Securinin (BioDeep_00000396437)

Main id: BioDeep_00000003873

 

PANOMIX_OTCML-2023


代谢物信息卡片


8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aS,11bS)-

化学式: C13H15NO2 (217.1103)
中文名称: 别一叶萩碱, 一叶秋碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4
InChI: InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2

描述信息

Virosecurinine is a member of indolizines.
Virosecurinine is a natural product found in Flueggea suffruticosa and Phyllanthus niruri with data available.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from Phyllanthus glaucus [1].

同义名列表

28 个代谢物同义名

8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aS,11bS)-; 9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one; Benzofurano[7a,7,6-a,b]indolisin-2(1H)-one, 5a,7,8,9,10,10a,10b,11-octahydro-; 14-oxa-7-azatetracyclo[6.6.1.0^{1,11}.0^{2,7}]pentadeca-9,11-dien-13-one; 14-oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one; Securinan-11-one, (7beta,9beta)-; (7beta,9beta)securinan-11-one; Securinan-11-one, (2.alpha.)-; Securinan-11-one, (2alpha)-; SWZMSZQQJRKFBP-UHFFFAOYSA-N; (+)-Viroallosecurinine; Viroallosecurinine; 2-Allosecurinine; viro-securinine; Allasecurinine; Virosecurinine; Phyllochrysine; allosecurinine; Oprea1_546685; Allosecurinin; NCI60_000178; NCI60_000177; NCI60_000179; Securinine; Securinin; (-)-Securinine; Securinine; Securinine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, ANXA5, BCL2, MTOR, PTEN, PTTG1
Peripheral membrane protein 2 ANXA5, MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Nucleus 6 BCL2, INPPL1, MKI67, MTOR, PTEN, PTTG1
cytosol 7 ANXA5, BCL2, BCR, INPPL1, MTOR, PTEN, PTTG1
dendrite 1 MTOR
nuclear body 1 MKI67
phagocytic vesicle 1 MTOR
nucleoplasm 3 MKI67, MTOR, PTEN
Cell membrane 2 ABCB1, ADRB3
Cytoplasmic side 1 MTOR
lamellipodium 1 INPPL1
Cell projection, axon 1 BCR
Multi-pass membrane protein 2 ABCB1, ADRB3
Golgi apparatus membrane 1 MTOR
Synapse 1 BCR
cell surface 1 ABCB1
glutamatergic synapse 1 BCR
Golgi apparatus 1 INPPL1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 INPPL1
Lysosome 1 MTOR
plasma membrane 5 ABCB1, ADRB3, BCR, ICAM3, PTEN
Membrane 8 ABCB1, ANXA5, BCL2, BCR, ICAM3, INPPL1, MKI67, MTOR
apical plasma membrane 2 ABCB1, PTEN
axon 2 BCR, CCK
extracellular exosome 4 ABCB1, ANXA5, BCR, ICAM3
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 BCL2
extracellular space 1 CCK
Schaffer collateral - CA1 synapse 1 BCR
mitochondrion 1 BCL2
protein-containing complex 2 BCL2, BCR
Microsome membrane 1 MTOR
filopodium 1 INPPL1
postsynaptic density 2 BCR, PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 ICAM3
Secreted 1 CCK
extracellular region 3 ANXA5, CCK, PTEN
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
dendritic spine 2 BCR, PTEN
nucleolus 1 MKI67
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 INPPL1
pore complex 1 BCL2
focal adhesion 1 ANXA5
Cell projection, dendritic spine 2 BCR, PTEN
Nucleus, PML body 2 MTOR, PTEN
PML body 2 MTOR, PTEN
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 INPPL1
Cell projection, filopodium 1 INPPL1
receptor complex 1 ADRB3
Cell projection, neuron projection 1 PTEN
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTEN
cell projection 1 PTEN
Chromosome 1 MKI67
Nucleus, nucleolus 1 MKI67
spindle pole 1 INPPL1
Cytoplasm, cytoskeleton, spindle pole 1 INPPL1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Nucleus speckle 1 INPPL1
myelin sheath 1 BCL2
basal plasma membrane 1 INPPL1
Schmidt-Lanterman incisure 1 PTEN
vesicle membrane 1 ANXA5
Basal cell membrane 1 INPPL1
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, phagosome 1 MTOR
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN


文献列表

  • Wen Hou, Ying Meng, Xiao-Fang Xu, Zhi-Xing Huang, Jun Liu, Zhen-Ya Wang, Jing Lin, Wei-Min Chen. Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance. European journal of medicinal chemistry. 2019 Dec; 183(?):111726. doi: 10.1016/j.ejmech.2019.111726. [PMID: 31585275]
  • Egor Chirkin, William Atkatlian, Quyên Do, Thomas Gaslonde, Thi-Hanh Dufat, Sylvie Michel, Pascale Lemoine, Grégory Genta-Jouve, François-Hugues Porée. Chiroptical study and absolute configuration of securinine oxidation products. Natural product research. 2015; 29(13):1235-42. doi: 10.1080/14786419.2015.1023727. [PMID: 25790256]
  • Gang Zhang, Maidong Li, Shuwen Han, Dongyun Chen, Ying Wang, Wencai Ye, Zhaoning Ji. Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism. Molecular medicine reports. 2014 Nov; 10(5):2365-71. doi: 10.3892/mmr.2014.2531. [PMID: 25189629]
  • Wei Yuan, Ping Zhu, Kedi Cheng, Chao Meng, Lin Ma, Feng Wu, Huixin Zhu. Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids. Natural product research. 2007 Mar; 21(3):234-42. doi: 10.1080/14786410701189781. [PMID: 17365714]
  • Hai-yan Wu, Jin-yun Zhou. [Studies on chemical constituents from leaves of Securinega suffruticosa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Jun; 29(6):535-7. doi: . [PMID: 15706917]