Paromomycin (BioDeep_00000003480)

 

Secondary id: BioDeep_00001868233

human metabolite blood metabolite Chemicals and Drugs Antibiotics Volatile Flavor Compounds natural product


代谢物信息卡片


(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol

化学式: C23H45N5O14 (615.296287)
中文名称: 巴龙霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.1%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

描述信息

Paromomycin is only found in individuals that have used or taken this drug. It is an oligosaccharide antibiotic produced by various streptomyces. [PubChem]Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID P126

同义名列表

44 个代谢物同义名

(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside; (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-a-D-glucopyranoside; D-Streptamine,O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-O-b-D-ribofuranosyl-(1®5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1®4)]-2-deoxy-; Paromomycin, beta D glucopyranosyl isomer; Paromomycin, beta-D-glucopyranosyl-isomer; beta-D-Glucopyranosyl-isomer paromomycin; Parke davis brand OF paromomycin sulfate; Cheminova brand OF paromomycin sulfate; Monarch brand OF paromomycin sulfate; Pfizer brand OF paromomycin sulfate; Paromomycin sulfate (1:1); Paromomycin sulfate (2:5); Phosphate, paromomycin; Paromomycin phosphate; Paramomycin sulphate; Sulfate, paromomycin; Paromomycin sulfate; Paramomycin sulfate; Paromomycin I; Paromomycinum; Paromomycine; Hydroxymycin; Zygomycin a1; Gabbromicina; Paucimycinum; Paromomicina; Gabbromycin; Paromomycin; Monomycin a; Paramomycin; Aminosidine; Crestomycin; Neomycin e; Aminosidin; Paucimycin; Catenulin; Estomycin; Humatin; R-400; R 400; PRM; Paromomycin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad243. [PMID: 37418629]
  • Yiğit Kaçar, Ahmet Tarık Baykal, Levent Aydin, Hasan Batmaz. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis. Veterinary immunology and immunopathology. 2022 Jun; 248(?):110429. doi: 10.1016/j.vetimm.2022.110429. [PMID: 35500421]
  • Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children. Pediatric clinics of North America. 2022 02; 69(1):79-97. doi: 10.1016/j.pcl.2021.08.003. [PMID: 34794678]
  • Luka Verrest, Monique Wasunna, Gilbert Kokwaro, Rashid Aman, Ahmed M Musa, Eltahir A G Khalil, Mahmoud Mudawi, Brima M Younis, Asrat Hailu, Zewdu Hurissa, Workagegnehu Hailu, Samson Tesfaye, Eyasu Makonnen, Yalemtsehay Mekonnen, Alwin D R Huitema, Jos H Beijnen, Smita A Kshirsagar, Jaya Chakravarty, Madhukar Rai, Shyam Sundar, Fabiana Alves, Thomas P C Dorlo. Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients. Clinical pharmacokinetics. 2021 11; 60(11):1463-1473. doi: 10.1007/s40262-021-01036-8. [PMID: 34105063]
  • Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu. Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia. PLoS neglected tropical diseases. 2021 08; 15(8):e0009713. doi: 10.1371/journal.pntd.0009713. [PMID: 34464401]
  • Sapna Jain Chowdhary, Amit Chowdhary, Govind Prasad Agrawal, Ashish Jain. A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery. ACS biomaterials science & engineering. 2021 01; 7(1):157-165. doi: 10.1021/acsbiomaterials.0c01165. [PMID: 33350804]
  • Tiget Ayelgn Mengstie, Hiwot Tezera Endale, Tadele Mulaw, Aman Mossa Abdella, Rezika Mohammed, Tabarak Malik, Gashaw Dessie. Assessment of serum amylase, lipase and associated factors among patients with visceral leishmaniasis treated with sodium stibogluconate/paromomycin at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. PloS one. 2021; 16(10):e0257229. doi: 10.1371/journal.pone.0257229. [PMID: 34597312]
  • Kerem Teralı, Buket Baddal, Hayrettin Ozan Gülcan. Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment. Journal of molecular graphics & modelling. 2020 11; 100(?):107697. doi: 10.1016/j.jmgm.2020.107697. [PMID: 32739642]
  • Shabi Parvez, Ganesh Yadagiri, Aakriti Singh, Archana Karole, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath. Improvising anti-leishmanial activity of amphotericin B and paromomycin using co-delivery in d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored nano-lipid carrier system. Chemistry and physics of lipids. 2020 09; 231(?):104946. doi: 10.1016/j.chemphyslip.2020.104946. [PMID: 32621810]
  • Asma Tariq, Rana Muhammad Mateen, Muhammad Sohail Afzal, Mahjabeen Saleem. Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2020 Sep; 98(?):166-175. doi: 10.1016/j.ijid.2020.06.063. [PMID: 32579907]
  • Shabi Parvez, Ganesh Yadagiri, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis. Scientific reports. 2020 07; 10(1):12243. doi: 10.1038/s41598-020-69276-5. [PMID: 32699361]
  • Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics. Bioorganic & medicinal chemistry letters. 2020 07; 30(13):127218. doi: 10.1016/j.bmcl.2020.127218. [PMID: 32360102]
  • D Kasabalis, M K Chatzis, K Apostolidis, T Petanides, L V Athanasiou, P G Xenoulis, A Mataragka, J Ikonomopoulos, L S Leontides, M N Saridomichelakis. A randomized, blinded, controlled clinical trial comparing the efficacy of aminosidine (paromomycin)-allopurinol combination with the efficacy of meglumine antimoniate-allopurinol combination for the treatment of canine leishmaniosis due to Leishmania infantum. Experimental parasitology. 2020 Jul; 214(?):107903. doi: 10.1016/j.exppara.2020.107903. [PMID: 32360142]
  • Ignace C Roseboom, Bas Thijssen, Hilde Rosing, Jane Mbui, Jos H Beijnen, Thomas P C Dorlo. Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma. Journal of pharmaceutical and biomedical analysis. 2020 Jun; 185(?):113245. doi: 10.1016/j.jpba.2020.113245. [PMID: 32199328]
  • Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro. Experimental parasitology. 2020 May; 212(?):107873. doi: 10.1016/j.exppara.2020.107873. [PMID: 32165146]
  • Albert Bernet Sánchez, Alba Bellés Bellés, Jesus Aramburu Arnuelos, Alfredo Jover Sanz, Eva Sesé Abizanda, Montserrat Vallverdú Vidal, Mercè García González. Entamoeba histolytica liver abscess case: could stool PCR avoid it?. Diagnosis (Berlin, Germany). 2020 01; 7(1):69-73. doi: 10.1515/dx-2019-0006. [PMID: 31256063]
  • Shabi Parvez, Ganesh Yadagiri, Archana Karole, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity. Frontiers in cellular and infection microbiology. 2020; 10(?):570573. doi: 10.3389/fcimb.2020.570573. [PMID: 33178626]
  • Mojdeh Khosravi, Hanieh Mohammad Rahimi, Delaram Doroud, Elnaz Sadat Mirsamadi, Hamed Mirjalali, Mohammad Reza Zali. In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis. Frontiers in cellular and infection microbiology. 2020; 10(?):33. doi: 10.3389/fcimb.2020.00033. [PMID: 32117807]
  • Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania. Nature communications. 2019 12; 10(1):5627. doi: 10.1038/s41467-019-13344-6. [PMID: 31819054]
  • Dipti Debnath, Md Akil Hossain, Munny Das, Asma Kabir, Md Ibrahim, Mohammad Nurul Amin, Amrita Chowdhury, Rokeya Pervin. Characterization of Transplasma Membrane Electron Transport Chain in Wild and Drug-Resistant Leishmania donovani Promastigote and Amastigote. Acta parasitologica. 2019 Dec; 64(4):710-719. doi: 10.2478/s11686-019-00050-y. [PMID: 30941668]
  • Ander Burgaña, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García-Puig, Tomas M Perez-Porcuna. Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. International journal for parasitology. Drugs and drug resistance. 2019 12; 11(?):95-100. doi: 10.1016/j.ijpddr.2019.10.005. [PMID: 31759244]
  • D Kasabalis, M K Chatzis, K Apostolidis, P G Xenoulis, A Buono, T Petanides, L S Leontides, Z S Polizopoulou, J M Steiner, J S Suchodolski, M N Saridomichelakis. Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study. Experimental parasitology. 2019 Nov; 206(?):107768. doi: 10.1016/j.exppara.2019.107768. [PMID: 31539540]
  • José Ignacio Manzano, Jelena Konstantinović, Diletta Scaccabarozzi, Ana Perea, Aleksandar Pavić, Loredana Cavicchini, Nicoletta Basilico, Francisco Gamarro, Bogdan A Šolaja. 4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania. European journal of medicinal chemistry. 2019 Oct; 180(?):28-40. doi: 10.1016/j.ejmech.2019.07.010. [PMID: 31299585]
  • Shinichiro Nakamura, Iori Itagaki, Takahiro Nakagawa, Ikuo Kawamoto, Takahiro Asano, Daichi Arakawa, Hideaki Tsuchiya. Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys. Experimental animals. 2019 Aug; 68(3):285-292. doi: 10.1538/expanim.18-0133. [PMID: 30814394]
  • Clare F Collett, Carl Kitson, Nicola Baker, Heather B Steele-Stallard, Marie-Victoire Santrot, Sebastian Hutchinson, David Horn, Sam Alsford. Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. Antimicrobial agents and chemotherapy. 2019 08; 63(8):. doi: 10.1128/aac.00795-19. [PMID: 31160283]
  • Anne E Rivas, Donal M Boyer, Kevin Torregrosa, William J Orrico, Jean A Paré. TREATMENT OF CRYPTOSPORIDIUM SERPENTIS INFECTION IN A KING COBRA ( OPHIOPHAGUS HANNAH) WITH PAROMOMYCIN. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2018 12; 49(4):1061-1063. doi: 10.1638/2018-0080.1. [PMID: 30592920]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Curcumin: A promising treatment for Cryptosporidium parvum infection in immunosuppressed BALB/c mice. Experimental parasitology. 2018 Dec; 195(?):59-65. doi: 10.1016/j.exppara.2018.10.008. [PMID: 30385266]
  • Huawen Lin, Paul F Cliften, Susan K Dutcher. MAPINS, a Highly Efficient Detection Method That Identifies Insertional Mutations and Complex DNA Rearrangements. Plant physiology. 2018 12; 178(4):1436-1447. doi: 10.1104/pp.18.00474. [PMID: 30206105]
  • Md Sakhawat Hossain, Amresh Kumar, A F M Akhtar Hossain, Md Mahshin, Abhijit Sharma, Md Akter Hossain, Varun Sharma, Rashidul Haque, A K M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal. Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme. Infectious diseases of poverty. 2018 Aug; 7(1):80. doi: 10.1186/s40249-018-0461-0. [PMID: 30099967]
  • Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Comparative efficacy of curcumin and paromomycin against Cryptosporidium parvum infection in a BALB/c model. Veterinary parasitology. 2018 Jan; 250(?):7-14. doi: 10.1016/j.vetpar.2017.12.008. [PMID: 29329627]
  • Christina Petridou, Adnan Al-Badri, Anjana Dua, Matthew Dryden, Kordo Saeed. Learning points from a case of severe amoebic colitis. Le infezioni in medicina. 2017 Sep; 25(3):281-284. doi: NULL. [PMID: 28956549]
  • Muslim Raza, Yang Jiang, Yun Wei, Aftab Ahmad, Ajmal Khan, Yuan Qipeng. Insights from spectroscopic and in-silico techniques for the exploitation of biomolecular interactions between Human serum albumin and Paromomycin. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):242-253. doi: 10.1016/j.colsurfb.2017.05.076. [PMID: 28601753]
  • Laura Escolà-Vergé, Maider Arando, Martí Vall, Roger Rovira, Mateu Espasa, Elena Sulleiro, Pere Armengol, Francesc Zarzuela, María-Jesús Barberá. Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2017 Jul; 22(30):. doi: 10.2807/1560-7917.es.2017.22.30.30581. [PMID: 28797327]
  • Gilles Darcis, Gert Van der Auwera, Jean-Baptiste Giot, Marie-Pierre Hayette, Françoise Tassin, Jorge Arrese Estrada, Lieselotte Cnops, Michel Moutschen, Laurence de Leval, Philippe Leonard. Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy. BMC infectious diseases. 2017 07; 17(1):478. doi: 10.1186/s12879-017-2571-x. [PMID: 28687071]
  • M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra. Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability. Indian journal of pharmacology. 2017 Jul; 49(4):297-303. doi: 10.4103/ijp.ijp_651_16. [PMID: 29326490]
  • M Heidari-Kharaji, T Taheri, D Doroud, S Habibzadeh, A Badirzadeh, S Rafati. Enhanced paromomycin efficacy by solid lipid nanoparticle formulation against Leishmania in mice model. Parasite immunology. 2016 Oct; 38(10):599-608. doi: 10.1111/pim.12340. [PMID: 27213964]
  • Maryam Heidari Kharaji, Delaram Doroud, Tahereh Taheri, Sima Rafati. Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica. AAPS PharmSciTech. 2016 Oct; 17(5):1110-9. doi: 10.1208/s12249-015-0439-1. [PMID: 26552399]
  • Kotnala Balaraju, Chang-Jin Kim, Dong-Jin Park, Ki-Woong Nam, Kecheng Zhang, Mee Kyung Sang, Kyungseok Park. Paromomycin Derived from Streptomyces sp. AG-P 1441 Induces Resistance against Two Major Pathogens of Chili Pepper. Journal of microbiology and biotechnology. 2016 Sep; 26(9):1542-50. doi: 10.4014/jmb.1603.03019. [PMID: 27291677]
  • Maryam Heidari-Kharaji, Tahereh Taheri, Delaram Doroud, Sima Habibzadeh, Sima Rafati. Solid lipid nanoparticle loaded with paromomycin: in vivo efficacy against Leishmania tropica infection in BALB/c mice model. Applied microbiology and biotechnology. 2016 Aug; 100(16):7051-60. doi: 10.1007/s00253-016-7422-y. [PMID: 26960322]
  • Maria Manuela Gaspar, Susana Calado, Joana Pereira, Helena Ferronha, Ivone Correia, Helena Castro, Ana M Tomás, Maria Eugénia Meirinhos Cruz. Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems. Nanomedicine : nanotechnology, biology, and medicine. 2015 Oct; 11(7):1851-60. doi: 10.1016/j.nano.2015.06.008. [PMID: 26169150]
  • Femke-Anouska Heinsen, Henrik Knecht, Sven C Neulinger, Ruth A Schmitz, Carolin Knecht, Tanja Kühbacher, Philip C Rosenstiel, Stefan Schreiber, Anette K Friedrichs, Stephan J Ott. Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin. Gut microbes. 2015 Jul; 6(4):243-54. doi: 10.1080/19490976.2015.1062959. [PMID: 26178862]
  • L V Athanasiou, G C Batzias, M N Saridomichelakis, G Delis, N Soubasis, V I Kontos, T S Rallis. Pharmacokinetics and tolerability of aminosidine after repeated administrations using an optimal dose regimen in healthy dogs and in dogs with leishmaniosis. Veterinary parasitology. 2014 Sep; 205(1-2):365-70. doi: 10.1016/j.vetpar.2014.06.019. [PMID: 24998095]
  • Dominique Wakefield, Louise Thompson, Stuart Bruce. A Lilliputian army under the floorboards: persistent delirium with complete though prolonged recovery. BMJ case reports. 2014 May; 2014(?):. doi: 10.1136/bcr-2013-202639. [PMID: 24792019]
  • Agnes Kurniawan, Sri W Dwintasari, Lisa Connelly, Rosely A B Nichols, Evy Yunihastuti, Teguh Karyadi, Samsuridjal Djauzi. Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia. Annals of epidemiology. 2013 Nov; 23(11):720-3. doi: 10.1016/j.annepidem.2013.07.019. [PMID: 23972618]
  • William R Ravis, Alejandro Llanos-Cuentas, Nestor Sosa, Mara Kreishman-Deitrick, Karen M Kopydlowski, Carl Nielsen, Kirsten S Smith, Philip L Smith, Janet H Ransom, Yuh-Jing Lin, Max Grogl. Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis. Antimicrobial agents and chemotherapy. 2013 Oct; 57(10):4809-15. doi: 10.1128/aac.00628-13. [PMID: 23877689]
  • Chelsea Marie, William Arthur Petri. Amoebic dysentery. BMJ clinical evidence. 2013 Aug; 2013(?):. doi: . [PMID: 23991750]
  • Wahid Khan, Shyam S Sharma, Neeraj Kumar. Bioanalytical method development, pharmacokinetics, and toxicity studies of paromomycin and paromomycin loaded in albumin microspheres. Drug testing and analysis. 2013 Jun; 5(6):453-60. doi: 10.1002/dta.339. [PMID: 22447374]
  • Christopher J Pantazis, Sarah Fisk, Kerri Mills, Barry S Flinn, Vladimir Shulaev, Richard E Veilleux, Yinghui Dan. Development of an efficient transformation method by Agrobacterium tumefaciens and high throughput spray assay to identify transgenic plants for woodland strawberry (Fragaria vesca) using NPTII selection. Plant cell reports. 2013 Mar; 32(3):329-37. doi: 10.1007/s00299-012-1366-1. [PMID: 23160638]
  • Irina Sizova, Andre Greiner, Mayanka Awasthi, Suneel Kateriya, Peter Hegemann. Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases. The Plant journal : for cell and molecular biology. 2013 Mar; 73(5):873-82. doi: 10.1111/tpj.12066. [PMID: 23137232]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yanfei Tao, Dongmei Chen, Huan Yu, Lingli Huang, Zhaoying Liu, Xiaoqin Cao, Caixia Yan, Yuanhu Pan, Zhenli Liu, Zonghui Yuan. Simultaneous determination of 15 aminoglycoside(s) residues in animal derived foods by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. Food chemistry. 2012 Nov; 135(2):676-83. doi: 10.1016/j.foodchem.2012.04.086. [PMID: 22868145]
  • Thomas Krahn, Christie Gilmour, Justin Tilak, Sebastien Fraud, Nicholas Kerr, Calvin Ho-Fung Lau, Keith Poole. Determinants of intrinsic aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 2012 Nov; 56(11):5591-602. doi: 10.1128/aac.01446-12. [PMID: 22908149]
  • Praveen Kumar, Antoni Rúbies, Ramon Companyó, Francesc Centrich. Determination of aminoglycoside residues in kidney and honey samples by hydrophilic interaction chromatography-tandem mass spectrometry. Journal of separation science. 2012 Oct; 35(20):2710-7. doi: 10.1002/jssc.201200344. [PMID: 23065931]
  • Guilherme Carneiro, Marta Gontijo Aguiar, Ana Paula Fernandes, Lucas Antônio Miranda Ferreira. Drug delivery systems for the topical treatment of cutaneous leishmaniasis. Expert opinion on drug delivery. 2012 Sep; 9(9):1083-97. doi: 10.1517/17425247.2012.701204. [PMID: 22724539]
  • Nisha Singh, Manish Kumar, Rakesh Kumar Singh. Leishmaniasis: current status of available drugs and new potential drug targets. Asian Pacific journal of tropical medicine. 2012 Jun; 5(6):485-97. doi: 10.1016/s1995-7645(12)60084-4. [PMID: 22575984]
  • Yonca Acikgoz, Ozan Ozkaya, Kenan Bek, Gurkan Genc, Sema Gulnar Sensoy, Murat Hokelek. Cryptosporidiosis: a rare and severe infection in a pediatric renal transplant recipient. Pediatric transplantation. 2012 Jun; 16(4):E115-9. doi: 10.1111/j.1399-3046.2011.01473.x. [PMID: 21320246]
  • Katja Herzog, Henryk Flachowsky, Holger B Deising, Magda-Viola Hanke. Heat-shock-mediated elimination of the nptII marker gene in transgenic apple (Malus×domestica Borkh.). Gene. 2012 Apr; 498(1):41-9. doi: 10.1016/j.gene.2012.01.074. [PMID: 22349025]
  • Joline Goossens, Virginie Vandenbroucke, Frank Pasmans, Siegrid De Baere, Mathias Devreese, Ann Osselaere, Elin Verbrugghe, Freddy Haesebrouck, Sarah De Saeger, Mia Eeckhout, Kris Audenaert, Geert Haesaert, Patrick De Backer, Siska Croubels. Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs. Toxins. 2012 04; 4(4):281-95. doi: 10.3390/toxins4040281. [PMID: 22606377]
  • Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn. Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies. Journal of controlled release : official journal of the Controlled Release Society. 2012 Mar; 158(3):461-9. doi: 10.1016/j.jconrel.2011.12.019. [PMID: 22226775]
  • Maryam Ghadiri, Shohreh Fatemi, Alireza Vatanara, Delaram Doroud, Abdolhossein Rouholamini Najafabadi, Majid Darabi, Amir Abbas Rahimi. Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size. International journal of pharmaceutics. 2012 Mar; 424(1-2):128-37. doi: 10.1016/j.ijpharm.2011.12.037. [PMID: 22227603]
  • H J J Koehorst-van Putten, E Sudarmonowati, M Herman, I J Pereira-Bertram, A M A Wolters, H Meima, N de Vetten, C J J M Raemakers, R G F Visser. Field testing and exploitation of genetically modified cassava with low-amylose or amylose-free starch in Indonesia. Transgenic research. 2012 Feb; 21(1):39-50. doi: 10.1007/s11248-011-9507-9. [PMID: 21465166]
  • Atsushi Oda, Takako Narumi, Tuoping Li, Takumi Kando, Yohei Higuchi, Katsuhiko Sumitomo, Seiichi Fukai, Tamotsu Hisamatsu. CsFTL3, a chrysanthemum FLOWERING LOCUS T-like gene, is a key regulator of photoperiodic flowering in chrysanthemums. Journal of experimental botany. 2012 Feb; 63(3):1461-77. doi: 10.1093/jxb/err387. [PMID: 22140240]
  • Meenakshi Sharma, Rakesh Sehgal, Sukhbir Kaur. Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis. PLoS neglected tropical diseases. 2012; 6(5):e1629. doi: 10.1371/journal.pntd.0001629. [PMID: 22563510]
  • Olivier Vandenberg, Françoise Robberecht, Nicolas Dauby, Catherine Moens, Hana Talabani, Eddy Dupont, Jean Menotti, Tom van Gool, Jack Levy. Management of a Cryptosporidium hominis outbreak in a day-care center. The Pediatric infectious disease journal. 2012 Jan; 31(1):10-5. doi: 10.1097/inf.0b013e318235ab64. [PMID: 22094626]
  • Vanitha S Raman, Malcolm S Duthie, Christopher B Fox, Greg Matlashewski, Steven G Reed. Adjuvants for Leishmania vaccines: from models to clinical application. Frontiers in immunology. 2012; 3(?):144. doi: 10.3389/fimmu.2012.00144. [PMID: 22701453]
  • Dan Wang, Valery Belakhov, Jeyakumar Kandasamy, Timor Baasov, Su-Chen Li, Yu-Teh Li, David M Bedwell, Kim M Keeling. The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse. Molecular genetics and metabolism. 2012 Jan; 105(1):116-25. doi: 10.1016/j.ymgme.2011.10.005. [PMID: 22056610]
  • Amine Toumi, Sadok Chlif, Jihene Bettaieb, Nissaf Ben Alaya, Aicha Boukthir, Zaher E Ahmadi, Afif Ben Salah. Temporal dynamics and impact of climate factors on the incidence of zoonotic cutaneous leishmaniasis in central Tunisia. PLoS neglected tropical diseases. 2012; 6(5):e1633. doi: 10.1371/journal.pntd.0001633. [PMID: 22563513]
  • David Gonzalez-Ballester, Wirulda Pootakham, Florence Mus, Wenqiang Yang, Claudia Catalanotti, Leonardo Magneschi, Amaury de Montaigu, Jose J Higuera, Matthew Prior, Aurora Galván, Emilio Fernandez, Arthur R Grossman. Reverse genetics in Chlamydomonas: a platform for isolating insertional mutants. Plant methods. 2011 Jul; 7(?):24. doi: 10.1186/1746-4811-7-24. [PMID: 21794168]
  • F Del Chierico, M Onori, S Di Bella, E Bordi, N Petrosillo, D Menichella, S M Cacciò, F Callea, L Putignani. Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples. Annals of tropical medicine and parasitology. 2011 Jul; 105(5):339-49. doi: 10.1179/1364859411y.0000000025. [PMID: 21929875]
  • Gabriele Philipps, Danuta Krawietz, Anja Hemschemeier, Thomas Happe. A pyruvate formate lyase-deficient Chlamydomonas reinhardtii strain provides evidence for a link between fermentation and hydrogen production in green algae. The Plant journal : for cell and molecular biology. 2011 Apr; 66(2):330-40. doi: 10.1111/j.1365-313x.2011.04494.x. [PMID: 21219510]
  • Olivier Le Bihan, Raphaël Chèvre, Stéphane Mornet, Boris Garnier, Bruno Pitard, Olivier Lambert. Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale. Nucleic acids research. 2011 Mar; 39(4):1595-609. doi: 10.1093/nar/gkq921. [PMID: 21078679]
  • M Buehlmann, T Bruderer, R Frei, A F Widmer. Effectiveness of a new decolonisation regimen for eradication of extended-spectrum β-lactamase-producing Enterobacteriaceae. The Journal of hospital infection. 2011 Feb; 77(2):113-7. doi: 10.1016/j.jhin.2010.09.022. [PMID: 21194789]
  • Paola Ferrante, Dennis R Diener, Joel L Rosenbaum, Giovanni Giuliano. Nickel and low CO₂-controlled motility in Chlamydomonas through complementation of a paralyzed flagella mutant with chemically regulated promoters. BMC plant biology. 2011 Jan; 11(?):22. doi: 10.1186/1471-2229-11-22. [PMID: 21266063]
  • Anh Vu Nguyen, Joerg Toepel, Steven Burgess, Andreas Uhmeyer, Olga Blifernez, Anja Doebbe, Ben Hankamer, Peter Nixon, Lutz Wobbe, Olaf Kruse. Time-course global expression profiles of Chlamydomonas reinhardtii during photo-biological H₂ production. PloS one. 2011; 6(12):e29364. doi: 10.1371/journal.pone.0029364. [PMID: 22242116]
  • Beat B Fischer, Rik Il Eggen, Krishna K Niyogi. Characterization of singlet oxygen-accumulating mutants isolated in a screen for altered oxidative stress response in Chlamydomonas reinhardtii. BMC plant biology. 2010 Dec; 10(?):279. doi: 10.1186/1471-2229-10-279. [PMID: 21167020]
  • Partha Roy, Suvadra Das, Tanmoy Bera, Subhasis Mondol, Arup Mukherjee. Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations. International journal of nanomedicine. 2010 Dec; 5(?):1113-21. doi: 10.2147/ijn.s14787. [PMID: 21270962]
  • Ing-Marie Jonsson, Jarmo T Juuti, Patrice François, Rana AlMajidi, Milla Pietiäinen, Myriam Girard, Catharina Lindholm, Manfred J Saller, Arnold J M Driessen, Pentti Kuusela, Maria Bokarewa, Jacques Schrenzel, Vesa P Kontinen. Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall. PloS one. 2010 Dec; 5(12):e14209. doi: 10.1371/journal.pone.0014209. [PMID: 21151985]
  • Nina E Hahn, Saverio V Capuano. Successful treatment of cryptosporidiosis in 2 common marmosets (Callithrix jacchus) by using paromomycin. Journal of the American Association for Laboratory Animal Science : JAALAS. 2010 Nov; 49(6):873-5. doi: . [PMID: 21205457]
  • Arthur R Grossman, Steven J Karpowicz, Mark Heinnickel, David Dewez, Blaise Hamel, Rachel Dent, Krishna K Niyogi, Xenie Johnson, Jean Alric, Francis-André Wollman, Huiying Li, Sabeeha S Merchant. Phylogenomic analysis of the Chlamydomonas genome unmasks proteins potentially involved in photosynthetic function and regulation. Photosynthesis research. 2010 Nov; 106(1-2):3-17. doi: 10.1007/s11120-010-9555-7. [PMID: 20490922]
  • Huawen Lin, Alan L Kwan, Susan K Dutcher. Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii. PLoS genetics. 2010 Sep; 6(9):e1001105. doi: 10.1371/journal.pgen.1001105. [PMID: 20838591]
  • Wirulda Pootakham, David Gonzalez-Ballester, Arthur R Grossman. Identification and regulation of plasma membrane sulfate transporters in Chlamydomonas. Plant physiology. 2010 Aug; 153(4):1653-68. doi: 10.1104/pp.110.157875. [PMID: 20498339]
  • Byung-Guk Kang, Xia Ye, Lori D Osburn, C N Stewart, Zong-Ming Cheng. Transgenic hybrid aspen overexpressing the Atwbc19 gene encoding an ATP-binding cassette transporter confers resistance to four aminoglycoside antibiotics. Plant cell reports. 2010 Jun; 29(6):643-50. doi: 10.1007/s00299-010-0850-8. [PMID: 20383769]
  • Michael Zhuo Wang, Xiaohua Zhu, Anuradha Srivastava, Qiang Liu, J Mark Sweat, Trupti Pandharkar, Chad E Stephens, Ed Riccio, Toufan Parman, Manoj Munde, Swati Mandal, Rentala Madhubala, Richard R Tidwell, W David Wilson, David W Boykin, James Edwin Hall, Dennis E Kyle, Karl A Werbovetz. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrobial agents and chemotherapy. 2010 Jun; 54(6):2507-16. doi: 10.1128/aac.00250-10. [PMID: 20368397]
  • J Leclercq, L Lardet, F Martin, T Chapuset, G Oliver, P Montoro. The green fluorescent protein as an efficient selection marker for Agrobacterium tumefaciens-mediated transformation in Hevea brasiliensis (Müll. Arg). Plant cell reports. 2010 May; 29(5):513-22. doi: 10.1007/s00299-010-0840-x. [PMID: 20306052]
  • Hafez M Hafez, Rüdiger Hauck, Wael Gad, Koen De Gussem, Abdulrahman Lotfi. Pilot study on the efficacy of paromomycin as a histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis. Archives of animal nutrition. 2010 Feb; 64(1):77-84. doi: 10.1080/17450390903478851. [PMID: 20496863]
  • Priya Joyce, Melissa Kuwahata, Nicole Turner, Prakash Lakshmanan. Selection system and co-cultivation medium are important determinants of Agrobacterium-mediated transformation of sugarcane. Plant cell reports. 2010 Feb; 29(2):173-83. doi: 10.1007/s00299-009-0810-3. [PMID: 20041254]
  • Mautusi Mitra, Anastasios Melis. Genetic and biochemical analysis of the TLA1 gene in Chlamydomonas reinhardtii. Planta. 2010 Feb; 231(3):729-40. doi: 10.1007/s00425-009-1083-3. [PMID: 20012986]
  • K Róna, G Klausz, E Keller, M Szakay, P Laczay, M Shem-Tov, P Székely-Körmöczy. Determination of paromomycin residues in turkey tissues by liquid chromatography/mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Nov; 877(30):3792-8. doi: 10.1016/j.jchromb.2009.09.018. [PMID: 19801206]
  • Ming-Ta Wang, Ming-Han Liu, C R Chris Wang, Sarah Y Chang. Silver-coated gold nanoparticles as concentrating probes and matrices for surface-assisted laser desorption/ionization mass spectrometric analysis of aminoglycosides. Journal of the American Society for Mass Spectrometry. 2009 Oct; 20(10):1925-32. doi: 10.1016/j.jasms.2009.06.018. [PMID: 19682921]
  • J El-On, L Ozer, J Gopas, R Sneir, A Golan-Goldhirsh. Nuphar lutea: in vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Aug; 16(8):788-92. doi: 10.1016/j.phymed.2009.01.011. [PMID: 19303752]
  • J El-On, L Ozer, J Gopas, R Sneir, H Enav, N Luft, G Davidov, A Golan-Goldhirsh. Antileishmanial activity in Israeli plants. Annals of tropical medicine and parasitology. 2009 Jun; 103(4):297-306. doi: 10.1179/136485909x440827. [PMID: 19508747]
  • Janice M Zale, S Agarwal, S Loar, C M Steber. Evidence for stable transformation of wheat by floral dip in Agrobacterium tumefaciens. Plant cell reports. 2009 Jun; 28(6):903-13. doi: 10.1007/s00299-009-0696-0. [PMID: 19308413]
  • P B Vinod, Raj Kumar Sharma. Opportunistic infections (non-cytomegalovirus) in live related renal transplant recipients. Indian journal of urology : IJU : journal of the Urological Society of India. 2009 Apr; 25(2):161-8. doi: 10.4103/0970-1591.39547. [PMID: 19672339]
  • Krishna Pandey, Prabhat Kumar Sinha, Vidyanand Ravi Das, Sanjiva Bimal, Shubhankar K Singh, Pradeep Das. Pharmacotherapeutic options for visceral leishmaniasis-current scenario. Clinical medicine. Pathology. 2009 Jan; 2(?):1-4. doi: . [PMID: 21151542]
  • Sujata Agarwal, Star Loar, Camille Steber, Janice Zale. Floral transformation of wheat. Methods in molecular biology (Clifton, N.J.). 2009; 478(?):105-13. doi: 10.1007/978-1-59745-379-0_6. [PMID: 19009441]
  • Parandis Daneshgar, Parviz Norouzi, Mohammad Reza Ganjali, Rasoul Dinarvand, Ali Akbar Moosavi-Movahedi. Determination of diclofenac on a dysprosium nanowire- modified carbon paste electrode accomplished in a flow injection system by advanced filtering. Sensors (Basel, Switzerland). 2009; 9(10):7903-18. doi: 10.3390/s91007903. [PMID: 22408485]
  • Ahmed M A Massoud, Adel O Hafez, Abdel-Gawad E Abdel-Gawad, Atef M El-Shazly, Tosson A Morsy. Mirazid alone or combined with Paromomycin in treating cryptosporidiosis parvum in immunocompetent hospitalized patients. Journal of the Egyptian Society of Parasitology. 2008 Aug; 38(2):399-418. doi: . [PMID: 18853615]
  • César Petri, Hong Wang, Nuria Alburquerque, Mohamed Faize, Lorenzo Burgos. Agrobacterium-mediated transformation of apricot (Prunus armeniaca L.) leaf explants. Plant cell reports. 2008 Aug; 27(8):1317-24. doi: 10.1007/s00299-008-0550-9. [PMID: 18449544]
  • N Shiva Prakash, V Prasad, Thillai P Chidambram, Shoba Cherian, T L Jayaprakash, Santanu Dasgupta, Qi Wang, Michael T Mann, T Michael Spencer, Raghava S Boddupalli. Effect of promoter driving selectable marker on corn transformation. Transgenic research. 2008 Aug; 17(4):695-704. doi: 10.1007/s11248-007-9149-0. [PMID: 17952623]