Harpagoside (BioDeep_00000000377)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(E)-3-phenylprop-2-enoic acid [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] ester

化学式: C24H30O11 (494.1788)
中文名称: 哈巴俄苷
谱图信息: 最多检出来源 Viridiplantae(otcml) 36.7%

分子结构信息

SMILES: CC1(CC(C2(C1C(OC=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O)OC(=O)C=CC4=CC=CC=C4
InChI: InChI=1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1

描述信息

Harpagoside is a terpene glycoside.
Harpagoside is a natural product found in Verbascum lychnitis, Verbascum sinuatum, and other organisms with data available.
See also: Harpagophytum procumbens root (part of); Harpagophytum zeyheri root (part of).
Origin: Plant; SubCategory_DNP: Monoterpenoids, Iridoid monoterpenoids
Harpagoside is isolated from Harpagophytum procumbens. Harpagoside has inhibitory effects on COX-1 and COX-2 activity and inhibits NO production[1].
Harpagoside is isolated from Harpagophytum procumbens. Harpagoside has inhibitory effects on COX-1 and COX-2 activity and inhibits NO production[1].

同义名列表

36 个代谢物同义名

(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate; (1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-7-yl (2E)-3-phenylprop-2-enoate; (1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate; [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate; (1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside; .BETA.-D-GLUCOPYRANOSIDE, (1S,4AS,5R,7S,7AS)-1,4A,5,6,7,7A-HEXAHYDRO-4A,5-DIHYDROXY-7-METHYL-7-(((2E)-1-OXO-3-PHENYL-2-PROPENYL)OXY)CYCLOPENTA(C)PYRAN-1-YL; beta-D-GLUCOPYRANOSIDE, (1S,4AS,5R,7S,7AS)-1,4A,5,6,7,7A-HEXAHYDRO-4A,5-DIHYDROXY-7-METHYL-7-(((2E)-1-OXO-3-PHENYL-2-PROPENYL)OXY)CYCLOPENTA(C)PYRAN-1-YL; Harpagoside, European Pharmacopoeia (EP) Reference Standard; Harpagoside, primary pharmaceutical reference standard; Harpagoside, analytical standard; KVRQGMOSZKPBNS-FMHLWDFHSA-N; HARPAGOSIDE [WHO-DD]; HARPAGOSIDE [INCI]; Prestwick3_000988; UNII-8KGS1DC5ZU; harpagoside-B; E-harpagoside; MEGxp0_000469; BPBio1_001161; ACon0_000056; ACon1_000134; Harpagoside; Harpagosid; 8KGS1DC5ZU; Harpaside; (E)-3-phenylprop-2-enoic acid [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] ester; [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate; (E)-3-phenylacrylic acid [(1S,4aS,5R,7S,7aS)-4a,5-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] ester; EINECS 242-881-6; BSPBio_001055; LMPR01020111; 19210-12-9; C09783; NCGC00179325-04_C24H30O11_(1S,4aS,5R,7S,7aS)-1-(beta-D-Glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl (2E)-3-phenylacrylate; 6-Epiharpagoside; Harpagoside



数据库引用编号

53 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

119 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, BCL2, BDNF, BGLAP, CASP3, CYP3A4, NFKB1, NOS2, PIK3CA, PTEN, PTGS2, TNFSF11
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP1A2, CYP3A4, PTGS2
Nucleus 6 BCL2, CASP3, FOS, NFKB1, NOS2, PTEN
cytosol 8 ACP5, BCL2, CASP3, FOS, NFKB1, NOS2, PIK3CA, PTEN
dendrite 2 BDNF, BGLAP
nucleoplasm 5 CASP3, FOS, NFKB1, NOS2, PTEN
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 3 ABCB1, TNF, TNFSF11
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 ABCB1
cell surface 3 ABCB1, BMP2, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 GDNF
Golgi membrane 1 INS
neuronal cell body 2 CASP3, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NOS2
Lysosome 1 ACP5
plasma membrane 7 ABCB1, BMP2, NOS2, PIK3CA, PTEN, TNF, TNFSF11
Membrane 6 ABCB1, ACP5, BCL2, BDNF, CYP3A4, TNFSF11
apical plasma membrane 2 ABCB1, PTEN
axon 1 BDNF
caveola 1 PTGS2
extracellular exosome 1 ABCB1
endoplasmic reticulum 3 BCL2, FOS, PTGS2
extracellular space 8 BDNF, BGLAP, BMP2, GDNF, IL6, INS, TNF, TNFSF11
perinuclear region of cytoplasm 3 BDNF, NOS2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, NFKB1
protein-containing complex 2 BCL2, PTGS2
intracellular membrane-bounded organelle 3 BMP2, CYP1A2, CYP3A4
Microsome membrane 3 CYP1A2, CYP3A4, PTGS2
postsynaptic density 2 CASP3, PTEN
Secreted 7 BDNF, BGLAP, BMP2, GDNF, IL6, INS, TNFSF11
extracellular region 10 BDNF, BGLAP, BMP2, GDNF, IL6, INS, NFKB1, PTEN, TNF, TNFSF11
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 NFKB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
dendritic spine 1 PTEN
perikaryon 1 BGLAP
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
vesicle 1 BGLAP
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 PTEN
neuron projection 2 PTEN, PTGS2
chromatin 2 FOS, NFKB1
cell projection 1 PTEN
phagocytic cup 1 TNF
endosome lumen 1 INS
myelin sheath 1 BCL2
secretory granule lumen 2 INS, NFKB1
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 5 BDNF, BGLAP, IL6, INS, PTGS2
nuclear matrix 1 FOS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Schmidt-Lanterman incisure 1 PTEN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
myelin sheath adaxonal region 1 PTEN
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
BMP receptor complex 1 BMP2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xiao Yu, Qishu Jiao, Yanyan Jiang, Shuzhen Guo, Wei Zhang, Bin Liu. Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong'an Decoction. Current drug metabolism. 2020; 21(12):979-993. doi: 10.2174/1567201817666200731170731. [PMID: 32735517]
  • Lina Su, Yinghui Deng, Nianzu Chen, Xiuwen Zhang, Taomin Huang. Infrared-assisted extraction followed by high performance liquid chromatography to determine angoroside C, cinnamic acid, and harpagoside content in Scrophularia ningpoensis. BMC complementary and alternative medicine. 2019 Jun; 19(1):130. doi: 10.1186/s12906-019-2552-2. [PMID: 31200712]
  • Zhan-Yun Shen, Bo Zhu, Quan-Long Zhang, Lu-Ping Qin. [Isolation and identification of endophytic fungi producing harpagoside and harpagide from Scrophularia ningpoensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 May; 44(10):2046-2050. doi: 10.19540/j.cnki.cjcmm.20190301.008. [PMID: 31355559]
  • Yin Wu, Pengqian Wang, Haotian Yang, Feng Sui. UPLC-Q-TOF-MS and UPLC-MS/MS methods for metabolism profiles and pharmacokinetics of major compounds in Xuanmai Ganjie Granules. Biomedical chromatography : BMC. 2019 Mar; 33(3):e4449. doi: 10.1002/bmc.4449. [PMID: 30513133]
  • Sonja Axmann, Karin Hummel, Katharina Nöbauer, Ebrahim Razzazi-Fazeli, Karin Zitterl-Eglseer. Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract. Journal of veterinary pharmacology and therapeutics. 2019 Jan; 42(1):37-44. doi: 10.1111/jvp.12716. [PMID: 30242850]
  • Jing-Zhe Wang, Yi-Fan Zhang, Feng Xu, Ming-Ying Shang, Guang-Xue Liu, Shao-Qing Cai. Investigation of the in vivo metabolism of harpagoside and distribution of its metabolites in rats by HPLC-IT-TOF-MSn. Biomedical chromatography : BMC. 2018 Jul; 32(7):e4218. doi: 10.1002/bmc.4218. [PMID: 29470860]
  • Alina Diuzheva, Simone Carradori, Vasil Andruch, Marcello Locatelli, Elisa De Luca, Matteo Tiecco, Raimondo Germani, Luigi Menghini, Alessio Nocentini, Paola Gratteri, Cristina Campestre. Use of Innovative (Micro)Extraction Techniques to Characterise Harpagophytum procumbens Root and its Commercial Food Supplements. Phytochemical analysis : PCA. 2018 May; 29(3):233-241. doi: 10.1002/pca.2737. [PMID: 29143440]
  • Delu Che, Jiao Cao, Rui Liu, Jue Wang, Yajing Hou, Tao Zhang, Nan Wang. Harpagoside-induced anaphylactic reaction in an IgE-independent manner both in vitro and in vivo. Immunopharmacology and immunotoxicology. 2018 Apr; 40(2):173-178. doi: 10.1080/08923973.2018.1424900. [PMID: 29355053]
  • Tuan-Wu Cao, Wen-Bing Huang, Jian-Wei Shi, Wei He. [Binding interaction of harpagoside and bovine serum albumin: spectroscopic methodologies and molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Mar; 43(5):993-1000. doi: 10.19540/j.cnki.cjcmm.2018.0031. [PMID: 29676099]
  • Chen Chen, Haifeng Zhang, Hongliang Xu, Rui Xue, Yake Zheng, Tianwen Wu, Yajun Lian. Harpagoside Rescues the Memory Impairments in Chronic Cerebral Hypoperfusion Rats by Inhibiting PTEN Activity. Journal of Alzheimer's disease : JAD. 2018; 63(2):445-455. doi: 10.3233/jad-171170. [PMID: 29614669]
  • Claudio Ferrante, Lucia Recinella, Marcello Locatelli, Paolo Guglielmi, Daniela Secci, Lidia Leporini, Annalisa Chiavaroli, Sheila Leone, Sara Martinotti, Luigi Brunetti, Michele Vacca, Luigi Menghini, Giustino Orlando. Protective Effects Induced by Microwave-Assisted Aqueous Harpagophytum Extract on Rat Cortex Synaptosomes Challenged with Amyloid β-Peptide. Phytotherapy research : PTR. 2017 Aug; 31(8):1257-1264. doi: 10.1002/ptr.5850. [PMID: 28635142]
  • Marcello Locatelli, Claudio Ferrante, Simone Carradori, Daniela Secci, Lidia Leporini, Annalisa Chiavaroli, Sheila Leone, Lucia Recinella, Giustino Orlando, Sara Martinotti, Luigi Brunetti, Michele Vacca, Luigi Menghini. Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model. Phytotherapy research : PTR. 2017 Jun; 31(6):937-944. doi: 10.1002/ptr.5821. [PMID: 28447368]
  • Bruna Isabela Biazi, Gláucia Fernanda Rocha D'Epiro, Thalita Alves Zanetti, Marcelo Tempesta de Oliveira, Lucia Regina Ribeiro, Mário Sérgio Mantovani. Risk Assessment via Metabolism and Cell Growth Inhibition in a HepG2/C3A Cell Line Upon Treatment with Arpadol and its Active Component Harpagoside. Phytotherapy research : PTR. 2017 Mar; 31(3):387-394. doi: 10.1002/ptr.5757. [PMID: 27991703]
  • Abdul Haseeb, Mohammad Yunus Ansari, Tariq M Haqqi. Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 02; 35(2):311-320. doi: 10.1002/jor.23262. [PMID: 27082319]
  • Narasimharao Kondamudi, Matthew W Turner, Owen M McDougal. Harpagoside Content in Devil's Claw Extracts. Natural product communications. 2016 Sep; 11(9):1215-1216. doi: . [PMID: 30807002]
  • P Schopohl, P Grüneberg, M F Melzig. The influence of harpagoside and harpagide on TNFα-secretion and cell adhesion molecule mRNA-expression in IFNγ/LPS-stimulated THP-1 cells. Fitoterapia. 2016 Apr; 110(?):157-65. doi: 10.1016/j.fitote.2016.03.005. [PMID: 26979254]
  • Shiow-Yunn Sheu, Yi-Wen Hong, Jui-Sheng Sun, Man-Hai Liu, Ching-Yun Chen, Cherng-Jyh Ke. Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity. BMC complementary and alternative medicine. 2015 Sep; 15(?):324. doi: 10.1186/s12906-015-0842-x. [PMID: 26370415]
  • Gang Cao, Xin Wu, Qinglin Li, Hao Cai, Baochang Cai, Xuemei Zhu. Influence of processing procedure on the quality of Radix Scrophulariae: a quantitative evaluation of the main compounds obtained by accelerated solvent extraction and high-performance liquid chromatography. Journal of separation science. 2015 Feb; 38(3):390-4. doi: 10.1002/jssc.201401141. [PMID: 25431110]
  • Katarina Hostanska, Joerg Melzer, Matthias Rostock, Andy Suter, Reinhard Saller. Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix. The Journal of pharmacy and pharmacology. 2014 Nov; 66(11):1606-14. doi: 10.1111/jphp.12242. [PMID: 25175765]
  • Nontobeko P Mncwangi, Alvaro M Viljoen, Jianping Zhao, Ilze Vermaak, Wei Chen, Ikhlas Khan. What the devil is in your phytomedicine? Exploring species substitution in Harpagophytum through chemometric modeling of 1H-NMR and UHPLC-MS datasets. Phytochemistry. 2014 Oct; 106(?):104-115. doi: 10.1016/j.phytochem.2014.06.012. [PMID: 25041697]
  • Jian Cheng, Liu-Qing Di, Jin-Jun Shan, Xiao-Li Zhao, An Kang, Xiao-Lin Bi, Jun-Song Li. [Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Apr; 39(8):1502-8. doi: . [PMID: 25039191]
  • Milen I Georgiev, Nina Ivanovska, Kalina Alipieva, Petya Dimitrova, Robert Verpoorte. Harpagoside: from Kalahari Desert to pharmacy shelf. Phytochemistry. 2013 Aug; 92(?):8-15. doi: 10.1016/j.phytochem.2013.04.009. [PMID: 23642455]
  • Jinfeng Tian, Xiaoli Ye, Yuanhong Shang, Yafei Deng, Kai He, Xuegang Li. Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography. Journal of separation science. 2012 Oct; 35(19):2659-64. doi: 10.1002/jssc.201200337. [PMID: 23001886]
  • Wen Zhou, Lin Jiang, Xiao-Juan Wang, Hong Tao, Xi-Kang Zhen, Ji-Teng Hu. [HPLC fingerprint of scrophulariae radix from southwest China]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Aug; 35(8):1230-3. doi: ". [PMID: 23320352]
  • Erzsébet Háznagy-Radnai, Ágnes Balogh, Szilvia Czigle, Imre Máthé, Judit Hohmann, Gábor Blazsó. Antiinflammatory activities of Hungarian Stachys species and their iridoids. Phytotherapy research : PTR. 2012 Apr; 26(4):505-9. doi: 10.1002/ptr.3582. [PMID: 21887806]
  • Xiaoyu Sun, Zhongkui Xiong, Yongfang Zhang, Ya Meng, Gang Xu, Zhiming Xia, Jiamei Li, Rui Zhang, Zunji Ke, Zongqin Xia, Yaer Hu. Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor. Journal of neurochemistry. 2012 Mar; 120(6):1072-83. doi: 10.1111/j.1471-4159.2011.07635.x. [PMID: 22192054]
  • Yun'e Bai, Pengfei Yuan, Qinghui Wang, Suli Wang, Yuewei Ge, Zhengri Niu, Mingying Shang, Guangxue Liu, Chen Li, Shaoqing Cai. [Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Oct; 36(19):2697-702. doi: . [PMID: 22242433]
  • Liuqiang Zhang, Li Feng, Qi Jia, Jinwen Xu, Rui Wang, Zhengtao Wang, Yingchun Wu, Yiming Li. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorganic & medicinal chemistry. 2011 Aug; 19(16):4882-6. doi: 10.1016/j.bmc.2011.06.069. [PMID: 21775152]
  • Shuting Yang, Jinghui Li, Yunpeng Zhao, Binlong Chen, Chengxin Fu. Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl. Journal of agricultural and food chemistry. 2011 Mar; 59(5):1612-21. doi: 10.1021/jf104702u. [PMID: 21322564]
  • Xuemei Zhang, Rui Wang, Rui An, Ximin Wu, Xinhong Wang, Yiming Li. [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Mar; 36(6):709-11. doi: . [PMID: 21710734]
  • Maryam Modarai, Andy Suter, Andreas Kortenkamp, Michael Heinrich. The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations. The Journal of pharmacy and pharmacology. 2011 Mar; 63(3):429-38. doi: 10.1111/j.2042-7158.2010.01235.x. [PMID: 21749392]
  • Maria Cecilia Anauate, Luce Maria Torres, Suzana Beatriz Veríssimo de Mello. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytotherapy research : PTR. 2010 Sep; 24(9):1365-9. doi: 10.1002/ptr.3124. [PMID: 20812280]
  • Kazunori Inaba, Kazuya Murata, Shunsuke Naruto, Hideaki Matsuda. Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages. Journal of natural medicines. 2010 Apr; 64(2):219-22. doi: 10.1007/s11418-010-0395-8. [PMID: 20177800]
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