Estriol (BioDeep_00000003767)

 

Secondary id: BioDeep_00000398242

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol

化学式: C18H24O3 (288.1725354)
中文名称: 雌三醇
谱图信息: 最多检出来源 Viridiplantae(plant) 0.59%

分子结构信息

SMILES: CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O
InChI: InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3

描述信息

Estriol is a metabolite of estrone metabolized via 16alpha-hydroxyestrone through the enzyme 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) or to 2- or 4-hydroxyestrone (catechol estrogens) by the action of catecho-O-methyltransferase (EC 2.1.1.6). The latter metabolites can be formed in the brain and may compete with receptors for catecholamines. Metabolites are conjugated with sulfate or glucuronide before excretion by the kidney. During pregnancy, estriol constitutes 60-70\\\\% of the total estrogens, increasing to 300-500-fold in relation to non-pregnant women. The late term human fetus produces relatively large amounts of 16 alphahydroxy DHEA, which serves the mother as a precursor of estriol. It has been shown that 90\\\\% of the precursors for the formation of estriol are of fetal origin. If abnormal maternal serum screening results, specifically low levels of unconjugated estriol in the second trimester are detected, a diagnosis of Smith-Lemli-Opitz syndrome (SLOS),or RSH is suspected. SLOS is an autosomal recessive disorder caused by mutations of the gene encoding 7-dehydrocholesterol reductase (EC 1.3.1.21, DHCR7). (PMID: 16202579, 16112271, 16097001).
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CA - Natural and semisynthetic estrogens, plain
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CC - Estrogens, combinations with other drugs
Estriol (also oestriol) is one of the three main estrogens produced by the human body. Estriol is found in common bean and pomegranate.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Estriol is a G protein-coupled estrogen receptor antagonist that can act on estrogen receptor-negative breast cancer cells.
Estriol is a G protein-coupled estrogen receptor antagonist that can act on estrogen receptor-negative breast cancer cells.

同义名列表

81 个代谢物同义名

(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol; 13beta-Methyl-1,3,5(10)-gonatriene-3,16alpha,17beta-triol; (16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol; (16beta,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol; 3,16alpha,17beta-Trihydroxy-Delta(1,3,5)-estratriene; 3,16alpha,17beta-Trihydroxyestra-1,3,5(10)-triene; 3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene; estra-1,3,5(10)-triene-3,16α,17β-triol; 13β-Methyl-1,3,5(10)-gonatriene-3,16α,17β-triol; 13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol; (16Α,17β)-estra-1,3,5(10)-triene-3,16,17-triol; (16a,17b)-Estra-1,3,5(10)-triene-3,16,17-triol; 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol; 3,16a,17b-Trihydroxy-delta(1,3,5)-estratriene; Estra-1,3,5(10)-triene-3,16beta,17beta-triol; 3,16a,17b-Trihydroxyestra-1,3,5(10)-triene; 3,16α,17β-Trihydroxyestra-1,3,5(10)-triene; 3,16a,17b-Trihydroxy-δ(1,3,5)-estratriene; 3,16Α,17β-trihydroxy-δ(1,3,5)-estratriene; Estra-1,3,5(10)-triene-3,16a,17b-triol; 1,3,5(10)-Estratriene-3,16-a,17b-triol; 1,3,5(10)-Estratriene-3,16-α,17β-triol; 16alpha-Hydroxy-17beta-estradiol; 16-alpha-Hydroxy-estradiol; Follicular hormone hydrate; 16 alpha Hydroxy estradiol; 16alpha-Hydroxyoestradiol; 16-alpha,17-beta-Oestriol; 16-alpha-Hydroxyestradiol; 16alpha-Hydroxyestradiol; 16-alpha,17-beta-Estriol; 16beta Hydroxy estradiol; 16beta-Hydroxy-estradiol; 3,16alpha,17beta-Estriol; 16alpha,17beta-Oestriol; 16-hydroxy-17-estradiol; 16alpha,17beta Estriol; 16alpha,17beta-Estriol; 16a-Hydroxyestradiol; 16Α-hydroxyestradiol; 3,16a,17b-Estriol; 3,16α,17β-Estriol; Trihydroxyestrin; 16Α,17β-estriol; 16a,17b-Estriol; 16alpha-Estriol; 16-Epiestriol; Hemostyptanon; Ortho-gynest; Orgastyptin; 16a-Estriol; Colpovister; Oestratriol; 16α-Estriol; Aacifemine; Tridestrin; Oestriolum; Estratriol; Ovo-vinces; Epiestriol; Deuslon a; Ovesterin; Deuslon-a; Ovestrion; Ovestinon; Colpogyn; Klimax e; Oestriol; Klimoral; Destriol; Hormomed; Triovex; Theelol; Incurin; Gynasan; Estriel; Orestin; Ovestin; Estriol; Holin V; Oekolp



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(6)

  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine
  • Estrone Metabolism: 2-Hydroxyestrone + S-Adenosylmethionine ⟶ 2-Methoxyestrone + S-Adenosylhomocysteine

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chen Han, Haiying Bao. Therapeutic effects and mechanisms of Inonotus hispidus extract and active monomer compounds in a rat mammary gland hyperplasia model. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117274. doi: 10.1016/j.jep.2023.117274. [PMID: 37797875]
  • Emmanuel Stephen Odinga, Xian Zhou, Evance Omondi Mbao, Qurban Ali, Michael Gatheru Waigi, Margaret L Shiraku, Wanting Ling. Distribution, ecological fate, and risks of steroid estrogens in environmental matrices. Chemosphere. 2022 Dec; 308(Pt 2):136370. doi: 10.1016/j.chemosphere.2022.136370. [PMID: 36113656]
  • Xiaoli Zhang, Na Yang, Min Wang, JiaJia Ge, Huaijun Zhu, Jun He, Weihong Ge. Establishment and validation of a sensitive LC-MS/MS method for quantification of urinary estrogens in women with gestational diabetes mellitus. Journal of pharmaceutical and biomedical analysis. 2022 Nov; 221(?):115044. doi: 10.1016/j.jpba.2022.115044. [PMID: 36126614]
  • Ying Li, Yanqiu Zhou, Zongwei Cai, Ruizhen Li, Pei Leng, Hongxiu Liu, Juan Liu, Gaga Mahai, Yuanyuan Li, Shunqing Xu, Wei Xia. Associations of benzotriazoles and benzothiazoles with estrogens and androgens among pregnant women: A cohort study with repeated measurements. The Science of the total environment. 2022 Sep; 838(Pt 2):155998. doi: 10.1016/j.scitotenv.2022.155998. [PMID: 35588816]
  • Zhao Tang, Ze-Hua Liu, Wu Chen, Chen Wang, Ya-Jiang Wu, Hao Wang, Zhi Dang, Yu Liu. Twelve natural estrogens in urines of six threatened or endangered mammalian species in Zoo Park: implications and their potential risk. Environmental science and pollution research international. 2022 Jul; 29(32):49404-49410. doi: 10.1007/s11356-022-20554-x. [PMID: 35504991]
  • Yongjuan Meng, Jinling Pu, Jiamei Gan, Jianping Li. Molecularly imprinted electrochemiluminescence sensor based on ZIF-8 doped with CdSe quantum dots for the detection of trace estriol. Luminescence : the journal of biological and chemical luminescence. 2022 Jul; 37(7):1109-1119. doi: 10.1002/bio.4264. [PMID: 35470931]
  • Yiming Chen, Yijie Chen, Yezhen Shi, Wenwen Ning, Xiaoying Wang, Liyao Li, Huimin Zhang. External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days. Medical science monitor : international medical journal of experimental and clinical research. 2022 Apr; 28(?):e935573. doi: 10.12659/msm.935573. [PMID: 35414638]
  • Qiaoxuan Zhang, Kai Bai, Meiran Wu, Haibiao Lin, Jun Yan, Min Zhan, Fen Ouyang, Peifeng Ke, Liqiao Han, Junhua Zhuang, Xianzhang Huang. Development of human serum matrix-based unconjugated estriol-certified reference material by recommended ID-LC-MS/MS reference method. Analytical and bioanalytical chemistry. 2022 Mar; 414(7):2523-2531. doi: 10.1007/s00216-022-03896-w. [PMID: 35211786]
  • Lin Zhu, Xiang Yu, Qian Li, Yuanyuan Zhang, Yiguang Jin, Lina Du. Estriol dissolving microneedle patches for protection against ionizing radiation-induced injury. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105881. doi: 10.1016/j.ejps.2021.105881. [PMID: 34004344]
  • Hudson C Polonini, Eli Dijkers, Anderson O Ferreira, Clark Zander, Sarah Taylor. Compatibility of Estradiol, Estriol, Estrone, Progesterone, and Testosterone Single Formulation in Fitalite, Versatile, or HRT Supreme Cream Base. International journal of pharmaceutical compounding. 2021 Jul; 25(4):336-343. doi: . [PMID: 34297696]
  • Natalícia de Jesus Antunes, Raimundo Vieira de Oliveira Filho, Jaime de Oliveira Ilha, Ronilson A Moreno, André Felipe Nahoum, Ralph-Steven Wedemeyer, André Warnke, Gilberto De Nucci. Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Jun; 26(3):184-194. doi: 10.1080/13625187.2021.1884219. [PMID: 33645377]
  • Li Yu, Miao Liu, Zhenxin Wang, Te Liu, Suying Liu, Beili Wang, Baishen Pan, Xi Dong, Wei Guo. Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome. Reproductive biology and endocrinology : RB&E. 2021 May; 19(1):74. doi: 10.1186/s12958-021-00749-6. [PMID: 34001150]
  • Gokhan Karakoc, Mert Turgal, Hasan Eroglu, Caner Cakir, And Yavuz, Aykan Yucel. Relations between second-trimester aneuploidy screening results and prediction of labour induction success in term pregnancies. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2021 May; 41(4):527-531. doi: 10.1080/01443615.2020.1755619. [PMID: 32496936]
  • Nèvine Te West, Richard Day, Garry Graham, Michael Wright, Christopher White, Gordana Popovic, Kate Hilda Moore. Serum concentrations of estriol vary widely after application of vaginal oestriol cream. British journal of clinical pharmacology. 2021 05; 87(5):2354-2360. doi: 10.1111/bcp.14635. [PMID: 33129232]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Pearl La Marca-Ghaemmaghami, Roland Zimmermann, Marina Haller, Ulrike Ehlert. Cortisol and estriol responses to awakening in the first pregnancy trimester: Associations with maternal stress and resilience factors. Psychoneuroendocrinology. 2021 03; 125(?):105120. doi: 10.1016/j.psyneuen.2020.105120. [PMID: 33385739]
  • Keiko Mouri, Keiko Shimizu. Stability of chimpanzee (Pan troglodytes) urinary reproductive hormones during long-term preservation on filter paper. Primates; journal of primatology. 2021 Mar; 62(2):289-296. doi: 10.1007/s10329-020-00864-9. [PMID: 32955646]
  • Savitree Pranpanus, Ounjai Kor-Anantakul, Thitima Suntharasaj, Chitkasaem Suwanrath, Tharangrut Hanprasertpong, Ninlapa Pruksanusak, Chusana Petpichetchian, Manaphat Suksai, Natthicha Chainarong, Rapphon Sawaddisan. Ethnic-specific reference range affects the efficacy of quadruple test as a universal screening for Down syndrome in a developing country. PloS one. 2021; 16(5):e0251381. doi: 10.1371/journal.pone.0251381. [PMID: 33984018]
  • Ekramy Halawa, Lamia Ryad, Nahla S El-Shenawy, Rasha A Al-Eisa, Heba N Gad El-Hak. Evaluation of acetamiprid and azoxystrobin residues and their hormonal disrupting effects on male rats using liquid chromatography-tandem mass spectrometry. PloS one. 2021; 16(12):e0259383. doi: 10.1371/journal.pone.0259383. [PMID: 34855766]
  • Eric J M Lentz, Alison L Park, Alec W R Langlois, Tianhua Huang, Wendy S Meschino, Joel G Ray. Risk of Severe Maternal Morbidity or Death in Relation to Prenatal Biochemical Screening: Population-Based Cohort Study. American journal of perinatology. 2021 01; 38(1):44-59. doi: 10.1055/s-0039-1694731. [PMID: 31412403]
  • Joshua A Bornhorst, Paola A Ramos, Elizabeth R Sutterer, Nicole M Herrli, Daniel J Figdore, Tifani L Flieth, Karl M Ness, Erica M Fatica, Alicia Algeciras-Schimnich. Evaluation of sporadic bovine alkaline phosphatase interference in the Beckman Access unconjugated estriol (uE3) assay affecting maternal serum screening results. Clinical biochemistry. 2021 Jan; 87(?):93-99. doi: 10.1016/j.clinbiochem.2020.11.007. [PMID: 33188774]
  • Chase R Cawyer, Elena Lobashevksy, Glenda Corley-Topham, Sarah Anderson, John Owen, Akila Subramaniam. Association between Maternal Serum Hormones along the Maternal-Fetal Hypothalamic-Pituitary-Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction. American journal of perinatology. 2020 10; 37(12):1195-1200. doi: 10.1055/s-0040-1708801. [PMID: 32215880]
  • Maedeh Amini, Anoshirvan Kazemnejad, Farid Zayeri, Ali Montazeri, Aliakbar Rasekhi, Azam Amirian, Nourossadat Kariman. Diagnostic accuracy of maternal serum multiple marker screening for early detection of gestational diabetes mellitus in the absence of a gold standard test. BMC pregnancy and childbirth. 2020 Jun; 20(1):375. doi: 10.1186/s12884-020-03068-7. [PMID: 32591020]
  • Shih-Yin Huang, You-Chen Wang, Wan-Chen Yin, Li-Fen Teng, Yu-Ching Huang, Yu-Lin Wu, Tsia-Shu Lo. Is maternal serum inhibin A a good predictor in preterm labor? - Experience from a community hospital in Taiwan. Biomedical journal. 2020 04; 43(2):183-188. doi: 10.1016/j.bj.2019.08.001. [PMID: 32387268]
  • Nevine I D Te West, Ric O Day, Basia Hiley, Chris White, Mike Wright, Kate H Moore. Estriol serum levels in new and chronic users of vaginal estriol cream: A prospective observational study. Neurourology and urodynamics. 2020 04; 39(4):1137-1144. doi: 10.1002/nau.24331. [PMID: 32270905]
  • Barbara A Cohn, Piera M Cirillo. In utero and postnatal programing of dehydroepiandrosterone sulfate (DHEAS) in young adult women. Reproductive toxicology (Elmsford, N.Y.). 2020 03; 92(?):148-154. doi: 10.1016/j.reprotox.2019.05.062. [PMID: 31173873]
  • Drew B Day, Brent R Collett, Emily S Barrett, Nicole R Bush, Shanna H Swan, Christina Wang, Sheela Sathyanarayana. Prenatal sex hormones and behavioral outcomes in children. Psychoneuroendocrinology. 2020 03; 113(?):104547. doi: 10.1016/j.psyneuen.2019.104547. [PMID: 31901731]
  • Claudia Weinheimer, Haimei Wang, Jessica M Comstock, Purneet Singh, Zhengming Wang, Brent A Locklear, Kasi L Goodwin, J Alan Maschek, James E Cox, Michelle L Baack, Lisa A Joss-Moore. Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reproductive sciences (Thousand Oaks, Calif.). 2020 02; 27(2):631-643. doi: 10.1007/s43032-019-00065-w. [PMID: 32046449]
  • Jiufeng Li, Wenxin Zhang, Hongzhi Zhao, Yanqiu Zhou, Shunqing Xu, Yuanyuan Li, Wei Xia, Zongwei Cai. Trimester-specific, gender-specific, and low-dose effects associated with non-monotonic relationships of bisphenol A on estrone, 17β-estradiol and estriol. Environment international. 2020 01; 134(?):105304. doi: 10.1016/j.envint.2019.105304. [PMID: 31726358]
  • Jiuzhi Li, Liuxu Li, Ying Bian, Yang Yu, Zhonghua Qiang, Yuexiang Zhang, Huiqiang Li. Quantitation of estradiol by competitive light-initiated chemiluminescent assay using estriol as competitive antigen. Journal of clinical laboratory analysis. 2020 Jan; 34(1):e23014. doi: 10.1002/jcla.23014. [PMID: 31444844]
  • Bing Li, Jiaqing Hao, Xiaofang Yan, Maiying Kong, Edward R Sauter. A-FABP and oestrogens are independently involved in the development of breast cancer. Adipocyte. 2019 12; 8(1):379-385. doi: 10.1080/21623945.2019.1690827. [PMID: 31755351]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Kaeli J Yamashiro, Laura A Galganski, Shinjiro Hirose. What you need to know about maternal-fetal medicine. Seminars in pediatric surgery. 2019 Aug; 28(4):150822. doi: 10.1053/j.sempedsurg.2019.07.005. [PMID: 31451176]
  • Cihan Inan, N Cenk Sayin, Z Nihal Dolgun, Hakan Gurkan, Selen Gursoy Erzincan, Isil Uzun, Havva Sutcu, Sinan Ates, Emine Atli, Fusun Varol. Prenatal diagnosis of chromosomal polymorphisms: most commonly observed polymorphism on Chromosome 9 have associations with low PAPP-A values. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2019 May; 32(10):1688-1695. doi: 10.1080/14767058.2017.1416079. [PMID: 29262756]
  • Emily S Barrett, Omar Mbowe, Sally W Thurston, Samantha Butts, Christina Wang, Ruby Nguyen, Nicole Bush, J Bruce Redmon, Sukrita Sheshu, Shanna H Swan, Sheela Sathyanarayana. Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort. Maternal and child health journal. 2019 Mar; 23(3):397-407. doi: 10.1007/s10995-018-02705-0. [PMID: 30659461]
  • Karin B Michels, Nadine Binder, Frédérique Courant, Adrian A Franke, Anja Osterhues. Urinary excretion of sex steroid hormone metabolites after consumption of cow milk: a randomized crossover intervention trial. The American journal of clinical nutrition. 2019 02; 109(2):402-410. doi: 10.1093/ajcn/nqy279. [PMID: 30698629]
  • Xiaosong Yuan, Wei Long, Jianbing Liu, Bin Zhang, Wenbai Zhou, Jian Jiang, Bin Yu, Huiyan Wang. Associations of serum markers screening for Down's syndrome with pregnancy outcomes: A Chinese retrospective cohort study. Clinica chimica acta; international journal of clinical chemistry. 2019 Feb; 489(?):130-135. doi: 10.1016/j.cca.2018.12.001. [PMID: 30529497]
  • Sujinun Nunthapiwat, Ratanaporn Sekararithi, Chanane Wanapirak, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong. Second Trimester Serum Biomarker Screen for Fetal Aneuploidies as a Predictor of Preterm Delivery: A Population-Based Study. Gynecologic and obstetric investigation. 2019; 84(4):326-333. doi: 10.1159/000495614. [PMID: 30602167]
  • Ad Brouwers, Pieter G Dingjan, Ben Dujardin, Everardus J van Zoelen, Paul Lips, Louis J Gooren. Hypertrophic osteoarthropathy: estrogens, prostaglandinE2, prostaglandin A2, and the inflammatory reflex. Clinical rheumatology. 2019 Jan; 38(1):211-222. doi: 10.1007/s10067-018-4044-z. [PMID: 29480386]
  • Vilma L Johnsson, Nina G Pedersen, Katharina Worda, Elisabeth Krampl-Bettelheim, Lillian Skibsted, Stefan Hinterberger, Isolde Strobl, Maria E Bowman, Roger Smith, Ann Tabor, Line Rode. Plasma progesterone, estradiol, and unconjugated estriol concentrations in twin pregnancies: Relation with cervical length and preterm delivery. Acta obstetricia et gynecologica Scandinavica. 2019 01; 98(1):86-94. doi: 10.1111/aogs.13464. [PMID: 30218572]
  • I J M Duijkers, I Klingmann, R Prinz, M Wargenau, S Hrafnsdottir, Th B Magnusdottir, C Klipping. Effect on endometrial histology and pharmacokinetics of different dose regimens of progesterone vaginal pessaries, in comparison with progesterone vaginal gel and placebo. Human reproduction (Oxford, England). 2018 11; 33(11):2131-2140. doi: 10.1093/humrep/dey288. [PMID: 30265306]
  • Xianzhang Huang, Qiaoxuan Zhang, Songbai Zheng, Jianbing Wang, Liqiao Han, Haibiao Lin, Peifeng Ke, Junhua Zhuang, Zhimin Tim Cao. Measurement of human serum unconjugated estriol without derivatization using liquid chromatography-tandem mass spectrometry candidate reference method and compared with two immunoassays. Analytical and bioanalytical chemistry. 2018 Sep; 410(24):6257-6267. doi: 10.1007/s00216-018-1236-y. [PMID: 30006726]
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