Prostaglandin D2 (BioDeep_00000003317)

 

Secondary id: BioDeep_00000629490

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid

化学式: C20H32O5 (352.2249622)
中文名称: 前列腺素 D2
谱图信息: 最多检出来源 Homo sapiens(blood) 0.19%

分子结构信息

SMILES: CCCCCC(C=CC1C(C(CC1=O)O)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1

描述信息

Prostaglandin D2 (or PGD2) is a prostaglandin that is actively produced in various organs such as the brain, spleen, thymus, bone marrow, uterus, ovary, oviduct, testis, prostate and epididymis, and is involved in many physiological events. PGD2 binds to the prostaglandin D2 receptor (PTGDR) which is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. PGD2 promotes sleep; regulates body temperature, olfactory function, hormone release, and nociception in the central nervous system; prevents platelet aggregation; and induces vasodilation and bronchoconstriction. PGD2 is also released from mast cells as an allergic and inflammatory mediator. Prostaglandin H2 is an unstable intermediate formed from PGG2 by the action of cyclooxygenase (COX) in the arachidonate cascade. In mammalian systems, it is efficiently converted into more stable arachidonate metabolites, such as PGD2, PGE2, PGF2a by the action of three groups of enzymes, PGD synthases (PGDS), PGE synthases and PGF synthases, respectively. PGDS catalyzes the isomerization of PGH2 to PGD2. Two types of PGD2 synthase are known. Lipocalin-type PGD synthase is present in cerebrospinal fluid, seminal plasma and may play an important role in male reproduction. Another PGD synthase, hematopoietic PGD synthase is present in the spleen, fallopian tube, endometrial gland cells, extravillous trophoblasts and villous trophoblasts, and perhaps plays an important role in female reproduction. Recent studies demonstrate that PGD2 is probably involved in multiple aspects of inflammation through its dual receptor systems, DP and CRTH2. (PMID:12148545)Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Prostaglandin D2 (or PGD2) is a prostaglandin that is actively produced in various organs such as the brain, spleen, thymus, bone marrow, uterus, ovary, oviduct, testis, prostate and epididymis, and is involved in many physiological events. PGD2 binds to the prostaglandin D2 receptor (PTGDR) which is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. PGD2 promotes sleep; regulates body temperature, olfactory function, hormone release, and nociception in the central nervous system; prevents platelet aggregation; and induces vasodilation and bronchoconstriction. PGD2 is also released from mast cells as an allergic and inflammatory mediator.
Chemical was purchased from CAY 12010, (Lot 0436713-1); Diagnostic ions: 351.1, 333.0, 271.3, 233.1, 189.1

同义名列表

42 个代谢物同义名

(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid; (5Z,9-alpha,13E,15S)-9,15-Dihydroxy-11-oxo-prosta-5,13-dien-1-Oic acid; (5Z,9alpha,13E,15S)-9,15-Dihydroxy-11-oxo-prosta-5,13-dien-1-Oic acid; (5Z,13E)-(15S)-9-alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,9-alpha,13E,15S)-9,15-Dihydroxy-11-oxo-prosta-5,13-dien-1-Oate; (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,9alpha,13E,15S)-9,15-Dihydroxy-11-oxo-prosta-5,13-dien-1-Oate; (5Z,13E,15S)-9-alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E)-(15S)-9-alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E,15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dien-1-Oic acid; (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-9Α,15-dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E)-(15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E,15S)-9-alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E,15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E,15S)-9Α,15-dihydroxy-11-oxoprosta-5,13-dienoic acid; (5Z,13E,15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dien-1-Oate; (5Z,13E)-(15S)-9Α,15-dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E,15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate; (5Z,13E,15S)-9Α,15-dihydroxy-11-oxoprosta-5,13-dienoate; 9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid; 9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoate; alpha, 11-Dehydroprostaglandin F2; F2 alpha, 11-Dehydroprostaglandin; 11-Dehydroprostaglandin F2 alpha; F2alpha, 11-Dehydroprostaglandin; 11-Dehydroprostaglandin F2-alpha; 11 Dehydroprostaglandin F2 alpha; 11-Dehydroprostaglandin F2alpha; 11 Dehydroprostaglandin F2alpha; 11-Dehydroprostaglandin F2-α; 11-Dehydroprostaglandin F2-a; D2, Prostaglandin; Prostaglandin D2; 41598-07-6; PGD2; Prostaglandin D2



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(12)

BioCyc(0)

PlantCyc(0)

代谢反应

221 个相关的代谢反应过程信息。

Reactome(170)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yi-Fan Kang, Jin-Xin Liu, Kai Xu, Xue-Li Li, Xiang Lu. sPLA2GIB Promotes PGD2 and IL-13 Production in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps. The Laryngoscope. 2023 Aug; ?(?):. doi: 10.1002/lary.30977. [PMID: 37594194]
  • Yuya Miyamoto, Masatoshi Nakatsuji, Takuya Yoshida, Tadayasu Ohkubo, Takashi Inui. Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX. The FEBS journal. 2023 08; 290(16):3983-3996. doi: 10.1111/febs.16791. [PMID: 37021622]
  • Akane Hayashi, Naoaki Sakamoto, Koji Kobayashi, Takahisa Murata. Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion. Frontiers in immunology. 2023; 14(?):1276852. doi: 10.3389/fimmu.2023.1276852. [PMID: 37942331]
  • Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson. Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3. Journal of lipid research. 2022 12; 63(12):100310. doi: 10.1016/j.jlr.2022.100310. [PMID: 36370807]
  • Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Peng. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4574-4582. doi: 10.19540/j.cnki.cjcmm.20220217.701. [PMID: 36164862]
  • Junxia Feng, Meizhi Lu, Wenhao Li, Jingchun Li, Ping Meng, Zukai Li, Xuejuan Gao, Yunfang Zhang. PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation. Molecular and cellular biochemistry. 2022 Jul; 477(7):1959-1971. doi: 10.1007/s11010-022-04419-y. [PMID: 35380292]
  • Nadia Elshareif, Chaitanya K Gavini, Virginie Mansuy-Aubert. LXR agonist modifies neuronal lipid homeostasis and decreases PGD2 in the dorsal root ganglia in western diet-fed mice. Scientific reports. 2022 06; 12(1):10754. doi: 10.1038/s41598-022-14604-0. [PMID: 35750708]
  • Deping Kong, Ying Yu. Prostaglandin D2 signaling and cardiovascular homeostasis. Journal of molecular and cellular cardiology. 2022 06; 167(?):97-105. doi: 10.1016/j.yjmcc.2022.03.011. [PMID: 35367459]
  • Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan P Jastrzębski, Karol G Makowczenko, Monika Golubska, Iwona Bogacka. PPARγ regulates the expression of genes involved in the DNA damage response in an inflamed endometrium. Scientific reports. 2022 03; 12(1):4026. doi: 10.1038/s41598-022-07986-8. [PMID: 35256739]
  • Carlos Antonio Trindade da Silva, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Rosanna Tarkany Basting, Marcelo Henrique Napimoga. Peroxisome proliferator-activated receptor-gamma (PPARγ) and its immunomodulation function: current understanding and future therapeutic implications. Expert review of clinical pharmacology. 2022 Mar; 15(3):295-303. doi: 10.1080/17512433.2022.2071697. [PMID: 35481412]
  • Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang. Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes. Neurotoxicity research. 2022 Feb; 40(1):154-172. doi: 10.1007/s12640-020-00318-6. [PMID: 34997457]
  • Ko Fujimori. Prostaglandin D2 and F2α as Regulators of Adipogenesis and Obesity. Biological & pharmaceutical bulletin. 2022; 45(8):985-991. doi: 10.1248/bpb.b22-00210. [PMID: 35908908]
  • Xin Hu, Ye-An Zhang, Ben Chen, Zi Jin, Mei-Lin Lin, Ming Li, Hong-Xia Mei, Jia-Chao Lu, Yu-Qiang Gong, Sheng-Wei Jin, Sheng-Xing Zheng. Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome. International immunopharmacology. 2022 Jan; 102(?):108348. doi: 10.1016/j.intimp.2021.108348. [PMID: 34920958]
  • Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-Kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa, Keisuke Yoshikawa. A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus. Journal of neuroinflammation. 2021 Dec; 18(1):304. doi: 10.1186/s12974-021-02361-2. [PMID: 34961526]
  • Sonja Rittchen, Katharina Jandl, Ilse Lanz, Bernhard Reiter, Nerea Ferreirós, Daniel Kratz, Jörg Lindenmann, Luka Brcic, Thomas Bärnthaler, Reham Atallah, Horst Olschewski, Eva M Sturm, Akos Heinemann. Monocytes and Macrophages Serve as Potent Prostaglandin D2 Sources during Acute, Non-Allergic Pulmonary Inflammation. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111697. [PMID: 34769126]
  • Nagisa Ito, Tatsuro Nakamura, Naoaki Sakamoto, Akane Hayashi, Takahisa Murata. Extraction and measurement of urinary tetranor-PGDM in disposable diapers. Journal of pharmacological sciences. 2021 Oct; 147(2):208-210. doi: 10.1016/j.jphs.2021.06.011. [PMID: 34384569]
  • Carl Eguez, Michelle A Clark, Ann Tenneil O'Connor. 15-Deoxy-Δ-12,14-prostaglandin J2 effects in vascular smooth muscle cells: Implications in vascular smooth muscle cell proliferation and contractility. Prostaglandins & other lipid mediators. 2021 10; 156(?):106583. doi: 10.1016/j.prostaglandins.2021.106583. [PMID: 34332056]
  • Tatsuro Nakamura. The roles of lipid mediators in type I hypersensitivity. Journal of pharmacological sciences. 2021 Sep; 147(1):126-131. doi: 10.1016/j.jphs.2021.06.001. [PMID: 34294363]
  • Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter. Prostaglandins, leukotrienes, and essential fatty acids. 2021 09; 172(?):102323. doi: 10.1016/j.plefa.2021.102323. [PMID: 34392133]
  • Heng Liu, R N V Krishna Deepak, Anna Shiriaeva, Cornelius Gati, Alexander Batyuk, Hao Hu, Uwe Weierstall, Wei Liu, Lei Wang, Vadim Cherezov, Hao Fan, Cheng Zhang. Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. Proceedings of the National Academy of Sciences of the United States of America. 2021 08; 118(32):. doi: 10.1073/pnas.2102813118. [PMID: 34341104]
  • Misato Kida, Tatsuro Nakamura, Yuki Fujiwara, Masataka Nakamura, Takahisa Murata. PGD2 /CRTH2 signaling promotes acquired immunity against bee venom by enhancing IgE production. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 06; 35(6):e21616. doi: 10.1096/fj.202002748rr. [PMID: 33978990]
  • Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney. Clinical and experimental nephrology. 2021 May; 25(5):445-455. doi: 10.1007/s10157-021-02021-y. [PMID: 33595729]
  • Christoph Schmöcker, Heike Gottschall, Katharina M Rund, Laura Kutzner, Fabian Nolte, Annika I Ostermann, Dirk Hartmann, Nils Helge Schebb, Karsten H Weylandt. Oxylipin patterns in human colon adenomas. Prostaglandins, leukotrienes, and essential fatty acids. 2021 04; 167(?):102269. doi: 10.1016/j.plefa.2021.102269. [PMID: 33812217]
  • Salma Mani, Xavier Norel, Mathilde Varret, Sarra Bchir, Amel Ben Anes, Abdelahamid Garrouch, Zouhair Tabka, Dan Longrois, Karim Chahed. Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort. Prostaglandins, leukotrienes, and essential fatty acids. 2021 03; 166(?):102252. doi: 10.1016/j.plefa.2021.102252. [PMID: 33545665]
  • Meng Yuan, Yue Zhang, Tong Hua, Xiang-Li Liu, Tong Liu, Ru-Yu Yuan, Guang-Ping Li, Yi Zhu, Xu Zhang. Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a beneficial eicosanoid-pattern in patients with acute myocardial infarction: A randomized, controlled trial. Clinical nutrition (Edinburgh, Scotland). 2021 02; 40(2):445-459. doi: 10.1016/j.clnu.2020.05.034. [PMID: 33041091]
  • Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan Paweł Jastrzębski, Iwona Bogacka. Transcriptome analysis of porcine endometrium after LPS-induced inflammation: effects of the PPAR-gamma ligands in vitro†. Biology of reproduction. 2021 01; 104(1):130-143. doi: 10.1093/biolre/ioaa200. [PMID: 33112378]
  • Christine L Hammond, Elisa Roztocil, Mithra O Gonzalez, Steven E Feldon, Collynn F Woeller. MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK. Investigative ophthalmology & visual science. 2021 01; 62(1):29. doi: 10.1167/iovs.62.1.29. [PMID: 33507228]
  • S Inagaki, T Nakamura, Y Hamasaki, K Yamamoto-Hanada, T Fukuie, M Narita, T Shimosawa, T Murata, Y Ohya. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clinical and experimental dermatology. 2021 Jan; 46(1):130-134. doi: 10.1111/ced.14393. [PMID: 32705704]
  • R Stokes Peebles. Urine: A Lens for Asthma Pathogenesis and Treatment?. American journal of respiratory and critical care medicine. 2021 01; 203(1):1-3. doi: 10.1164/rccm.202007-2899ed. [PMID: 32791002]
  • Nanae Nagata, Sakura Masuko, Rikako Inoue, Tatsuro Nakamura, Kosuke Aritake, Takahisa Murata. Development of Monoclonal Antibody-Based EIA for Tetranor-PGDM which Reflects PGD2 Production in the Body. Journal of immunology research. 2021; 2021(?):5591115. doi: 10.1155/2021/5591115. [PMID: 33997056]
  • Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh. 15-Deoxy-△12,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis. Frontiers in immunology. 2021; 12(?):615803. doi: 10.3389/fimmu.2021.615803. [PMID: 33633749]
  • Hiromi Koma, Yasuhiro Yamamoto, Noboru Okamura, Tatsurou Yagami. A plausible involvement of plasmalemmal voltage-dependent anion channel 1 in the neurotoxicity of 15-deoxy-Δ12,14 -prostaglandin J2. Brain and behavior. 2020 12; 10(12):e01866. doi: 10.1002/brb3.1866. [PMID: 33200588]
  • Sonja Rittchen, Kathrin Rohrer, Wolfgang Platzer, Eva Knuplez, Thomas Bärnthaler, Leigh M Marsh, Reham Atallah, Katharina Sinn, Walter Klepetko, Neha Sharma, Chandran Nagaraj, Akos Heinemann. Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4. Biochemical pharmacology. 2020 12; 182(?):114277. doi: 10.1016/j.bcp.2020.114277. [PMID: 33038299]
  • Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu, Jian Zhang, Yujun Shen. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages. Circulation research. 2020 10; 127(10):1323-1336. doi: 10.1161/circresaha.120.316784. [PMID: 32912104]
  • Ajay Gupta, Kate Chander Chiang. Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease. Medical hypotheses. 2020 Oct; 143(?):110122. doi: 10.1016/j.mehy.2020.110122. [PMID: 32759007]
  • L Li, E Y Lai, X Cao, W J Welch, C S Wilcox. Endothelial prostaglandin D2 opposes angiotensin II contractions in mouse isolated perfused intracerebral microarterioles. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2020 Oct; 21(4):1470320320966177. doi: 10.1177/1470320320966177. [PMID: 33094663]
  • Shakeel Shahzad, Mark Willcox. Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J2) for effective treatment and reduction in the death toll. Medical hypotheses. 2020 Oct; 143(?):110080. doi: 10.1016/j.mehy.2020.110080. [PMID: 32683221]
  • Mengwen Li, Xinsheng Fan, Qinfei Yue, Fangyuan Hu, Yiming Zhang, Chan Zhu. The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice. International immunopharmacology. 2020 Sep; 86(?):106696. doi: 10.1016/j.intimp.2020.106696. [PMID: 32570040]
  • Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T Diwakar, Baiye Ruan, Siyang Hao, K Sandeep Prabhu, Robert F Paulson. Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation. Blood. 2020 07; 136(2):235-246. doi: 10.1182/blood.2019003480. [PMID: 32350523]
  • Zhe Peng, Miaomiao Li, Xiaodan Tan, Pu Xiang, Hong Wang, Ying Luo, Yang Yang, Haifeng Huang, Zhihao Chen, Hui Xia, Yuke Li, Jiahua Zhang, Chao Gu, Maozhu Liu, Qiong Wang, Mengyuan Chen, Junqing Yang. miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2. Biochemical pharmacology. 2020 07; 177(?):113983. doi: 10.1016/j.bcp.2020.113983. [PMID: 32311346]
  • Shadab Abadpour, Björn Tyrberg, Simen W Schive, Charlotte Wennberg Huldt, Peter Gennemark, Erik Ryberg, Tina Rydén-Bergsten, David M Smith, Olle Korsgren, Stanko Skrtic, Hanne Scholz, Maria Sörhede Winzell. Inhibition of the prostaglandin D2-GPR44/DP2 axis improves human islet survival and function. Diabetologia. 2020 07; 63(7):1355-1367. doi: 10.1007/s00125-020-05138-z. [PMID: 32350565]
  • Hiroaki Hayashi, Yuma Fukutomi, Chihiro Mitsui, Keiichi Kajiwara, Kentaro Watai, Yosuke Kamide, Yuto Nakamura, Yuto Hamada, Yasuhiro Tomita, Kiyoshi Sekiya, Takahiro Tsuburai, Kenji Izuhara, Keiko Wakahara, Naozumi Hashimoto, Yoshinori Hasegawa, Masami Taniguchi. Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial. American journal of respiratory and critical care medicine. 2020 06; 201(12):1488-1498. doi: 10.1164/rccm.201906-1215oc. [PMID: 32142372]
  • Tianming Wang, Xueyan Zhang, Yiwen Ye, Rong Shi, Yueming Ma. Quantification of prostaglandins E2 and D2 using liquid chromatography-tandem mass spectrometry in a mouse ear edema model. Analytical methods : advancing methods and applications. 2020 06; 12(22):2865-2871. doi: 10.1039/d0ay00506a. [PMID: 32930210]
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