Kanamycin B (BioDeep_00000003440)

 

Secondary id: BioDeep_00001868262

Chemicals and Drugs natural product


代谢物信息卡片


Kanamycin B

化学式: C18H37N5O10 (483.254)
中文名称: 卡那霉素 B
谱图信息: 最多检出来源 Homo sapiens(otcml) 29.32%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)N)N
InChI: InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID B028
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain[1][2].

同义名列表

4 个代谢物同义名

Kanamycin B; BECANAMYCIN; Bekanamycin; Kanamycin B



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, GJA1, MAPK14, NOTCH2NLA, TYR
Endoplasmic reticulum membrane 1 GJA1
Nucleus 5 ALB, GJA1, MAPK14, RNASEH2B, RNASEH2C
cytosol 4 ALB, GJA1, MAPK14, SCLY
centrosome 1 ALB
nucleoplasm 6 CD2, GJA1, MAPK14, RNASEH2B, SCNN1G, TSFM
Cell membrane 4 CD2, GJA1, GJA3, GJB2
Multi-pass membrane protein 4 GJA1, GJA3, GJB2, SCNN1G
Golgi apparatus membrane 1 MGAT1
cell junction 1 GJA1
cell surface 1 CD2
glutamatergic synapse 1 MAPK14
Golgi apparatus 6 ALB, ATRN, CD2, GJA1, MGAT1, SCLY
Golgi membrane 2 GJA1, MGAT1
Cytoplasm, cytosol 1 SCLY
Lysosome 1 TYR
plasma membrane 6 ATRN, CD2, GJA1, GJA3, GJB2, SCNN1G
Membrane 1 MGAT1
apical plasma membrane 2 GJA1, SCNN1G
extracellular exosome 5 ALB, ATRN, LYZ, MGAT1, SCNN1G
endoplasmic reticulum 2 ALB, GJA1
extracellular space 4 ALB, ATRN, CXCL8, LYZ
perinuclear region of cytoplasm 3 GJB2, MGAT1, TYR
gap junction 2 GJA1, GJB2
intercalated disc 1 GJA1
mitochondrion 3 GJA1, MAPK14, TSFM
protein-containing complex 2 ALB, CD2
intracellular membrane-bounded organelle 2 GJA1, TYR
Single-pass type I membrane protein 3 ATRN, CD2, TYR
Secreted 3 ALB, CXCL8, NOTCH2NLA
extracellular region 6 ALB, CD2, CXCL8, LYZ, MAPK14, NOTCH2NLA
cytoplasmic side of plasma membrane 1 CD2
[Isoform 2]: Secreted 1 ATRN
anchoring junction 1 ALB
external side of plasma membrane 2 CD2, SCNN1G
Extracellular vesicle 1 MGAT1
Melanosome membrane 1 TYR
cell-cell junction 1 CD2
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 MGAT1
Apical cell membrane 1 SCNN1G
Cytoplasm, perinuclear region 1 MGAT1
Membrane raft 1 GJA1
focal adhesion 1 GJA1
Cell junction, gap junction 3 GJA1, GJA3, GJB2
connexin complex 3 GJA1, GJA3, GJB2
contractile muscle fiber 1 GJA1
fascia adherens 1 GJA1
intermediate filament 1 GJA1
lateral plasma membrane 2 GJA1, GJB2
nuclear speck 1 MAPK14
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
[Isoform 3]: Secreted 1 ATRN
sodium channel complex 1 SCNN1G
Melanosome 1 TYR
Golgi-associated vesicle membrane 1 GJA1
cell body 1 GJB2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
tight junction 1 GJA1
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 MGAT1
endoplasmic reticulum-Golgi intermediate compartment 1 GJB2
[Isoform 1]: Cell membrane 1 ATRN
ribonuclease H2 complex 2 RNASEH2B, RNASEH2C
cell-cell contact zone 1 GJA1
astrocyte projection 1 GJB2
catalytic complex 1 SCLY
ciliary transition fiber 1 ALB


文献列表

  • Katherine Yasmin M Garcia, Chayanard Phukhamsakda, Mark Tristan J Quimque, Kevin D Hyde, Marc Stadler, Allan Patrick G Macabeo. Catechol-Bearing Polyketide Derivatives from Sparticola junci. Journal of natural products. 2021 07; 84(7):2053-2058. doi: 10.1021/acs.jnatprod.1c00415. [PMID: 34197704]
  • Xiaoxia Li, Ping Wu, Hanxiang Li, Jinghua Xue, Hanhong Xu, Xiaoyi Wei. Antibacterial and Cytotoxic Phenyltetracenoid Polyketides from Streptomyces morookaense. Journal of natural products. 2021 06; 84(6):1806-1815. doi: 10.1021/acs.jnatprod.1c00208. [PMID: 34081476]
  • Takeshi Kodama, Takuya Ito, Dya Fita Dibwe, So-Yeun Woo, Hiroyuki Morita. Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. Bioorganic & medicinal chemistry letters. 2017 06; 27(11):2397-2400. doi: 10.1016/j.bmcl.2017.04.017. [PMID: 28416134]
  • C-W T Chang, J Y Takemoto. Antifungal Amphiphilic Aminoglycosides. MedChemComm. 2014 Aug; 5(8):1048-1057. doi: 10.1039/c4md00078a. [PMID: 25110571]
  • Jing-Ran Li, Dong-Dong Li, Rong-Rong Wang, Jian Sun, Jing-Jun Dong, Qian-Ru Du, Fei Fang, Wei-Ming Zhang, Hai-Liang Zhu. Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity. European journal of medicinal chemistry. 2014 Mar; 75(?):438-47. doi: 10.1016/j.ejmech.2013.11.020. [PMID: 24561667]
  • Fei Zhang, Qing Wen, She-Feng Wang, Baloch Shahla Karim, Yu-Shun Yang, Jia-Jia Liu, Wei-Ming Zhang, Hai-Liang Zhu. Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory. Bioorganic & medicinal chemistry letters. 2014 Jan; 24(1):90-5. doi: 10.1016/j.bmcl.2013.11.079. [PMID: 24332628]
  • Cheng-Wei T Chang, Marina Fosso, Yukie Kawasaki, Sanjib Shrestha, Mekki F Bensaci, Jinhua Wang, Conrad K Evans, Jon Y Takemoto. Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides. The Journal of antibiotics. 2010 Nov; 63(11):667-72. doi: 10.1038/ja.2010.110. [PMID: 20924381]
  • Alexander V Birk, Edward J Dubovi, Xianchao Zhang, Hazel H Szeto. Antiviral activity of geneticin against bovine viral diarrhoea virus. Antiviral chemistry & chemotherapy. 2008; 19(1):33-40. doi: 10.1177/095632020801900105. [PMID: 18610556]
  • Wai Siang Law, Pavel Kubán, Ling Ling Yuan, Jian Hong Zhao, Sam Fong Yau Li, Peter C Hauser. Determination of tobramycin in human serum by capillary electrophoresis with contactless conductivity detection. Electrophoresis. 2006 May; 27(10):1932-8. doi: 10.1002/elps.200500819. [PMID: 16619300]
  • D Carrier, N Chartrand, W Matar. Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers. An infrared spectroscopic investigation. Biochemical pharmacology. 1997 Feb; 53(3):401-8. doi: 10.1016/s0006-2952(96)00765-4. [PMID: 9065744]
  • T Yamasaki, Y Narita, H Hoshi, S Aburaki, H Kamei, T Naito, H Kawaguchi. Synthesis and biological activity of 1-N-[4-(substituted)amidino and guanidino-2-hydroxybutyryl]kanamycins A and B. The Journal of antibiotics. 1991 Jun; 44(6):646-58. doi: 10.7164/antibiotics.44.646. [PMID: 2071490]
  • M Yoshida, T Koeda. Effect of aminoglycoside antibiotics on the electrical stimulation-induced contractile response of the guinea-pig ureter. Nihon Heikatsukin Gakkai zasshi. 1989 Jun; 25(3):75-87. doi: 10.1540/jsmr1965.25.75. [PMID: 2607711]
  • H Beck, P Eikenberg, K Sack. [Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)]. Arzneimittel-Forschung. 1980; 30(2):288-94. doi: . [PMID: 6155127]
  • R Giura, B Roccamo, M Donghi, M Landriscina. [Nephrotoxicity of aminoglycoside antibiotics]. Giornale italiano di chemioterapia. 1979 Jan; 26(1-2):297-300. doi: NULL. [PMID: 554820]
  • D Azzena, U Armani, S Trasciatti. [Kanendomycin in the treatment of urinary tract infections]. Giornale italiano di chemioterapia. 1977 Jan; 24(1-2):1-6. doi: NULL. [PMID: 615750]
  • K Sack, B Züllich, P Eikenberg. [Comparative studies on the problem of nephrotoxicity of the aminoglycosides: kanamycin, amikacin, butirosin and kanendomycin]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin. 1976; 82 Pt 2(?):1538-40. doi: NULL. [PMID: 70900]