.
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Journal of environmental management.
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CPT: pharmacometrics & systems pharmacology.
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American journal of obstetrics and gynecology.
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Journal of medicinal chemistry.
2019 02; 62(3):1562-1576. doi:
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Drug metabolism and pharmacokinetics.
2019 Feb; 34(1):87-94. doi:
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BMJ evidence-based medicine.
2018 12; 23(6):233-234. doi:
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Environmental pollution (Barking, Essex : 1987).
2018 Nov; 242(Pt A):962-969. doi:
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PLoS medicine.
2018 09; 15(9):e1002652. doi:
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The Journal of chemical physics.
2018 Aug; 149(7):072310. doi:
10.1063/1.5027004. [PMID: 30134730] - Jennifer L Goldman, Leon van Haandel. Trimethoprim: The overlooked component of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions.
Pharmacoepidemiology and drug safety.
2018 08; 27(8):949-951. doi:
10.1002/pds.4574. [PMID: 29869446] - Ákos Nyerges, Bálint Csörgő, Gábor Draskovits, Bálint Kintses, Petra Szili, Györgyi Ferenc, Tamás Révész, Eszter Ari, István Nagy, Balázs Bálint, Bálint Márk Vásárhelyi, Péter Bihari, Mónika Számel, Dávid Balogh, Henrietta Papp, Dorottya Kalapis, Balázs Papp, Csaba Pál. Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
Proceedings of the National Academy of Sciences of the United States of America.
2018 06; 115(25):E5726-E5735. doi:
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The Journal of antimicrobial chemotherapy.
2018 06; 73(6):1700-1707. doi:
10.1093/jac/dky031. [PMID: 29394363] - Kai-Che Wei, Chenglen Sy, Shang-Yin Wu, Tzu-Jung Chuang, Wei-Chun Huang, Ping-Chin Lai. Pneumocystis jirovecii pneumonia in HIV-uninfected, rituximab treated non-Hodgkin lymphoma patients.
Scientific reports.
2018 05; 8(1):8321. doi:
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Bioconjugate chemistry.
2018 05; 29(5):1729-1735. doi:
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Annals of internal medicine.
2018 05; 168(10):JC58. doi:
10.7326/acpjc-2018-168-10-058. [PMID: 29800434] - Robert Pickard, Thomas Chadwick, Yemi Oluboyede, Catherine Brennand, Alexander von Wilamowitz-Moellendorff, Doreen McClurg, Jennifer Wilkinson, Laura Ternent, Holly Fisher, Katherine Walton, Elaine McColl, Luke Vale, Ruth Wood, Mohamed Abdel-Fattah, Paul Hilton, Mandy Fader, Simon Harrison, James Larcombe, Paul Little, Anthony Timoney, James N'Dow, Heather Armstrong, Nicola Morris, Kerry Walker, Nikesh Thiruchelvam. Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT.
Health technology assessment (Winchester, England).
2018 05; 22(24):1-102. doi:
10.3310/hta22240. [PMID: 29766842] - Stephen Caltabiano, Kelly M Mahar, Karyn Lister, David Tenero, Ramiya Ravindranath, Borut Cizman, Alexander R Cobitz. The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects.
Pharmacology research & perspectives.
2018 04; 6(2):e00327. doi:
10.1002/prp2.327. [PMID: 29545948] - Remigiusz Gałęcki, Rajmund Sokół. Treatment of cryptosporidiosis in captive green iguanas (Iguana iguana).
Veterinary parasitology.
2018 Mar; 252(?):17-21. doi:
10.1016/j.vetpar.2018.01.018. [PMID: 29559143] - Tomohisa Nakada, Toshiyuki Kudo, Toshiyuki Kume, Hiroyuki Kusuhara, Kiyomi Ito. Quantitative analysis of elevation of serum creatinine via renal transporter inhibition by trimethoprim in healthy subjects using physiologically-based pharmacokinetic model.
Drug metabolism and pharmacokinetics.
2018 Feb; 33(1):103-110. doi:
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Journal of agricultural and food chemistry.
2018 Jan; 66(4):822-830. doi:
10.1021/acs.jafc.7b04355. [PMID: 29293328] - Giovanni Lorenzin, Giorgio Piccinelli, Lucrezia Carlassara, Francesco Scolari, Francesca Caccuri, Arnaldo Caruso, Maria Antonia De Francesco. Myroides odoratimimus urinary tract infection in an immunocompromised patient: an emerging multidrug-resistant micro-organism.
Antimicrobial resistance and infection control.
2018; 7(?):96. doi:
10.1186/s13756-018-0391-4. [PMID: 30094005] - C O'Halloran, N Walsh, M C O'Grady, L Barry, C Hooton, G D Corcoran, B Lucey. Assessment of the comparability of CLSI, EUCAST and Stokes antimicrobial susceptibility profiles for Escherichia coli uropathogenic isolates.
British journal of biomedical science.
2018 Jan; 75(1):24-29. doi:
10.1080/09674845.2017.1392736. [PMID: 29210602] - William Malcolm, Eilidh Fletcher, Kimberley Kavanagh, Ashutosh Deshpande, Camilla Wiuff, Charis Marwick, Marion Bennie. Risk factors for resistance and MDR in community urine isolates: population-level analysis using the NHS Scotland Infection Intelligence Platform.
The Journal of antimicrobial chemotherapy.
2018 Jan; 73(1):223-230. doi:
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PloS one.
2018; 13(7):e0200272. doi:
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International journal of antimicrobial agents.
2018 Jan; 51(1):123-127. doi:
10.1016/j.ijantimicag.2017.04.018. [PMID: 28668675] - Marita Debess Magnussen, Hannes Gislason, Shahin Gaini, Karl G Kristinsson. Antibacterial Susceptibilities of Escherichia coli from Community-Acquired Urinary Tract Infections in the Faroe Islands, Associations with Antibacterial Sales, and Comparison with Iceland and Denmark.
Microbial drug resistance (Larchmont, N.Y.).
2018 Jan; 24(1):40-47. doi:
10.1089/mdr.2017.0034. [PMID: 28537778] - Joren De Smet, Siska Croubels, Patrick De Backer, Mathias Devreese. Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs.
International journal of antimicrobial agents.
2017 Dec; 50(6):707-714. doi:
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Pharmacology research & perspectives.
2017 10; 5(5):. doi:
10.1002/prp2.357. [PMID: 28971610] - Emil List Larsen, Vanja Cejvanovic, Laura Kofoed Kjaer, Morten Thorup Pedersen, Sara Daugaard Popik, Lina Kallehave Hansen, Jon Traerup Andersen, Espen Jimenez-Solem, Kasper Broedbaek, Morten Petersen, Allan Weimann, Trine Henriksen, Jens Lykkesfeldt, Christian Torp-Pedersen, Henrik Enghusen Poulsen. Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials.
British journal of clinical pharmacology.
2017 08; 83(8):1643-1653. doi:
10.1111/bcp.13261. [PMID: 28185274] - Kang Li, Gitte Petersen, Lisa Barco, Kristian Hvidtfeldt, Liping Liu, Anders Dalsgaard. Salmonella Weltevreden in integrated and non-integrated tilapia aquaculture systems in Guangdong, China.
Food microbiology.
2017 Aug; 65(?):19-24. doi:
10.1016/j.fm.2017.01.014. [PMID: 28400002] - Elena García Lobato, Claudia García Lobato, Susana Martín Clavo. [Addisonian crisis induced by tacrolimus and trimethoprim in patient with adrenal insufficiency].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria.
2017 May; 41(3):423-424. doi:
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The Science of the total environment.
2017 Jan; 576(?):671-682. doi:
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PloS one.
2017; 12(6):e0178541. doi:
10.1371/journal.pone.0178541. [PMID: 28591134] - Rui Sun, James F Dama, Jeffrey S Tan, John P Rose, Gregory A Voth. Transition-Tempered Metadynamics Is a Promising Tool for Studying the Permeation of Drug-like Molecules through Membranes.
Journal of chemical theory and computation.
2016 Oct; 12(10):5157-5169. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1603-7. doi:
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Journal of veterinary pharmacology and therapeutics.
2016 Oct; 39(5):504-13. doi:
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BMC veterinary research.
2016 Sep; 12(?):209. doi:
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Analytica chimica acta.
2016 Aug; 934(?):80-7. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2016 Aug; 33(8):1299-311. doi:
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Zoonoses and public health.
2016 May; 63(3):241-50. doi:
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British poultry science.
2016 Apr; 57(2):179-84. doi:
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The Journal of pediatrics.
2016 Apr; 171(?):116-21. doi:
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Environmental science & technology.
2016 Mar; 50(5):2573-83. doi:
10.1021/acs.est.5b05604. [PMID: 26840504] - Kasper Meidahl Petersen, Kasper Eplov, Torben Kjær Nielsen, Espen Jimenez-Solem, Morten Petersen, Kasper Broedbaek, Sara Daugaard Popik, Lina Kallehave Hansen, Henrik Enghusen Poulsen, Jon Trærup Andersen. The Effect of Trimethoprim on Serum Folate Levels in Humans: A Randomized, Double-Blind, Placebo-Controlled Trial.
American journal of therapeutics.
2016 Mar; 23(2):e382-7. doi:
10.1097/mjt.0000000000000372. [PMID: 26566149] - Liye Wang, Lingli Huang, Yuanhu Pan, Kamil Kuča, Blanka Klímová, Qinghua Wu, Shuyu Xie, Ijaz Ahmad, Dongmei Chen, Yanfei Tao, Dan Wan, Zhenli Liu, Zonghui Yuan. Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats.
Scientific reports.
2016 Feb; 6(?):20370. doi:
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Molecular pharmaceutics.
2016 Feb; 13(2):512-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Dec; 1007(?):127-31. doi:
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