fosinopril (BioDeep_00000397579)
Main id: BioDeep_00000002441
代谢物信息卡片
(2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-(1-oxopropoxy)propoxy]-(4-phenylbutyl)phosphoryl]-1-oxoethyl]-2-pyrrolidinecarboxylic acid
化学式: C30H46NO7P (563.3011736)
中文名称: 福辛普利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)O)C3CCCCC3
InChI: InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30+,39?/m1/s1
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
CONFIDENCE standard compound; INTERNAL_ID 2247
同义名列表
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:5163
- ChEBI: CHEBI:93870
- KEGG: C07016
- KEGGdrug: D07992
- PubChem: 55891
- PubChem: 6708482
- ChEMBL: CHEMBL3306578
- ChEMBL: CHEMBL1886787
- MeSH: Fosinopril
- CAS: 474519-28-3
- CAS: 98048-97-6
- MoNA: AU224734
- MoNA: AU224711
- MoNA: AU224710
- MoNA: AU224709
- MoNA: AU224708
- MoNA: AU224707
- MoNA: AU224755
- MoNA: AU224754
- MoNA: AU224753
- MoNA: AU224752
- MoNA: AU224751
- MoNA: AU224705
- MoNA: AU224704
- MoNA: AU224703
- MoNA: AU224702
- MoNA: AU224701
- PubChem: 9228
- NIKKAJI: J261.844C
- RefMet: Fosinopril
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jun Wu, Yingtao Xu, Zikai Geng, Jianqing Zhou, Qingping Xiong, Zhimeng Xu, Hailun Li, Yun Han. Chitosan oligosaccharide alleviates renal fibrosis through reducing oxidative stress damage and regulating TGF-β1/Smads pathway.
Scientific reports.
2022 11; 12(1):19160. doi:
10.1038/s41598-022-20719-1. [PMID: 36357407] - Giuseppe Mancia, Rita Facchetti, Fosca Quarti-Trevano, Guido Grassi. Antihypertensive drug treatment in white-coat hypertension: data from the Plaque HYpertension Lipid-Lowering Italian Study.
Journal of hypertension.
2022 10; 40(10):1909-1917. doi:
10.1097/hjh.0000000000003176. [PMID: 35881420] - Junjun Li, Fuxing Ge, Shana Wuken, Shungang Jiao, Panlong Chen, Meiwen Huang, Xiaoli Gao, Juan Liu, Pengfei Tu, Xingyun Chai, Luqi Huang. Zerumbone, a humulane sesquiterpene from Syringa pinnatifolia, attenuates cardiac fibrosis by inhibiting of the TGF-β1/Smad signaling pathway after myocardial infarction in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154078. doi:
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Journal of the American Heart Association.
2022 04; 11(7):e023182. doi:
10.1161/jaha.121.023182. [PMID: 35322670] - Swati D Bhende, Murali Balaram Varanasi, Konde Abbulu. A sensitive and efficient LC-MS/MS method for the bioanalysis of fosinopril diacid from human plasma and its application for a bioequivalence study in humans.
Biomedical chromatography : BMC.
2021 May; 35(5):e5047. doi:
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Medicine.
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2018 Dec; 32(12):e4362. doi:
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Journal of molecular recognition : JMR.
2018 08; 31(8):e2716. doi:
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PloS one.
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2013 Jul; 24(4):737-42. doi:
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Journal of applied toxicology : JAT.
2013 Jun; 33(6):458-65. doi:
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Cell biochemistry and biophysics.
2012 Dec; 64(3):205-11. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Aug; 60(2):339-46. doi:
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
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Diabetologia.
2012 Mar; 55(3):566-78. doi:
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Pharmacological research.
2012 Mar; 65(3):285-96. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Feb; 60(?):32-43. doi:
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BMC nephrology.
2012 Jan; 13(?):3. doi:
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2011 Jan; 36(1):27-33. doi:
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Kidney & blood pressure research.
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Nutrition & metabolism.
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
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Nephrology (Carlton, Vic.).
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2010 Feb; 35(2):152-8. doi:
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Kidney & blood pressure research.
2010; 33(3):186-92. doi:
10.1159/000316703. [PMID: 20571281] - Jie-Wen Guo, Li-Ming Li, Guang-Qing Qiu, Zhi-Jun Deng, Yong-Heng Fu, Min Yang, Jing-Qiang Pan, Ruo-Xuan Liu. [Effects of Panax notoginseng saponins on ACE2 and TNF-alpha in rats with post-myocardial infarction-ventricular remodeling].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2010 Jan; 33(1):89-92. doi:
. [PMID: 20518313] - Salvatore De Cosmo, Nicola Motterlini, Sabrina Prudente, Fabio Pellegrini, Roberto Trevisan, Antonio Bossi, Giuseppe Remuzzi, Vincenzo Trischitta, Piero Ruggenenti. Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT.
Diabetes.
2009 Dec; 58(12):2920-9. doi:
10.2337/db09-0407. [PMID: 19720797] - Jie-wen Guo, Zhi-jun Deng, Yong-heng Fu, Min Yang, Bin Ren, Jing-qiang Pan, Ruo-xuan Liu. [Effects of Panax notoginsenoside on TNF-alpha and MMP-2 expressions in rats with post-myocardial infarction ventricular remodeling and the mechanism].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2009 Oct; 29(10):2048-50. doi:
". [PMID: 19861263] - Xia Zhang, Zhong-Zhuan Li, Dong-Fang Liu, Xin Xu, Zhe-Chuan Mei, Wei Shen. Angiotensin-converting enzyme inhibitors improve hepatic steatosis by modulating expression of tumour necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 in rats with type 2 diabetes.
Clinical and experimental pharmacology & physiology.
2009 Jul; 36(7):631-6. doi:
10.1111/j.1440-1681.2008.05129.x. [PMID: 19076162] - Tazeen H Jafar, Zeeshan Qadri, Shiraz Hashmi. Prevalence of microalbuminuria and associated electrocardiographic abnormalities in an Indo-Asian population.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Jul; 24(7):2111-6. doi:
10.1093/ndt/gfp042. [PMID: 19225011] - Seyed Ali Sadjadi, James I McMillan, Navin Jaipaul, Patricia Blakely, Su Su Hline. A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers.
Therapeutics and clinical risk management.
2009 Jun; 5(3):547-52. doi:
10.2147/tcrm.s5176. [PMID: 19707264] - Qilin Ma, Lijie Yang, Tianlun Yang, Ming Sun, Shenbin Wu, Yanggen Ning. [Plasma tissue factor and serum angiotensin II and the therapeutic effect of different dosages of fosinopril on chronic heart failure].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2009 May; 34(5):448-52. doi:
. [PMID: 19483295] - Enrico Agabiti-Rosei, Enzo Porteri, Damiano Rizzoni. Arterial stiffness, hypertension, and rational use of nebivolol.
Vascular health and risk management.
2009; 5(1):353-60. doi:
10.2147/vhrm.s3056. [PMID: 19475771] - Alberto F Rubio-Guerra, David Castro-Serna, Cesar I Elizalde Barrera, Luz M Ramos-Brizuela. Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors.
Integrated blood pressure control.
2009; 2(?):55-62. doi:
10.2147/ibpc.s6232. [PMID: 21949615] - Jen-Wei Chou, Cheng-Ju Yu, Po-Heng Chuang, Hsueh-Chou Lai, Chang-Hu Hsu, Ken-Sheng Cheng, Cheng-Yuan Peng, I-Ping Chiang. Successful treatment of fosinopril-induced severe cholestatic jaundice with plasma exchange.
The Annals of pharmacotherapy.
2008 Dec; 42(12):1887-92. doi:
10.1345/aph.1l229. [PMID: 19017832] - Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H H Neubert, Hannelore Daniel, Matthias Brandsch. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
The Journal of pharmacology and experimental therapeutics.
2008 Nov; 327(2):432-41. doi:
10.1124/jpet.108.143339. [PMID: 18713951] - Tian-feng Tang, Qiao-ling Zhou, Li-li Zhu, Rong Tang, Xiang Ao. [Effects of fosinopril and losartan on the expression of Toll- like receptor 4 in renal tubular epithelia cells].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2008 Oct; 33(10):958-65. doi:
. [PMID: 19001741] - Fabiana Filigheddu, Giuseppe Argiolas, Emanuela Bulla, Chiara Troffa, Patrizia Bulla, Simone Fadda, Roberta Zaninello, Simona Degortes, Francesca Frau, Silvia Pitzoi, Nicola Glorioso. Clinical variables, not RAAS polymorphisms, predict blood pressure response to ACE inhibitors in Sardinians.
Pharmacogenomics.
2008 Oct; 9(10):1419-27. doi:
10.2217/14622416.9.10.1419. [PMID: 18855530] - Ebtehal El-Demerdash, Omar M Abdel Salam, Seham A El-Batran, Heba M I Abdallah, Nermeen M Shaffie. Inhibition of the renin-angiotensin system attenuates the development of liver fibrosis and oxidative stress in rats.
Clinical and experimental pharmacology & physiology.
2008 Feb; 35(2):159-67. doi:
10.1111/j.1440-1681.2007.04797.x. [PMID: 17900296] - Seema Basi, Pierre Fesler, Albert Mimran, Julia B Lewis. Microalbuminuria in type 2 diabetes and hypertension: a marker, treatment target, or innocent bystander?.
Diabetes care.
2008 Feb; 31 Suppl 2(?):S194-201. doi:
10.2337/dc08-s249. [PMID: 18227485] - Michèle Kessler, Faiez Zannad, Philippe Lehert, Jean Pierre Grünfeld, Christian Thuilliez, Alain Leizorovicz, Philippe Lechat. Predictors of cardiovascular events in patients with end-stage renal disease: an analysis from the Fosinopril in dialysis study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Dec; 22(12):3573-9. doi:
10.1093/ndt/gfm417. [PMID: 17611249] - Ruud M A van de Wal, Pim van der Harst, Wim B M Gerritsen, Fal van der Horst, Thijs H W Plokker, Ron T Gansevoort, Wiek H van Gilst, Adriaan A Voors. Plasma matrix metalloproteinase-9 and ACE-inhibitor-induced improvement of urinary albumin excretion in non-diabetic, microalbuminuric subjects.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2007 Dec; 8(4):177-80. doi:
10.3317/jraas.2007.029. [PMID: 18205096] - Ping Li, Jing Yan, Yu Sun, Frank J Burczynski, Yuewen Gong. Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins.
Nephrology (Carlton, Vic.).
2007 Oct; 12(5):466-73. doi:
10.1111/j.1440-1797.2007.00828.x. [PMID: 17803470] - Shao-bin Duan, Qin Zou, Ying-juan Li, You-ming Peng, Fu-you Liu, Yu-hui Wang, Xiang-qing Xu, Wen-ling Jiang, Ying-hong Liu, Jun Li. [Nephrotoxicity of high- and low-osmolar contrast media: Protective role of fosinopril or telmisartan in a rat model].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2007 Oct; 32(5):812-8. doi:
. [PMID: 18007076] - Yu-hua Song. [Observation on therapeutic effects of combined acupuncture and medicine therapy and simple medication on renal hypertension of chronic kidney disease].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2007 Sep; 27(9):641-4. doi:
. [PMID: 17926612] - Shuangjin Cui, Fang Feng, Ming Ma, Han Liu, Yun Chen. Development and validation of liquid chromatography-tandem mass spectrometric method for simultaneous determination of fosinopril and its active metabolite fosinoprilat in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):143-51. doi:
10.1016/j.jchromb.2007.04.019. [PMID: 17482898] - Hua Lin, Nicola King. Demonstration of functional dipeptide transport with expression of PEPT2 in guinea pig cardiomyocytes.
Pflugers Archiv : European journal of physiology.
2007 Mar; 453(6):915-22. doi:
10.1007/s00424-006-0171-5. [PMID: 17120020] - Amir Kazory, I David Weiner. Primary hyperaldosteronism in a patient with end-stage renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Mar; 22(3):917-9. doi:
10.1093/ndt/gfl702. [PMID: 17127694] - Xiang-Mei Chen, Yi-Ping Chen, Jian Chen. [Multicentered, randomized, controlled clinical trial on patients with IgA nephropathy of Qi-yin deficiency syndrome type].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2007 Feb; 27(2):101-5. doi:
. [PMID: 17342992] - V B Simonenko, I N Medvedev, V V Tolmachev. [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome].
Klinicheskaia meditsina.
2007; 85(4):24-7. doi:
NULL. [PMID: 17564032] - Xiang-Mei Chen, Yi-Ping Chen, Zhu-Liang Zhou. [Prospective, multi-centered, randomized and controlled trial on effect of Shenle Capsule in treating patients with IgA nephropathy of Fei-Pi qi-deficiency syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Dec; 26(12):1061-5. doi:
. [PMID: 17205814] - Jarir Atthobari, Auke H Brantsma, Ron T Gansevoort, Sipke T Visser, Folkert W Asselbergs, Wiek H van Gilst, Paul E de Jong, Lolkje T W de Jong-van den Berg. The effect of statins on urinary albumin excretion and glomerular filtration rate: results from both a randomized clinical trial and an observational cohort study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Nov; 21(11):3106-14. doi:
10.1093/ndt/gfl244. [PMID: 16720593] - Ruud M A van de Wal, Ron T Gansevoort, Pim van der Harst, Frans Boomsma, H W Thijs Plokker, Dirk J van Veldhuisen, Paul E de Jong, Wiek H van Gilst, Adriaan A Voors. Predictors of angiotensin-converting enzyme inhibitor-induced reduction of urinary albumin excretion in nondiabetic patients.
Hypertension (Dallas, Tex. : 1979).
2006 Nov; 48(5):870-6. doi:
10.1161/01.hyp.0000244082.26293.2d. [PMID: 17000930] - F Zannad, M Kessler, P Lehert, J P Grünfeld, C Thuilliez, A Leizorovicz, P Lechat. Prevention of cardiovascular events in end-stage renal disease: results of a randomized trial of fosinopril and implications for future studies.
Kidney international.
2006 Oct; 70(7):1318-24. doi:
10.1038/sj.ki.5001657. [PMID: 16871247] - Pim van der Harst, Adriaan A Voors, Wiek H van Gilst, Michael Böhm, Dirk J van Veldhuisen. Statins in the treatment of chronic heart failure: a systematic review.
PLoS medicine.
2006 Aug; 3(8):e333. doi:
10.1371/journal.pmed.0030333. [PMID: 16933967] - Zhuwen Yi, Zhihui Li, Xiao-Chuan Wu, Qing-Nan He, Xi-Qiang Dang, Xiao-Jie He. Effect of fosinopril in children with steroid-resistant idiopathic nephrotic syndrome.
Pediatric nephrology (Berlin, Germany).
2006 Jul; 21(7):967-72. doi:
10.1007/s00467-006-0096-4. [PMID: 16773409] - P C Y Tong, G T C Ko, W-B Chan, R C W Ma, W-Y So, M K W Lo, K-F Lee, R Ozaki, C-C Chow, C S Cockram, J C N Chan. The efficacy and tolerability of fosinopril in Chinese type 2 diabetic patients with moderate renal insufficiency.
Diabetes, obesity & metabolism.
2006 May; 8(3):342-7. doi:
10.1111/j.1463-1326.2005.00514.x. [PMID: 16634995] - E M Hodson, D Habashy, J C Craig. Interventions for idiopathic steroid-resistant nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2006 Apr; ?(2):CD003594. doi:
10.1002/14651858.cd003594.pub3. [PMID: 16625586] - Anton C Schoolwerth, Michael M Engelgau, Thomas H Hostetter, Kathy H Rufo, Dolph Chianchiano, William M McClellan, David G Warnock, Frank Vinicor. Chronic kidney disease: a public health problem that needs a public health action plan.
Preventing chronic disease.
2006 Apr; 3(2):A57. doi:
NULL. [PMID: 16539798] - Jean-Christophe Luthi, W Dana Flanders, Michel Burnier, Bernard Burnand, William M McClellan. Anemia and chronic kidney disease are associated with poor outcomes in heart failure patients.
BMC nephrology.
2006 Mar; 7(?):3. doi:
10.1186/1471-2369-7-3. [PMID: 16515712] - Jarir Atthobari, Folkert W Asselbergs, Cornelis Boersma, Robin de Vries, Hans L Hillege, Wiek H van Gilst, Ron T Gansevoort, Paul E de Jong, Lolkje T W de Jong-van den Berg, Maarten J Postma. Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal and vascular endstage disease intervention trial (PREVEND IT).
Clinical therapeutics.
2006 Mar; 28(3):432-44. doi:
10.1016/j.clinthera.2006.03.012. [PMID: 16750458] - Jennifer Foster, William Reisman, Nathalie Lepage, Guido Filler. Influence of commonly used drugs on the accuracy of cystatin C-derived glomerular filtration rate.
Pediatric nephrology (Berlin, Germany).
2006 Feb; 21(2):235-8. doi:
10.1007/s00467-005-2075-6. [PMID: 16240157] - Li Zhang, Ji Ma, Yong Gu, Shanyan Lin. Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats.
Nephron. Experimental nephrology.
2006; 104(3):e103-11. doi:
10.1159/000094549. [PMID: 16837815]