Fluperlapine (BioDeep_00000003126)

 

Secondary id: BioDeep_00000405823

human metabolite blood metabolite


代谢物信息卡片


6-fluoro-10-(4-methylpiperazin-1-yl)-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,9,11,13-heptaene

化学式: C19H20FN3 (309.1641)
中文名称: 氟扑来平
谱图信息: 最多检出来源 Homo sapiens(blood) 62.99%

分子结构信息

SMILES: CN1CCN(C2=Nc3cc(F)ccc3Cc3ccccc32)CC1
InChI: InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist

同义名列表

4 个代谢物同义名

6-fluoro-10-(4-methylpiperazin-1-yl)-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,9,11,13-heptaene; 3-fluoro-6-(4-Methylpiperazinyl)-11H-dibenz(b,e)azepine; FLUPERLAPINE; Fluperlapine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ADRA1A, CASP1, SLC6A3
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 2 DRD1, GABBR1
Nucleus 5 ADRA1A, DRD1, FOS, MPO, NCL
cytosol 3 ADRA1A, CASP1, FOS
dendrite 3 DRD2, HTR2C, HTR7
mitochondrial membrane 1 GABBR1
nucleoplasm 4 ADRA1A, FOS, MPO, NCL
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 13 ADRA1A, CASP1, DRD1, DRD2, GABBR1, GRID1, HTR2C, HTR7, ITPRIP, SLC6A2, SLC6A3, SLC6A4, TNF
Cell projection, axon 1 SLC6A3
Multi-pass membrane protein 10 ADRA1A, DRD1, DRD2, GABBR1, GRID1, HTR2C, HTR7, SLC6A2, SLC6A3, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 4 DRD2, HTR2C, HTR7, SLC6A4
cell cortex 1 NCL
cell surface 3 SLC6A2, SLC6A3, TNF
dendritic shaft 1 GABBR1
glutamatergic synapse 5 DRD1, DRD2, GABBR1, GRID1, ICAM5
Golgi membrane 1 DRD2
neuronal cell body 3 GABBR1, SLC6A3, TNF
postsynapse 1 ICAM5
presynaptic membrane 6 DRD1, DRD2, GABBR1, SLC6A2, SLC6A3, SLC6A4
synaptic vesicle 1 GABBR1
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 1 MPO
Presynapse 1 SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 15 ADRA1A, CASP1, DRD1, DRD2, GABBR1, GRID1, HTR2C, HTR7, ICAM5, ITPRIP, NCL, SLC6A2, SLC6A3, SLC6A4, TNF
synaptic vesicle membrane 2 DRD2, SLC6A2
Membrane 7 GABBR1, ICAM5, ITPRIP, NCL, SLC6A2, SLC6A3, SLC6A4
axon 3 DRD2, SLC6A2, SLC6A3
caveola 1 ADRA1A
extracellular exosome 3 GRID1, MPO, NCL
endoplasmic reticulum 1 FOS
extracellular space 4 CXCL1, GABBR1, MPO, TNF
Schaffer collateral - CA1 synapse 1 GABBR1
protein-containing complex 1 CASP1
intracellular membrane-bounded organelle 3 ADRA1A, MPO, NTS
Single-pass type I membrane protein 2 ICAM5, ITPRIP
Secreted 1 NTS
extracellular region 4 CXCL1, MPO, NTS, TNF
neuronal cell body membrane 2 SLC6A2, SLC6A3
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
external side of plasma membrane 1 TNF
dendritic spine 3 DRD1, DRD2, GABBR1
perikaryon 1 DRD2
nucleolus 2 CASP1, NCL
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 6 DRD1, DRD2, GABBR1, GRID1, SLC6A3, SLC6A4
Membrane raft 3 SLC6A3, SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
microtubule 1 CASP1
axolemma 1 GABBR1
G protein-coupled GABA receptor complex 1 GABBR1
GABA-ergic synapse 4 DRD1, DRD2, GABBR1, GRID1
flotillin complex 1 SLC6A3
Cell projection, dendritic spine 1 DRD1
secretory granule 1 MPO
lateral plasma membrane 1 DRD2
NLRP3 inflammasome complex 1 CASP1
Nucleus outer membrane 1 ITPRIP
nuclear outer membrane 1 ITPRIP
Postsynaptic cell membrane 2 GABBR1, GRID1
Cell projection, neuron projection 2 SLC6A3, SLC6A4
neuron projection 2 SLC6A3, SLC6A4
cilium 2 DRD1, DRD2
chromatin 1 FOS
phagocytic cup 1 TNF
Chromosome 1 NCL
cytoplasmic ribonucleoprotein granule 1 NCL
Nucleus, nucleolus 1 NCL
non-motile cilium 2 DRD1, DRD2
spliceosomal complex 1 NCL
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
Membrane, caveola 1 ADRA1A
Cornified envelope 1 NCL
Cell projection, dendrite 2 DRD1, GABBR1
azurophil granule 1 MPO
trans-Golgi network membrane 1 HTR7
nuclear matrix 1 FOS
axon terminus 3 DRD2, NTS, SLC6A3
specific granule lumen 1 CXCL1
tertiary granule lumen 1 CXCL1
endocytic vesicle 1 DRD2
transport vesicle 1 NTS
azurophil granule lumen 1 MPO
postsynaptic density membrane 1 GRID1
AIM2 inflammasome complex 1 CASP1
phagocytic vesicle lumen 1 MPO
ribonucleoprotein complex 1 NCL
protein-DNA complex 1 FOS
canonical inflammasome complex 1 CASP1
dopaminergic synapse 2 DRD2, SLC6A3
Cell projection, cilium membrane 1 DRD1
G protein-coupled receptor heterodimeric complex 1 GABBR1
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
G protein-coupled receptor complex 2 DRD1, DRD2
macropinosome membrane 1 NCL
G protein-coupled serotonin receptor complex 1 HTR2C
serotonergic synapse 1 SLC6A4
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • M Tatsumi, K Jansen, R D Blakely, E Richelson. Pharmacological profile of neuroleptics at human monoamine transporters. European journal of pharmacology. 1999 Mar; 368(2-3):277-83. doi: 10.1016/s0014-2999(99)00005-9. [PMID: 10193665]
  • A R Takacs. Ancillary approaches to toxicokinetic evaluations. Toxicologic pathology. 1995 Mar; 23(2):179-86. doi: 10.1177/019262339502300212. [PMID: 7569673]
  • V Fischer, B Vogels, G Maurer, R E Tynes. The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6. The Journal of pharmacology and experimental therapeutics. 1992 Mar; 260(3):1355-60. doi: . [PMID: 1545398]
  • J G Dain, J M Jaffe. Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1988 Mar; 16(2):238-42. doi: . [PMID: 2898340]
  • K H Schellenberg, M Linder, A Groeppelin, F Erni. Experience with routine applications of liquid chromatography-mass spectrometry in the pharmaceutical industry. Journal of chromatography. 1987 May; 394(1):239-51. doi: 10.1016/s0021-9673(01)94176-7. [PMID: 3597621]
  • G Ferber, M Matejcek, E Krebs, R Friedmann. Investigation of the effect of fluperlapine on the EEG in schizophrenic patients. Neuropsychobiology. 1987; 18(1):43-50. doi: 10.1159/000118391. [PMID: 2895433]
  • G A Gudelsky, J I Koenig, M Simonovic, T Koyama, T Ohmori, H Y Meltzer. Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat. Journal of neural transmission. 1987; 68(3-4):227-40. doi: 10.1007/bf02098500. [PMID: 3104536]
  • W W Fleischhacker, C Stuppäck, C Moser, H Schubert, H Hinterhuber. Fluperlapine vs haloperidol: a comparison of their neuroendocrinological profiles and the influence on serum lipids. Pharmacopsychiatry. 1986 May; 19(3):111-4. doi: 10.1055/s-2007-1017166. [PMID: 2873601]