Tubocurarine (BioDeep_00000003814)
Secondary id: BioDeep_00000422649
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁸,²².0²⁷,³¹.0¹⁶,³⁴]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium
化学式: C37H41N2O6+ (609.2964)
中文名称: D-筒箭毒碱
谱图信息:
最多检出来源 Homo sapiens(blood) 32.85%
分子结构信息
SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC
InChI: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
描述信息
Tubocurarine is only found in individuals that have used or taken this drug. It is a neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarines positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents > M03AA - Curare alkaloids
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
同义名列表
13 个代谢物同义名
(1S,16R)-9,21-dihydroxy-10,25-dimethoxy-15,15,30-trimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2³,⁶.1⁸,¹².1¹⁸,²².0²⁷,³¹.0¹⁶,³⁴]hexatriaconta-3,5,8(34),9,11,18(33),19,21,24,26,31,35-dodecaen-15-ium; 7,12-Dihydroxy-6,6-dimethoxy-2,2,2-trimethyltubocuraranium; d-tubocurarine chloride; Isoquinoline alkaloid; Tubocurarine Chloride; (+)-Tubocurarine; D-Tubocurarine; Tubocurarinum; D-Tubocurare; Tubocurarine; Tubocurarin; Tubocurare; Tubocurarine
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:9774
- KEGG: C07547
- PubChem: 6000
- HMDB: HMDB0015330
- DrugBank: DB01199
- ChEMBL: CHEMBL339427
- Wikipedia: Tubocurarine_chloride
- MeSH: Tubocurarine
- KNApSAcK: C00001927
- chemspider: 5778
- CAS: 57-95-4
- PubChem: 9750
- PDB-CCD: TC9
- 3DMET: B02127
- NIKKAJI: J193.260H
- RefMet: Tubocurarine
- KNApSAcK: 9774
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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British journal of anaesthesia.
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1995 Jul; 65(1):104-10. doi:
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Planta medica.
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1994 May; 80(5):1148-54. doi:
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Anaesthesia.
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1991 Jul; 15(3):186-90. doi:
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The Journal of allergy and clinical immunology.
1991 Mar; 87(3):655-61. doi:
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1990 Sep; 28(3):323-8. doi:
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