candesartan (BioDeep_00000397561)
Main id: BioDeep_00000001532
代谢物信息卡片
candesartan
化学式: C24H20N6O3 (440.159681)
中文名称: 坎地沙坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
InChI: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2137
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].
同义名列表
2 个代谢物同义名
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:3347
- KEGG: C07468
- KEGGdrug: D00522
- PubChem: 2541
- DrugBank: DB13919
- ChEMBL: CHEMBL1016
- CAS: 139481-59-7
- MoNA: AU213718
- MoNA: AU213717
- MoNA: AU213709
- MoNA: AU213708
- MoNA: AU213707
- MoNA: AU213755
- MoNA: AU213754
- MoNA: AU213753
- MoNA: AU213752
- MoNA: AU213751
- PubChem: 9671
- NIKKAJI: J540.291C
- RefMet: Candesartan
- medchemexpress: HY-B0205
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Noha A T Abbas, Fawkia A Fayed, Rabab Saber El Sebaey, Heba A Hassan. Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Oct; ?(?):. doi:
10.1007/s00210-023-02771-4. [PMID: 37831115] - Jin Wook Lee, Hyun-Oh Gu, Yunshin Jung, YunJae Jung, Seung-Yong Seo, Jeong-Hee Hong, In-Sun Hong, Dae Ho Lee, Ok-Hee Kim, Byung-Chul Oh. Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation.
Experimental & molecular medicine.
2023 May; ?(?):. doi:
10.1038/s12276-023-00982-6. [PMID: 37121975] - Tian Xia, Lu-Lu Xu, Peng-Yue Guo, Wan-Ting Shi, Yan-Qiong Cheng, Ai-Jun Liu. Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo.
Pharmacology research & perspectives.
2023 04; 11(2):e01064. doi:
10.1002/prp2.1064. [PMID: 36810974] - Lena Neuper, Daniel Kummer, Désirée Forstner, Jacqueline Guettler, Nassim Ghaffari-Tabrizi-Wizsy, Cornelius Fischer, Herbert Juch, Olivia Nonn, Martin Gauster. Candesartan Does Not Activate PPARγ and Its Target Genes in Early Gestation Trophoblasts.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012326. [PMID: 36293183] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Sagarika Majhi, Lubhan Singh, Mohd Yasir. Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity.
Vascular health and risk management.
2022; 18(?):857-866. doi:
10.2147/vhrm.s381485. [PMID: 36536768] - Reetu R Singh, Zoe McArdle, Lindsea C Booth, Clive N May, Geoff A Head, Karen M Moritz, Markus P Schlaich, Kate M Denton. Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage.
Hypertension (Dallas, Tex. : 1979).
2022 01; 79(1):261-270. doi:
10.1161/hypertensionaha.121.18354. [PMID: 34739764] - Valeria R Martínez, Evelina G Ferrer, Patricia Am Williams. Candesartan, losartan and valsartan Zn(II) complexes interactions with bovine serum albumin.
Future medicinal chemistry.
2022 01; 14(1):9-16. doi:
10.4155/fmc-2021-0216. [PMID: 34730021] - Germana Silva Vasconcelos, Manuel Alves Dos Santos Júnior, Aline Santos Monte, Francisco Eliclécio Rodrigues da Silva, Camila Nayane de Carvalho Lima, Abelardo Barbosa Moreira Lima Neto, Ingridy da Silva Medeiros, Antonio Lucio Teixeira, David Freitas de Lucena, Silvânia Maria Mendes Vasconcelos, Danielle S Macedo. Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 12; 111(?):110348. doi:
10.1016/j.pnpbp.2021.110348. [PMID: 33984421] - Viktor Rotbain Curovic, Pedro Magalhães, Tianlin He, Tine W Hansen, Harald Mischak, Peter Rossing. Urinary peptidome and diabetic retinopathy in the DIRECT-Protect 1 and 2 trials.
Diabetic medicine : a journal of the British Diabetic Association.
2021 09; 38(9):e14634. doi:
10.1111/dme.14634. [PMID: 34228837] - Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito. High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation.
Journal of the American Heart Association.
2021 07; 10(14):e016543. doi:
10.1161/jaha.120.016543. [PMID: 34259014] - Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jul; 43(5):462-473. doi:
10.1080/10641963.2021.1901110. [PMID: 33775188] - Antonia Anna Lukito, Allen Widysanto, Theo Audi Yanto Lemuel, Ignatius Bima Prasetya, Billy Massie, Mira Yuniarti, Nicolaski Lumbuun, Raymond Pranata, Cindy Meidy, Eka Julianta Wahjoepramono, Irawan Yusuf. Candesartan as a tentative treatment for COVID-19: A prospective non-randomized open-label study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Jul; 108(?):159-166. doi:
10.1016/j.ijid.2021.05.019. [PMID: 34038766] - Xin-Jun Cai, Zeng Wang, Ying-Ying Xu, Gao-Yi Yang, Ruo-Ying Zhang, Yu Wang. Candesartan treatment enhances liposome penetration and anti-tumor effect via depletion of tumor stroma and normalization of tumor vessel.
Drug delivery and translational research.
2021 06; 11(3):1186-1197. doi:
10.1007/s13346-020-00842-0. [PMID: 32822012] - Aida M Abreu Diaz, Gergana O Drumeva, Philippe Laporte, Luis M Alonso Martinez, Daniil R Petrenyov, Jean-François Carrier, Jean N DaSilva. Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors.
Nuclear medicine and biology.
2021 May; 96-97(?):41-49. doi:
10.1016/j.nucmedbio.2021.03.003. [PMID: 33798796] - Fedor Simko, Tomas Baka. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?.
Clinical science (London, England : 1979).
2021 04; 135(8):1009-1014. doi:
10.1042/cs20210182. [PMID: 33881142] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Lea Wagmann, Aline C Vollmer, Lucas Lauder, Felix Mahfoud, Markus R Meyer. Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis.
Molecules (Basel, Switzerland).
2021 Mar; 26(5):. doi:
10.3390/molecules26051495. [PMID: 33803489] - Luis Michel Alonso Martinez, Jean N DaSilva. Development of a novel [18 F]fluorobenzyl derivative of the AT1 receptor antagonist Candesartan.
Journal of labelled compounds & radiopharmaceuticals.
2021 03; 64(3):120-128. doi:
10.1002/jlcr.3892. [PMID: 33084079] - Zhe Li, Yuxi Lin, Yi-You Huang, Runduo Liu, Chang-Guo Zhan, Xin Wang, Hai-Bin Luo. Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(8):. doi:
10.1073/pnas.2024937118. [PMID: 33568500] - Chunlong Ma, Jun Wang. Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(8):. doi:
10.1073/pnas.2024420118. [PMID: 33568498] - Maria A Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M Labandeira, Gemma Navarro, Rafael Franco, Jose L Labandeira-Garcia, Ana I Rodriguez-Perez. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19.
Clinical science (London, England : 1979).
2021 02; 135(3):465-481. doi:
10.1042/cs20201511. [PMID: 33479758] - Christine Trabolsi, Wafaa Takash Chamoun, Akram Hijazi, Cendrine Nicoletti, Marc Maresca, Mohamad Nasser. Study of Neuroprotection by a Combination of the Biological Antioxidant (Eucalyptus Extract) and the Antihypertensive Drug Candesartan against Chronic Cerebral Ischemia in Rats.
Molecules (Basel, Switzerland).
2021 Feb; 26(4):. doi:
10.3390/molecules26040839. [PMID: 33562701] - Kristina Gundlach, Katharina Wolf, Isam Salem, Olaf Randerath, Dan Seiler. Safety of Candesartan, Amlodipine, and Atorvastatin in Combination: Interaction Study in Healthy Subjects.
Clinical pharmacology in drug development.
2021 02; 10(2):190-197. doi:
10.1002/cpdd.787. [PMID: 32388918] - Kristina Rodionova, Martin Hindermann, Karl Hilgers, Christian Ott, Roland E Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting. AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects?.
Kidney & blood pressure research.
2021; 46(3):331-341. doi:
10.1159/000515616. [PMID: 34034251] - Nahla E El-Ashmawy, Hoda A El-Bahrawy, Heba H Ashmawy, Eman G Khedr. Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis.
PloS one.
2021; 16(5):e0251408. doi:
10.1371/journal.pone.0251408. [PMID: 33984042] - Takaichi Suehiro, Kazuhiko Tsuruya, Hisako Yoshida, Hiroaki Tsujikawa, Shunsuke Yamada, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Takanari Kitazono. Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial.
Kidney & blood pressure research.
2021; 46(2):173-184. doi:
10.1159/000512365. [PMID: 33677450] - Chang-Mu Chen, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Chih-Kang Chiang, Chen-Tien Wu, Shing-Hwa Liu. Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Dec; 79(?):153352. doi:
10.1016/j.phymed.2020.153352. [PMID: 33007732] - Ravinder Verma, Deepak Kaushik. Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential.
Drug delivery.
2020 Dec; 27(1):756-771. doi:
10.1080/10717544.2020.1760961. [PMID: 32397771] - N Morollón, R Belvís, A De Dios, N Pagès, C González-Oria, G Latorre, S Santos-Lasaosa. Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology's Headache Study Group.
Neurologia (Barcelona, Spain).
2020 Nov; 35(9):628-632. doi:
10.1016/j.nrl.2020.07.007. [PMID: 32896463] - Abdel G Elkahloun, Juan M Saavedra. Candesartan could ameliorate the COVID-19 cytokine storm.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110653. doi:
10.1016/j.biopha.2020.110653. [PMID: 32942152] - Hongyu Yang, Xiaoshan Song, Zhimiao Wei, Chunmei Xia, Jijiang Wang, Linlin Shen, Jin Wang. TLR4/MyD88/NF-κB Signaling in the Rostral Ventrolateral Medulla Is Involved in the Depressor Effect of Candesartan in Stress-Induced Hypertensive Rats.
ACS chemical neuroscience.
2020 10; 11(19):2978-2988. doi:
10.1021/acschemneuro.0c00029. [PMID: 32898417] - Mohammad AlQudah, Taben M Hale, Michael P Czubryt. Targeting the renin-angiotensin-aldosterone system in fibrosis.
Matrix biology : journal of the International Society for Matrix Biology.
2020 09; 91-92(?):92-108. doi:
10.1016/j.matbio.2020.04.005. [PMID: 32422329] - Ming-Jia Chen, Yu-Jia Wei, Xing-Xuan Dong, Jie-Yu Liu, Qiu-Yu Chen, Guo-Xing Zhang. The effect of candesartan on chronic stress induced imbalance of glucose homeostasis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Aug; 128(?):110300. doi:
10.1016/j.biopha.2020.110300. [PMID: 32485572] - Natsumi Yamamura-Miyazaki, Toshimi Michigami, Kenichi Satomura, Maki Urushihara, Shoji Kagami, Katsusuke Yamamoto. Reduction in urinary angiotensinogen levels and improvement of proteinuria by renin-angiotensin system blockade in pediatric chronic kidney disease patients with very low birth weight.
Pediatric nephrology (Berlin, Germany).
2020 07; 35(7):1307-1314. doi:
10.1007/s00467-020-04520-8. [PMID: 32162100] - Juyoung Shin, Hun-Sung Kim, Tong Min Kim, Hyunah Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon. The short-term effects of angiotensin II receptor blockers on albuminuria and renal function in Korean patients.
Basic & clinical pharmacology & toxicology.
2020 May; 126(5):424-431. doi:
10.1111/bcpt.13369. [PMID: 31765038] - Aimin Tan, Xuan Gui, Molly Wong, Hui Deng, Guifen Gu, Constantine Fanaras, John C Fanaras. Simultaneous quantification of candesartan and irbesartan in rabbit eye tissues by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2020 May; 34(5):e4808. doi:
10.1002/bmc.4808. [PMID: 32100318] - Abdel G Elkahloun, Juan M Saavedra. Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.
Molecular neurobiology.
2020 Mar; 57(3):1656-1673. doi:
10.1007/s12035-019-01800-9. [PMID: 31811565] - Sofia Kiriakidi, Christos Chatzigiannis, Christina Papaemmanouil, Andreas G Tzakos, Thomas Mavromoustakos. Exploring the role of the membrane bilayer in the recognition of candesartan by its GPCR AT1 receptor.
Biochimica et biophysica acta. Biomembranes.
2020 03; 1862(3):183142. doi:
10.1016/j.bbamem.2019.183142. [PMID: 31830465] - Misari Patel, Charmy Kothari. Quantitative bio-analysis of pitavastatin and candesartan in rat plasma by HPLC-UV: Assessment of pharmacokinetic drug-drug interaction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Feb; 1138(?):121962. doi:
10.1016/j.jchromb.2019.121962. [PMID: 31915110] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Misari Patel, Charmy Kothari. A simple, rapid and fully validated HPLC method for simultaneous quantitative bio-analysis of rosuvastatin and candesartan in rat plasma: Application to pharmacokinetic interaction study.
Biomedical chromatography : BMC.
2019 Oct; 33(10):e4607. doi:
10.1002/bmc.4607. [PMID: 31141832] - Elle Dagmar Coberger, Berit Packert Jensen, Judith Maree Dalrymple. Transfer of Candesartan Into Human Breast Milk.
Obstetrics and gynecology.
2019 09; 134(3):481-484. doi:
10.1097/aog.0000000000003446. [PMID: 31403599] - Dandan Wu, Xiaoting Tang, Liliqiang Ding, Jingang Cui, Peiwei Wang, Xiaoye Du, Jianyun Yin, Wenjian Wang, Yu Chen, Teng Zhang. Candesartan attenuates hypertension-associated pathophysiological alterations in the gut.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Aug; 116(?):109040. doi:
10.1016/j.biopha.2019.109040. [PMID: 31170664] - Dirk Thomas, Yuwang Liu, Herbert Stein, Boris Weimann. Investigation of bioequivalence, safety, and tolerability of a fixed-dose combination of nifedipine GITS and candesartan compared with the corresponding loose-dose combination under fed conditions
.
International journal of clinical pharmacology and therapeutics.
2019 Aug; 57(8):420-428. doi:
10.5414/cp203200. [PMID: 31232274] - Robert P Carroll, Sue Deayton, Timothy Emery, Watsala Munasinghe, Eleni Tsiopelas, Adrian Fleet, Meg Lake, Ian Humphreys, Maisarah Jalalonmuhali, Patrick Coates. Proactive treatment of angiotensin receptor antibodies in kidney transplantation with plasma exchange and/or candesartan is safe and associated with excellent graft survival at 4 years: A single centre Australian experience.
Human immunology.
2019 Aug; 80(8):573-578. doi:
10.1016/j.humimm.2019.04.005. [PMID: 31014826] - Prem Pais, Hyejung Jung, Antonio Dans, Jun Zhu, Lisheng Liu, Deepak Kamath, Jackie Bosch, Eva Lonn, Salim Yusuf. Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study.
European journal of preventive cardiology.
2019 05; 26(7):681-697. doi:
10.1177/2047487318819019. [PMID: 30537846] - Jackie Bosch, Martin O'Donnell, Balakumar Swaminathan, Eva Marie Lonn, Mikul Sharma, Gilles Dagenais, Rafael Diaz, Kamlesh Khunti, Basil S Lewis, Alvaro Avezum, Claes Held, Matyas Keltai, Christopher Reid, William D Toff, Antonio Dans, Lawrence A Leiter, Karen Sliwa, Shun Fu Lee, Janice M Pogue, Robert Hart, Salim Yusuf. Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.
Neurology.
2019 03; 92(13):e1435-e1446. doi:
10.1212/wnl.0000000000007174. [PMID: 30814321] - Hebatalla I Ahmed, Eman A Mohamed. Candesartan and epigallocatechin-3-gallate ameliorate gentamicin-induced renal damage in rats through p38-MAPK and NF-κB pathways.
Journal of biochemical and molecular toxicology.
2019 Mar; 33(3):e22254. doi:
10.1002/jbt.22254. [PMID: 30368989] - Izabela Zakrocka, Katarzyna M Targowska-Duda, Artur Wnorowski, Tomasz Kocki, Krzysztof Jóźwiak, Waldemar A Turski. Angiotensin II type 1 receptor blockers decrease kynurenic acid production in rat kidney in vitro.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 02; 392(2):209-217. doi:
10.1007/s00210-018-1572-7. [PMID: 30370429] - Uma Markan, Samhitha Pasupuleti, Celina M Pollard, Arianna Perez, Beatrix Aukszi, Anastasios Lymperopoulos. The place of ARBs in heart failure therapy: is aldosterone suppression the key?.
Therapeutic advances in cardiovascular disease.
2019 Jan; 13(?):1753944719868134. doi:
10.1177/1753944719868134. [PMID: 31401939] - Ying Yu, Haifeng Jiang, Yangyang Niu, Xiaoqin Zhang, Yingying Zhang, X I Liu, Tao Qi, Chen Yu. Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells.
Anais da Academia Brasileira de Ciencias.
2019; 91(2):e20180699. doi:
10.1590/0001-3765201920180699. [PMID: 31038541] - Ewa Klara Stuermer, Manuela Besser, Nils Terberger, Hagen Sjard Bachmann, Anna-Lena Severing. Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.
Skin pharmacology and physiology.
2019; 32(3):162-172. doi:
10.1159/000499433. [PMID: 31018213] - Patrick N Cunningham, Zhiying Wang, Megan L Grove, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Yan Gong, John G Gums, Julie A Johnson, Stephen T Turner, Eric Boerwinkle, Arlene B Chapman. Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.
PloS one.
2019; 14(9):e0221957. doi:
10.1371/journal.pone.0221957. [PMID: 31532792] - Shaista Hamid, Anwar Ejaz Beg, Iyad Naeem Muhammad, Sohail Hassan, Amir Hassan, Arfa Akram, Neyama Alladin. Development and validation of HPLC method for the determination of Candesartan in human plasma.
Pakistan journal of pharmaceutical sciences.
2018 Nov; 31(6):2323-2327. doi:
NULL. [PMID: 30473499] - Rong Rong, Gaizun Hu, Wanting Wang, Yoshikazu Muroya, Takahiro Miura, Yoshiko Ogawa, Masahiro Kohzuki, Osamu Ito. Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor.
Prostaglandins & other lipid mediators.
2018 11; 139(?):80-86. doi:
10.1016/j.prostaglandins.2018.09.003. [PMID: 30227249] - Mohammad Saleem, Xitao Wang, Indira Pokkunuri, Mohammad Asghar. Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.
American journal of physiology. Renal physiology.
2018 11; 315(5):F1478-F1483. doi:
10.1152/ajprenal.00194.2018. [PMID: 30110572] - Jinliang Liu, Shinji Yasuno, Koji Oba, Manako Konda, Chikako Ichihara, Hiromi Kitao, Yoshihiro Kuwabara, Kenji Ueshima. Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan.
Journal of hypertension.
2018 09; 36(9):1921-1928. doi:
10.1097/hjh.0000000000001780. [PMID: 29750680] - Gilles R Dagenais, Hyejung Jung, Eva Lonn, Peter M Bogaty, Mahshid Dehghan, Claes Held, Alvaro Avezum, Petr Jansky, Matyàs Keltai, Lawrence A Leiter, Patricio Lopez-Jaramillo, William D Toff, Jackie Bosch, Salim Yusuf. Effects of Lipid-Lowering and Antihypertensive Treatments in Addition to Healthy Lifestyles in Primary Prevention: An Analysis of the HOPE-3 Trial.
Journal of the American Heart Association.
2018 07; 7(15):. doi:
10.1161/jaha.118.008918. [PMID: 30033433] - Xudong Zhao, Xietong Wang. Candesartan targeting of angiotensin II type 1 receptor demonstrates benefits for hypertension in pregnancy via the NF‑κB signaling pathway.
Molecular medicine reports.
2018 Jul; 18(1):705-714. doi:
10.3892/mmr.2018.9070. [PMID: 29845261] - Simon de Denus, Marie-Pierre Dubé, René Fouodjio, Thao Huynh, Marie-Hélène LeBlanc, Serge Lepage, Richard Sheppard, Nadia Giannetti, Joël Lavoie, Asmaa Mansour, Sylvie Provost, Valérie Normand, Ian Mongrain, Mathieu Langlois, Eileen O'Meara, Anique Ducharme, Normand Racine, Marie-Claude Guertin, Jacques Turgeon, Michael S Phillips, Jean-Lucien Rouleau, Jean-Claude Tardif, Michel White. A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.
Pharmacogenomics.
2018 05; 19(7):599-612. doi:
10.2217/pgs-2018-0004. [PMID: 29701105] - Olga Gawryś, Iwona Baranowska, Katarzyna Gawarecka, Ewa Świeżewska, Jolanta Dyniewicz, Krzysztof H Olszyński, Marek Masnyk, Marek Chmielewski, Elżbieta Kompanowska-Jezierska. Innovative lipid-based carriers containing cationic derivatives of polyisoprenoid alcohols augment the antihypertensive effectiveness of candesartan in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2018 Apr; 41(4):234-245. doi:
10.1038/s41440-018-0011-y. [PMID: 29440705] - A Maruschak, E Shorikov, I Timofiichuk, I Davydenko, K Slobodyan. PATHOMORPHOLOGY OF THE MYOCARDIUM, KIDNEY AND LIVER IN SPONTANEOUSLY HYPERTENSIVE RATS TREATED WITH SHORT AND LONG-TERM USE RAMIPRIL AND CANDESARTAN.
Georgian medical news.
2018 Mar; ?(276):135-143. doi:
NULL. [PMID: 29697397] - Ahmed M Amer, Ahmed N Allam, Ossama Y Abdallah. Comparative Pharmaceutical Evaluation of Candesartan and Candesartan Cilexetil: Physicochemical Properties, In Vitro Dissolution and Ex Vivo In Vivo Studies.
AAPS PharmSciTech.
2018 Feb; 19(2):661-667. doi:
10.1208/s12249-017-0879-x. [PMID: 28948575] - Takanori Yasu, Akiko Mutoh, Hiroshi Wada, Mayumi Kobayashi, Yuji Kikuchi, Shinichi Momomura, Shinichiro Ueda. Renin-Angiotensin System Inhibitors Can Prevent Intravenous Lipid Infusion-Induced Myocardial Microvascular Dysfunction and Leukocyte Activation.
Circulation journal : official journal of the Japanese Circulation Society.
2018 01; 82(2):494-501. doi:
10.1253/circj.cj-17-0809. [PMID: 28954968] - Elena Tassi, En Yin Lai, Lingli Li, Glenn Solis, Yifan Chen, William E Kietzman, Patricio E Ray, Anna T Riegel, William J Welch, Christopher S Wilcox, Anton Wellstein. Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Hypertension (Dallas, Tex. : 1979).
2018 01; 71(1):160-167. doi:
10.1161/hypertensionaha.117.10268. [PMID: 29158353] - Kazuhiko Tsuruya, Hisako Yoshida. Brain Atrophy and Cognitive Impairment in Chronic Kidney Disease.
Contributions to nephrology.
2018; 196(?):27-36. doi:
10.1159/000485694. [PMID: 30041201] - Kentaro Kohagura, Hisatomi Arima, Hitoshi Miyasato, Tung-Huei Chang, Masanobu Yamazato, Hiroyuki Kobori, Akira Nishiyama, Kunitoshi Iseki, Yusuke Ohya. Add-On Effect of Angiotensin Receptor Blockade (Candesartan) on Clinical Remission in Active IgA Nephropathy Patients Treated with Steroid Pulse Therapy and Tonsillectomy: a Randomized, Parallel-Group Comparison Trial.
Kidney & blood pressure research.
2018; 43(3):780-792. doi:
10.1159/000489914. [PMID: 29794482] - Sylvia Cechova, Fan Dong, Fang Chan, Michael J Kelley, Phillip Ruiz, Thu H Le. MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.
Journal of the American Society of Nephrology : JASN.
2018 01; 29(1):155-167. doi:
10.1681/asn.2015060707. [PMID: 28993503] - Morten Lindhardt, Frederik Persson, Petra Zürbig, Angelique Stalmach, Harald Mischak, Dick de Zeeuw, Hiddo Lambers Heerspink, Ronald Klein, Trevor Orchard, Massimo Porta, John Fuller, Rudolf Bilous, Nish Chaturvedi, Hans-Henrik Parving, Peter Rossing. Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2017 Nov; 32(11):1866-1873. doi:
10.1093/ndt/gfw292. [PMID: 27507891] - Elizabeth A Owens, Li Jie, Beverly A S Reyes, Elisabeth J Van Bockstaele, Patrick Osei-Owusu. Elastin insufficiency causes hypertension, structural defects and abnormal remodeling of renal vascular signaling.
Kidney international.
2017 11; 92(5):1100-1118. doi:
10.1016/j.kint.2017.04.044. [PMID: 28754555] - H A Murad, Z J Gazzaz, S S Ali, M S Ibraheem. Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2017 Sep; 50(11):e6665. doi:
10.1590/1414-431x20176665. [PMID: 28953991] - Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai. The simultaneous UPLC-MS/MS determination of emerging drug combination; candesartan and chlorthalidone in human plasma and its application.
Biomedical chromatography : BMC.
2017 Sep; 31(9):. doi:
10.1002/bmc.3946. [PMID: 28178366] - V Buda, M Andor, C Cristescu, M Voicu, F Cochera, P Tuduce, L Petrescu, M C Tomescu. The effect of candesartan on pentraxin-3 plasma levels as marker of endothelial dysfunction in patients with essential arterial hypertension.
Irish journal of medical science.
2017 Aug; 186(3):621-629. doi:
10.1007/s11845-017-1580-5. [PMID: 28220370] - Sergei M Danilov, Stan I Tovsky, David E Schwartz, Randal O Dull. ACE Phenotyping as a Guide Toward Personalized Therapy With ACE Inhibitors.
Journal of cardiovascular pharmacology and therapeutics.
2017 07; 22(4):374-386. doi:
10.1177/1074248416686188. [PMID: 28587581] - Yandao Wang, Jieli Huang, Xi Liu, Yangyang Niu, Liqin Zhao, Ying Yu, Li Zhou, Limin Lu, Chen Yu. β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis.
American journal of physiology. Renal physiology.
2017 07; 313(1):F1-F8. doi:
10.1152/ajprenal.00588.2016. [PMID: 28274926] - Martin Mildner, Helge Müller-Fielitz, Ines Stölting, Olaf Jöhren, Muscha Steckelings, Walter Raasch. Glucagon increase after chronic AT1 blockade is more likely related to an indirect leptin-dependent than to a pancreatic α-cell-dependent mechanism.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 May; 390(5):505-518. doi:
10.1007/s00210-017-1346-7. [PMID: 28144709] - Nilo César do Vale Baracho, Kátia Daniela da Silveira, Natália Pessoa Rocha, Thiago Macedo Cordeiro, Victor Feracin, Regina Maria Pereira, Marconi Augusto Aguiar Dos Reis, Mauro Martins Teixeira, Ana Cristina Simões E Silva. Urinary cytokine profiles according to the site of blockade of the renin-angiotensin system in nephrectomized rats.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2017 Apr; 39(2):108-118. doi:
10.5935/0101-2800.20170028. [PMID: 29069238] - András D Tóth, Pál Gyombolai, Bence Szalai, Péter Várnai, Gábor Turu, László Hunyady. Angiotensin type 1A receptor regulates β-arrestin binding of the β2-adrenergic receptor via heterodimerization.
Molecular and cellular endocrinology.
2017 02; 442(?):113-124. doi:
10.1016/j.mce.2016.11.027. [PMID: 27908837] - Xin Cao, Yuji Nakamura, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. L/N-type Ca2+ channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient.
Heart and vessels.
2017 Jan; 32(1):105-108. doi:
10.1007/s00380-016-0865-3. [PMID: 27325120] - Rongzhong Huang, Yuxing Feng, Ying Wang, Xiaoxia Qin, Narayan Dhruvaraj Melgiri, Yang Sun, Xingsheng Li. Comparative Efficacy and Safety of Antihypertensive Agents for Adult Diabetic Patients with Microalbuminuric Kidney Disease: A Network Meta-Analysis.
PloS one.
2017; 12(1):e0168582. doi:
10.1371/journal.pone.0168582. [PMID: 28045910] - Robert P Carroll, Michael Riceman, Christopher M Hope, Anna Zeng, Sue Deayton, Greg D Bennett, P T Coates. Angiotensin II type-1 receptor antibody (AT1Rab) associated humoral rejection and the effect of peri operative plasma exchange and candesartan.
Human immunology.
2016 Dec; 77(12):1154-1158. doi:
10.1016/j.humimm.2016.08.009. [PMID: 27542526] - Stephen R Spindler, Patricia L Mote, James M Flegal. Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice.
Age (Dordrecht, Netherlands).
2016 Dec; 38(5-6):379-391. doi:
10.1007/s11357-016-9948-4. [PMID: 27590905] - Kevin Damman, Scott D Solomon, Marc A Pfeffer, Karl Swedberg, Salim Yusuf, James B Young, Jean L Rouleau, Christopher B Granger, John J V McMurray. Worsening renal function and outcome in heart failure patients with reduced and preserved ejection fraction and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme.
European journal of heart failure.
2016 12; 18(12):1508-1517. doi:
10.1002/ejhf.609. [PMID: 27427441] - Min Jung Kim, Joo Hui Kim, Il Young Kim, Dong Won Lee, Soo Bong Lee. Reninoma Masked by the Use of an Angiotensin Receptor Blocker.
Iranian journal of kidney diseases.
2016 Nov; 10(6):413-415. doi:
NULL. [PMID: 27904001] - Caryn Hampton, Xiaoyan Zhou, Birgit T Priest, Lee-Yuh Pai, John P Felix, Brande Thomas-Fowlkes, Jessica Liu, Martin Kohler, Jianying Xiao, Aaron Corona, Olga Price, Charles Gill, Kashmira Shah, Cordelia Rasa, Vince Tong, Karen Owens, James Ormes, Haifeng Tang, Sophie Roy, Kathleen A Sullivan, Joseph M Metzger, Magdalena Alonso-Galicia, Gregory J Kaczorowski, Alexander Pasternak, Maria L Garcia. The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
The Journal of pharmacology and experimental therapeutics.
2016 10; 359(1):194-206. doi:
10.1124/jpet.116.235150. [PMID: 27432892] - Glaucia E Callera, Tayze T Antunes, Jose W Correa, Danielle Moorman, Alexey Gutsol, Ying He, Aurelie Nguyen Dinh Cat, Ana M Briones, Augusto C Montezano, Kevin D Burns, Rhian M Touyz. Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.
Bioscience reports.
2016 10; 36(5):. doi:
10.1042/bsr20160344. [PMID: 27612496] - Fangtian Fan, Chao Tian, Li Tao, Hongyan Wu, Zhaoguo Liu, Cunsi Shen, Guorong Jiang, Yin Lu. Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):704-711. doi:
10.1016/j.biopha.2016.07.039. [PMID: 27470571] - Niels H Buus, Michael J Mulvany, Hans Eiskjær, Kent L Christensen, Karin Skov. Renal resistance and long-term blood pressure in individuals genetically predisposed for essential hypertension: 10-year follow-up of the Danish Hypertension Prevention Project.
Journal of hypertension.
2016 06; 34(6):1170-7. doi:
10.1097/hjh.0000000000000919. [PMID: 27054529] - Aleksander Skoczylas, Grzegorz Piecha, Andrzej Więcek. Effects of antihypertensive treatment on plasma apelin, resistin, and visfatin concentrations.
Polskie Archiwum Medycyny Wewnetrznej.
2016 Apr; 126(4):243-53. doi:
10.20452/pamw.3390. [PMID: 27129086] - Zheng Wang, Chunyu Zeng, Van Anthony M Villar, Shi-You Chen, Prasad Konkalmatt, Xiaoyan Wang, Laureano D Asico, John E Jones, Yu Yang, Hironobu Sanada, Robin A Felder, Gilbert M Eisner, Matthew R Weir, Ines Armando, Pedro A Jose. Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
Hypertension (Dallas, Tex. : 1979).
2016 Feb; 67(2):325-34. doi:
10.1161/hypertensionaha.115.05962. [PMID: 26667412] - Vanja Forjan, Lea Cvitkovič Maričič, Helena Prosen, Darinka Brodnjak Vončina. Determination of Candesartan in Human Plasma with Liquid Chromatography - Tandem Mass Spectrometry.
Acta chimica Slovenica.
2016; 63(1):38-46. doi:
10.17344/acsi.2015.1836. [PMID: 26970787] - Masaki Hatanaka, Jun-Ya Kaimori, Satoko Yamamoto, Isao Matsui, Takayuki Hamano, Yoshitsugu Takabatake, Carolyn M Ecelbarger, Shiro Takahara, Yoshitaka Isaka, Hiromi Rakugi. Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice.
PloS one.
2016; 11(1):e0147786. doi:
10.1371/journal.pone.0147786. [PMID: 26807585] - Shigehiro Karashima, Takashi Yoneda, Mitsuhiro Kometani, Masashi Ohe, Shunsuke Mori, Toshitaka Sawamura, Kenji Furukawa, Masakazu Yamagishi, Yoshiyu Takeda. Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2016 ; 38(7):565-570. doi:
10.3109/10641963.2016.1151526. [PMID: 27651039] - Izumi Ujihara, Suzuro Hitomi, Kentaro Ono, Yasuaki Kakinoki, Hirofumi Hashimoto, Yoichi Ueta, Kiyotoshi Inenaga. The ethanol metabolite acetaldehyde induces water and salt intake via two distinct pathways in the central nervous system of rats.
Neuropharmacology.
2015 Dec; 99(?):589-99. doi:
10.1016/j.neuropharm.2015.08.023. [PMID: 26298003] - Iman O Sherif, Laila A Al-Mutabagani, Anwar M Alnakhli, Mohamed A Sobh, Hoda E Mohammed. Renoprotective effects of angiotensin receptor blocker and stem cells in acute kidney injury: Involvement of inflammatory and apoptotic markers.
Experimental biology and medicine (Maywood, N.J.).
2015 Dec; 240(12):1572-9. doi:
10.1177/1535370215577582. [PMID: 25825359] - H Oz, D Gavish, A Hass, M Shargorodsky. Effect of angiotensin II receptor blockers, candesartan, on osteoprotegerin level in hypertensive patients: Link between bone and RAAS.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2015 Sep; 16(3):547-52. doi:
10.1177/1470320314566017. [PMID: 25694056] - Mark Del Borgo, Yan Wang, Sanja Bosnyak, Morimer Khan, Pia Walters, Iresha Spizzo, Patrick Perlmutter, Lucinda Hilliard, Kate Denton, Marie-Isabel Aguilar, Robert E Widdop, Emma S Jones. β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
Clinical science (London, England : 1979).
2015 Sep; 129(6):505-13. doi:
10.1042/cs20150077. [PMID: 26186568] - Motohiro Shimizu, Satoshi Hoshide, Joji Ishikawa, Yuichiro Yano, Kazuo Eguchi, Kazuomi Kario. Correlation of Central Blood Pressure to Hypertensive Target Organ Damages During Antihypertensive Treatment: The J-TOP Study.
American journal of hypertension.
2015 Aug; 28(8):980-6. doi:
10.1093/ajh/hpu250. [PMID: 25548141]