5-HETE (BioDeep_00000003305)
Main id: BioDeep_00000594376
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C20H32O3 (320.2351322)
中文名称: 5(S)-羟化二十烷四烯酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.2%
Last reviewed on 2024-10-28.
Cite this Page
5-HETE. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/5-hete (retrieved
2024-11-03) (BioDeep RN: BioDeep_00000003305). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(=C\[C@@H](CCCC(=O)O)O)/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m0/s1
描述信息
5-Hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.; 5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in Arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then it is converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback. 5-HETE is found in corn.
5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.
同义名列表
34 个代谢物同义名
5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,Z,Z,Z)-(+-)-isomer; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (S)-(e,Z,Z,Z)-isomer; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, R-(e,Z,Z,Z)-isomer; (5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-eicosatetraenoic acid; (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,Z,Z,Z)-isomer; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid, (e,e,Z,Z)-isomer; (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid; (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoate; (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate; 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid; (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid; 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid; 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoate; 5S-Hydroxy-6,8,11,14-(e,Z,Z,Z)-eicosatetraenoic acid; (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate; 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate; 5-L-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5S-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid; 5-L-Hydroxy-6,8,11,14-eicosatetraenoate; 5S-Hydroxy-6,8,11,14-eicosatetraenoate; 5-Hydroxy-6,8,11,14-eicosatetraenoate; 5(S)-Hydroxyeicosatetraenoic acid; 5-Hydroxyeicosatetraenoic acid; FA(20:4(5S-OH,6E,8Z,11Z,14Z)); 5(S)-Hydroxyeicosatetraenoate; FA(20:4(5-OH,6E,8Z,11Z,14Z)); 5-Hydroxyeicosatetraenoate; 5-Hydroxyarachidonic acid; 5(S)-HETE; 5S-HETE; 5-Hete
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:28209
- KEGG: C04805
- PubChem: 5280733
- PubChem: 1771
- HMDB: HMDB0011134
- Metlin: METLIN45684
- ChEMBL: CHEMBL164813
- Wikipedia: 5-Hydroxyeicosatetraenoic_acid
- KNApSAcK: C00000423
- foodb: FDB001434
- chemspider: 4444314
- CAS: 70608-72-9
- MoNA: UT000174
- MoNA: UT000173
- MoNA: UT000177
- MoNA: UT000172
- MoNA: UT000178
- MoNA: UT000180
- MoNA: UT000175
- MoNA: UT000179
- MoNA: UT000176
- PMhub: MS000008762
- PubChem: 7367
- LipidMAPS: LMFA03060002
- 3DMET: B01791
- NIKKAJI: J390.336B
- RefMet: 5-HETE
- RefMet: 5S-HETE
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
53 个相关的代谢反应过程信息。
Reactome(5)
- Synthesis of 5-eicosatetraenoic acids:
5S-HpETE + GSH ⟶ 5S-HETE + GSSG + H2O
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Fatty acid metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Arachidonic acid metabolism:
H+ + e- + prostaglandin G2 ⟶ H2O + prostaglandin H2
BioCyc(0)
WikiPathways(2)
- Arachidonic acid (AA, ARA) oxylipin metabolism:
HXB3 ⟶ Trioxilin B3
- Eicosanoid synthesis:
PGD2 ⟶ PGJ2
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(46)
- Rofecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Diclofenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Sulindac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Celecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Ketorolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Suprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Bromfenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Indomethacin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Mefenamic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Oxaprozin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Nabumetone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Naproxen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Diflunisal Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Meloxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Valdecoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Antipyrine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Antrafenine Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Carprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Etoricoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Ibuprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Flurbiprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Magnesium Salicylate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Lumiracoxib Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Lornoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Phenylbutazone Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Nepafenac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Trisalicylate-Choline Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Tolmetin Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Tiaprofenic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Tenoxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Salsalate Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Salicylate-Sodium Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Salicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Arachidonic Acid Metabolism:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Fenoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Leukotriene C4 Synthesis Deficiency:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Piroxicam Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Acetylsalicylic Acid Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Etodolac Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Ketoprofen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
- Acetaminophen Action Pathway:
Glutathione + Leukotriene A4 ⟶ Leukotriene C4
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
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Journal of pharmacological sciences.
2021 Sep; 147(1):126-131. doi:
10.1016/j.jphs.2021.06.001
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Cancer medicine.
2021 08; 10(15):5246-5255. doi:
10.1002/cam4.4066
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Arthritis & rheumatology (Hoboken, N.J.).
2021 06; 73(6):955-962. doi:
10.1002/art.41631
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Biomolecules.
2021 01; 11(1):. doi:
10.3390/biom11010113
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Rheumatology (Oxford, England).
2020 11; 59(11):3515-3525. doi:
10.1093/rheumatology/keaa273
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Cells.
2020 09; 9(9):. doi:
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BMC nephrology.
2020 09; 21(1):394. doi:
10.1186/s12882-020-02053-8
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Nature chemical biology.
2020 07; 16(7):783-790. doi:
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Science signaling.
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Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
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Scientific reports.
2018 07; 8(1):10056. doi:
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Nutrition, metabolism, and cardiovascular diseases : NMCD.
2018 06; 28(6):575-581. doi:
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Prostaglandins & other lipid mediators.
2018 05; 136(?):1-8. doi:
10.1016/j.prostaglandins.2018.03.002
. [PMID: 29577973] - Charles Austin Pickens, Lorraine M Sordillo, Chen Zhang, Jenifer I Fenton. Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE).
Metabolism: clinical and experimental.
2017 05; 70(?):177-191. doi:
10.1016/j.metabol.2017.01.034
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Molecular nutrition & food research.
2017 02; 61(2):. doi:
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Vox sanguinis.
2017 Jan; 112(1):25-32. doi:
10.1111/vox.12453
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PloS one.
2017; 12(12):e0188621. doi:
10.1371/journal.pone.0188621
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Biochemical and biophysical research communications.
2016 09; 478(3):1338-43. doi:
10.1016/j.bbrc.2016.08.124
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Journal of pharmaceutical and biomedical analysis.
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. [PMID: 27262108] - William S Powell, Joshua Rokach. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Biochimica et biophysica acta.
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10.1016/j.bbalip.2014.10.008
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PloS one.
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Prostaglandins & other lipid mediators.
2012 Oct; 99(1-2):51-6. doi:
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Free radical biology & medicine.
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PloS one.
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Cancer prevention research (Philadelphia, Pa.).
2011 Nov; 4(11):1929-37. doi:
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The Journal of trauma.
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Lipids in health and disease.
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