7-ACA (BioDeep_00000003764)
Secondary id: BioDeep_00000406519, BioDeep_00000898065, BioDeep_00001872690
代谢物信息卡片
化学式: C10H12N2O5S (272.0466902)
中文名称: 7-氨基头孢烷酸
谱图信息:
最多检出来源 Macaca mulatta(otcml) 22.22%
分子结构信息
SMILES: CC(=O)OCC1=C(C(=O)O)N2C(=O)C(N)C2SC1
InChI: InChI=1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:2255
- KEGG: C07756
- PubChem: 441328
- PubChem: 13729
- Metlin: METLIN64538
- ChEMBL: CHEMBL1615585
- ChEMBL: CHEMBL1161449
- CAS: 108260-00-0
- CAS: 68090-55-1
- CAS: 957-68-6
- PMhub: MS000011423
- PubChem: 9958
- PDB-CCD: 4KR
- 3DMET: B02139
- NIKKAJI: J7.191I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Weitao Zhang, Hanyue Xue, Chen Zhou, Zuguo Zheng, Mingming Xing, Hang Chu, Ping Li, Naixia Zhang, Yongjun Dang, Xiaojun Xu. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis.
Biochemical and biophysical research communications.
2022 09; 622(?):184-191. doi:
10.1016/j.bbrc.2022.07.033. [PMID: 35932530] - Petra Luckner, Matthias Brandsch. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2005 Jan; 59(1):17-24. doi:
10.1016/j.ejpb.2004.07.008. [PMID: 15567297] - Loredano Pollegioni, Laura Caldinelli, Gianluca Molla, Silvia Sacchi, Mirella S Pilone. Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources.
Biotechnology progress.
2004 Mar; 20(2):467-73. doi:
10.1021/bp034206q. [PMID: 15058991] - Wei Zhang, Xi Huang, Guoping Zhao, Weihong Jiang. Affinity labeled glutaryl-7-amino cephalosporanic acid acylase C130 can hydrolyze the inhibitor during crystallization.
Biochemical and biophysical research communications.
2004 Jan; 313(3):555-8. doi:
10.1016/j.bbrc.2003.11.154. [PMID: 14697226] - Songcheng Zhu, Yunliu Yang, Guoping Zhao, Weihong Jiang. A rapid and specific method to screen environmental microorganisms for cephalosporin acylase activity.
Journal of microbiological methods.
2003 Jul; 54(1):131-5. doi:
10.1016/s0167-7012(03)00013-7. [PMID: 12732432] - Patricia A Arndt, George Garratty. Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin.
American journal of clinical pathology.
2002 Aug; 118(2):256-62. doi:
10.1309/jfje-vukn-221t-g6ev. [PMID: 12162687] - X Li, W Zhang, X Mao, X Cai, Y L Yang, G P Zhao, W H Jiang. [Establishment of detective systems for GL-7ACA acylase expression].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2001 Nov; 17(6):673-7. doi:
. [PMID: 11910763] - D Monti, G Carrea, S Riva, E Baldaro, G Frare. Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase.
Biotechnology and bioengineering.
2000 Oct; 70(2):239-44. doi:
10.1002/1097-0290(20001020)70:2<239::aid-bit13>3.0.co;2-i. [PMID: 10972935] - T Shimizu, S Souma, N Nagakura, T Masuzawa, Y Iwamoto, Y Yanagihara. Epitope analysis of aztreonam by antiaztreonam monoclonal antibodies and possible consequences in beta-lactams hypersensitivity.
International archives of allergy and immunology.
1992; 98(4):392-7. doi:
10.1159/000236216. [PMID: 1384868] - M JAGO. ANTIBACTERIAL ACTIVITY OF SOME DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID AGAINST STAPHYLOCOCCUS AUREUS AND SYNERGISM BETWEEN THESE AND OTHER ANTIBIOTICS.
British journal of pharmacology and chemotherapy.
1964 Feb; 22(?):22-33. doi:
10.1111/j.1476-5381.1964.tb01540.x. [PMID: 14126054] - C W GODZESKI, G BRIER, D E PAVEY. Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique.
Applied microbiology.
1963 Mar; 11(?):122-7. doi:
10.1128/am.11.2.122-127.1963. [PMID: 13963283]