Tubocurarine (BioDeep_00000003814)
Secondary id: BioDeep_00000422649
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
化学式: C37H41N2O6+ (609.2964466000001)
中文名称: D-筒箭毒碱
谱图信息:
最多检出来源 Homo sapiens(blood) 0.9%
分子结构信息
SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC
InChI: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
描述信息
Tubocurarine is only found in individuals that have used or taken this drug. It is a neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarines positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents > M03AA - Curare alkaloids
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
同义名列表
13 个代谢物同义名
(1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁸,²².0²⁷,³¹.0¹⁶,³⁴]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium; 7,12-Dihydroxy-6,6-dimethoxy-2,2,2-trimethyltubocuraranium; d-tubocurarine chloride; Isoquinoline alkaloid; Tubocurarine Chloride; (+)-Tubocurarine; D-Tubocurarine; Tubocurarinum; D-Tubocurare; Tubocurarine; Tubocurarin; Tubocurare; Tubocurarine
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:9774
- KEGG: C07547
- PubChem: 6000
- HMDB: HMDB0015330
- DrugBank: DB01199
- ChEMBL: CHEMBL339427
- Wikipedia: Tubocurarine_chloride
- MeSH: Tubocurarine
- KNApSAcK: C00001927
- chemspider: 5778
- CAS: 57-95-4
- PubChem: 9750
- PDB-CCD: TC9
- 3DMET: B02127
- NIKKAJI: J193.260H
- RefMet: Tubocurarine
- KNApSAcK: 9774
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Tam H Nguyen, Guillaume Maucort, Robert K P Sullivan, Mitja Schenning, Nickolas A Lavidis, Adam McCluskey, Phillip J Robinson, Frederic A Meunier. Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion.
PloS one.
2012; 7(5):e36913. doi:
10.1371/journal.pone.0036913
. [PMID: 22629340] - Xiufang Guo, Mercedes Gonzalez, Maria Stancescu, Herman H Vandenburgh, James J Hickman. Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system.
Biomaterials.
2011 Dec; 32(36):9602-11. doi:
10.1016/j.biomaterials.2011.09.014
. [PMID: 21944471] - Adak Nasiripourdori, Valérie Taly, Thomas Grutter, Antoine Taly. From toxins targeting ligand gated ion channels to therapeutic molecules.
Toxins.
2011 03; 3(3):260-93. doi:
10.3390/toxins3030260
. [PMID: 22069709] - Carmen Cifuentes-Diaz, Fabrice Chareyre, Marta Garcia, Jérôme Devaux, Michèle Carnaud, Grégoire Levasseur, Michiko Niwa-Kawakita, Sheila Harroch, Jean-Antoine Girault, Marco Giovannini, Laurence Goutebroze. Protein 4.1B contributes to the organization of peripheral myelinated axons.
PloS one.
2011; 6(9):e25043. doi:
10.1371/journal.pone.0025043
. [PMID: 21966409] - Ryan E Pavlovicz, Brandon J Henderson, Andrew B Bonnell, R Thomas Boyd, Dennis B McKay, Chenglong Li. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.
PloS one.
2011; 6(9):e24949. doi:
10.1371/journal.pone.0024949
. [PMID: 21949802] - Sylvia Wagner, Jürgen Kufleitner, Anja Zensi, Miriam Dadparvar, Sascha Wien, Judith Bungert, Tikva Vogel, Franz Worek, Jörg Kreuter, Hagen von Briesen. Nanoparticulate transport of oximes over an in vitro blood-brain barrier model.
PloS one.
2010 Dec; 5(12):e14213. doi:
10.1371/journal.pone.0014213
. [PMID: 21151975] - Mi Ja Yun, Yoon Hee Kim, Young Kwon Go, Ji Eun Shin, Choon Gun Ryu, Won Kim, Nam Jong Paik, Moon Ku Han, Sang Hwan Do, Woo Suk Jung. Remifentanil attenuates muscle fasciculations by succinylcholine.
Yonsei medical journal.
2010 Jul; 51(4):585-9. doi:
10.3349/ymj.2010.51.4.585
. [PMID: 20499427] - David M Pereira, Federico Ferreres, Jorge M A Oliveira, Luís Gaspar, Joana Faria, Patrícia Valentão, Mariana Sottomayor, Paula B Andrade. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Jul; 17(8-9):646-52. doi:
10.1016/j.phymed.2009.10.008
. [PMID: 19962870] - Catherine M Greene, Hugh Ramsay, Robert J Wells, Shane J O'Neill, Noel G McElvaney. Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor.
Mediators of inflammation.
2010; 2010(?):423241. doi:
10.1155/2010/423241
. [PMID: 20379354] - Guoqiang Zhang, Kelly A Kernan, Alison Thomas, Sarah Collins, Yumei Song, Ling Li, Weizhong Zhu, Renee C Leboeuf, Allison A Eddy. A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.
The Journal of biological chemistry.
2009 Oct; 284(42):29050-64. doi:
10.1074/jbc.m109.010249
. [PMID: 19690163] - W Pascale ter Beek, Pilar Martínez-Martínez, Mario Losen, Marc H de Baets, Axel R Wintzen, Jan J G M Verschuuren, Erik H Niks, Sjoerd G van Duinen, Angela Vincent, Peter C Molenaar. The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates.
The American journal of pathology.
2009 Oct; 175(4):1536-44. doi:
10.2353/ajpath.2009.090040
. [PMID: 19745065] - Man Liu, James P Dilger. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor.
Molecular pharmacology.
2009 Jan; 75(1):166-73. doi:
10.1124/mol.108.051060
. [PMID: 18842832] - Elaine Campana Sanches Bornia, Erika Bando, Miguel Machinski, Monalisa Wolski Pereira, Wilson Alves-Do-Prado. Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium.
Journal of anesthesia.
2009; 23(4):513-9. doi:
10.1007/s00540-009-0790-z
. [PMID: 19921360] - Steeve H Thany, Raphael Courjaret, Bruno Lapied. Effect of calcium on nicotine-induced current expressed by an atypical alpha-bungarotoxin-insensitive nAChR2.
Neuroscience letters.
2008 Jun; 438(3):317-21. doi:
10.1016/j.neulet.2008.04.065
. [PMID: 18485593] - Keiji Hirai, Yoshifumi Katayama, Gabriel Peltre, Shigeru Tsuji. Ultrastructural visualization of the transmembranous and cytomatrix-related part of nicotinic acetylcholine receptor of frog motor endplate by means of an immunochemical avidity of IgG for d-tubocurarine.
Folia histochemica et cytobiologica.
2008; 46(1):111-6. doi:
10.2478/v10042-008-0016-5
. [PMID: 18296273] - Marc Hammarlund, Mark T Palfreyman, Shigeki Watanabe, Shawn Olsen, Erik M Jorgensen. Open syntaxin docks synaptic vesicles.
PLoS biology.
2007 Aug; 5(8):e198. doi:
10.1371/journal.pbio.0050198
. [PMID: 17645391] - Phillip P Smith, Christopher P Smith, Timothy B Boone, George T Somogyi. Is abdominal wall contraction important for normal voiding in the female rat?.
BMC urology.
2007 Mar; 7(?):5. doi:
10.1186/1471-2490-7-5
. [PMID: 17343732] - Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K Cassels, Isabel Bermudez. alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.
Molecular pharmacology.
2006 Aug; 70(2):755-68. doi:
10.1124/mol.106.023044
. [PMID: 16720757] - I I Krivoĭ, T M Drabkina, A N Vasil'ev, V V Kravtsova, F Mandel. [Analysis of the interaction between nicotinic acetylcholine receptor and Na+,K(+)-ATPase in the rat skeletal muscle and the Torpedo electric organ membrane preparation].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2006 Feb; 92(2):191-203. doi:
NULL
. [PMID: 16739652] - W C Bowman. Neuromuscular block.
British journal of pharmacology.
2006 Jan; 147 Suppl 1(?):S277-86. doi:
10.1038/sj.bjp.0706404
. [PMID: 16402115] - Loredana Riganti, Cosetta Matteoni, Silvia Di Angelantonio, Andrea Nistri, Annalisa Gaimarri, Fabio Sparatore, Caterina Canu-Boido, Francesco Clementi, Cecilia Gotti. Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells.
British journal of pharmacology.
2005 Dec; 146(8):1096-109. doi:
10.1038/sj.bjp.0706434
. [PMID: 16273122] - M R Lee. Curare: the South American arrow poison.
The journal of the Royal College of Physicians of Edinburgh.
2005 Feb; 35(1):83-92. doi:
"
. [PMID: 15825249] - María T Buznego, Héctor Pérez-Saad. Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
Epilepsy & behavior : E&B.
2004 Dec; 5(6):847-51. doi:
10.1016/j.yebeh.2004.07.006
. [PMID: 15582831] - Walter Raasch, Peter Dominiak, Andreas Ziegler, Andreas Dendorfer. Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation.
Hypertension (Dallas, Tex. : 1979).
2004 Sep; 44(3):346-51. doi:
10.1161/01.hyp.0000138406.13413.0e
. [PMID: 15262904] - Ulyana Lalo, Yuri Pankratov, Oleg Krishtal, R Alan North. Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells.
British journal of pharmacology.
2004 Aug; 142(8):1227-32. doi:
10.1038/sj.bjp.0705878
. [PMID: 15277311] - A L F Camurça-Vasconcelos, N R F Nascimento, C M Sousa, L M Melo, S M Morais, C M L Bevilaqua, M F G Rocha. Neuromuscular effects and acute toxicity of an ethyl acetate extract of Spigelia anthelmia Linn.
Journal of ethnopharmacology.
2004 Jun; 92(2-3):257-61. doi:
10.1016/j.jep.2004.03.005
. [PMID: 15138009] - M F Pediconi, C E Gallegos, E B De Los Santos, F J Barrantes. Metabolic cholesterol depletion hinders cell-surface trafficking of the nicotinic acetylcholine receptor.
Neuroscience.
2004; 128(2):239-49. doi:
10.1016/j.neuroscience.2004.06.007
. [PMID: 15350637] - G Lopes, R B Bazotte, R Curi, W Alves-Do-Prado. L- and DL-carnitine induce tetanic fade in rat neuromuscular preparation.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2003 Sep; 36(9):1255-62. doi:
10.1590/s0100-879x2003000900017
. [PMID: 12937794] - V Cirimele, M Villain, G Pépin, B Ludes, P Kintz. Screening procedure for eight quaternary nitrogen muscle relaxants in blood by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jun; 789(1):107-13. doi:
10.1016/s1570-0232(03)00070-9
. [PMID: 12726849] - Travis Dunckley, Ronald J Lukas. Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line.
The Journal of biological chemistry.
2003 May; 278(18):15633-40. doi:
10.1074/jbc.m210389200
. [PMID: 12588870] - Pierre Wins, Ilca Margineanu, Jacques Penelle, Luc Angenot, Thierry Grisar, Lucien Bettendorff. Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Mar; 367(3):253-9. doi:
10.1007/s00210-003-0692-9
. [PMID: 12644897] - Paul A Davies, Wei Wang, Tim G Hales, Ewen F Kirkness. A novel class of ligand-gated ion channel is activated by Zn2+.
The Journal of biological chemistry.
2003 Jan; 278(2):712-7. doi:
10.1074/jbc.m208814200
. [PMID: 12381728] - Aaron J Middlebrook, Cherie Martina, Yung Chang, Ronald J Lukas, Dominick DeLuca. Effects of nicotine exposure on T cell development in fetal thymus organ culture: arrest of T cell maturation.
Journal of immunology (Baltimore, Md. : 1950).
2002 Sep; 169(6):2915-24. doi:
10.4049/jimmunol.169.6.2915
. [PMID: 12218105] - K Finlayson, J McLuckie, J Hern, I Aramori, H J Olverman, J S Kelly. Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes.
Neuropharmacology.
2001 Sep; 41(3):341-50. doi:
10.1016/s0028-3908(01)00067-3
. [PMID: 11522325] - T Mitsui, K Okada, T Kuhara, T Hashizume, S Okazaki, M Kawajiri, T Matsumoto. Mesangial proliferative glomerulonephritis with deposits of anti-nicotinic acetylcholine receptor antibody in a patient with myasthenia gravis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2001 Sep; 8(5):454-6. doi:
10.1054/jocn.2000.0824
. [PMID: 11535018] - C A Brady, I M Stanford, I Ali, L Lin, J M Williams, A E Dubin, A G Hope, N M Barnes. Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.
Neuropharmacology.
2001 Aug; 41(2):282-4. doi:
10.1016/s0028-3908(01)00074-0
. [PMID: 11489465] - T L Tieman, D J Steel, Y Gor, J Kehoe, J H Schwartz, S J Feinmark. A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons.
Journal of neurophysiology.
2001 May; 85(5):2150-8. doi:
10.1152/jn.2001.85.5.2150
. [PMID: 11353029] - R Desai, A Peretz, H Idelson, P Lazarovici, B Attali. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.
The Journal of biological chemistry.
2000 Dec; 275(51):39954-63. doi:
10.1074/jbc.m001562200
. [PMID: 10991935] - B Balestra, S Vailati, M Moretti, W Hanke, F Clementi, C Gotti. Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype.
Molecular pharmacology.
2000 Aug; 58(2):300-11. doi:
10.1124/mol.58.2.300
. [PMID: 10908297] - S Mochizuki, T Watanabe, A Miyake, M Saito, K Furuichi. Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.
European journal of pharmacology.
2000 Jul; 399(2-3):97-106. doi:
10.1016/s0014-2999(00)00371-x
. [PMID: 10884508] - M Shah, D G Haylett. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
British journal of pharmacology.
2000 Feb; 129(4):627-30. doi:
10.1038/sj.bjp.0703111
. [PMID: 10683185] - H Tsukagoshi, T Morita, K Takahashi, F Kunimoto, F Goto. Cecal ligation and puncture peritonitis model shows decreased nicotinic acetylcholine receptor numbers in rat muscle: immunopathologic mechanisms?.
Anesthesiology.
1999 Aug; 91(2):448-60. doi:
10.1097/00000542-199908000-00020
. [PMID: 10443609] - G A Gronert, D L Fung, S C Haskins, E P Steffey. Deep sedation and mechanical ventilation without paralysis for 3 weeks in normal beagles: exaggerated resistance to metocurine in gastrocnemius muscle.
Anesthesiology.
1999 Jun; 90(6):1741-5. doi:
10.1097/00000542-199906000-00032
. [PMID: 10360874] - K Sato, K Windisch, I Matko, E S Vizi. Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery.
British journal of anaesthesia.
1999 Jun; 82(6):904-9. doi:
10.1093/bja/82.6.904
. [PMID: 10562787] - J Zhang, Y Xiao, G Abdrakhmanova, W Wang, L Cleemann, K J Kellar, M Morad. Activation and Ca2+ permeation of stably transfected alpha3/beta4 neuronal nicotinic acetylcholine receptor.
Molecular pharmacology.
1999 Jun; 55(6):970-81. doi:
10.1124/mol.55.6.970
. [PMID: 10347237] - A Bloc, E Bugnard, Y Dunant, J Falk-Vairant, M Israël, F Loctin, E Roulet. Acetylcholine synthesis and quantal release reconstituted by transfection of mediatophore and choline acetyltranferase cDNAs.
The European journal of neuroscience.
1999 May; 11(5):1523-34. doi:
10.1046/j.1460-9568.1999.00571.x
. [PMID: 10215905] - Y Xiao, E L Meyer, J M Thompson, A Surin, J Wroblewski, K J Kellar. Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function.
Molecular pharmacology.
1998 Aug; 54(2):322-33. doi:
10.1124/mol.54.2.322
. [PMID: 9687574] - Z P Yang, W D Dettbarn. Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy.
Journal of physiology, Paris.
1998 Jun; 92(3-4):157-61. doi:
10.1016/s0928-4257(98)80002-8
. [PMID: 9789800] - W Ridtitid, W Rattanaprom, P Thaina, S Chittrakarn, M Sunbhanich. Neuromuscular blocking activity of methanolic extract of Piper sarmentosum leaves in the rat phrenic nerve-hemidiaphragm preparation.
Journal of ethnopharmacology.
1998 Jun; 61(2):135-42. doi:
10.1016/s0378-8741(98)00025-7
. [PMID: 9683344] - A M Brown, A G Hope, J J Lambert, J A Peters. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A).
The Journal of physiology.
1998 Mar; 507 ( Pt 3)(?):653-65. doi:
10.1111/j.1469-7793.1998.653bs.x
. [PMID: 9508827] - S P Gawade. Comparative evaluation of mechanism of neuromuscular (n-m) blockade due to enhydrotoxin-A (EsNTx-a) and D-tubocurarine (d-TC).
Journal of natural toxins.
1998 Feb; 7(1):95-9. doi:
"
. [PMID: 9689605] - K A Duca, K P Chiu, T Sullivan, S A Berman, S Bursztajn. Nuclear clustering in myotubes: a proposed role in acetylcholine receptor mRNA expression.
Biochimica et biophysica acta.
1998 Jan; 1401(1):1-20. doi:
10.1016/s0167-4889(97)00118-3
. [PMID: 9459482] - H R Arias. Topology of ligand binding sites on the nicotinic acetylcholine receptor.
Brain research. Brain research reviews.
1997 Oct; 25(2):133-91. doi:
10.1016/s0165-0173(97)00020-9
. [PMID: 9403137] - V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. Cloning and characterization of two human polyspecific organic cation transporters.
DNA and cell biology.
1997 Jul; 16(7):871-81. doi:
10.1089/dna.1997.16.871
. [PMID: 9260930] - J A Pawelczyk, R A Pawelczyk, J Warberg, J H Mitchell, N H Secher. Cardiovascular and catecholamine responses to static exercise in partially curarized humans.
Acta physiologica Scandinavica.
1997 May; 160(1):23-8. doi:
10.1046/j.1365-201x.1997.00115.x
. [PMID: 9179307] - J M Midgley, J B Stenlake. Neuromuscular blockade: offset anomalies. Are they simply potency-related receptor bonding effects?.
The Journal of pharmacy and pharmacology.
1997 Apr; 49(4):416-20. doi:
10.1111/j.2042-7158.1997.tb06816.x
. [PMID: 9232540] - Z P Yang, J Morrow, A Wu, L J Roberts, W D Dettbarn. Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo.
Biochemical pharmacology.
1996 Jul; 52(2):357-61. doi:
10.1016/0006-2952(96)00214-6
. [PMID: 8694861] - A G Hope, J A Peters, A M Brown, J J Lambert, T P Blackburn. Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.
British journal of pharmacology.
1996 Jul; 118(5):1237-45. doi:
10.1111/j.1476-5381.1996.tb15529.x
. [PMID: 8818349] - Z P Yang, W D Dettbarn. Diisopropylphosphorofluoridate-induced cholinergic hyperactivity and lipid peroxidation.
Toxicology and applied pharmacology.
1996 May; 138(1):48-53. doi:
10.1006/taap.1996.0096
. [PMID: 8658512] - D A Protti, R Reisin, T A Mackinley, O D Uchitel. Calcium channel blockers and transmitter release at the normal human neuromuscular junction.
Neurology.
1996 May; 46(5):1391-6. doi:
10.1212/wnl.46.5.1391
. [PMID: 8628488] - A Evoli, A P Batocchi, M Lo Monaco, S Servidei, L Padua, L Majolini, P Tonali. Clinical heterogeneity of seronegative myasthenia gravis.
Neuromuscular disorders : NMD.
1996 May; 6(3):155-61. doi:
10.1016/0960-8966(96)00009-0
. [PMID: 8784802] - Z Li, N Forester, A Vincent. Modulation of acetylcholine receptor function in TE671 (rhabdomyosarcoma) cells by non-AChR ligands: possible relevance to seronegative myasthenia gravis.
Journal of neuroimmunology.
1996 Feb; 64(2):179-83. doi:
10.1016/0165-5728(95)00169-7
. [PMID: 8632060] - J F Antognini, R Wood, G A Gronert. Metocurine pharmacokinetics and pharmacodynamics in goats.
Journal of veterinary pharmacology and therapeutics.
1995 Dec; 18(6):464-7. doi:
10.1111/j.1365-2885.1995.tb00627.x
. [PMID: 8789701] - M Naguib, A H Samarkandi, H S Bakhamees, M A Magboul, A K el-Bakry. Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine.
British journal of anaesthesia.
1995 Nov; 75(5):588-92. doi:
10.1093/bja/75.5.588
. [PMID: 7577286] - C Kim, M Hirose, J A Martyn. d-Tubocurarine accentuates the burn-induced upregulation of nicotinic acetylcholine receptors at the muscle membrane.
Anesthesiology.
1995 Aug; 83(2):309-15. doi:
10.1097/00000542-199508000-00011
. [PMID: 7631953] - D W Bonhaus, E Stefanich, D N Loury, S A Hsu, R M Eglen, E H Wong. Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors.
Journal of neurochemistry.
1995 Jul; 65(1):104-10. doi:
10.1046/j.1471-4159.1995.65010104.x
. [PMID: 7790853] - J Takeda, E Ueda, J Takahashi, K Fukushima. Plasma N-methylhistamine concentration as an indicator of histamine release by intravenous d-tubocurarine in humans: preliminary study in five patients by radioimmunoassay kits.
Anesthesia and analgesia.
1995 May; 80(5):1015-7. doi:
10.1097/00000539-199505000-00028
. [PMID: 7537026] - M Das, J R Vedasiromoni, S P Chauhan, D K Ganguly. Effect of the hot-water extract of black tea (Camellia sinensis) on the rat diaphragm.
Planta medica.
1994 Oct; 60(5):470-1. doi:
10.1055/s-2006-959535
. [PMID: 7997479] - J F Antognini, N D Kien. A method for preferential delivery of volatile anesthetics to the in situ goat brain.
Anesthesiology.
1994 May; 80(5):1148-54. doi:
10.1097/00000542-199405000-00024
. [PMID: 8017652] - J Watkins. Adverse reaction to neuromuscular blockers: frequency, investigation, and epidemiology.
Acta anaesthesiologica Scandinavica. Supplementum.
1994; 102(?):6-10. doi:
10.1111/j.1399-6576.1994.tb04030.x
. [PMID: 7976160] - B Fredette, U Rutishauser, L Landmesser. Regulation and activity-dependence of N-cadherin, NCAM isoforms, and polysialic acid on chick myotubes during development.
The Journal of cell biology.
1993 Dec; 123(6 Pt 2):1867-88. doi:
10.1083/jcb.123.6.1867
. [PMID: 8276904] - T Weiser, F W Bentrup. Pharmacology of the SV channel in the vacuolar membrane of Chenopodium rubrum suspension cells.
The Journal of membrane biology.
1993 Oct; 136(1):43-54. doi:
10.1007/bf00241488
. [PMID: 7505827] - M Rechtman, H Majewski. A facilitatory effect of anti-angiotensin drugs on vagal bradycardia in the pithed rat and guinea-pig.
British journal of pharmacology.
1993 Sep; 110(1):289-96. doi:
10.1111/j.1476-5381.1993.tb13807.x
. [PMID: 8220890] - D Aslanian, P Grof, J L Galzi, J P Changeux. A Raman spectroscopic study of acetylcholine receptor-rich membranes from Torpedo marmorata. Interaction of the receptor with carbamylcholine and (+)-tubocurarine.
Biochimica et biophysica acta.
1993 Jun; 1148(2):291-302. doi:
10.1016/0005-2736(93)90142-m
. [PMID: 8504123] - T Kotani, Y Miwa, K Fukushima, T Aoki, K Uchida, H Nagashima. [The effect of ionized calcium concentration on muscle contraction and on the effect of non-depolarizing neuromuscular blocking agent].
Masui. The Japanese journal of anesthesiology.
1992 Dec; 41(12):1905-9. doi:
NULL
. [PMID: 1479659] - C Gotti, W Hanke, W R Schlue, L Briscini, M Moretti, F Clementi. A functional alpha-bungarotoxin receptor is present in chick cerebellum: purification and characterization.
Neuroscience.
1992 Sep; 50(1):117-27. doi:
10.1016/0306-4522(92)90386-g
. [PMID: 1357590] - C S Kim, F J Arnold, M S Itani, J A Martyn. Decreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes.
Anesthesiology.
1992 Sep; 77(3):500-6. doi:
10.1097/00000542-199209000-00015
. [PMID: 1519788] - V Hatta, A Saxena, H L Kaul. Phenytoin reduces suxamethonium-induced myalgia.
Anaesthesia.
1992 Aug; 47(8):664-7. doi:
10.1111/j.1365-2044.1992.tb02386.x
. [PMID: 1519714] - H Otsuka, K Abe, M Oka. Effects of human recombinant IL-1 on d-tubocurarine-induced histamine release from isolated rat peritoneal mast cells.
Agents and actions.
1992 Jul; 36(3-4):178-82. doi:
. [PMID: 1382370]
- M Fujinaga, J M Baden, R I Mazze. Developmental toxicity of nondepolarizing muscle relaxants in cultured rat embryos.
Anesthesiology.
1992 Jun; 76(6):999-1003. doi:
10.1097/00000542-199206000-00021
. [PMID: 1350890] - C W Hogue, J M Ward, M S Itani, J A Martyn. Tolerance and upregulation of acetylcholine receptors follow chronic infusion of d-tubocurarine.
Journal of applied physiology (Bethesda, Md. : 1985).
1992 Apr; 72(4):1326-31. doi:
10.1152/jappl.1992.72.4.1326
. [PMID: 1592722] - C McLoughlin, P Elliott, G McCarthy, R K Mirakhur. Muscle pains and biochemical changes following suxamethonium administration after six pretreatment regimens.
Anaesthesia.
1992 Mar; 47(3):202-6. doi:
10.1111/j.1365-2044.1992.tb02118.x
. [PMID: 1566986] - E M Lieberman, E Sanzenbacher. Mechanisms of glutamate activation of axon-to-Schwann cell signaling in the squid.
Neuroscience.
1992; 47(4):931-9. doi:
10.1016/0306-4522(92)90041-y
. [PMID: 1349735] - M Naguib, M Abdulatif, A Absood. Comparative effects of pipecuronium and tubocurarine on plasma concentrations of histamine in humans.
British journal of anaesthesia.
1991 Sep; 67(3):320-2. doi:
10.1093/bja/67.3.320
. [PMID: 1654967] - S Sinha, J Newsom-Davis, K Mills, N Byrne, B Lang, A Vincent. Autoimmune aetiology for acquired neuromyotonia (Isaacs' syndrome).
Lancet (London, England).
1991 Jul; 338(8759):75-7. doi:
10.1016/0140-6736(91)90073-x
. [PMID: 1676468] - O Y Hu, C H Chou, W Ho, S T Ho. Determination of vecuronium in blood by HPLC with UV and electrochemical detection: a pilot study in man.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences.
1991 Jul; 15(3):186-90. doi:
NULL
. [PMID: 1687880] - M L Vitale, A Rodríguez Del Castillo, L Tchakarov, J M Trifaró. Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin.
The Journal of cell biology.
1991 Jun; 113(5):1057-67. doi:
10.1083/jcb.113.5.1057
. [PMID: 1645735] - C K Buckner, J Ro, J Brendel, R I Fishleder, J A Will, R Conklin, F M Graziano. Studies of desensitization and cross-desensitization to immunologic and nonimmunologic stimuli that evoke contraction and histamine release in superfused guinea pig trachea.
The Journal of allergy and clinical immunology.
1991 Mar; 87(3):655-61. doi:
10.1016/0091-6749(91)90384-z
. [PMID: 1706369] - G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products.
1991 Jan; 54(1):143-54. doi:
10.1021/np50073a012
. [PMID: 1710653] - S Oshita, S Denda, Y Fujiwara, H Takeshita, F Kosaka. Pretreatment with d-tubocurarine, vecuronium, and pancuronium attenuates succinylcholine-induced increases in plasma norepinephrine concentrations in humans.
Anesthesia and analgesia.
1991 Jan; 72(1):84-8. doi:
10.1213/00000539-199101000-00015
. [PMID: 1670598] - P Dominiak, A Blöchl. Does converting enzyme inhibition change the neuronal and extraneuronal uptake of catecholamines?.
Basic research in cardiology.
1991; 86 Suppl 3(?):149-56. doi:
10.1007/978-3-662-30769-4_14
. [PMID: 1838245] - G Zukauskas, K Dapsys. Bioelectrical homeostasis as a component of acupuncture mechanism.
Acupuncture & electro-therapeutics research.
1991; 16(3-4):117-26. doi:
NULL
. [PMID: 1685620] - T C Brown, M Gregory, B Bell, D Clare. Response to nondepolarizing muscle relaxants in children with tumours.
Anaesthesia and intensive care.
1990 Nov; 18(4):460-5. doi:
10.1177/0310057x9001800407
. [PMID: 2176439] - C W Hogue, M S Itani, J A Martyn. Resistance to d-tubocurarine in lower motor neuron injury is related to increased acetylcholine receptors at the neuromuscular junction.
Anesthesiology.
1990 Oct; 73(4):703-9. doi:
10.1097/00000542-199010000-00016
. [PMID: 2221439] - E Tareilus, W Hanke, H Breer. Neuronal acetylcholine receptor channels from insects: a comparative electrophysiological study.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology.
1990 Sep; 167(4):521-6. doi:
10.1007/bf00190822
. [PMID: 1701832] - W S Kuo, S T Ho, O Y Hu, C H Li, C S Hwing. [The study of pretreatment with diphenylhydantoin or D-tubocurarine on succinylcholine-induced adverse effects].
Ma zui xue za zhi = Anaesthesiologica Sinica.
1990 Sep; 28(3):323-8. doi:
NULL
. [PMID: 2277574] - F deBros, R Okutani, E Inada, K Lawrence. Determination of alcuronium in plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1990 Aug; 529(2):449-54. doi:
10.1016/s0378-4347(00)83853-0
. [PMID: 2229263] - Y Gu, A Franco, P D Gardner, J B Lansman, J R Forsayeth, Z W Hall. Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells.
Neuron.
1990 Aug; 5(2):147-57. doi:
10.1016/0896-6273(90)90305-y
. [PMID: 2383398] - R S Annan, C Kim, J Martyn. Measurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography.
1990 Mar; 526(1):228-34. doi:
10.1016/s0378-4347(00)82503-7
. [PMID: 2341537]