Norlaudanosoline (BioDeep_00000003342)
Secondary id: BioDeep_00000015315, BioDeep_00001869308
human metabolite Endogenous
代谢物信息卡片
化学式: C16H17NO4 (287.1158)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 10.54%
分子结构信息
SMILES: C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC(=C(C=C3)O)O
InChI: InChI=1S/C16H17NO4/c18-13-2-1-9(6-14(13)19)5-12-11-8-16(21)15(20)7-10(11)3-4-17-12/h1-2,6-8,12,17-21H,3-5H2
描述信息
Norlaudanosoline (CAS: 4747-99-3), also known as tetrahydropapaveroline, belongs to the class of organic compounds known as benzylisoquinolines. These are organic compounds containing an isoquinoline to which a benzyl group is attached. Norlaudanosoline is a very strong basic compound (based on its pKa). Norlaundanosoline is a key intermediate in the synthesis of the benzylisoquinoline alkaloids, providing the upper isoquinoline portion of the morphinan skeleton. It is involved in alkaloid biosynthesis and is synthesized by the enzyme (S)-norlaudanosoline synthase.
Formerly believed to be a biosynthetic precursor of morphine in Papaver somniferum, now disproved
同义名列表
9 个代谢物同义名
(1S)-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol; (1S)-1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-isoquinolinediol; 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-isoquinolinediol; (S)-(-)-Tetrahydropapaveroline; (S)-Tetrahydropapaveroline; (-)-Tetrahydropapaveroline; Tetrahydropapaveroline; (S)-Norlaudanosoline; norlaudanosoline
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:28651
- KEGG: C02916
- PubChem: 439845
- PubChem: 18519
- HMDB: HMDB0012486
- Metlin: METLIN64403
- ChEMBL: CHEMBL348881
- Wikipedia: Tetrahydropapaveroline
- foodb: FDB008796
- chemspider: 388889
- CAS: 10139-29-4
- CAS: 57073-15-1
- PMhub: MS000009512
- PubChem: 5839
- PDB-CCD: 2H4
- 3DMET: B01612
- NIKKAJI: J761.884K
- LOTUS: LTS0172452
- wikidata: Q27103884
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaotao Tuo, Zhiyin Yu, Junheng Li, Yuxin Qi, Guoqing Peng, Sheng-Xiong Huang, Xueshuang Huang, Jian-Ping Huang. Characterization of two putative norlaudanosoline methyltransferases from Aristolochia debilis.
Journal of plant physiology.
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Bioscience, biotechnology, and biochemistry.
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