Isovaline (BioDeep_00000003357)

   


代谢物信息卡片


(S)-2-AMINO-2-METHYLBUTYRIC ACID

化学式: C5H11NO2 (117.079)
中文名称: 2-氨基-2-甲基丁酸, D(-)-异缬氨酸, DL-异缬氨酸
谱图信息: 最多检出来源 Homo sapiens(plant) 4.12%

分子结构信息

SMILES: CCC(C)(C(=O)O)N
InChI: InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)

描述信息

KEIO_ID A189

同义名列表

4 个代谢物同义名

(S)-2-AMINO-2-METHYLBUTYRIC ACID; 2-Amino-2-methylbutanoate; D-Isovaline; Isovaline



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AANAT, AKT1, CA1, PIK3C3, PIK3CG, PMP2, SLC38A2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 2 AKT1, PMP2
autophagosome 1 PIK3C3
cytosol 9 AANAT, AKT1, CA1, PIK3C3, PIK3CG, PMP2, PRKCQ, SLC2A1, SLC2A4
dendrite 1 SLC38A2
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 SLC2A4
nucleoplasm 1 AKT1
Cell membrane 8 AKT1, GRID1, IGF1R, PIK3CG, SLC12A2, SLC2A1, SLC2A4, SLC38A2
lamellipodium 1 AKT1
Multi-pass membrane protein 5 GRID1, SLC12A2, SLC2A1, SLC2A4, SLC38A2
Golgi apparatus membrane 1 MGAT1
cell cortex 1 AKT1
glutamatergic synapse 3 AKT1, GRID1, PIK3C3
Golgi apparatus 1 MGAT1
Golgi membrane 3 INS, MGAT1, SLC2A1
mitochondrial inner membrane 1 ATP5ME
neuronal cell body 3 IGF1R, SLC12A2, SLC38A2
postsynapse 1 AKT1
sarcolemma 3 SLC2A1, SLC2A4, SLC38A2
Presynapse 2 SLC2A1, SLC2A4
endosome 1 PIK3C3
plasma membrane 9 AKT1, GRID1, IGF1R, PIK3CG, PRKCQ, SLC12A2, SLC2A1, SLC2A4, SLC38A2
Membrane 8 AKT1, IGF1R, MGAT1, PIK3C3, PIK3CG, SLC12A2, SLC2A1, SLC2A4
apical plasma membrane 2 SLC12A2, SLC2A1
axon 2 IGF1R, SLC38A2
basolateral plasma membrane 2 SLC12A2, SLC2A1
brush border 1 SLC38A2
caveola 2 IGF1R, SLC2A1
extracellular exosome 7 CA1, GRID1, MGAT1, PMP2, SLC12A2, SLC2A1, SLC2A4
extracellular space 5 IGF1, IGF2, IL6, INS, PYY
perinuclear region of cytoplasm 3 AANAT, MGAT1, SLC2A4
intercalated disc 1 SLC2A1
mitochondrion 1 ATP5ME
protein-containing complex 1 AKT1
intracellular membrane-bounded organelle 1 IGF1R
Single-pass type I membrane protein 1 IGF1R
Secreted 4 IGF1, IGF2, IL6, INS
extracellular region 5 IGF1, IGF2, IL6, INS, PYY
centriolar satellite 1 PRKCQ
photoreceptor inner segment 1 SLC2A1
external side of plasma membrane 1 SLC2A4
Extracellular vesicle 2 MGAT1, SLC12A2
multivesicular body 1 SLC2A4
T-tubule 2 IGF1R, SLC2A4
Z disc 1 SLC2A1
microtubule cytoskeleton 1 AKT1
midbody 2 PIK3C3, SLC2A1
cell-cell junction 1 AKT1
clathrin-coated pit 1 SLC2A4
Single-pass type II membrane protein 1 MGAT1
vesicle 1 AKT1
postsynaptic membrane 1 GRID1
Cytoplasm, perinuclear region 2 MGAT1, SLC2A4
Membrane raft 1 SLC2A4
spindle 1 AKT1
GABA-ergic synapse 2 GRID1, PIK3C3
Peroxisome 1 PIK3C3
sarcoplasmic reticulum 1 SLC2A4
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 SLC12A2
axoneme 1 PIK3C3
Postsynaptic cell membrane 1 GRID1
Late endosome 1 PIK3C3
receptor complex 1 IGF1R
neuron projection 1 SLC12A2
ciliary basal body 1 AKT1
cell projection 1 SLC12A2
phagocytic vesicle membrane 1 PIK3C3
cell periphery 1 SLC12A2
blood microparticle 1 SLC2A1
Basolateral cell membrane 1 SLC12A2
Endomembrane system 1 SLC2A4
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
female germ cell nucleus 1 SLC2A1
Cytoplasmic vesicle membrane 2 SLC12A2, SLC2A4
Melanosome 1 SLC2A1
cell body 1 SLC12A2
myelin sheath 1 PMP2
basal plasma membrane 1 SLC12A2
clathrin-coated vesicle 1 SLC2A4
exocytic vesicle 1 IGF1
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
cortical actin cytoskeleton 1 SLC2A1
platelet alpha granule lumen 2 IGF1, IGF2
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 INS, MGAT1
postsynaptic density membrane 1 GRID1
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
vesicle membrane 1 SLC2A4
female pronucleus 1 SLC2A1
proton-transporting ATP synthase complex 1 ATP5ME
postsynaptic endosome 1 PIK3C3
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
Autolysosome 1 PIK3C3
alphav-beta3 integrin-IGF-1-IGF1R complex 2 IGF1, IGF1R
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
interleukin-6 receptor complex 1 IL6
insulin receptor complex 1 IGF1R
protein kinase complex 1 IGF1R
glucose transporter complex 1 SLC2A1
cell body membrane 1 SLC12A2
cell projection membrane 1 SLC12A2
insulin-responsive compartment 1 SLC2A4
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CG


文献列表

  • Chie Suzuki, Atsushi B Tsuji, Koichi Kato, Hitomi Sudo, Ming-Rong Zhang, Tsuneo Saga. Preclinical evaluation of 2-amino-2-[11C]methyl-butanoic acid as a potential tumor-imaging agent in a mouse model. Nuclear medicine communications. 2015 Nov; 36(11):1107-12. doi: 10.1097/mnm.0000000000000364. [PMID: 26259115]
  • G Tajima, H Yofune, A D Bahagia Febriani, Y Nishimura, H Ono, N Sakura. A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography. Journal of inherited metabolic disease. 2004; 27(5):633-9. doi: 10.1023/b:boli.0000042988.31581.ed. [PMID: 15669679]