Coenzyme Q10 (BioDeep_00000003871)

 

Secondary id: BioDeep_00000858391

human metabolite Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

化学式: C59H90O4 (862.6839)
中文名称: 辅酶Q10
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 31.47%

分子结构信息

SMILES: C1(OC)C(=O)C(C)=C(C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C)C(=O)C=1OC
InChI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

描述信息

Coenzyme Q10 (ubiquinone) is a naturally occurring compound widely distributed in animal organisms and in humans. The primary compounds involved in the biosynthesis of ubiquinone are 4-hydroxybenzoate and the polyprenyl chain. An essential role of coenzyme Q10 is as an electron carrier in the mitochondrial respiratory chain. Moreover, coenzyme Q10 is one of the most important lipophilic antioxidants, preventing the generation of free radicals as well as oxidative modifications of proteins, lipids, and DNA, it and can also regenerate the other powerful lipophilic antioxidant, alpha-tocopherol. Antioxidant action is a property of the reduced form of coenzyme Q10, ubiquinol (CoQ10H2), and the ubisemiquinone radical (CoQ10H*). Paradoxically, independently of the known antioxidant properties of coenzyme Q10, the ubisemiquinone radical anion (CoQ10-) possesses prooxidative properties. Decreased levels of coenzyme Q10 in humans are observed in many pathologies (e.g. cardiac disorders, neurodegenerative diseases, AIDS, cancer) associated with intensive generation of free radicals and their action on cells and tissues. In these cases, treatment involves pharmaceutical supplementation or increased consumption of coenzyme Q10 with meals as well as treatment with suitable chemical compounds (i.e. folic acid or B-group vitamins) which significantly increase ubiquinone biosynthesis in the organism. Estimation of coenzyme Q10 deficiency and efficiency of its supplementation requires a determination of ubiquinone levels in the organism. Therefore, highly selective and sensitive methods must be applied, such as HPLC with UV or coulometric detection. For a number of years, coenzyme Q (CoQ10 in humans) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in plasma, and extensively investigated its antioxidant role. These two functions constitute the basis on which research supporting the clinical use of CoQ10 is founded. Also at the inner mitochondrial membrane level, coenzyme Q is recognized as an obligatory co-factor for the function of uncoupling proteins and a modulator of the transition pore. Furthermore, recent data reveal that CoQ10 affects expression of genes involved in human cell signalling, metabolism, and transport and some of the effects of exogenously administered CoQ10 may be due to this property. Coenzyme Q is the only lipid soluble antioxidant synthesized endogenously. In its reduced form, CoQH2, ubiquinol, inhibits protein and DNA oxidation but it is the effect on lipid peroxidation that has been most deeply studied. Ubiquinol inhibits the peroxidation of cell membrane lipids and also that of lipoprotein lipids present in the circulation. Dietary supplementation with CoQ10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoproteins to the initiation of lipid peroxidation. Moreover, CoQ10 has a direct anti-atherogenic effect, which has been demonstrated in apolipoprotein E-deficient mice fed with a high-fat diet. (PMID: 15928598, 17914161).
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C - Cardiovascular system > C01 - Cardiac therapy
C26170 - Protective Agent > C275 - Antioxidant
D018977 - Micronutrients > D014815 - Vitamins
Same as: D01065
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

46 个代谢物同义名

2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl- 2,5-cyclohexadiene-1,4-dione; 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone; (all-e)-2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; (all-e)-2,3-Dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31-octamethyl-2,6,10,14,18,22,26,30-dotriacontaoctaenyl)-2,5-cyclohexadiene-1,4-dione; 2-((all-e)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-p-benzoquinone; 2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-p-benzoquinone; 2,3-Dimethoxy-5-methyl-6-decaprenylbenzoquinone; 4-Ethyl-5-fluoropyrimidine; all-trans-Ubiquinone; CoQ10;Ubiquinone-10; Unispheres Q 10; Bio-quinone Q10; Ubiquinone Q10; Ubidecarenone; CO-Enzyme Q10; Ubiquinone 50; Ubiquinone 10; Ubiquinone-10; PureSorb Q 40; Aqua Q 10l10; coenzyme Q10; coenzyme-Q10; Unbiquinone; Bio-quinon; Kaneka Q10; Neuquinone; Ubiquinone; Neuquinon; Li-Q-sorb; Q-Gel 100; Liquid-Q; Aqua Q10; Kudesan; Ensorb; Adelir; Q 10AA; CoQ 10; Q-Ter; Q-Gel; Q 199; CoQ10; CoQ; Q10; Q; Ubiquinone-10



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(7)

BioCyc(2)

PlantCyc(0)

代谢反应

587 个相关的代谢反应过程信息。

Reactome(125)

BioCyc(4)

WikiPathways(1)

Plant Reactome(408)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(48)

PharmGKB(0)

71 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 AXIN2, PINK1, SNCA
Peripheral membrane protein 2 COQ6, COQ7
Endoplasmic reticulum membrane 2 HMGCR, HSP90B1
Nucleus 7 AXIN2, COQ7, CYC1, HSP90B1, PINK1, SNCA, TFAM
cytosol 6 AXIN2, DHODH, HSP90B1, PINK1, SNCA, TFAM
dendrite 1 MT-ND1
mitochondrial membrane 2 ETFDH, MT-ND1
centrosome 1 AXIN2
nucleoplasm 1 DHODH
Cell projection, axon 1 SNCA
Multi-pass membrane protein 7 ATP4A, COQ2, HMGCR, MT-CYB, MT-ND1, SDHC, UCP1
Synapse 1 SNCA
cell cortex 1 SNCA
Golgi apparatus 1 COQ6
growth cone 2 PINK1, SNCA
mitochondrial inner membrane 13 ATP5ME, COQ2, COQ6, COQ7, COQ9, CYC1, DHODH, ETFDH, MT-CYB, MT-ND1, PINK1, SDHC, UCP1
neuronal cell body 2 MT-ND1, SNCA
postsynapse 1 SNCA
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PINK1
Lysosome 1 SNCA
plasma membrane 3 ATP4A, AXIN2, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 12 ATP4A, COQ2, COQ7, CYC1, DHODH, ETFDH, HMGCR, HSP90B1, MT-CYB, PINK1, SDHC, SNCA
apical plasma membrane 1 ATP4A
axon 2 PINK1, SNCA
extracellular exosome 1 HSP90B1
endoplasmic reticulum 3 HMGCR, HSP90B1, PINK1
extracellular space 2 ATP4A, SNCA
perinuclear region of cytoplasm 3 HSP90B1, PINK1, SNCA
mitochondrion 16 ATP5ME, COQ2, COQ6, COQ7, COQ9, CYC1, DHODH, ETFDH, MT-CYB, MT-ND1, PDSS1, PINK1, SDHC, SNCA, TFAM, UCP1
protein-containing complex 3 HSP90B1, SNCA, TFAM
Secreted 1 SNCA
extracellular region 2 HSP90B1, SNCA
Mitochondrion outer membrane 1 PINK1
Single-pass membrane protein 3 CYC1, DHODH, PINK1
mitochondrial outer membrane 1 PINK1
mitochondrial matrix 2 PDSS1, TFAM
actin cytoskeleton 1 SNCA
beta-catenin destruction complex 1 AXIN2
midbody 1 HSP90B1
Apical cell membrane 1 ATP4A
Mitochondrion inner membrane 10 COQ2, COQ6, COQ7, CYC1, DHODH, MT-CYB, MT-ND1, PINK1, SDHC, UCP1
Matrix side 3 COQ2, COQ6, COQ7
focal adhesion 1 HSP90B1
mitochondrial nucleoid 1 TFAM
peroxisomal membrane 1 HMGCR
mitochondrial intermembrane space 1 PINK1
collagen-containing extracellular matrix 1 HSP90B1
chromatin 1 PINK1
cell projection 1 COQ6
supramolecular fiber 1 SNCA
Chromosome 1 COQ7
cytoskeleton 1 PINK1
Melanosome 1 HSP90B1
cell body 1 PINK1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
respiratory chain complex I 1 MT-ND1
endoplasmic reticulum lumen 1 HSP90B1
axon terminus 1 SNCA
respiratory chain complex II (succinate dehydrogenase) 1 SDHC
respiratory chain complex III 2 CYC1, MT-CYB
Sarcoplasmic reticulum lumen 1 HSP90B1
Lewy body 1 PINK1
ubiquinone biosynthesis complex 3 COQ6, COQ7, COQ9
proton-transporting ATP synthase complex 1 ATP5ME
transferase complex 1 PDSS1
astrocyte projection 1 PINK1
endocytic vesicle lumen 1 HSP90B1
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
inclusion body 1 SNCA
endoplasmic reticulum chaperone complex 1 HSP90B1
potassium:proton exchanging ATPase complex 1 ATP4A
Mitochondrion matrix, mitochondrion nucleoid 1 TFAM
extrinsic component of mitochondrial inner membrane 2 COQ6, COQ7
heterotetrameric polyprenyl diphosphate synthase complex 1 PDSS1


文献列表

  • Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek. CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model. Cell and tissue research. 2024 Jun; 396(3):371-397. doi: 10.1007/s00441-024-03880-z. [PMID: 38499882]
  • Behbood Khazravi, Mahdi Khodaei-Motlagh, Reza Masoudi, Mohammad Yahyaei. Coenzyme Q10 preserves buck's sperm quality during cryopreservation process in plant-based extender. Animal reproduction science. 2024 Jun; 265(?):107487. doi: 10.1016/j.anireprosci.2024.107487. [PMID: 38723402]
  • Minjun Liao, Xueke He, Yangyang Zhou, Weiqiang Peng, Xiao-Mei Zhao, Miao Jiang. Coenzyme Q10 in atherosclerosis. European journal of pharmacology. 2024 May; 970(?):176481. doi: 10.1016/j.ejphar.2024.176481. [PMID: 38493916]
  • Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang. The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation. Molecular nutrition & food research. 2024 May; 68(9):e2400147. doi: 10.1002/mnfr.202400147. [PMID: 38643378]
  • Eman I Elgizawy, Ghada S Amer, Eman A Ali, Fatma S Alqalashy, Marwa M Ibrahim, Asmaa A Abdel Latif, Anwar M Shaban. Comparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia. Scientific reports. 2024 04; 14(1):9798. doi: 10.1038/s41598-024-59884-w. [PMID: 38684784]
  • Yuan Xiao, Ranjing Wang, Shang Kong, Tingting Zhao, Yongli Situ, Hong Nie. Comparison of Protective Effect of Tri-circulator and Coenzyme Q10 on Myocardial Injury and the Mechanism Study by Zebrafish Model. Cardiovascular toxicology. 2024 Feb; ?(?):. doi: 10.1007/s12012-024-09828-7. [PMID: 38316695]
  • Meng Meng, Jiaying Wang, Changyuan Wang, Jianyu Zhao, Huihan Wang, Yukun Zhang, Huijun Sun, Mozhen Liu. Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway. Calcified tissue international. 2024 Feb; 114(2):182-199. doi: 10.1007/s00223-023-01161-5. [PMID: 38055044]
  • Xiaochun Ye, Shaohui Zhang. Clinical Observation of Trimetazidine Combined With Coenzyme Q10 in the Treatment of Myocardial Damage Caused by COVID-19. American journal of therapeutics. 2024 Jan; 31(1):e59-e61. doi: 10.1097/mjt.0000000000001488. [PMID: 38231584]
  • Ingrid D L Souza, Vivian Saez, Claudia R E Mansur. Lipid nanoparticles containing coenzyme Q10 for topical applications: An overview of their characterization. Colloids and surfaces. B, Biointerfaces. 2023 Oct; 230(?):113491. doi: 10.1016/j.colsurfb.2023.113491. [PMID: 37574615]
  • Xiang Luo, Sha Ao, Hongze Wu, David Julian McClements, Likun Fang, Mengyu Huang, Yanyan Zhou, Xuguang Yin, Meiyang Xi, Tao Cai, Kewu Zhu. Hyaluronic Acid Poly(glyceryl)10-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions. Journal of agricultural and food chemistry. 2023 Jul; 71(29):11180-11194. doi: 10.1021/acs.jafc.3c02322. [PMID: 37436914]
  • Gaolong Zhong, Yuanxu Li, Feiyang Ma, Yihui Huo, Jianzhao Liao, Qingyue Han, Lianmei Hu, Zhaoxin Tang. Copper Exposure Induced Chicken Hepatotoxicity: Involvement of Ferroptosis Mediated by Lipid Peroxidation, Ferritinophagy, and Inhibition of FSP1-CoQ10 and Nrf2/SLC7A11/GPX4 Axis. Biological trace element research. 2023 Jul; ?(?):. doi: 10.1007/s12011-023-03773-2. [PMID: 37474886]
  • Fengya Zhu, Shao Yin, Bin Yang, Siyun Li, Xia Feng, Tianyu Wang, Deya Che. TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis. Reproductive biology and endocrinology : RB&E. 2023 Jul; 21(1):64. doi: 10.1186/s12958-023-01119-0. [PMID: 37464357]
  • Taher Modarressi, Arsalan Derakhshan. Letter to the Editor From Modarressi and Derakhshan: 'Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials'. The Journal of clinical endocrinology and metabolism. 2023 07; 108(8):e646. doi: 10.1210/clinem/dgad117. [PMID: 36866570]
  • Nicholas Angelopoulos, Rodis D Paparodis, Ioannis Androulakis, Anastasios Boniakos, Georgia Argyrakopoulou, Sarantis Livadas. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023 Jun; 15(12):. doi: 10.3390/nu15122682. [PMID: 37375586]
  • Yu Zhao, Xiaoli Zhao, Guangyin Zhang, Ruihong Ma, Qiang Geng, Bin Ouyang, Tian Xia. Efficacy of coenzyme Q10 supplementation for male infertility with high sperm DNA fragmentation index: a protocol for a systematic review and meta-analysis. BMJ open. 2023 Jun; 13(6):e068368. doi: 10.1136/bmjopen-2022-068368. [PMID: 37280035]
  • Ying Huang, Ruxiang Ge, Gege Lou, Nengzuo Jiang, Xiaoming Zhu, Yazhe Guo, Haokun Liu, Xuanyu Liu, Xinhua Chen. The influence of dietary Coenzyme Q10 on growth performance, antioxidant capacity and resistance against Aeromonas hydrophila of juvenile European eel (Anguilla anguilla). Fish & shellfish immunology. 2023 May; 138(?):108834. doi: 10.1016/j.fsi.2023.108834. [PMID: 37207885]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Armin Ahmadi, Gwenaelle Begue, Ana P Valencia, Jennifer E Norman, Benjamin Lidgard, Brian J Bennett, Matthew P Van Doren, David J Marcinek, Sili Fan, David K Prince, Jorge L Gamboa, Jonathan Himmelfarb, Ian H de Boer, Bryan R Kestenbaum, Baback Roshanravan. Randomized crossover clinical trial of coenzyme Q10 and nicotinamide ribosome in chronic kidney disease. JCI insight. 2023 May; ?(?):. doi: 10.1172/jci.insight.167274. [PMID: 37159264]
  • Hoda Atapour-Mashhad, Mojgan Nejabat, Farzin Hadizadeh, Afsaneh Hoseinsalari, Shiva Golmohammadzadeh. Preparation, Characterization, and Molecular Dynamic Simulation of Novel Coenzyme Q10 Loaded Nanostructured Lipid Carriers. Current pharmaceutical design. 2023; 29(27):2177-2190. doi: 10.2174/1381612829666230911105913. [PMID: 37694784]
  • Xinyu Nie, Xinru Dong, Yuge Hu, Fangjun Xu, Cong Hu, Chang Shu. Coenzyme Q10 Stimulate Reproductive Vatality. Drug design, development and therapy. 2023; 17(?):2623-2637. doi: 10.2147/dddt.s386974. [PMID: 37667786]
  • Sihua Wen, Kai Yang, Yunfeng Bai, Yanan Wu, Ding Liu, Xu Wu, Xiaofei Zhang, Jing Sun. Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway. Drug design, development and therapy. 2023; 17(?):939-957. doi: 10.2147/dddt.s393995. [PMID: 37006723]
  • Ezgi Şaman, Martina Cebova, Andrej Barta, Martina Koneracka, Vlasta Zavisova, Anita Eckstein-Andicsova, Martin Danko, Jaroslav Mosnacek, Olga Pechanova. Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010276. [PMID: 36613727]
  • Zhihao Liu, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Meitong Liu, Shanshan Hou, Xiaoxi Dong, Zhaxinima, Yan Yang. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. The Journal of clinical endocrinology and metabolism. 2022 12; 108(1):232-249. doi: 10.1210/clinem/dgac585. [PMID: 36337001]
  • Shanqin Qi, Qi Liang, Lixia Yang, Xueyuan Zhou, Kun Chen, Ji Wen. Effect of Coenzyme Q10 and transcutaneous electrical acupoint stimulation in assisted reproductive technology: a retrospective controlled study. Reproductive biology and endocrinology : RB&E. 2022 Dec; 20(1):167. doi: 10.1186/s12958-022-01043-9. [PMID: 36476305]
  • Louisa Fadjri Kusuma Wardhani, Ivana Purnama Dewi, Kresna Nugraha Setia Putra, Andrianto Andrianto, Djoko Soemantri. The physiological insight of Coenzyme-Q10 administration in preventing the incidence of reperfusion arrhythmia among patients undergoing coronary artery bypass grafting surgery. Journal of basic and clinical physiology and pharmacology. 2022 Nov; 33(6):695-701. doi: 10.1515/jbcpp-2021-0329. [PMID: 35858280]
  • Leila Hosseini, Alireza Majdi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Mojtaba Ziaee, Sepideh Rahigh Aghsan, Mohammad Farzipour, Javad Mahmoudi. Coenzyme Q10 ameliorates aging-induced memory deficits via modulation of apoptosis, oxidative stress, and mitophagy in aged rats. Experimental gerontology. 2022 10; 168(?):111950. doi: 10.1016/j.exger.2022.111950. [PMID: 36089173]
  • Ruijie Wang, Yiting Chen, Zezhong Tian, Meiyan Zhu, Bingying Zhang, Sijin Du, Yanzhang Li, Zhihao Liu, Shanshan Hou, Yan Yang. Coenzyme Q10 Attenuates Human Platelet Aggregation Induced by SARS-CoV-2 Spike Protein via Reducing Oxidative Stress In Vitro. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012345. [PMID: 36293203]
  • Kumar Rajesh, M I Khan, Prasad Mahesh, Srivastav Ritesh Kumar, Srivastav Shiv Kumar. Preclinical and Clinical Role of Coenzyme Q10 Supplementation in Various Pathological States. Drug research. 2022 Sep; 72(7):367-371. doi: 10.1055/a-1835-1738. [PMID: 35724675]
  • F Martinez-Martin, E Corbella, I Sarasa, F Trias, D Petitbò, M Licerán, R M Sánchez-Hernández, D Martin, A Sánchez, C Arnás, S de Dios, M Florido, X Pintó. Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk. Semergen. 2022 Sep; 48(6):403-410. doi: 10.1016/j.semerg.2022.04.005. [PMID: 35606250]
  • Jinchao Zou, Zezhong Tian, Yimin Zhao, Xiaofen Qiu, Yuheng Mao, Kongyao Li, Yilin Shi, Dan Zhao, Ying Liang, Qiuhua Ji, Wenhua Ling, Yan Yang. Coenzyme Q10 supplementation improves cholesterol efflux capacity and antiinflammatory properties of high-density lipoprotein in Chinese adults with dyslipidemia. Nutrition (Burbank, Los Angeles County, Calif.). 2022 09; 101(?):111703. doi: 10.1016/j.nut.2022.111703. [PMID: 35700592]
  • Swapnil Tripathi, Dharati Parmar, Shabrin Fathima, Samir Raval, Gyanendra Singh. Coenzyme Q10, Biochanin A and Phloretin Attenuate Cr(VI)-Induced Oxidative Stress and DNA Damage by Stimulating Nrf2/HO-1 Pathway in the Experimental Model. Biological trace element research. 2022 Aug; ?(?):. doi: 10.1007/s12011-022-03358-5. [PMID: 35953644]
  • Shankun Zhao, Weizhou Wu, Jian Liao, Xinsheng Zhang, Maolei Shen, Xin Li, Qi Lin, Chaoliang Cao. Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury. Cellular & molecular biology letters. 2022 Jul; 27(1):57. doi: 10.1186/s11658-022-00361-5. [PMID: 35869439]
  • Md Al Mamun, Md Mahamodun Nabi, Tomohito Sato, Shuhei Aramaki, Yusuke Takanashi, Takumi Sakamoto, Kaito Hizume, Chikako Mori, Maiha Yasue, Masataka Ozaki, Ariful Islam, Tomoaki Kahyo, Makoto Horikawa, Yutaka Takahashi, Shigetoshi Okazaki, Kentaro Ohishi, Yu Nagashima, Keiji Seno, Yoshihiro Hotta, Mitsutoshi Setou. Coenzyme Q10 in the eye isomerizes by sunlight irradiation. Scientific reports. 2022 07; 12(1):12104. doi: 10.1038/s41598-022-16343-8. [PMID: 35840805]
  • Tatiane G Hammerschmidt, Bruna Donida, Jéssica L Faverzani, Alana P Moura, Bianca G Dos Reis, Andryele Z Machado, Rejane G Kessler, Fernanda M Sebastião, Luiza S Reinhardt, Dinara J Moura, Carmen R Vargas. Cytokine profile and cholesterol levels in patients with Niemann-Pick type C disease presenting neurological symptoms: in vivo effect of miglustat and in vitro effect of N-acetylcysteine and coenzyme Q10. Experimental cell research. 2022 07; 416(2):113175. doi: 10.1016/j.yexcr.2022.113175. [PMID: 35487270]
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  • Sára Szuróczki, Gorkhmaz Abbaszade, Károly Bóka, Peter Schumann, Meina Neumann-Schaal, Erika Tóth. Szabonella alba gen. nov., sp. nov., a motile alkaliphilic bacterium of the family Rhodobacteraceae isolated from a soda lake. International journal of systematic and evolutionary microbiology. 2022 Jan; 72(1):. doi: 10.1099/ijsem.0.005219. [PMID: 35099369]
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  • Francesco Pallotti, Christian Bergamini, Costanza Lamperti, Romana Fato. The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010128. [PMID: 35008564]
  • Zhe Li, Wenjin Hu, Shushi Huang, Yuanlin Huang, Fei Li, Qiaozhen Wang, Zhanhua Tao, Xinli Pan. Acuticoccus mangrovi sp. nov., with an antibacterial property, isolated from mangrove sediment. International journal of systematic and evolutionary microbiology. 2021 Dec; 71(12):. doi: 10.1099/ijsem.0.005137. [PMID: 34874250]
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  • Zhaohui Liu, Yan Li, Chunlei Li, Lili Yu, Yulin Chang, Min Qu. Delivery of coenzyme Q10 with mitochondria-targeted nanocarrier attenuates renal ischemia-reperfusion injury in mice. Materials science & engineering. C, Materials for biological applications. 2021 Dec; 131(?):112536. doi: 10.1016/j.msec.2021.112536. [PMID: 34857313]
  • Shih-Yao Lin, Asif Hameed, Chia-Fang Tsai, Chiu-Chung Young. Vineibacter terrae gen. nov., sp. nov., an ammonium-assimilating and nitrate-reducing bacterium isolated from vineyard soil. International journal of systematic and evolutionary microbiology. 2021 Dec; 71(12):. doi: 10.1099/ijsem.0.005111. [PMID: 34878378]
  • Yingning Wang, Fang Ma, Jixian Yang, Haijuan Guo, Delin Su. Xanthobacter dioxanivorans sp. nov., a 1,4-dioxane-degrading bacterium. International journal of systematic and evolutionary microbiology. 2021 Dec; 71(12):. doi: 10.1099/ijsem.0.005139. [PMID: 34882528]
  • Dongjun Kim, Yeonjae Yoo, Jong Seong Khim, Dongmin Yang, Duleepa Pathiraja, Byeonghyeok Park, In-Geol Choi, Jae-Jin Kim. Altererythrobacter lutimaris sp. nov., a marine bacterium isolated from a tidal flat and reclassification of Altererythrobacter deserti, Altererythrobacter estronivorus and Altererythrobacter muriae as Tsuneonella deserti comb. nov., Croceicoccus estronivorus comb. nov. and Alteripontixanthobacter muriae comb. nov. International journal of systematic and evolutionary microbiology. 2021 Dec; 71(12):. doi: 10.1099/ijsem.0.005134. [PMID: 34874248]
  • Mukadder Sunar, Gulce Naz Yazici, Renad Mammadov, Nezahat Kurt, Yusuf Kemal Arslan, Halis Süleyman. Coenzyme Q10 effect on cisplatin-induced oxidative retinal injury in rats. Cutaneous and ocular toxicology. 2021 Dec; 40(4):312-318. doi: 10.1080/15569527.2021.1949336. [PMID: 34325578]
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  • Manuela R Martinefski, María F Yamasato, María B Di Carlo, Jorge R Daruich, Valeria P Tripodi. Coenzyme Q10 deficiency in patients with hereditary hemochromatosis. Clinics and research in hepatology and gastroenterology. 2021 11; 45(6):101624. doi: 10.1016/j.clinre.2021.101624. [PMID: 33676282]
  • Young-Ok Kim, Jae Koo Noh, Dong-Gyun Kim, In-Suk Park, Sooyeon Park, Jung-Hoon Yoon. Paenihalocynthiibacter styelae gen. nov., sp. nov., isolated from stalked sea squirt Styela clava. International journal of systematic and evolutionary microbiology. 2021 Nov; 71(11):. doi: 10.1099/ijsem.0.005085. [PMID: 34752209]
  • Weizhen Tan, Rannar Airik. Primary coenzyme Q10 nephropathy, a potentially treatable form of steroid-resistant nephrotic syndrome. Pediatric nephrology (Berlin, Germany). 2021 11; 36(11):3515-3527. doi: 10.1007/s00467-020-04914-8. [PMID: 33479824]
  • Nilima Pradhan, Charan Singh, Arti Singh. Coenzyme Q10 a mitochondrial restorer for various brain disorders. Naunyn-Schmiedeberg's archives of pharmacology. 2021 11; 394(11):2197-2222. doi: 10.1007/s00210-021-02161-8. [PMID: 34596729]
  • Peter Kämpfer, Hans-Jürgen Busse, Dominique Clermont, Alexis Criscuolo, Stefanie P Glaeser. Devosia equisanguinis sp. nov., isolated from horse blood. International journal of systematic and evolutionary microbiology. 2021 Nov; 71(11):. doi: 10.1099/ijsem.0.005090. [PMID: 34788212]
  • Hamid Reza Rafieian-Naeini, Mahdi Zhandi, Mostafa Sadeghi, Ali Reza Yousefi, Andrew Parks Benson. Effects of coenzyme Q10 on reproductive performance of laying Japanese quail (Coturnix japonica) under cadmium challenge. Poultry science. 2021 Nov; 100(11):101418. doi: 10.1016/j.psj.2021.101418. [PMID: 34600273]
  • Geeta Chhetri, Minchung Kang, Jiyoun Kim, Inhyup Kim, Yoonseop So, Taegun Seo. Sphingosinicella flava sp. nov., indole acetic acid producing bacteria isolated from maize field soil. International journal of systematic and evolutionary microbiology. 2021 Oct; 71(10):. doi: 10.1099/ijsem.0.005038. [PMID: 34605389]
  • Soo-Yeon Choi, Ji-Sung Oh, Dong-Hyun Roh. Parasphingopyxis marina sp. nov. isolated from coastal seawater. International journal of systematic and evolutionary microbiology. 2021 Oct; 71(10):. doi: 10.1099/ijsem.0.005049. [PMID: 34633920]
  • Farnaz Farsi, Nasser Ebrahimi-Daryani, Fereshteh Golab, Abolfazl Akbari, Leila Janani, Mohammad Yahya Karimi, Pardis Irandoost, Naimeh Mesri Alamdari, Shahram Agah, Mohammadreza Vafa. A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis. European journal of nutrition. 2021 Sep; 60(6):3397-3410. doi: 10.1007/s00394-021-02514-2. [PMID: 33620550]
  • Zachary A Kemmerer, Kyle P Robinson, Jonathan M Schmitz, Mateusz Manicki, Brett R Paulson, Adam Jochem, Paul D Hutchins, Joshua J Coon, David J Pagliarini. UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae. Nature communications. 2021 08; 12(1):4769. doi: 10.1038/s41467-021-25084-7. [PMID: 34362905]
  • Sara Gutierrez-Patricio, Jose L Gonzalez-Pimentel, Ana Zelia Miller, Bernardo Hermosin, Cesareo Saiz-Jimenez, Valme Jurado. Paracoccus onubensis sp. nov., a novel alphaproteobacterium isolated from the wall of a show cave. International journal of systematic and evolutionary microbiology. 2021 Aug; 71(8):. doi: 10.1099/ijsem.0.004942. [PMID: 34388083]
  • Xun-Ke Sun, Ya-Ning Zhang, Yu-Yao Jia, Yan-Lin Zhong, Guan-Jun Chen, Zong-Jun Du. Palleronia sediminis sp. nov. and Flavivirga algicola sp. nov., two marine bacteria isolated from offshore areas near Weihai. International journal of systematic and evolutionary microbiology. 2021 Aug; 71(8):. doi: 10.1099/ijsem.0.004949. [PMID: 34370661]
  • Ekaterina N Tikhonova, Denis S Grouzdev, Irina K Kravchenko. Xanthobacter oligotrophicus sp.nov., isolated from paper mill sewage. International journal of systematic and evolutionary microbiology. 2021 Aug; 71(8):. doi: 10.1099/ijsem.0.004972. [PMID: 34410902]
  • Christina D'Agrosa, Charles L Cai, Faisal Siddiqui, Karen Deslouches, Stephen Wadowski, Jacob V Aranda, Kay D Beharry. Comparison of coenzyme Q10 or fish oil for prevention of intermittent hypoxia-induced oxidative injury in neonatal rat lungs. Respiratory research. 2021 Jul; 22(1):196. doi: 10.1186/s12931-021-01786-w. [PMID: 34225702]
  • Masanori Kobayashi, Chie Tsuzuki, Marika Kobayashi, Hinano Tsuchiya, Yume Yamashita, Kanako Ueno, Moe Onozawa, Masato Kobayashi, Eiichi Kawakami, Tatsuya Hori. Effect of supplementation with the reduced form of coenzyme Q10 on semen quality and antioxidant status in dogs with poor semen quality: Three case studies. The Journal of veterinary medical science. 2021 Jul; 83(7):1044-1049. doi: 10.1292/jvms.21-0174. [PMID: 34011783]
  • Juan Du, Yang Liu, Tao Pei, Ming-Rong Deng, Honghui Zhu. Salipiger mangrovisoli sp. nov., isolated from mangrove soil and the proposal for the reclassification of Paraphaeobacter pallidus as Salipiger pallidus comb. nov. International journal of systematic and evolutionary microbiology. 2021 Jul; 71(7):. doi: 10.1099/ijsem.0.004892. [PMID: 34270400]
  • Fanny Fontaine, Damien Legallois, Christian Créveuil, Mohamed Chtourou, Laurent Coulbault, Paul Milliez, Amir Hodzic, Eric Saloux, Farzin Beygui, Stéphane Allouche. Is plasma concentration of coenzyme Q10 a predictive marker for left ventricular remodelling after revascularization for ST-segment elevation myocardial infarction?. Annals of clinical biochemistry. 2021 07; 58(4):327-334. doi: 10.1177/00045632211001100. [PMID: 33622041]
  • Shih-Yao Lin, Chia-Fang Tsai, Asif Hameed, Yu-Shan Tang, Chiu-Chung Young. Description of Devosia faecipullorum sp. nov., harboring antibiotic- and toxic compound-resistace genes, isolated from poultry manure. International journal of systematic and evolutionary microbiology. 2021 Jul; 71(7):. doi: 10.1099/ijsem.0.004901. [PMID: 34287119]
  • Sheng Cui, Kang Luo, Yi Quan, Sun Woo Lim, Yoo Jin Shin, Kyung Eun Lee, Hong Lim Kim, Eun Jeong Ko, Ju Hwan Kim, Sang J Chung, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang. Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy. The Korean journal of internal medicine. 2021 07; 36(4):949-961. doi: 10.3904/kjim.2020.211. [PMID: 33430574]
  • Amira Mohamed Mohsen, Mostafa Mohamed Younis, Abeer Salama, Asmaa Badawy Darwish. Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10. Journal of pharmaceutical sciences. 2021 07; 110(7):2677-2686. doi: 10.1016/j.xphs.2021.02.007. [PMID: 33600809]
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  • Osama Y Alshogran, Shreen D Nusair, Tamam El-Elimat, Karem H Alzoubi, Abdullah Obeidat, Maya Sweidan. Evaluation of coenzyme Q10 combined with or without N-acetyl cysteine or atorvastatin for preventing contrast-induced kidney injury in diabetic rats. Naunyn-Schmiedeberg's archives of pharmacology. 2021 07; 394(7):1403-1410. doi: 10.1007/s00210-021-02070-w. [PMID: 33630121]
  • Ni Luh Dewi Aryani, Siswandono Siswodihardjo, Widji Soeratri, Nadia Fitria Indah Sari. Development, characterization, molecular docking, and in vivo skin penetration of coenzyme Q10 nanostructured lipid carriers using tristearin and stearyl alcohol for dermal delivery. Journal of basic and clinical physiology and pharmacology. 2021 Jun; 32(4):517-525. doi: 10.1515/jbcpp-2020-0512. [PMID: 34214318]
  • Fudi Wang, Junxia Min. DHODH tangoing with GPX4 on the ferroptotic stage. Signal transduction and targeted therapy. 2021 06; 6(1):244. doi: 10.1038/s41392-021-00656-7. [PMID: 34145214]
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  • Sooyeon Park, Jung-Hoon Yoon. Sulfitobacter aestuariivivens sp. nov., isolated from a tidal flat. International journal of systematic and evolutionary microbiology. 2021 Jun; 71(6):. doi: 10.1099/ijsem.0.004827. [PMID: 34161219]
  • Victor Adán Lanceta, Yolanda Romero Salas, María Luisa Justa Roldán, María Concepción García Jiménez, Gema Ariceta Iraola. Encephalopathy, kidney failure and retinopathy. CoQ10 deficiency due to COQ8B mutation. Anales de pediatria. 2021 06; 94(6):415-417. doi: 10.1016/j.anpede.2020.05.008. [PMID: 34090639]
  • Yu-Wen Wang, Wen-Ting Ren, Yuan-You Xu, Xin-Qi Zhang. Muriiphilus fusiformis gen. nov., sp. nov., a novel non-marine bacterium belonging to the Roseobacter group, and reclassification of Maritimibacter lacisalsi (Zhong et al. 2015) as Muriicola lacisalsi gen. nov., comb. nov. International journal of systematic and evolutionary microbiology. 2021 Jun; 71(6):. doi: 10.1099/ijsem.0.004859. [PMID: 34181513]
  • Soon Dong Lee, Sung-Min Kim, Hong Lim Yang, Yeong-Sik Byeon, In Seop Kim. Hongsoonwoonella zoysiae gen. nov., sp. nov., a new member of the family Stappiaceae isolated from a tidal mudflat. Archives of microbiology. 2021 May; 203(4):1335-1343. doi: 10.1007/s00203-020-02083-8. [PMID: 33386867]
  • Mingzhe Li, Baoan Ning, Tianhui Wang. The mechanism and prevention of mitochondrial injury after exercise. Journal of physiology and biochemistry. 2021 May; 77(2):215-225. doi: 10.1007/s13105-021-00802-3. [PMID: 33650090]
  • Mathias J Holmberg, Lars W Andersen, Ari Moskowitz, Katherine M Berg, Michael N Cocchi, Maureen Chase, Xiaowen Liu, Duncan M Kuhn, Anne V Grossestreuer, Anne Kirstine Hoeyer-Nielsen, Hans Kirkegaard, Michael W Donnino. Ubiquinol (reduced coenzyme Q10) as a metabolic resuscitator in post-cardiac arrest: A randomized, double-blind, placebo-controlled trial. Resuscitation. 2021 05; 162(?):388-395. doi: 10.1016/j.resuscitation.2021.01.041. [PMID: 33577964]