5-HETE (BioDeep_00000003305)

 

Secondary id: BioDeep_00000594376

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid

化学式: C20H32O3 (320.2351)
中文名称: 5(S)-羟化二十烷四烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 40.84%

Reviewed

Last reviewed on 2024-10-28.

Cite this Page

5-HETE. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/5-hete (retrieved 2024-12-27) (BioDeep RN: BioDeep_00000003305). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(=C\[C@@H](CCCC(=O)O)O)/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m0/s1

描述信息

5-Hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.; 5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in Arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then it is converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback. 5-HETE is found in corn.
5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.

同义名列表

35 个代谢物同义名

5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,Z,Z,Z)-(+-)-isomer; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (S)-(e,Z,Z,Z)-isomer; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, R-(e,Z,Z,Z)-isomer; (5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-eicosatetraenoic acid; (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,Z,Z,Z)-isomer; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,e,Z,Z)-isomer; (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoate; (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate; 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid; (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid; 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid; 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoate; 5S-Hydroxy-6,8,11,14-(e,Z,Z,Z)-eicosatetraenoic acid; (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate; 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate; 5-L-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5S-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5-L-Hydroxy-6,8,11,14-eicosatetraenoate; 5S-Hydroxy-6,8,11,14-eicosatetraenoate; 5-Hydroxy-6,8,11,14-eicosatetraenoate; 5(S)-Hydroxyeicosatetraenoic acid; 5-Hydroxyeicosatetraenoic acid; FA(20:4(5S-OH,6E,8Z,11Z,14Z)); 5(S)-Hydroxyeicosatetraenoate; FA(20:4(5-OH,6E,8Z,11Z,14Z)); 5-Hydroxyeicosatetraenoate; 5-Hydroxyarachidonic acid; 5(S)-HETE; 5S-HETE; 5-Hete; 5(S)-HETE



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

53 个相关的代谢反应过程信息。

Reactome(5)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACSL4, ALB, ALOX5, BCL2, PLA2G12A, PRKX, PRL, PTGS1, PTGS2
Peripheral membrane protein 3 ALOX5, PTGS1, PTGS2
Endoplasmic reticulum membrane 4 ACSL4, BCL2, PTGS1, PTGS2
Nucleus 6 ALB, BCL2, LMNA, PLCZ1, PRKX, PRL
cytosol 7 ALB, ALOX5, BCL2, GSR, LMNA, PLCZ1, PRKCQ
centrosome 1 ALB
nucleoplasm 5 ALOX5, LMNA, PLCZ1, PRKX, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 ACSL4, CYSLTR2
Multi-pass membrane protein 2 CYSLTR2, OXER1
Golgi apparatus 2 ALB, PTGS1
Cytoplasm, cytosol 1 ALOX5
plasma membrane 7 ACSL4, CYSLTR2, F2, IGHE, LTB, OXER1, PRKCQ
Membrane 4 ACSL4, BCL2, LTB, OXER1
caveola 1 PTGS2
extracellular exosome 5 ACSL4, ALB, F2, GSR, PTGS1
endoplasmic reticulum 4 ACSL4, ALB, BCL2, PTGS2
extracellular space 8 ALB, ALOX5, CXCL8, F2, IGHE, IL6, LTB, PRL
perinuclear region of cytoplasm 3 ALOX5, LMNA, PLCZ1
mitochondrion 3 ACSL4, BCL2, GSR
protein-containing complex 3 ALB, BCL2, PTGS2
intracellular membrane-bounded organelle 1 PTGS1
Microsome membrane 3 ACSL4, PTGS1, PTGS2
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 IGHE
Secreted 6 ALB, CXCL8, F2, IL6, PLA2G12A, PRL
extracellular region 8 ALB, ALOX5, CXCL8, F2, IGHE, IL6, PLA2G12A, PRL
Mitochondrion outer membrane 2 ACSL4, BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 ACSL4, BCL2
mitochondrial matrix 1 GSR
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
Nucleus membrane 2 ALOX5, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 ALOX5, BCL2, LMNA
external side of plasma membrane 1 GSR
nucleolus 1 PLCZ1
Single-pass type II membrane protein 1 LTB
Cytoplasm, perinuclear region 2 ALOX5, PLCZ1
pore complex 1 BCL2
peroxisomal membrane 1 ACSL4
collagen-containing extracellular matrix 1 F2
intermediate filament 1 LMNA
nuclear speck 1 LMNA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
chromatin 1 PRL
IgE immunoglobulin complex 1 IGHE
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, F2
[Isoform 2]: Cell membrane 1 IGHE
site of double-strand break 1 LMNA
nuclear envelope 2 ALOX5, LMNA
Nucleus envelope 2 ALOX5, LMNA
Endomembrane system 1 PTGS1
endosome lumen 1 PRL
Lipid droplet 1 ACSL4
mitochondria-associated endoplasmic reticulum membrane contact site 1 ACSL4
Nucleus, nucleoplasm 1 LMNA
myelin sheath 1 BCL2
Peroxisome membrane 1 ACSL4
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
Golgi lumen 1 F2
endoplasmic reticulum lumen 4 ALB, F2, IL6, PTGS2
nuclear matrix 2 ALOX5, LMNA
platelet alpha granule lumen 1 ALB
Single-pass type III membrane protein 1 ACSL4
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 2 ALOX5, LMNA
nuclear envelope lumen 1 ALOX5
nuclear lamina 1 LMNA
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
Nucleus lamina 1 LMNA
[Isoform C]: Nucleus speckle 1 LMNA
lamin filament 1 LMNA
sperm head 1 PLCZ1
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
ciliary transition fiber 1 ALB


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