Cefdinir (BioDeep_00000003108)
Secondary id: BioDeep_00000398928
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C14H13N5O5S2 (395.0358)
中文名称: 头孢地尼
谱图信息:
最多检出来源 Homo sapiens(blood) 61.14%
分子结构信息
SMILES: C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NO)c3csc(=N)[nH]3)C2SC1
InChI: InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
描述信息
Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
16 个代谢物同义名
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R,Z)-7-(2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R,Z)-7-(2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-(2 (2-Aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid; Abbott brand OF cefdinir; Cefdinirum; Cefdirnir; Cefdinyl; cefdinir; Omnicef; Cefzon; CFDN; Cefdinir
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:3485
- KEGG: C08110
- KEGGdrug: D00917
- PubChem: 6915944
- PubChem: 6803597
- HMDB: HMDB0014675
- Metlin: METLIN44426
- DrugBank: DB00535
- ChEMBL: CHEMBL927
- Wikipedia: Cefdinir
- MeSH: Cefdinir
- chemspider: 5291705
- CAS: 91832-40-5
- PMhub: MS000008090
- PubChem: 10310
- NIKKAJI: J227.563E
- RefMet: Cefdinir
- KNApSAcK: 3485
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Khalid Eljaaly, Samah Alshehri. Cefdinir-induced red stool and purple discoloration of nutritional formula: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Feb; 26(2):286-288. doi:
10.1016/j.jiac.2019.08.014. [PMID: 31548123] - Hiroyo Hashimoto, Hideaki Miyachi, Koki Kataoka, Yugo Maru, Yaei Togawa, Hiroyuki Matsue. Case of fertility treatment-induced Stevens-Johnson syndrome with a severe ocular complication.
The Journal of dermatology.
2019 Nov; 46(11):1042-1045. doi:
10.1111/1346-8138.15072. [PMID: 31489686] - Shaylyn Vogler, Emily Pavich. Pyelonephritis treatment in the community emergency department: Cephalosporins vs. first-line agents.
The American journal of emergency medicine.
2018 11; 36(11):2054-2057. doi:
10.1016/j.ajem.2018.08.016. [PMID: 30119986] - Hepeng Wang, Pengyuan Sun, Changyuan Wang, Qiang Meng, Zhihao Liu, Xiaokui Huo, Huijun Sun, Xiaodong Ma, Jinyong Peng, Kexin Liu. Pharmacokinetic changes of cefdinir and cefditoren and its molecular mechanisms in acute kidney injury in rats.
The Journal of pharmacy and pharmacology.
2018 Nov; 70(11):1503-1512. doi:
10.1111/jphp.12994. [PMID: 30047127] - Meryl Perlman, Harland Winter. Do Not Always Reach for the Scope When You See Red.
Journal of pediatric gastroenterology and nutrition.
2018 Sep; 67(3):e64. doi:
10.1097/mpg.0000000000002055. [PMID: 29901553] - Xiaoya Zhao, Zhenzuo Jiang, Fan Yang, Yan Wang, Xiumei Gao, Yuefei Wang, Xin Chai, Guixiang Pan, Yan Zhu. Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids.
PloS one.
2016; 11(12):e0167032. doi:
10.1371/journal.pone.0167032. [PMID: 27907030] - Zhao Chen, Xiaoli Bi, Ji Li, Yuanjun Tang, Guorong Fan, Dongmei Sun. Application and optimization of organic-inorganic hybrid monolithic capillary electrochromatography for in vivo cefdinir determination with microdialysis.
Journal of separation science.
2016 Jan; 39(2):440-9. doi:
10.1002/jssc.201500817. [PMID: 26549514] - Li Liu, Feixiang Cheng. [Analysis of the interaction between cefdinir and bovine serum albumin by spectrometry].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2015 Sep; 40(9):979-86. doi:
10.11817/j.issn.1672-7347.2015.09.006. [PMID: 26408617] - Yu Chul Kim, In-Bong Kim, Chi-Kyoung Noh, Holly P Quach, In-Soo Yoon, Edwin C Y Chow, Myungsoo Kim, Hyo-Eon Jin, Kwan Hyung Cho, Suk-Jae Chung, K Sandy Pang, Han-Joo Maeng. Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.
Journal of pharmaceutical sciences.
2014 Nov; 103(11):3793-3805. doi:
10.1002/jps.24195. [PMID: 25266751] - Prasant Kumar Jena, Shilpa Singh, Bhumika Prajapati, G Nareshkumar, Tejal Mehta, Sriram Seshadri. Impact of targeted specific antibiotic delivery for gut microbiota modulation on high-fructose-fed rats.
Applied biochemistry and biotechnology.
2014 Apr; 172(8):3810-26. doi:
10.1007/s12010-014-0772-y. [PMID: 24574250] - Hyo-Eon Jin, In-Bong Kim, Chong-Kook Kim, Han-Joo Maeng. Determination of cefdinir levels in rat plasma and urine by high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics after oral and intravenous administration of cefdinir.
Biomedical chromatography : BMC.
2013 Nov; 27(11):1423-30. doi:
10.1002/bmc.2938. [PMID: 23712418] - Ji Li, Li Wang, Zhao Chen, Rui Xie, You Li, Taijun Hang, Guorong Fan. Development and validation of a rapid HPLC method for the determination of cefdinir in beagle dog plasma integrated with an automatic on-line solid-phase extraction following protein precipitation in the 96-well plate format.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 895-896(?):83-8. doi:
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Arzneimittel-Forschung.
2012 Jan; 62(1):9-13. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(24):2423-9. doi:
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Pediatrics international : official journal of the Japan Pediatric Society.
2011 Feb; 53(1):57-61. doi:
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Annals of emergency medicine.
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2008 Aug; 27(8):679-83. doi:
10.1007/s10096-008-0493-7. [PMID: 18299905] - Jason Lancaster, Lynne M Sylvia, Elisabeth Schainker. Nonbloody, red stools from coadministration of cefdinir and iron-supplemented infant formulas.
Pharmacotherapy.
2008 May; 28(5):678-81. doi:
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Journal of clinical pharmacy and therapeutics.
2007 Jun; 32(3):277-85. doi:
10.1111/j.1365-2710.2007.00826.x. [PMID: 17489880] - James A Karlowsky, Daryl J Hoban, Melanie R Decorby, Nancy M Laing, George G Zhanel. Fluoroquinolone-resistant urinary isolates of Escherichia coli from outpatients are frequently multidrug resistant: results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance study.
Antimicrobial agents and chemotherapy.
2006 Jun; 50(6):2251-4. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 834(1-2):163-9. doi:
10.1016/j.jchromb.2006.02.047. [PMID: 16531128] - Karen L Bowlware, George H McCracken, Juanita Lozano-Hernandez, Faryal Ghaffar. Cefdinir pharmacokinetics and tolerability in children receiving 25 mg/kg once daily.
The Pediatric infectious disease journal.
2006 Mar; 25(3):208-10. doi:
10.1097/01.inf.0000202210.22512.88. [PMID: 16511381] - Bema K Bonsu, Lori Shuler, Laura Sawicki, Pam Dorst, Daniel M Cohen. Susceptibility of recent bacterial isolates to cefdinir and selected antibiotics among children with urinary tract infections.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2006 Jan; 13(1):76-81. doi:
10.1197/j.aem.2005.07.032. [PMID: 16365328] - Ronald J Sawchuk, Belinda W Y Cheung, Ping Ji, Linda L Cartier. Microdialysis studies of the distribution of antibiotics into chinchilla middle ear fluid.
Pharmacotherapy.
2005 Dec; 25(12 Pt 2):140S-145S. doi:
10.1592/phco.2005.25.12part2.140s. [PMID: 16305284] - Yong-hong Xiao, Lei Gao, Yun Li, Yuan Lü, Jian Liu, Yan Liu. [Comparison of pharmacokinetics/pharmacodynamics of cefdinir, cefpodoxime proxetil and cefaclor against common bacteria of community acquired infections].
Zhonghua yi xue za zhi.
2004 Nov; 84(22):1867-71. doi:
. [PMID: 15631795] - Christopher S Lepsy, Robert J Guttendorf, Alan R Kugler, David E Smith. Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney.
Antimicrobial agents and chemotherapy.
2003 Feb; 47(2):689-96. doi:
10.1128/aac.47.2.689-696.2003. [PMID: 12543679] - David R P Guay. Cefdinir: an advanced-generation, broad-spectrum oral cephalosporin.
Clinical therapeutics.
2002 Apr; 24(4):473-89. doi:
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Drug metabolism and pharmacokinetics.
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The Journal of antimicrobial chemotherapy.
2001 Oct; 48(4):487-91. doi:
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The Journal of toxicological sciences.
2001 May; 26 Suppl 1(?):77-108. doi:
NULL. [PMID: 11400319] - Y Kimura, M Kawamura, M Owada, T Fujiwara, C Maesawa, K Hiramori. Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure.
Internal medicine (Tokyo, Japan).
2001 Feb; 40(2):114-7. doi:
10.2169/internalmedicine.40.114. [PMID: 11300142] - A P Leigh, M A Nemeth, C H Keyserling, L H Hotary, K J Tack. Cefdinir versus cefaclor in the treatment of uncomplicated urinary tract infection.
Clinical therapeutics.
2000 Jul; 22(7):818-25. doi:
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The Journal of pediatrics.
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The Journal of biological chemistry.
2000 Jan; 275(3):1699-707. doi:
10.1074/jbc.275.3.1699. [PMID: 10636865] - Y Tomino, M Fukui, C Hamada, S Inoue, S Osada. Pharmacokinetics of cefdinir and its transfer to dialysate in patients with chronic renal failure undergoing continuous ambulatory peritoneal dialysis.
Arzneimittel-Forschung.
1998 Aug; 48(8):862-7. doi:
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Antimicrobial agents and chemotherapy.
1998 Jul; 42(7):1718-21. doi:
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The American journal of physiology.
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Biochimica et biophysica acta.
1997 Mar; 1324(2):296-308. doi:
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Journal of pharmaceutical sciences.
1996 Sep; 85(9):984-9. doi:
10.1021/js950447j. [PMID: 8877891] - A Jacolot, M Tod, O Petitjean. Pharmacokinetic interaction between cefdinir and two angiotensin-converting enzyme inhibitors in rats.
Antimicrobial agents and chemotherapy.
1996 Apr; 40(4):979-82. doi:
10.1128/aac.40.4.979. [PMID: 8849263] - P J Cook, J M Andrews, R Wise, D Honeybourne. Distribution of cefdinir, a third generation cephalosporin antibiotic, in serum and pulmonary compartments.
The Journal of antimicrobial chemotherapy.
1996 Feb; 37(2):331-9. doi:
10.1093/jac/37.2.331. [PMID: 8707743] - M Richer, S Allard, L Manseau, F Vallée, R Pak, M LeBel. Suction-induced blister fluid penetration of cefdinir in healthy volunteers following ascending oral doses.
Antimicrobial agents and chemotherapy.
1995 May; 39(5):1082-6. doi:
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The Journal of antimicrobial chemotherapy.
1995 Jan; 35(1):53-66. doi:
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1993 Sep; 113(9):605-26. doi:
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The Japanese journal of antibiotics.
1993 Apr; 46(4):323-30. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
1993 Mar; 12(3):170-6. doi:
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Drugs under experimental and clinical research.
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The Japanese journal of antibiotics.
1992 Aug; 45(8):909-25. doi:
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The Japanese journal of antibiotics.
1992 Jan; 45(1):12-27. doi:
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The Japanese journal of antibiotics.
1992 Jan; 45(1):28-47. doi:
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The Japanese journal of antibiotics.
1992 Jan; 45(1):74-86. doi:
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The Japanese journal of antibiotics.
1991 Oct; 44(10):1158-67. doi:
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The Japanese journal of antibiotics.
1991 Oct; 44(10):1134-41. doi:
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The Japanese journal of antibiotics.
1991 Oct; 44(10):1142-57. doi:
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The Japanese journal of antibiotics.
1991 Oct; 44(10):1083-6. doi:
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The Japanese journal of antibiotics.
1991 Oct; 44(10):1119-33. doi:
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The Japanese journal of antibiotics.
1990 Oct; 43(10):1789-95. doi:
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The Japanese journal of antibiotics.
1990 Oct; 43(10):1783-8. doi:
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The Japanese journal of antibiotics.
1990 Oct; 43(10):1813-35. doi:
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The Japanese journal of antibiotics.
1990 Oct; 43(10):1806-12. doi:
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The Japanese journal of antibiotics.
1990 Aug; 43(8):1450-61. doi:
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The Japanese journal of antibiotics.
1990 Aug; 43(8):1407-13. doi:
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The Japanese journal of antibiotics.
1990 Aug; 43(8):1468-75. doi:
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