metronidazole (BioDeep_00000397715)

Main id: BioDeep_00000001549

 

Chemicals and Drugs


代谢物信息卡片


metronidazole

化学式: C6H9N3O3 (171.0643884)
中文名称: 甲硝唑
谱图信息: 最多检出来源 Homo sapiens(blood) 5.19%

分子结构信息

SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-]
InChI: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

描述信息

A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases > P01AB - Nitroimidazole derivatives
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01X - Other antibacterials > J01XD - Imidazole derivatives
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor
KEIO_ID M033
CONFIDENCE standard compound; EAWAG_UCHEM_ID 197
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].

同义名列表

1 个代谢物同义名

metronidazole



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Behnam Rahimi, Farnaz Malekifard, Bijan Esmaeilnejad. In vitro anti-Trichomonas gallinae effects of Ziziphus vulgaris L. and Camellia sinensis (L.) Kuntze extracts. Veterinary medicine and science. 2024 05; 10(3):e1432. doi: 10.1002/vms3.1432. [PMID: 38527006]
  • Qi Yao, Dongmei Lin, Yanyan Yang, Yuehong Zhuang. Combination of Doxycycline with Metronidazole Protects against Pyroptosis in Rats with Endometritis through the Modulation of TLR4/NF-κB Pathway. Discovery medicine. 2024 Jan; 36(180):140-149. doi: 10.24976/discov.med.202436180.13. [PMID: 38273754]
  • Mahmoud Rahdar, Seyedeh Tala Ramezaninia, Maryam Fasihi Karami, Azadeh Hasanzadeh, Hossein Ali Yousefi, Ardeshir Zargar. The Effect of Hydroalcoholic Extract of Quercus brantii and Artemisia aucheri Boiss Against Trichomonas vaginalis In vitro. Turkiye parazitolojii dergisi. 2023 12; 47(4):214-219. doi: 10.4274/tpd.galenos.2023.55264. [PMID: 38149441]
  • Qianqian Chen, Jingzhong Li, Zhensheng Wang, Wei Meng, Heng Wang, Zenglei Wang. A fluorescence-based assay for Trichomonas vaginalis drug screening. Parasites & vectors. 2023 Sep; 16(1):329. doi: 10.1186/s13071-023-05919-6. [PMID: 37723582]
  • Yuxiang Wang, Jinran Du, Dayan Zhang, Cong Jin, Jiangpo Chen, Zeyuan Wang, Tonglin Mei, Kaili Fu, Qingzeng Qian, Tieliang Pang. Primary antibiotic resistance in Helicobacter pylori in China: a systematic review and meta-analysis. Journal of global antimicrobial resistance. 2023 09; 34(?):30-38. doi: 10.1016/j.jgar.2023.05.014. [PMID: 37315738]
  • Lúcia G V Sousa, Sofia A Pereira, Nuno Cerca. Fighting polymicrobial biofilms in bacterial vaginosis. Microbial biotechnology. 2023 07; 16(7):1423-1437. doi: 10.1111/1751-7915.14261. [PMID: 37042412]
  • Linyuan Fan, Zhaohui Liu, Zhan Zhang, Huihui Bai. Antimicrobial Effects of Sophora flavescens Alkaloids on Metronidazole-Resistant Gardnerella vaginalis in Planktonic and Biofilm Conditions. Current microbiology. 2023 Jun; 80(8):263. doi: 10.1007/s00284-023-03378-x. [PMID: 37382659]
  • Shengjuan Hu, Yan Zhou, Yanhong Deng, Yang Bo, Xianmei Chen, Wei Yang, Ruichun Shi, Wei Zhao, Zhanbing Hou, Jianping Hu, Jianguo Liu, Xilong Zhang, Heli Yong, Ping Wang, Fei Li, Hailong Qi, Xiaoyun Wang, Lijuan Jin, Ting Cui, Haijiang Yong, Xue Li, Bin Yang, Yuehua Yu, Bin Ma, Lei Fu, Xuemei Wang, Zhen Ma, Na Tang, Yanjie You, Jianyang Guo, Xiaobing Yu, Li Yao, Ruiping Gao, Yanling Li, Ruijuan Xin, Jianfang Liu, Zhenzi Cao, Hongliang Li, Linke Ma, Shoucheng Ma, Ying Cao, Yuanyuan Tang, Jun Liu, Qian Hao, Xiaofei Li, Xuemei Li, Rui Mu, Min Niu, Xiaoming Su, Hengjun Gao. Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia. Helicobacter. 2023 Jun; 28(3):e12960. doi: 10.1111/hel.12960. [PMID: 37042045]
  • Babalola Aisosa Oni, Samuel Eshorame Sanni, Kingsley Chukwunonso Agu, Olusegun Stanley Tomomewo. Green synthesis of Ag nanoparticles from Argemone mexicana L. leaf extract coated with MOF-5 for the removal of metronidazole antibiotics from aqueous solution. Journal of environmental management. 2023 May; 342(?):118161. doi: 10.1016/j.jenvman.2023.118161. [PMID: 37210822]
  • Saulo Almeida de Menezes, Giulia Bongiorni Galego, Graziela de Vargas Rigo, Júlio César Ribeiro de Oliveira Farias de Aguiar, Bruno de Oliveira Veras, Lilian Cortez Sombra Vandesmet, Cícero Ramon Bezerra Dos Santos, Mariana Gomes Vidal Sampaio, Clécia de Carvalho Marques, Vilmar Luiz Lermen, Daniela Maria do Amaral Ferraz Navarro, Márcia Vanusa da Silva, Maria Tereza Dos Santos Correia, Tiana Tasca. Anti-Trichomonas vaginalis activity of essential oils extracted from Caatinga Myrtaceae species and chemical composition of Eugenia pohliana DC. Natural product research. 2023 Mar; 37(6):1042-1046. doi: 10.1080/14786419.2022.2101050. [PMID: 35848393]
  • Lingbing Zhang, Yandan Zhang, Xuejun Jiang, Lejiao Mao, Yinyin Xia, Yinzhen Fan, Na Li, Ziqi Jiang, Xia Qin, Yu Jiang, Gang Liu, Feng Qiu, Jun Zhang, Zhen Zou, Chengzhi Chen. Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles. Toxicology. 2023 02; 485(?):153390. doi: 10.1016/j.tox.2022.153390. [PMID: 36535435]
  • Julio César Carrero, Violeta Curay-Herrera, Lysette Chacón-Niño, Felix Krengel, Silvia-Laura Guzmán-Gutiérrez, Mayra Silva-Miranda, Luisa-Carolina González-Ramírez, Raúl J Bobes, Clara Espitia, Ricardo Reyes-Chilpa, Juan-Pedro Laclette. Potent Anti-amoebic Effects of Ibogaine, Voacangine and the Root Bark Alkaloid Fraction of Tabernaemontana arborea. Planta medica. 2023 Feb; 89(2):148-157. doi: 10.1055/a-1809-1157. [PMID: 35338475]
  • Faezeh Karami, Dara Dastan, Mohammad Fallah, Mohammad Matini. In vitro antitrichomonal activity of Satureja khuzestanica and main essential oil components carvacrol, thymol, and eugenol. Journal of infection in developing countries. 2023 Jan; 17(1):80-85. doi: 10.3855/jidc.16360. [PMID: 36795930]
  • Hui Zhang, Huiyun Zou, Ling Zhao, Xuewen Li. Seasonal distribution and dynamic evolution of antibiotics and evaluation of their resistance selection potential and ecotoxicological risk at a wastewater treatment plant in Jinan, China. Environmental science and pollution research international. 2023 Jan; ?(?):. doi: 10.1007/s11356-023-25202-6. [PMID: 36690854]
  • Fengyuan Qi, Shangrong Fan, Chao Fang, Lan Ge, Jinli Lyu, Zhuoqi Huang, Shaowei Zhao, Yuanqiang Zou, Liting Huang, Xinyang Liu, Yiheng Liang, Yongke Zhang, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Xiaowei Zhang. Orally administrated Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 can restore the vaginal health of patients recovering from bacterial vaginosis. Frontiers in immunology. 2023; 14(?):1125239. doi: 10.3389/fimmu.2023.1125239. [PMID: 37575226]
  • Rosan Zokhtareh, Mostafa Rahimnejad, Ghasem Najafpour-Darzi, Hassan Karimi-Maleh. A novel sensing platform for electrochemical detection of metronidazole antibiotic based on green-synthesized magnetic Fe3O4 nanoparticles. Environmental research. 2023 01; 216(Pt 3):114643. doi: 10.1016/j.envres.2022.114643. [PMID: 36341789]
  • Xueping Huang, Baihe Wu, Qiuzhao Chen, Yushan Chen, Xinhua Ji, Xiang Zhou, Biao Suo, Zhihui Lin, Xiaoling Zheng. Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China. PeerJ. 2023; 11(?):e15611. doi: 10.7717/peerj.15611. [PMID: 37456872]
  • Paula V Huertas-Abril, María-José Prieto-Álamo, Juan Jurado, Tamara García-Barrera, Nieves Abril. A selenium-enriched diet helps to recover liver function after antibiotic administration in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113519. doi: 10.1016/j.fct.2022.113519. [PMID: 36464106]
  • Sulistiawati, Kadek Saka Dwipayanti, Muhammad Azhar, Latifah Rahman, Ermina Pakki, Achmad Himawan, Andi Dian Permana. Enhanced skin localization of metronidazole using solid lipid microparticles incorporated into polymeric hydrogels for potential improved of rosacea treatment: An ex vivo proof of concept investigation. International journal of pharmaceutics. 2022 Nov; 628(?):122327. doi: 10.1016/j.ijpharm.2022.122327. [PMID: 36280218]
  • Nagwa Mostafa El-Sayed, Nagham Gamal Masoud. Medicinal plants as natural anti-parasitic agents against Blastocystis species. Recent advances in anti-infective drug discovery. 2022 Nov; ?(?):. doi: 10.2174/2772434418666221124123445. [PMID: 36424779]
  • Dina M M El-Shewehy, Gehad E Elshopakey, Amira Ismail, Shimaa S Hassan, Amany M Ramez. Therapeutic Potency of Ginger, Garlic, and Pomegranate Extracts Against Cryptosporidium parvum-Mediated Gastro-Splenic Damage in Mice. Acta parasitologica. 2022 Nov; ?(?):. doi: 10.1007/s11686-022-00635-0. [PMID: 36348178]
  • Zelin Ye, Yubin Cao, Cheng Miao, Wei Liu, Li Dong, Zongkai Lv, Zipporah Iheozor-Ejiofor, Chunjie Li. Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis. The Cochrane database of systematic reviews. 2022 10; 10(?):CD009197. doi: 10.1002/14651858.cd009197.pub5. [PMID: 36194420]
  • Carla Teresinha Endres, Graziela Vargas Rigo, Luciana Angelo Loges, Melissa Fontes Landell, Denise Brentan Silva, Alexandre José Macedo, Tiana Tasca. Mass Spectrometry Metabolomics Approach Reveals Anti-Trichomonas vaginalis Scaffolds from Marine Fungi. Marine biotechnology (New York, N.Y.). 2022 Oct; 24(5):1014-1022. doi: 10.1007/s10126-022-10164-6. [PMID: 36102994]
  • Sumit Arora, James Clarke, Eleftheria Tsakalozou, Priyanka Ghosh, Khondoker Alam, Jeffery E Grice, Michael S Roberts, Masoud Jamei, Sebastian Polak. Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model. Molecular pharmaceutics. 2022 09; 19(9):3139-3152. doi: 10.1021/acs.molpharmaceut.2c00229. [PMID: 35969125]
  • Adel Al-Gheethi, Narmatha Sundram, Rich Crane, Abdullah Alburihi, Radin Maya Saphira Radin Mohamed, Muhanna Mohammed Al-Shaibani, Efaq Ali Noman, Senthil Kumar Ponnusamy, Nor Amani Filzah Mohd Kamil. Metronidazole photocatalytic degradation by zinc oxide nanoparticles synthesized in watermelon peel extract; Advanced optimization, simulation and numerical models using machine learning applications. Environmental research. 2022 09; 212(Pt E):113537. doi: 10.1016/j.envres.2022.113537. [PMID: 35671799]
  • Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Sep; 40(9):843-853. doi: 10.3724/sp.j.1123.2021.12028. [PMID: 36156631]
  • Yuan-Yuan Dai, Chun Qin, Gan-Rong Huang, Yan-Chun Qin, Yong-Yi Huang, Yan-Qiang Huang, Li-Juan Zhao. Linolenic Acid-Metronidazole: a Compound Relieving Drug Resistance and Inhibiting Helicobacter pylori. Antimicrobial agents and chemotherapy. 2022 07; 66(7):e0007322. doi: 10.1128/aac.00073-22. [PMID: 35758720]
  • Mona G Baz, Sirria M Elmarhoumy, Eman M Saied, Hager S Zoghroban. Evaluation of the efficacy of gold nanoparticles on Giardia lamblia infection in experimental animals. Experimental parasitology. 2022 Jul; 238(?):108277. doi: 10.1016/j.exppara.2022.108277. [PMID: 35613683]
  • Yuta Kinoshita, Hidekazu Niwa, Eri Uchida-Fujii, Toshio Nukada, Takanori Ueno. Simultaneous Daily Fecal Microbiota Transplantation Fails to Prevent Metronidazole-Induced Dysbiosis of Equine Gut Microbiota. Journal of equine veterinary science. 2022 07; 114(?):104004. doi: 10.1016/j.jevs.2022.104004. [PMID: 35526726]
  • Xueqian Zhang, Ying You, LiLong Wang, Chunqing Ai, Linjuan Huang, Songtao Wang, Zhongfu Wang, Shuang Song, Beiwei Zhu. Anti-obesity effects of Laminaria japonica fucoidan in high-fat diet-fed mice vary with the gut microbiota structure. Food & function. 2022 Jun; 13(11):6259-6270. doi: 10.1039/d2fo00480a. [PMID: 35593392]
  • Katarzyna Pauter, Małgorzata Szultka-Młyńska, Michał Szumski, Anna Król-Górniak, Paweł Pomastowski, Bogusław Buszewski. CE-DAD-MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples. Electrophoresis. 2022 May; 43(9-10):978-989. doi: 10.1002/elps.202100190. [PMID: 34624141]
  • D Matmour, N Achachi, H Toumi. Quality of Active Pharmaceutical Ingredients Present on Algerian Soil: Control of Impurities of Ciprofloxacin, Metronidazole and Fluconazole. Annales pharmaceutiques francaises. 2022 May; 80(3):261-272. doi: 10.1016/j.pharma.2021.10.002. [PMID: 34687670]
  • Jingpeng Yang, Lingtong Meng, Hong Yang. Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model. Microbiology spectrum. 2022 04; 10(2):e0067222. doi: 10.1128/spectrum.00672-22. [PMID: 35311540]
  • Mingming Xu, Junfei Zhou, Ding Heng, Xiaorong Su, Monday M Onakpa, Yuefan Bai, Jin-Ao Duan, Chun-Tao Che, Hongkai Bi, Ming Zhao. Quinone Derivatives as Promising Anti-Helicobacter pylori Agents from Aerial Parts of Mitracarpus hirtus. Journal of natural products. 2022 04; 85(4):1029-1038. doi: 10.1021/acs.jnatprod.1c01163. [PMID: 35412828]
  • Patricia J Kissinger, Charlotte A Gaydos, Arlene C Seña, R Scott McClelland, David Soper, W Evan Secor, Davey Legendre, Kimberly A Workowski, Christina A Muzny. Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 04; 74(Suppl_2):S152-S161. doi: 10.1093/cid/ciac030. [PMID: 35416973]
  • Ibrahim Franklyn Kamara, Ajay M V Kumar, Anna Maruta, Bobson Derrick Fofanah, Charles Kuria Njuguna, Steven Shongwe, Francis Moses, Sia Morenike Tengbe, Joseph Sam Kanu, Sulaiman Lakoh, Alie H D Mansaray, Kalaiselvi Selvaraj, Mohammed Khogali, Rony Zachariah. Antibiotic Use in Suspected and Confirmed COVID-19 Patients Admitted to Health Facilities in Sierra Leone in 2020-2021: Practice Does Not Follow Policy. International journal of environmental research and public health. 2022 03; 19(7):. doi: 10.3390/ijerph19074005. [PMID: 35409687]
  • Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang. Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. Toxicology. 2022 02; 467(?):153088. doi: 10.1016/j.tox.2021.153088. [PMID: 34979169]
  • Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter Ten Dijke, Andreas Teufel, Alexander Marx, Peter R Mertens, Hua Wang, Matthias P A Ebert, Heike Bantel, Enrico N De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong-Lei Weng. Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure. Hepatology (Baltimore, Md.). 2022 02; 75(2):322-337. doi: 10.1002/hep.32119. [PMID: 34435364]
  • Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children. Pediatric clinics of North America. 2022 02; 69(1):79-97. doi: 10.1016/j.pcl.2021.08.003. [PMID: 34794678]
  • Caroline Rodrigues de Almeida, Renata Coltro Bezagio, Cristiane Maria Colli, Liara Izabela Lopes Romera, Ariana Ferrari, Mônica Lúcia Gomes. Elimination of Giardia duodenalis BIV in vivo using natural extracts in microbiome and dietary supplements. Parasitology international. 2022 Feb; 86(?):102484. doi: 10.1016/j.parint.2021.102484. [PMID: 34688884]
  • Hanui Park, Miji Lee, Jin Seon Jeong. A case of vasculitis triggered by infective endocarditis in a patient undergoing maintenance hemodialysis: a case report. BMC nephrology. 2022 01; 23(1):13. doi: 10.1186/s12882-021-02647-w. [PMID: 34979975]
  • Hoang Nhan Ho, Hoang Hao Le, Thien Giap Le, Thi Hong Anh Duong, Viet Quynh Tram Ngo, Cong Thuan Dang, Van Minh Nguyen, Tuan Hiep Tran, Chien Ngoc Nguyen. Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery. International journal of biological macromolecules. 2022 Jan; 194(?):1010-1018. doi: 10.1016/j.ijbiomac.2021.11.161. [PMID: 34843817]
  • Ayumi Eguchi, Sayaka Mizukami, Misato Nakamura, Sousuke Masuda, Hirotada Murayama, Masashi Kawashima, Mari Inohana, Rei Nagahara, Mio Kobayashi, Risako Yamashita, Suzuka Uomoto, Emi Makino, Ryoichi Ohtsuka, Naofumi Takahashi, Shim-Mo Hayashi, Robert R Maronpot, Makoto Shibutani, Toshinori Yoshida. Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. Environmental science and pollution research international. 2022 Jan; 29(1):779-789. doi: 10.1007/s11356-021-15689-2. [PMID: 34341928]
  • Abdurakhim Toychiev, Fikrat Kerimov, Jannat Islamova, Mukambar Shaislamova, Murod Mirzakhmedov, Nikolay Davis, Vladimir Syrov, Svetlana Osipova. Antiprotozoal effect of steroid hormone 20-hydroxyecdysone in giardiosis patients. Annals of parasitology. 2022; 68(3):605-615. doi: 10.17420/ap6803.467. [PMID: 36617399]
  • Prashant Singh, Eric J Alm, John M Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo. Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D. Gut microbes. 2022 Jan; 14(1):2020067. doi: 10.1080/19490976.2021.2020067. [PMID: 35014601]
  • Lingjia Shi, Dan Yang, Xin Wang. Clinical Effect of Metronidazole Vaginal Effervescent Tablet Combined with Flavescentis Sophora Suppository in the Treatment of Trichomonas Vaginitis. Contrast media & molecular imaging. 2022; 2022(?):1250755. doi: 10.1155/2022/1250755. [PMID: 36017023]
  • Nina Zemanová, Pavel Anzenbacher, Tomáš Hudcovic, Eva Anzenbacherová. Rapid Determination of Metronidazole and 2-Hydroxymetronidazole in Murine Blood Plasma. Journal of chromatographic science. 2022 Jan; 60(1):81-87. doi: 10.1093/chromsci/bmab049. [PMID: 33876238]
  • Noha M Badawi, Mona A Elkafrawy, Rania M Yehia, Dalia A Attia. Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence. Drug delivery. 2021 Dec; 28(1):814-825. doi: 10.1080/10717544.2021.1912211. [PMID: 33899634]
  • Sheng Kuang, Jinkang Xu, Miaomiao Chen, Yongliang Zhang, Fangzhen Shi, Xirong Lu. The influence of pretreatment with PPI on Helicobacter pylori eradication: A systematic review and meta-analysis. Medicine. 2021 Nov; 100(47):e27944. doi: 10.1097/md.0000000000027944. [PMID: 34964772]
  • Yalda Haghighi Shishavan, Mohammad Amjadi. A new enhanced chemiluminescence reaction based on polymer dots for the determination of metronidazole. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Nov; 260(?):119992. doi: 10.1016/j.saa.2021.119992. [PMID: 34082355]
  • Andrea L Maricuto, Viledy L Velásquez, Jacinto Pineda, David M Flora-Noda, Isaac Rodríguez, Crismar A Rodríguez-Inés, Óscar O Noya-González, Rosa Contreras, Óscar D Omaña-Ávila, Iván A Escalante-Pérez, Natasha A Camejo-Ávila, Nicolle A Kuffaty-Akkou, Fhabián S Carrión-Nessi, Martín Carballo, María E Landaeta, David A Forero-Peña. Amoebic liver abscess in a COVID-19 patient: a case report. BMC infectious diseases. 2021 Nov; 21(1):1134. doi: 10.1186/s12879-021-06819-9. [PMID: 34736397]
  • Diviyesh Panchani, Deepak Nair. Not always as simple as a UTI: An atypical case of Lemierre's syndrome, the forgotten disease. Clinical medicine (London, England). 2021 11; 21(6):e664-e666. doi: 10.7861/clinmed.2021-0579. [PMID: 34862229]
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