Tioconazole (BioDeep_00000003488)

 

Secondary id: BioDeep_00000398995

human metabolite blood metabolite


代谢物信息卡片


1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

化学式: C16H13Cl3N2OS (385.98141380000004)
中文名称: 噻康唑
谱图信息: 最多检出来源 Homo sapiens(blood) 16.41%

分子结构信息

SMILES: C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl
InChI: InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

描述信息

Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athletes foot, and tinea versicolor or sun fungus. Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
KEIO_ID T123; [MS2] KO009265
KEIO_ID T123

同义名列表

11 个代谢物同义名

1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; Monistat 1-day; tioconazole; Gyno-trosyd; Vagistat-1; Mykontral; Vagistat; Trosderm; Trosyd; Trosid; Trosyl



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maha M Abou El-Alamin, Maha A Sultan, Mostafa A Atia, Hassan Y Aboul-Enein. Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography. Combinatorial chemistry & high throughput screening. 2020; 23(10):991-1001. doi: 10.2174/1386207323666200220114818. [PMID: 32077818]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • L Wernli, G Bonkat, T C Gasser, A Bachmann, O Braissant. Use of isothermal microcalorimetry to quantify the influence of glucose and antifungals on the growth of Candida albicans in urine. Journal of applied microbiology. 2013 Nov; 115(5):1186-93. doi: 10.1111/jam.12306. [PMID: 23865534]
  • Catarina Costa, Carla Pires, Tânia R Cabrito, Adeline Renaudin, Michiyo Ohno, Hiroji Chibana, Isabel Sá-Correia, Miguel C Teixeira. Candida glabrata drug:H+ antiporter CgQdr2 confers imidazole drug resistance, being activated by transcription factor CgPdr1. Antimicrobial agents and chemotherapy. 2013 Jul; 57(7):3159-67. doi: 10.1128/aac.00811-12. [PMID: 23629708]
  • P V Macrae, M Kirrs, F S Pullen, M H Tarbit. Characterization of a quaternary, N-glucuronide metabolite of the imidazole antifungal, tioconazole. Drug metabolism and disposition: the biological fate of chemicals. 1990 Nov; 18(6):1100-2. doi: NULL. [PMID: 1981520]
  • F Latrille, J Perraud, J Stadler, A M Monro, B C Sutter. Effects of tioconazole on parturition and serum levels of 17 beta-oestradiol, progesterone, LH and PRL in the rat. Biochemical pharmacology. 1987 Apr; 36(7):1119-24. doi: 10.1016/0006-2952(87)90422-9. [PMID: 3566806]
  • F C Odds, S L Cheesman, A B Abbott. Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents. Sabouraudia. 1985 Dec; 23(6):415-24. doi: . [PMID: 3913012]
  • E T Houang, A G Lawrence. Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule. Antimicrobial agents and chemotherapy. 1985 Jun; 27(6):964-5. doi: 10.1128/aac.27.6.964. [PMID: 4026270]
  • E M Johnson, M D Richardson, D W Warnock. Effect of imidazole antifungals on the development of germ tubes by strains of Candida albicans. The Journal of antimicrobial chemotherapy. 1983 Oct; 12(4):303-16. doi: 10.1093/jac/12.4.303. [PMID: 6315670]