Rufloxacin (BioDeep_00000003174)
Secondary id: BioDeep_00000406015
human metabolite
代谢物信息卡片
7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
化学式: C17H18FN3O3S (363.1053)
中文名称: 如氟沙星
谱图信息:
最多检出来源 Homo sapiens(not specific) 1.83%
分子结构信息
SMILES: CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1
InChI: InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
描述信息
Rufloxacin belongs to the family of Phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
Same as: D02474
同义名列表
10 个代谢物同义名
7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid; 9-Fluoro-10-(N-(4-methyl)piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido(1,2,3De)-1,4-benzothiazine-6-carboxylic acid; Rufloxacin monohydrochloride; Rufloxacin monohydrobromide; Rufloxacin hydrochloride; Rufloxacin hydrobromide; Rufloxacin; MF 934; Qari; Rufloxacin
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:8909
- KEGG: C11240
- PubChem: 58258
- HMDB: HMDB0042009
- Metlin: METLIN68935
- DrugBank: DB13772
- ChEMBL: CHEMBL295619
- Wikipedia: Rufloxacin
- chemspider: 52489
- CAS: 101363-10-4
- PMhub: MS000008386
- PubChem: 13419
- NIKKAJI: J365.971B
- RefMet: Rufloxacin
- KNApSAcK: 8909
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jian-Chun Xu, Qi-Ming Lu, Li-Jie Fu, Yu-Ping Chen. [Qianlie Jiedu capsule combined with rufloxacin for chronic prostatitis: a randomized double-blind controlled clinical trial].
Zhonghua nan ke xue = National journal of andrology.
2010 Feb; 16(2):183-6. doi:
. [PMID: 20369705] - Emilia Ghelardi, Arianna Tavanti, Paola Davini, Francesco Celandroni, Sara Salvetti, Eva Parisio, Enrico Boldrini, Sonia Senesi, Mario Campa. A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis.
Antimicrobial agents and chemotherapy.
2004 Sep; 48(9):3396-401. doi:
10.1128/aac.48.9.3396-3401.2004. [PMID: 15328102] - Tilman M Bauer, Antonio Follo, Miguel Navasa, Jordi Vila, Ramon Planas, Gerardo Clemente, Victor Vargas, Felipe Bory, Pere Vaquer, Juan Rodés. Daily norfloxacin is more effective than weekly rufloxacin in prevention of spontaneous bacterial peritonitis recurrence.
Digestive diseases and sciences.
2002 Jun; 47(6):1356-61. doi:
10.1023/a:1015386901343. [PMID: 12064813] - X Z Zhang, X G Pan, S D Luo, K Luo, X L Shen. [Determination of rufloxacin in human plasma by high performance liquid chromatography].
Se pu = Chinese journal of chromatography.
2000 Mar; 18(2):175-7. doi:
. [PMID: 12541603] - M V Moretti, S Pauluzzi, M Cesana. Penetration of rufloxacin into the cerebrospinal fluid in patients with inflamed and uninflamed meninges.
Antimicrobial agents and chemotherapy.
2000 Jan; 44(1):73-7. doi:
10.1128/aac.44.1.73-77.2000. [PMID: 10602726] - G Condorelli, G De Guidi, S Giuffrida, S Sortino, R Chillemi, S Sciuto. Molecular mechanisms of photosensitization induced by drugs. XII. Photochemistry and photosensitization of rufloxacin: an unusual photodegradation path for the antibacterials containing a fluoroquinolone-like chromophore.
Photochemistry and photobiology.
1999 Sep; 70(3):280-6. doi:
. [PMID: 10483356] - K G Naber, M Well, K Hollauer, D Kirchbauer, W Witte. In vitro activity of enoxacin versus ciprofloxacin, fleroxacin, lomefloxacin, ofloxacin, pefloxacin, and rufloxacin against uropathogens.
Chemotherapy.
1998 Mar; 44(2):77-84. doi:
10.1159/000007096. [PMID: 9551236] - L Aguilar, M J Giménez, J Costa, R Dal-Ré, J Prieto. Suspicion of quinolone active metabolite following discrepancy between predicted and experimental urine bactericidal activities.
Antimicrobial agents and chemotherapy.
1997 May; 41(5):927-30. doi:
10.1128/aac.41.5.927. [PMID: 9145846] - D D'Antonio, E Pizzigallo, A Lacone, B Violante, A Di Marzio, M Lombardo, G Fioritoni, T Staniscia, F Romano. The impact of rufloxacin given as prophylaxis to patients with cancer on their oral and faecal microflora.
The Journal of antimicrobial chemotherapy.
1996 Nov; 38(5):839-47. doi:
10.1093/jac/38.5.839. [PMID: 8961053] - G Carlucci, P Mazzeo, G Palumbo. Simultaneous determination of rufloxacin, fenbufen and felbinac in human plasma using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1996 Jul; 682(2):315-9. doi:
10.1016/0378-4347(96)00073-4. [PMID: 8844425] - G Carlucci, P Mazzeo. Simultaneous determination of furprofen and rufloxacin in human plasma by high-performance liquid chromatography.
Journal of chromatographic science.
1996 Apr; 34(4):182-4. doi:
10.1093/chromsci/34.4.182. [PMID: 8901133] - A Marchese, E A Debbia, A Pesce, G C Schito. Bactericidal activity, morphological alterations, and synergistic interactions of rufloxacin, a new fluoroquinolone, alone and in combination with its N-desmethylate D derivative (MF 922).
Chemotherapy.
1996 Mar; 42(2):90-9. doi:
10.1159/000239427. [PMID: 8697894] - G Del Río, F Dalet, L Aguilar, J Caffaratti, R Dal-Ré. Single-dose rufloxacin versus 3-day norfloxacin treatment of uncomplicated cystitis: clinical evaluation and pharmacodynamic considerations.
Antimicrobial agents and chemotherapy.
1996 Feb; 40(2):408-12. doi:
10.1128/aac.40.2.408. [PMID: 8834888] - L Aguilar, I P Balcabao, P Salvá, M Martín, J Costa, J Prieto, R Dal-ré. Ex vivo antibacterial properties of rufloxacin compared with those of norfloxacin in a study with healthy volunteers.
Antimicrobial agents and chemotherapy.
1996 Jan; 40(1):17-21. doi:
10.1128/aac.40.1.17. [PMID: 8787872] - G Carlucci, P Mazzeo, G Palumbo. Simultaneous determination of rufloxacin and theophylline by high-performance liquid chromatography in human plasma.
The Analyst.
1995 Oct; 120(10):2493-5. doi:
10.1039/an9952002493. [PMID: 8540619] - M R Gismondo, L Drago, A Lombardi, C Fassina, M Cesana. Impact of rufloxacin and ciprofloxacin on the intestinal microflora in a germ-free mice model.
Chemotherapy.
1995 Jul; 41(4):281-8. doi:
10.1159/000239357. [PMID: 7555209] - F Marco, M J Giménez, M T Jiménez de Anta, M A Marcos, P Salvá, L Aguilar. Comparison of rufloxacin and norfloxacin effects on faecal flora.
The Journal of antimicrobial chemotherapy.
1995 Jun; 35(6):895-901. doi:
10.1093/jac/35.6.895. [PMID: 7559202] - S Furlanetto, P Gratteri, S Pinzauti, R Leardi, E Dreassi, G Santoni. Design and optimization of the variables in the adsorptive stripping voltammetric determination of rufloxacin in tablets, human plasma and urine.
Journal of pharmaceutical and biomedical analysis.
1995 Apr; 13(4-5):431-8. doi:
10.1016/0731-7085(95)01288-v. [PMID: 9696553] - G Carlucci, P Mazzeo. Simultaneous determination of rufloxacin and furprofen in plasma by derivative UV-spectrophotometry.
Farmaco (Societa chimica italiana : 1989).
1994 Jul; 49(7-8):527-8. doi:
. [PMID: 7945721] - A De Sarro, D Ammendola, G De Sarro. Effects of some quinolones on imipenem-induced seizures in DBA/2 mice.
General pharmacology.
1994 Mar; 25(2):369-79. doi:
10.1016/0306-3623(94)90068-x. [PMID: 8026738] - R Wise, J Andrews, B P Imbimbo, I Greaves, D Honeybourne. The penetration of rufloxacin into sites of potential infection in the respiratory tract.
The Journal of antimicrobial chemotherapy.
1993 Dec; 32(6):861-6. doi:
10.1093/jac/32.6.861. [PMID: 8144426] - G Privitera, G Nicastro, B P Imbimbo, M Cesana, M Visconti, F Lombardi, G Tagliabue, E Faleschini, F Colturani, P Franzini. Biliary excretion of rufloxacin in humans.
Antimicrobial agents and chemotherapy.
1993 Dec; 37(12):2545-9. doi:
10.1128/aac.37.12.2545. [PMID: 8109915] - W Klietmann, M Cesana, R K Rondel, J Focht. Double-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpatients with exacerbations of chronic bronchitis.
Antimicrobial agents and chemotherapy.
1993 Nov; 37(11):2298-306. doi:
10.1128/aac.37.11.2298. [PMID: 8285609] - V Cecchetti, A Fravolini, P G Pagella, A Savino, O Tabarrini. Quinolinecarboxylic acids. 3. Synthesis and antibacterial evaluation of 2-substituted-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acids related to rufloxacin.
Journal of medicinal chemistry.
1993 Oct; 36(22):3449-54. doi:
10.1021/jm00074a028. [PMID: 8230136] - D R Triger, F Granai, J Woodcock, R Wise, B P Imbimbo. Multiple-dose pharmacokinetics of rufloxacin in patients with cirrhosis.
Hepatology (Baltimore, Md.).
1993 Oct; 18(4):847-52. doi:
10.1002/hep.1840180415. [PMID: 8406358] - G Perry, T G Mant, P J Morrison, S Sacks, J Woodcook, R Wise, B P Imbimbo. Pharmacokinetics of rufloxacin in patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1993 Apr; 37(4):637-41. doi:
10.1128/aac.37.4.637. [PMID: 8388194] - L Bonina, M Carbone, P Mastroeni, G B Costa, P Mastroeni. Effects of rufloxacin in Salmonella typhimurium infection in mice.
Journal of chemotherapy (Florence, Italy).
1992 Dec; 4(6):353-7. doi:
10.1080/1120009x.1992.11739191. [PMID: 1337552] - R Wise, J M Andrews, R Matthews, M Wolstenholme. The in-vitro activity of two new quinolones: rufloxacin and MF 961.
The Journal of antimicrobial chemotherapy.
1992 Jun; 29(6):649-60. doi:
10.1093/jac/29.6.649. [PMID: 1324239] - S Gollapudi, V Perumal, H Thadepalli. Effect of rufloxacin on in-vitro proliferation and differentiation of human mononuclear cells.
The Journal of antimicrobial chemotherapy.
1992 Jun; 29(6):669-76. doi:
10.1093/jac/29.6.669. [PMID: 1324240] - J C Kisicki, R S Griess, C L Ott, G M Cohen, R J McCormack, W M Troetel, B P Imbimbo. Multiple-dose pharmacokinetics and safety of rufloxacin in normal volunteers.
Antimicrobial agents and chemotherapy.
1992 Jun; 36(6):1296-301. doi:
10.1128/aac.36.6.1296. [PMID: 1329618] - P Nucci, N Lombardo, F Cremonesi, M P Manitto, R Brancato, M Ghione. Ocular pharmacokinetics of rufloxacin a new fluoroquinolone antibiotic.
La Clinica terapeutica.
1992 Jun; 140(6):563-7. doi:
. [PMID: 1322259] - F Lombardi, R Ardemagni, V Colzani, M Visconti. High-performance liquid chromatographic determination of rufloxacin and its main active metabolite in biological fluids.
Journal of chromatography.
1992 Apr; 576(1):129-34. doi:
10.1016/0378-4347(92)80183-q. [PMID: 1323570] - R Rimoldi, M Fioretti, A Albrici, B P Imbimbo. Pharmacokinetics of rufloxacin once daily in patients with lower respiratory tract infections.
Infection.
1992 Mar; 20(2):89-93. doi:
10.1007/bf01711071. [PMID: 1316313] - R Cogo, R Rimoldi, R Mattina, B P Imbimbo. Steady-state pharmacokinetics of rufloxacin in elderly patients with lower respiratory tract infections.
Therapeutic drug monitoring.
1992 Feb; 14(1):36-41. doi:
10.1097/00007691-199202000-00006. [PMID: 1312263] - T B Vree, M van den Biggelaar-Martea, A Peeters, B P Imbimbo. High-performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites, N-desmethylrufloxacin and rufloxacinsulfoxide, in urine of rhesus monkey Macaca mulatta.
Journal of chromatography.
1992 Jan; 573(1):168-72. doi:
10.1016/0378-4347(92)80493-a. [PMID: 1314258] - G Segre, D Cerretani, L Moltoni, R Urso. Pharmacokinetics of rufloxacin in healthy volunteers.
European journal of clinical pharmacology.
1992; 42(1):101-5. doi:
10.1007/bf00314928. [PMID: 1311685] - T B Vree, M van den Biggelaar-Martea, B P Imbimbo. High performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites N-desmethylrufloxacin and rufloxacinsulfoxide in plasma and urine of humans.
European journal of drug metabolism and pharmacokinetics.
1992 Jan; 17(1):45-9. doi:
10.1007/bf03189987. [PMID: 1323466] - R Wise, J Johnson, N O'Sullivan, J M Andrews, B P Imbimbo. Pharmacokinetics and tissue penetration of rufloxacin, a long acting quinolone antimicrobial agent.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28(6):905-9. doi:
10.1093/jac/28.6.905. [PMID: 1667783] - J B Boerema, D Bach, C Jol, W Pahlmann. Penetration of rufloxacin into human prostatic tissue and fluid.
The Journal of antimicrobial chemotherapy.
1991 Oct; 28(4):547-54. doi:
10.1093/jac/28.4.547. [PMID: 1662190] - J B Boerema, W Bischoff, J Focht, K G Naber. An open multicentre study on the efficacy and safety of rufloxacin in patients with chronic bacterial prostatitis.
The Journal of antimicrobial chemotherapy.
1991 Oct; 28(4):587-97. doi:
10.1093/jac/28.4.587. [PMID: 1662192] - G Carlucci, P Mazzeo, D Fanini, G Palumbo. Determination of rufloxacin, a new tricyclic fluoroquinolone in biological fluids using high-performance liquid chromatography with ultraviolet detection.
Therapeutic drug monitoring.
1991 Sep; 13(5):448-51. doi:
10.1097/00007691-199109000-00010. [PMID: 1659757] - M Dirksen, J Focht, J Boerema. Rufloxacin once daily in acute exacerbations of chronic bronchitis.
Infection.
1991 Jul; 19(4):297-300. doi:
10.1007/bf01644971. [PMID: 1917050] - M Cesana, G Broccali, B P Imbimbo, A Crema. Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration.
International journal of clinical pharmacology, therapy, and toxicology.
1991 Apr; 29(4):133-8. doi:
. [PMID: 2071262] - G Carlucci, G Palumbo. Analytical procedure for the determination of rufloxacin, a new pyridobenzothiazine, in human serum and urine by high-performance liquid chromatography.
Journal of chromatography.
1991 Mar; 564(1):346-51. doi:
10.1016/0378-4347(91)80101-h. [PMID: 1860932] - B P Imbimbo, G Broccali, M Cesana, F Crema, G Attardo-Parrinello. Inter- and intrasubject variabilities in the pharmacokinetics of rufloxacin after single oral administration to healthy volunteers.
Antimicrobial agents and chemotherapy.
1991 Feb; 35(2):390-3. doi:
10.1128/aac.35.2.390. [PMID: 2024974] - R Mattina, G Bonfiglio, C E Cocuzza, G Gulisano, M Cesana, B P Imbimbo. Pharmacokinetics of rufloxacin in healthy volunteers after repeated oral doses.
Chemotherapy.
1991; 37(6):389-97. doi:
10.1159/000238885. [PMID: 1662127] - G Segre, D Cerretani, L Moltoni, R Urso. [Renal clearance of rufloxacin in the healthy volunteer].
Giornale italiano di chemioterapia.
1991 Jan; 38(1-3):123-6. doi:
NULL. [PMID: 1365563] - G Carlucci, D Fanini, G C Pantaleoni, G Palumbo. Rufloxacin, a new fluoroquinolone in biological fluids by high-performance liquid chromatography.
Acta physiologica Hungarica.
1990; 75 Suppl(?):49-50. doi:
NULL. [PMID: 2371900] - G Ravizzola, G Pinsi, F Pirali, D Colombrita, I Foresti, L Peroni, A Turano. Rufloxacin (MF-934): in vitro and in vivo antibacterial activity.
Drugs under experimental and clinical research.
1989; 15(1):11-5. doi:
. [PMID: 2743869] - A Farina. Fluorimetric assay of rufloxacin in serum and in pharmaceutical formulations.
Journal of pharmaceutical and biomedical analysis.
1989; 7(12):1579-83. doi:
10.1016/0731-7085(89)80168-2. [PMID: 2490546] - G Segre, D Cerretani, D Cerri, L Moltoni. A new tricyclic fluoroquinolone, rufloxacin (MF-934), with interesting antibacterial and pharmacokinetic characteristics.
Drugs under experimental and clinical research.
1988; 14(12):747-54. doi:
NULL. [PMID: 3253051]
