Oleuropein (BioDeep_00000003820)

Main id: BioDeep_00000298920

 

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


Methyl (2S,4S,E)-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-ethylidene-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydro-2H-pyran-5-carboxylate

化学式: C25H32O13 (540.1842822)
中文名称: 橄榄苦苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C1/[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC(=O)OCCc1ccc(O)c(O)c1
InChI: InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1

描述信息

Oleuropein is a secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars. It has a role as a plant metabolite, a radical scavenger, an anti-inflammatory agent, an antineoplastic agent, an antihypertensive agent, a NF-kappaB inhibitor, an apoptosis inducer, an antioxidant and a nutraceutical. It is a secoiridoid glycoside, a beta-D-glucoside, a methyl ester, a member of catechols, a diester and a member of pyrans.
Oleuropein is a natural product found in Jasminum officinale, Olea capensis, and other organisms with data available.
Oleuropein is found in fruits. Oleuropein is a bitter principle of olives. Nutriceutical with antioxidant properties.Oleuropein is a chemical compound found in olive leaf from the olive tree (and leaves of privet) together with other closely related compounds such as 10-hydroxyoleuropein, ligstroside, and 10-hydroxyligstroside. All these compounds are tyrosol esters of elenolic acid that are further hydroxylated and glycosylated. Oleuropein and its metabolite hydroxytyrosol have powerful antioxidant activity both in vivo and in vitro and give extra-virgin olive oil its bitter, pungent taste. Oleuropein preparations have been claimed to strengthen the immune system
A secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars.
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000890 - Anti-Infective Agents
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

同义名列表

47 个代谢物同义名

Methyl (2S,4S,E)-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-ethylidene-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydro-2H-pyran-5-carboxylate; Methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-pyran-5-carboxylic acid; methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-pyran-5-carboxylate; methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxo-ethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4H-pyran-3-carboxylate; methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate; methyl(4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate; 2H-PYRAN-4-ACETIC ACID, 3-ETHYLIDENE-2-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,4-DIHYDRO-5-(METHOXYCARBONYL)-, 2-(3,4-DIHYDROXYPHENYL)ETHYL ESTER, (2S-(2.ALPHA.,3E,4.BETA.))-; [2S-(2alpha,3E,4beta)]-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid 2-(3,4-dihydroxyphenyl)ethyl ester; [2S-(2alpha,3E,4beta)]-3-Ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate 2-(3,4-dihydroxyphenyl)ethyl ester; 2H-Pyran-4-acetic acid, 3-ethylidene-2-(.beta.-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)-; 2-(3,4-Dihydroxyphenyl)ethyl (2S-(2alpha,3E,4beta))-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid; [2S-(2a,3E,4b)]-3-Ethylidene-2-(b-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid 2-(3,4-dihydroxyphenyl)ethyl ester; [2S-(2Α,3E,4β)]-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid 2-(3,4-dihydroxyphenyl)ethyl ester; 2-(3,4-dihydroxyphenyl)ethyl (2S-(2alpha,3E,4beta))-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate; methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate; [2S-(2Α,3E,4β)]-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate 2-(3,4-dihydroxyphenyl)ethyl ester; [2S-(2a,3E,4b)]-3-Ethylidene-2-(b-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate 2-(3,4-dihydroxyphenyl)ethyl ester; 2-(3,4-Dihydroxyphenyl)ethyl (2S-(2α,3E,4β))-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid; 2-(3,4-Dihydroxyphenyl)ethyl (2S-(2a,3E,4b))-3-ethylidene-2-(b-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid; 2-(3,4-dihydroxyphenyl)ethyl [2S-(2α,3E,4β)]-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate; 2-(3,4-Dihydroxyphenyl)ethyl (2S-(2a,3E,4b))-3-ethylidene-2-(b-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate; 2-(3,4-Dihydroxyphenyl)ethyl (2S-(2α,3E,4β))-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate; 2H-PYRAN-4-ACETIC ACID, 5-CARBOXY-3-ETHYLIDENE-2-(.BETA.-D-GLUCOSYLOXY)-3,4-DIHYDRO-, 3,4-DIHYDROXYPHENETHYL 5-METHYL ESTER; Oleuropein, United States Pharmacopeia (USP) Reference Standard; Oleuropein, European Pharmacopoeia (EP) Reference Standard; Oleuropein, primary pharmaceutical reference standard; Oleuropein, analytical standard; RFWGABANNQMHMZ-ZCHJGGQASA-N; Oleuropein, >=80\\% (HPLC); Oleuropein, >=98.0\\%; OLEUROPEIN [USP-RS]; OLEUROPEIN [WHO-DD]; OLEUROPEIN [VANDF]; OLEUROPEIN [INCI]; OLEUROPEIN [MI]; UNII-2O4553545L; MEGxp0_000369; oleoeuropeine; oleoeuropein; ACon1_000443; Oleuroperin; Oleuropeine; Oleuropein; 2O4553545L; Opiace; (4S,5Z,6R)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-4H-pyran-3-carboxylic acid methyl ester; Oleuropein



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

194 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Serena Fiorito, Chiara Collevecchio, Roberto Spogli, Francesco Epifano, Salvatore Genovese. Novel procedures for olive leaves extracts processing: Selective isolation of oleuropein and elenolic acid. Food chemistry. 2024 Jul; 447(?):139038. doi: 10.1016/j.foodchem.2024.139038. [PMID: 38507946]
  • Qizhen Cui, Qingqing Liu, Yutong Fan, Chenhe Wang, Yufei Li, Shuyuan Li, Jianguo Zhang, Guodong Rao. Functional differentiation of olive PLP_deC genes: insights into metabolite biosynthesis and genetic improvement at the whole-genome level. Plant cell reports. 2024 Apr; 43(5):127. doi: 10.1007/s00299-024-03212-z. [PMID: 38652203]
  • Juhee Cho, Meriem Bejaoui, Kenichi Tominaga, Hiroko Isoda. Comparative Analysis of Olive-Derived Phenolic Compounds' Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084479. [PMID: 38674064]
  • Farhang Aliakbari, Kimia Marzookian, Soha Parsafar, Hamdam Hourfar, Zahra Nayeri, Arghavan Fattahi, Mohammad Raeiji, Narges Nasrollahi Boroujeni, Daniel E Otzen, Dina Morshedi. The impact of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity. Science advances. 2024 Apr; 10(14):eadl3406. doi: 10.1126/sciadv.adl3406. [PMID: 38569030]
  • Morgane Carrara, Mary T Kelly, Lauren Griffin, Delphine Margout-Jantac. Development and cross-validation of simple HPLC-fluorescence and UPLC-MS-UV methods for rapid determination of oleuropein in olive leaves. Phytochemical analysis : PCA. 2024 Apr; 35(3):476-482. doi: 10.1002/pca.3302. [PMID: 37984858]
  • Jose M Romero-Márquez, María D Navarro-Hortal, Tamara Y Forbes-Hernández, Alfonso Varela-López, Juan G Puentes, Cristina Sánchez-González, Sandra Sumalla-Cano, Maurizio Battino, Roberto García-Ruiz, Sebastián Sánchez, José L Quiles. Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity. Food chemistry. 2024 Jan; 444(?):138516. doi: 10.1016/j.foodchem.2024.138516. [PMID: 38306771]
  • Maria Kourti, Zoi Skaperda, Fotios Tekos, Panagiotis Stathopoulos, Christina Koutra, Alexios Leandros Skaltsounis, Demetrios Kouretas. The Bioactivity of a Hydroxytyrosol-Enriched Extract Originated after Direct Hydrolysis of Olive Leaves from Greek Cultivars. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020299. [PMID: 38257212]
  • Taghreed A Majrashi, Mahmoud A El Hassab, Sara H Mahmoud, Ahmed Mostafa, Engy A Wahsh, Eslam B Elkaeed, Fatma E Hassan, Wagdy M Eldehna, Shimaa M Abdelgawad. In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2. PloS one. 2024; 19(4):e0301086. doi: 10.1371/journal.pone.0301086. [PMID: 38662719]
  • Yajun Hou, Xuan Zhao, Yalin Wang, Yapeng Li, Caihong Chen, Xiu Zhou, Jingwei Jin, Jiming Ye, Dongli Li, Lishe Gan, Rihui Wu. Oleuropein-Rich Jasminum Grandiflorum Flower Extract Regulates the LKB1-PGC-1α Axis Related to the Attenuation of Hepatocellular Lipid Dysmetabolism. Nutrients. 2023 Dec; 16(1):. doi: 10.3390/nu16010058. [PMID: 38201888]
  • Đani Benčić, Monika Barbarić, Ana Mornar, Daniela Amidžić Klarić, Anamaria Brozovic, Sanja Dabelić, Mihaela Fadljević, Ana Karković Marković. Oleuropein in olive leaf, branch, and stem extracts: stability and biological activity in human cervical carcinoma and melanoma cells. Acta pharmaceutica (Zagreb, Croatia). 2023 Dec; 73(4):601-616. doi: 10.2478/acph-2023-0046. [PMID: 38147483]
  • Zeinab Amini-Farsani, Somayeh Hashemi Sheikhshabani, Nasibeh Shaygan, Samira Asgharzade. The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells. Biotechnology and applied biochemistry. 2023 Oct; ?(?):. doi: 10.1002/bab.2521. [PMID: 37849224]
  • Tabarek H Mahmood, Ali Al-Samydai, Mazen Al Sulaibi, Moath Alqaraleh, Anas Ibrahim Abed, Naeem Shalan, Alaa Alsanabrah, Shrouq Taiseer Alsotari, Hamdi Nsairat, Walhan Alshaer. Development of Pegylated Nano-Phytosome Formulation with Oleuropein and Rutin to Compare Anti-Colonic Cancer Activity with Olea Europaea Leaves Extract. Chemistry & biodiversity. 2023 Jul; ?(?):e202300534. doi: 10.1002/cbdv.202300534. [PMID: 37498138]
  • Fanghua Xu, Xuetao Yi, Xin Zhang, Dong Pei, Jiangjuan Yuan, Ningli Wang, Duolong Di, Weidan Zeng, Yun Liu, Han Wang. Identification of anti-photoaging components of Olea europaea leaves based on spectrum-effect relationship. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Jul; 1226(?):123807. doi: 10.1016/j.jchromb.2023.123807. [PMID: 37354734]
  • Mai Noureldein, Spyros Grigorakis, Abdessamie Kellil, Nikolaos Nenadis. White rice enrichment with phenols upon cooking in olive leaf infusion: A preliminary study. Journal of the science of food and agriculture. 2023 Jun; ?(?):. doi: 10.1002/jsfa.12821. [PMID: 37384660]
  • Asma Mahmoudi, Fatma Hadrich, Zouhaier Bouallagui, Ines Feki, Hela Ghorbel, Lobna Ayadi, Mohamed Chamkha, Sami Sayadi. Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses. Environmental science and pollution research international. 2023 Jun; ?(?):. doi: 10.1007/s11356-023-27836-y. [PMID: 37273043]
  • Zongchao Hong, Yi Lu, Bo Liu, Chongwang Ran, Xia Lei, Mengfan Wang, Songtao Wu, Yanfang Yang, Hezhen Wu. Glycolysis, a new mechanism of oleuropein against liver tumor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154770. doi: 10.1016/j.phymed.2023.154770. [PMID: 36963367]
  • Rodrigo Gonzalez-Ortega, Carla Daniela Di Mattia, Paola Pittia, Poklar Ulrih Natasa. Effect of heat treatment on phenolic composition and radical scavenging activity of olive leaf extract at different pH conditions: a spectroscopic and kinetic study. Journal of the science of food and agriculture. 2023 Mar; 103(4):2047-2056. doi: 10.1002/jsfa.12371. [PMID: 36461135]
  • Sirajudheen Anwar, Hammad Saleem, Umair Khurshid, Shabana Yasmeen Ansari, Saleh Alghamdi, Abdul Wali A Al-Khulaidi, Jonaid Ahmad Malik, Nafees Ahemad, Nasser A Awadh Ali. Comparative phytochemical composition, oleuropein quantification, antioxidant and cytotoxic properties of Olea europaea L. leaves. Natural product research. 2023 Mar; 37(6):1023-1029. doi: 10.1080/14786419.2022.2097230. [PMID: 35815778]
  • Jose M Romero-Márquez, Tamara Y Forbes-Hernández, María D Navarro-Hortal, Rosa Quirantes-Piné, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sánchez-González, Maurizio Battino, José L Quiles. Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease. International journal of molecular sciences. 2023 Feb; 24(5):. doi: 10.3390/ijms24054353. [PMID: 36901783]
  • Rosamaria Pennisi, Ichrak Ben Amor, Bochra Gargouri, Hamadi Attia, Rihab Zaabi, Ahlem Ben Chira, Mongi Saoudi, Anna Piperno, Paola Trischitta, Maria Pia Tamburello, Maria Teresa Sciortino. Analysis of Antioxidant and Antiviral Effects of Olive (Olea europaea L.) Leaf Extracts and Pure Compound Using Cancer Cell Model. Biomolecules. 2023 Jan; 13(2):. doi: 10.3390/biom13020238. [PMID: 36830607]
  • Monica Nardi, Steve Brocchini, Satyanarayana Somavarapu, Antonio Procopio. Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives. International journal of pharmaceutics. 2023 Jan; 631(?):122498. doi: 10.1016/j.ijpharm.2022.122498. [PMID: 36535454]
  • Eman M Kabbash, Zeinab T Abdel-Shakour, Sherweit H El-Ahmady, Michael Wink, Iriny M Ayoub. Comparative metabolic profiling of olive leaf extracts from twelve different cultivars collected in both fruiting and flowering seasons. Scientific reports. 2023 01; 13(1):612. doi: 10.1038/s41598-022-27119-5. [PMID: 36635360]
  • Yu Wang, Li Mei, Shuya Zhao, Xianghui Xing, Guofeng Wu. Effect of chitosan-oleuropein nanoparticles on dentin collagen cross-linking. Technology and health care : official journal of the European Society for Engineering and Medicine. 2023; 31(2):647-659. doi: 10.3233/thc-220195. [PMID: 36093647]
  • Fatma Hadrich, Asma Mahmoudi, Mohamed Chamkha, Hiroko Isoda, Sami Sayadi. Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway. Oxidative medicine and cellular longevity. 2023; 2023(?):6828230. doi: 10.1155/2023/6828230. [PMID: 36647430]
  • Xiao Sun, Xin-Yi Huang, Dong Pei, Jian-Fei Liu, Duo-Long Di. A model for continuous sample feed and separation with counter-current chromatography based on elution-extrusion mode and its application. Journal of separation science. 2022 Dec; 45(24):4364-4374. doi: 10.1002/jssc.202200589. [PMID: 36250417]
  • Franck Polia, Marie-Noelle Horcajada, Laure Poquet, Francisco A Tomás-Barberán, Rocío García-Villalba. A novel combined analytical UV and MS approach for the quantification of oleuropein metabolites in human biological samples when authentic standards are not available. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Nov; 1210(?):123457. doi: 10.1016/j.jchromb.2022.123457. [PMID: 36150306]
  • Rahşan Ilıkçı Sağkan, İlayda Kaya, Berna Akın, Hüsne Özen, İbrahim Bulduk, Serçin Özlem Çalışkan. [The Effect of Oleuropein on The Mitochondrial Membrane Potential and Generation of Reactive Oxygen Species on Leishmania tropica Promastigotes]. Mikrobiyoloji bulteni. 2022 Oct; 56(4):692-705. doi: 10.5578/mb.20229607. [PMID: 36458715]
  • Loredana Basiricò, Fabio Mastrogiovanni, Nicola Lacetera, Luca Santi, Roberta Bernini, Umberto Bernabucci. In vitro antioxidant and anti-inflammatory activity of an oleuropein-enriched extract obtained from olives leaves on BME-UV1 cells. Natural product research. 2022 Aug; ?(?):1-5. doi: 10.1080/14786419.2022.2106485. [PMID: 35921509]
  • Gabriele Rocchetti, Maria Luisa Callegari, Alice Senizza, Gianluca Giuberti, Jessica Ruzzolini, Annalisa Romani, Silvia Urciuoli, Chiara Nediani, Luigi Lucini. Oleuropein from olive leaf extracts and extra-virgin olive oil provides distinctive phenolic profiles and modulation of microbiota in the large intestine. Food chemistry. 2022 Jun; 380(?):132187. doi: 10.1016/j.foodchem.2022.132187. [PMID: 35086016]
  • Maha Benlarbi, Hedya Jemai, Khouloud Hajri, Sihem Mbarek, Emna Amri, Mariem Jebbari, Imane Hammoun, Basma Baccouche, Nourhène Boudhrioua Mihoubi, Ayachi Zemmal, Rafika Ben Chaouacha-Chekir, Wissal Dhifi. Neuroprotective effects of oleuropein on retina photoreceptors cells primary culture and olive leaf extract and oleuropein inhibitory effects on aldose reductase in a diabetic model: Meriones shawi. Archives of physiology and biochemistry. 2022 Jun; 128(3):593-600. doi: 10.1080/13813455.2019.1708119. [PMID: 31922452]
  • Sabrina Bossio, Anna Perri, Rocco Malivindi, Francesca Giordano, Vittoria Rago, Maria Mirabelli, Alessandro Salatino, Antonio Brunetti, Emanuela Alessandra Greco, Antonio Aversa. Oleuropein Counteracts Both the Proliferation and Migration of Intra- and Extragonadal Seminoma Cells. Nutrients. 2022 May; 14(11):. doi: 10.3390/nu14112323. [PMID: 35684123]
  • Ihab M Abdallah, Kamal M Al-Shami, Euitaek Yang, Junwei Wang, Claudia Guillaume, Amal Kaddoumi. Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model. ACS chemical neuroscience. 2022 04; 13(7):1002-1013. doi: 10.1021/acschemneuro.2c00005. [PMID: 35263086]
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