Chalepin (BioDeep_00000003796)

 

Secondary id: BioDeep_00001869224

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Heliettin

化学式: C19H22O4 (314.1518)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 85.71%

分子结构信息

SMILES: C=CC(C)(C)c1cc2cc3c(cc2oc1=O)OC(C(C)(C)O)C3
InChI: InChI=1S/C19H22O4/c1-6-18(2,3)13-8-11-7-12-9-16(19(4,5)21)22-14(12)10-15(11)23-17(13)20/h6-8,10,16,21H,1,9H2,2-5H3

描述信息

D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins

同义名列表

3 个代谢物同义名

Heliettin; Chalepin; Heliettin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANXA5, BCL2, BCL2L1, BID, BIRC5, CASP3, CASP8, CASP9, CHUK, GAPDH, IKBKB, IKBKG, MYC, NFKBIA, XIAP
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 BCL2
Mitochondrion membrane 2 BCL2L1, BID
Nucleus 13 BCL2, BIRC5, CASP3, CASP8, CASP9, CHUK, GAPDH, IKBKB, IKBKG, MYC, NFKBIA, PARP1, XIAP
cytosol 17 ANXA5, BCL2, BCL2L1, BID, BIRC5, CASP3, CASP8, CASP9, CHUK, DIABLO, GAPDH, IKBKB, IKBKG, NFKBIA, PARP1, TNFRSF10A, XIAP
nuclear body 1 PARP1
centrosome 1 BCL2L1
nucleoplasm 9 BIRC5, CASP3, CASP8, CHUK, IKBKG, MYC, NFKBIA, PARP1, XIAP
Cell membrane 1 TNFRSF10A
Cytoplasmic side 1 BCL2L1
lamellipodium 1 CASP8
Multi-pass membrane protein 1 KCNJ11
cell surface 2 TNFRSF10A, TNFRSF10B
glutamatergic synapse 2 CASP3, KCNJ11
Golgi apparatus 1 TNFRSF10A
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 CASP3, KCNJ11
presynaptic membrane 1 KCNJ11
sarcolemma 1 ANXA5
Cytoplasm, cytosol 5 BCL2L1, DIABLO, GAPDH, PARP1, TNFRSF10A
acrosomal vesicle 1 KCNJ11
endosome 1 KCNJ11
plasma membrane 5 GAPDH, KCNJ11, NFKBIA, TNFRSF10A, TNFRSF10B
synaptic vesicle membrane 1 BCL2L1
Membrane 10 ANXA5, BCL2, BID, DIABLO, GAPDH, KCNJ11, MYC, PARP1, TNFRSF10A, TNFRSF10B
extracellular exosome 2 ANXA5, GAPDH
endoplasmic reticulum 2 BCL2, BCL2L1
perinuclear region of cytoplasm 1 GAPDH
intercalated disc 1 KCNJ11
mitochondrion 7 BCL2, BCL2L1, BID, CASP8, CASP9, DIABLO, PARP1
protein-containing complex 7 BCL2, BIRC5, CASP8, CASP9, IKBKG, MYC, PARP1
intracellular membrane-bounded organelle 1 GAPDH
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TNFRSF10A
extracellular region 1 ANXA5
cytoplasmic side of plasma membrane 3 CHUK, DIABLO, IKBKB
Mitochondrion outer membrane 3 BCL2, BCL2L1, BID
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 4 BCL2, BCL2L1, BID, CASP8
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, GAPDH
CD40 receptor complex 3 CHUK, DIABLO, IKBKB
external side of plasma membrane 1 ANXA5
T-tubule 1 KCNJ11
microtubule cytoskeleton 2 BIRC5, GAPDH
nucleolus 2 MYC, PARP1
midbody 1 BIRC5
vesicle 1 GAPDH
Cell projection, lamellipodium 1 CASP8
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 2 IKBKB, TNFRSF10A
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 GAPDH
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 ANXA5
microtubule 1 BIRC5
spindle 1 BIRC5
axolemma 1 KCNJ11
mitochondrial intermembrane space 1 DIABLO
collagen-containing extracellular matrix 1 ANXA5
interphase microtubule organizing center 1 BIRC5
Zymogen granule membrane 1 ANXA5
chromatin 2 MYC, PARP1
mitotic spindle 1 IKBKG
Chromosome 2 BIRC5, PARP1
cytoskeleton 2 CASP8, GAPDH
centriole 1 BIRC5
Nucleus, nucleolus 2 MYC, PARP1
spindle pole 1 IKBKG
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 BIRC5
site of double-strand break 1 PARP1
serine/threonine protein kinase complex 1 IKBKB
nuclear envelope 3 KCNJ11, MYC, PARP1
Lipid droplet 1 GAPDH
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
monoatomic ion channel complex 1 KCNJ11
cell body fiber 1 KCNJ11
inward rectifying potassium channel 1 KCNJ11
Nucleus, nucleoplasm 1 MYC
cell body 1 CASP8
myelin sheath 1 BCL2
ubiquitin ligase complex 1 IKBKG
[Isoform 1]: Cytoplasm 1 BID
[Isoform 3]: Cytoplasm 1 BID
plasma membrane raft 1 TNFRSF10A
kinetochore 1 BIRC5
RNA polymerase II transcription repressor complex 1 MYC
apoptosome 1 CASP9
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
IkappaB kinase complex 3 CHUK, IKBKB, IKBKG
chromosome passenger complex 1 BIRC5
ribonucleoprotein complex 1 GAPDH
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 PARP1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
Rough endoplasmic reticulum 1 MYC
GAIT complex 1 GAPDH
site of DNA damage 1 PARP1
Myc-Max complex 1 MYC
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
I-kappaB/NF-kappaB complex 1 NFKBIA
caspase complex 1 CASP9
[BH3-interacting domain death agonist p15]: Mitochondrion membrane 1 BID
[BH3-interacting domain death agonist p13]: Mitochondrion membrane 1 BID
[Isoform 2]: Mitochondrion membrane 1 BID
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
nucleoplasmic reticulum 1 MYC


文献列表

  • Aldo Fabio Bazaldúa-Rodríguez, Ramiro Quintanilla-Licea, María Julia Verde-Star, Magda Elizabeth Hernández-García, Javier Vargas-Villarreal, Jesús Norberto Garza-González. Furanocoumarins from Ruta chalepensis with Amebicide Activity. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123684. [PMID: 34208750]
  • Lutfun Nahar, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul, Satyajit D Sarker. Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061609. [PMID: 33799365]
  • Musa Isah Fakai, Sri Nurestri Abd Malek, Saiful Anuar Karsani. Induction of apoptosis by chalepin through phosphatidylserine externalisations and DNA fragmentation in breast cancer cells (MCF7). Life sciences. 2019 Mar; 220(?):186-193. doi: 10.1016/j.lfs.2019.01.029. [PMID: 30682342]
  • Yongsheng Lin, Qian Wang, Qiong Gu, Hongao Zhang, Cheng Jiang, Jiayuan Hu, Yan Wang, Yuan Yan, Jun Xu. Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication. Journal of natural products. 2017 01; 80(1):53-60. doi: 10.1021/acs.jnatprod.6b00415. [PMID: 28093914]
  • Jaime Stella Moses Richardson, Gautam Sethi, Guan Serm Lee, Sri Nurestri Abdul Malek. Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells. BMC complementary and alternative medicine. 2016 Oct; 16(1):389. doi: 10.1186/s12906-016-1368-6. [PMID: 27729078]
  • Tutik Sri Wahyuni, Aty Widyawaruyanti, Maria Inge Lusida, Achmad Fuad, Soetjipto, Hiroyuki Fuchino, Nobuo Kawahara, Yoshitake Hayashi, Chie Aoki, Hak Hotta. Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves. Fitoterapia. 2014 Dec; 99(?):276-83. doi: 10.1016/j.fitote.2014.10.011. [PMID: 25454460]
  • Aleksandra Orlita, Matylda Sidwa-Gorycka, Jolanta Kumirska, Edmund Maliński, Ewa M Siedlecka, Jerzy Gajdus, Ewa Lojkowska, Piotr Stepnowski. Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors. Biotechnology progress. 2008 Jan; 24(1):128-33. doi: 10.1021/bp070261d. [PMID: 18052337]
  • G Emerole, M I Thabrew, V Anosa, D A Okorie. Structure-activity relationship in the toxicity of some naturally occurring coumarins-chalepin, imperatorin and oxypeucedanine. Toxicology. 1981; 20(1):71-80. doi: 10.1016/0300-483x(81)90107-4. [PMID: 7268793]