Ginsenoside Rg1 (BioDeep_00000304273)

Main id: BioDeep_00000000155

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(20E)-Ginsenoside F4

化学式: C42H72O14 (800.4922)
中文名称: 人参皂甙 Rg1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C6)(C32C)([H])C(C(C)(C4(C(O)6)[H])CCC(C(OC(C(O)5)OC(CO)C(C5O)O)(C)CCC=C(C)C)([H])4)(CC(C2(C(C(CC3)O)(C)C)[H])OC([H])(O1)C(C(O)C(O)C(CO)1)O)C
InChI: InChI=1S/C42H70O12/c1-20(2)11-10-12-21(3)23-13-16-41(8)29(23)24(44)17-27-40(7)15-14-28(45)39(5,6)36(40)25(18-42(27,41)9)52-38-35(33(49)31(47)26(19-43)53-38)54-37-34(50)32(48)30(46)22(4)51-37/h11-12,22-38,43-50H,10,13-19H2,1-9H3/b21-12+

描述信息

Isolated from ginseng. (20E)-Ginsenoside F4 is found in tea.
D002491 - Central Nervous System Agents
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

同义名列表

5 个代谢物同义名

(20E)-Ginsenoside F4; Ginsenoside Rg1; Panaxoside A; Panaxoside Rg1; Ginsenoside Rg1



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANG, BDNF, CA1, CASP3, CDKN2A, MAPK8, MTOR, NFE2L2, PIK3C3, PINK1, PRKAA2, RB1, SIRT1, TLR4, VEGFA
Peripheral membrane protein 1 MTOR
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 HMOX1, MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 13 ANG, CASP3, CDKN2A, HMOX1, MAPK8, MTOR, NFE2L2, PINK1, PRKAA2, RB1, RBL2, SIRT1, VEGFA
autophagosome 1 PIK3C3
cytosol 14 ANG, CA1, CASP3, CDKN2A, HMOX1, MAPK8, MTOR, NFE2L2, PIK3C3, PINK1, PRKAA2, RB1, RBL2, SIRT1
dendrite 3 BDNF, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 NFE2L2
nucleoplasm 10 CASP3, CDKN2A, HMOX1, MAPK8, MTOR, NFE2L2, PRKAA2, RB1, RBL2, SIRT1
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 1 TLR4
Cytoplasmic side 2 HMOX1, MTOR
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell surface 2 TLR4, VEGFA
glutamatergic synapse 2 CASP3, PIK3C3
Golgi apparatus 3 NFE2L2, PRKAA2, VEGFA
Golgi membrane 2 INS, MTOR
growth cone 2 ANG, PINK1
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 PINK1
neuronal cell body 3 ANG, CASP3, PRKAA2
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 NFE2L2, PINK1
Lysosome 1 MTOR
endosome 1 PIK3C3
plasma membrane 2 NFE2L2, TLR4
Membrane 8 BDNF, HMOX1, MTOR, PIK3C3, PINK1, PRKAA2, TLR4, VEGFA
axon 4 BDNF, MAPK8, PINK1, PRKAA2
extracellular exosome 2 CA1, RBL2
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 HMOX1, PINK1, VEGFA
extracellular space 7 ANG, BDNF, CCL2, HMOX1, IL10, INS, VEGFA
perinuclear region of cytoplasm 4 BDNF, HMOX1, PINK1, TLR4
adherens junction 1 VEGFA
mitochondrion 3 CDKN2A, PINK1, SIRT1
protein-containing complex 1 CDKN2A
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 6 ANG, BDNF, CCL2, IL10, INS, VEGFA
extracellular region 6 ANG, BDNF, CCL2, IL10, INS, VEGFA
Mitochondrion outer membrane 2 MTOR, PINK1
Single-pass membrane protein 1 PINK1
mitochondrial outer membrane 3 HMOX1, MTOR, PINK1
mitochondrial matrix 1 CDKN2A
transcription regulator complex 1 RBL2
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 4 ANG, CDKN2A, RBL2, SIRT1
midbody 1 PIK3C3
Early endosome 1 TLR4
Mitochondrion inner membrane 1 PINK1
heterochromatin 1 SIRT1
spindle 1 RB1
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 1 PIK3C3
basement membrane 1 ANG
Nucleus, PML body 2 MTOR, SIRT1
PML body 3 MTOR, RB1, SIRT1
mitochondrial intermembrane space 1 PINK1
secretory granule 1 VEGFA
axoneme 1 PIK3C3
nuclear speck 1 PRKAA2
nuclear inner membrane 1 SIRT1
Cell projection, ruffle 1 TLR4
Late endosome 1 PIK3C3
ruffle 1 TLR4
receptor complex 1 TLR4
chromatin 5 NFE2L2, PINK1, RB1, RBL2, SIRT1
mediator complex 1 NFE2L2
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 PIK3C3
Chromosome 2 ANG, RBL2
cytoskeleton 1 PINK1
Nucleus, nucleolus 2 ANG, CDKN2A
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 1 MTOR
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Nucleus, nucleoplasm 1 CDKN2A
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 SIRT1
cell body 1 PINK1
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BDNF, INS
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
SWI/SNF complex 1 RB1
presynaptic endosome 1 PIK3C3
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
Lewy body 1 PINK1
Cytoplasmic vesicle, phagosome 1 MTOR
postsynaptic endosome 1 PIK3C3
astrocyte projection 1 PINK1
Autolysosome 1 PIK3C3
angiogenin-PRI complex 1 ANG
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
senescence-associated heterochromatin focus 1 CDKN2A
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
[Isoform smARF]: Mitochondrion 1 CDKN2A
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Liangliang Kong, Yan Liu, Jingwei Li, Yanyan Wang, Pengmin Ji, Qifeng Shi, Min Han, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway. Journal of ethnopharmacology. 2024 Aug; 330(?):118205. doi: 10.1016/j.jep.2024.118205. [PMID: 38641079]
  • Hui Liu, Xiao-Qian Wu, Xiang-Ling Qin, Jin-Hao Zhu, Jin-Di Xu, Shan-Shan Zhou, Ming Kong, Hong Shen, Jie-Ge Huo, Song-Lin Li, He Zhu. Metals/bisulfite system involved generation of 24-sulfonic-25-ene ginsenoside Rg1, a potential quality control marker for sulfur-fumigated ginseng. Food chemistry. 2024 Aug; 448(?):139112. doi: 10.1016/j.foodchem.2024.139112. [PMID: 38569404]
  • Ruiqi Liu, Bin Zhang, Shuting Zou, Li Cui, Lin Lin, Lingchang Li. Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway. Journal of microbiology and biotechnology. 2024 Apr; 34(4):774-782. doi: 10.4014/jmb.2310.10043. [PMID: 38668684]
  • Baoyu Fu, Rui Ma, Fangbing Liu, Xuenan Chen, Manying Wang, Wenqi Jin, Shuai Zhang, Yanping Wang, Liwei Sun. New insights into ginsenoside Rg1 regulating the niche to inhibit age-induced germline stem cells depletion through targeting ECR/BMP signaling pathway in Drosophila. Aging. 2024 Feb; 16(4):3612-3630. doi: 10.18632/aging.205548. [PMID: 38364249]
  • Zhongjing Jiang, Linhua Deng, Mengjun Li, Emmanuel Alonge, Yanling Wang, Yunjia Wang. Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155284. doi: 10.1016/j.phymed.2023.155284. [PMID: 38176267]
  • Ning Jiang, Caihong Yao, Yiwen Zhang, Xinran Sun, M Iqbal Choudhary, Xinmin Liu. Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway. Journal of agricultural and food chemistry. 2024 Jan; 72(4):2362-2373. doi: 10.1021/acs.jafc.3c04618. [PMID: 38236060]
  • Huimin Zhou, Yan Liu, Yong Su, Pengmin Ji, Liangliang Kong, Ran Sun, Duoduo Zhang, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells. Journal of ethnopharmacology. 2024 Jan; 324(?):117794. doi: 10.1016/j.jep.2024.117794. [PMID: 38244950]
  • Junpeng Long, Yang Sun, Shasha Liu, Chen Chen, Qian Yan, Yuting Lin, Zhao Zhang, Shifeng Chu, Yantao Yang, Songwei Yang, Meiyu Lin, Xuan Liu, Jinping Liang, Naihong Chen, Qidi Ai. Ginsenoside Rg1 treats ischemic stroke by regulating CKLF1/CCR5 axis-induced neuronal cell pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155238. doi: 10.1016/j.phymed.2023.155238. [PMID: 38128394]
  • Yadan Hu, Chao Xiang, Dong Zhang, Fang Zhou, Dede Zhang. Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling. Folia histochemica et cytobiologica. 2024; 62(1):13-24. doi: 10.5603/fhc.97140. [PMID: 38563049]
  • Youbao Zhong, Qiuping Xiao, Jiaqi Huang, Songren Yu, Liling Chen, Qi Wan, Zheyan Zhang, Lin Luo, Lizhao Song, Haimei Zhao, Wen Zhou, Duanyong Liu. Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota-Lipid Metabolism-Th1/Th2/Th17 Cells Axis. Journal of agricultural and food chemistry. 2023 Dec; 71(50):20073-20091. doi: 10.1021/acs.jafc.3c04811. [PMID: 38064669]
  • Pengmin Ji, Qifeng Shi, Yan Liu, Min Han, Yong Su, Ran Sun, Huimin Zhou, Weizu Li, Weiping Li. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice. Renal failure. 2023 Dec; 45(1):2197075. doi: 10.1080/0886022x.2023.2197075. [PMID: 37017270]
  • Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo. Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus. Gut microbes. 2023 12; 15(2):2254946. doi: 10.1080/19490976.2023.2254946. [PMID: 37698853]
  • Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hu, Lei Xie, Cheng Peng, Zili You. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress. European journal of pharmacology. 2023 Oct; ?(?):176120. doi: 10.1016/j.ejphar.2023.176120. [PMID: 37863415]
  • Huan Liu, Rui Deng, Cheng-Wei Zhu, Hong-Kuan Han, Gang-Fan Zong, Lang Ren, Peng Cheng, Zhong-Hong Wei, Yang Zhao, Su-Yun Yu, Yin Lu. Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01158-8. [PMID: 37749237]
  • Qianyan Gao, Guodong Li, Yue Zu, Yanjiao Xu, Congyi Wang, Dong Xiang, Wenxi He, Tianze Shang, Xinwei Cheng, Dong Liu, Chengliang Zhang. Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation. Journal of ethnopharmacology. 2023 Aug; ?(?):117089. doi: 10.1016/j.jep.2023.117089. [PMID: 37634749]
  • Haifei Lu, Yini Zhang, Simiao Ran, Yumeng Chen, Zijing Ye, Mengying Huang, Ping Wang. Ginsenoside Rg1 alleviates sleep deprivation-induced learning and memory impairment by inhibiting excessive neuronal apoptosis in zebrafish. Neuroreport. 2023 Aug; 34(11):566-574. doi: 10.1097/wnr.0000000000001926. [PMID: 37384937]
  • Jiao-Jiao Wu, Li Zhang, Dong Liu, Jia Xia, Yu Yang, Fei Tang, Lu Chen, Hui Ao, Cheng Peng. Ginsenoside Rg1, lights up the way for the potential prevention of Alzheimer's disease due to its therapeutic effects on the drug-controllable risk factors of Alzheimer's disease. Journal of ethnopharmacology. 2023 Aug; ?(?):116955. doi: 10.1016/j.jep.2023.116955. [PMID: 37536646]
  • Jun Guo, Long Chen, Min Ma. Ginsenoside Rg1 Suppresses Ferroptosis of Renal Tubular Epithelial Cells in Sepsis-induced Acute Kidney Injury via the FSP1-CoQ10-NAD(P)H Pathway. Current medicinal chemistry. 2023 Jun; ?(?):. doi: 10.2174/0929867330666230607125054. [PMID: 37287288]
  • Yize Liu, Zheng-Yun Jin, Jun-Xia Wang, Danqi Wang, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, Lin-Hu Quan. Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition. Food & function. 2023 May; 14(10):4696-4705. doi: 10.1039/d2fo03142f. [PMID: 37186251]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Weidong Hu, Shicheng Bi, Jianjian Shao, Yiwen Qu, Li Zhang, Jun Li, Sihuai Chen, Yue Ma, Liting Cao. Ginsenoside Rg1 and Re alleviates inflammatory responses and oxidative stress of broiler chicks challenged by lipopolysaccharide. Poultry science. 2023 Apr; 102(4):102536. doi: 10.1016/j.psj.2023.102536. [PMID: 36764136]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Min Wen, Lipan Yang, Hefei Huang, Gu Ye, Yuntao Jiang, Xiaobo Lv. Development of na HPLC-MS/MS method for the determination of ginsenosides Rg1 and Rb1 from 'Shenmai' Injection in beagle dogs after single and multiple doses and application in pharmacokinetics. Biomedical chromatography : BMC. 2023 Mar; 37(3):e5565. doi: 10.1002/bmc.5565. [PMID: 36515658]
  • Silu Liu, Hongyan Pei, Weijia Chen, Xiaoying Zhu, Yu Wang, Jianming Li, Zhongmei He, Rui Du. Evaluating the effect of ginsenoside Rg1 on CPF-induced brain injury in mice via PI3k/AKT pathway. Journal of biochemical and molecular toxicology. 2023 Feb; ?(?):e23319. doi: 10.1002/jbt.23319. [PMID: 36811218]
  • Ying Zhang, Chunli Guo, Hongmei Liu, Lin Yang, Changying Ren, Tao Li, Jianxun Liu. Multiplex quantitation of 17 drug-derived components in human plasma after administration of a fixed herbal preparation of Sailuotong using combined online SPE-LC-MS/MS methods. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115843. doi: 10.1016/j.jep.2022.115843. [PMID: 36265676]
  • Yuli Han, Yong Su, Min Han, Yan Liu, Qifeng Shi, Xuewang Li, Penghui Wang, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115923. doi: 10.1016/j.jep.2022.115923. [PMID: 36375645]
  • Xuanxin Chen, Wei Xue, Jia Zhang, Jiayi Peng, Wenxiang Huang. Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis. Lipids in health and disease. 2023 Feb; 22(1):22. doi: 10.1186/s12944-023-01787-2. [PMID: 36759837]
  • Qian Qu, Shu-Peng Li, Qi Dong, Hong-Liang Du, Zhi-Hua Wang, Yi-Mu Ma, Xiao-Pei Gong, Yi-Qing Ding, Jing Zhou, Jia-Yan Chen, Meng-Jie Liu, Wei-Jie Lv, Shi-Ning Guo. Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 110(?):154645. doi: 10.1016/j.phymed.2023.154645. [PMID: 36634382]
  • Yuqian Zhu, Jingyao Chen, Jun Li, Chenqi Zhou, Xin Huang, Bingdi Chen. Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline. Frontiers in immunology. 2023; 14(?):1070679. doi: 10.3389/fimmu.2023.1070679. [PMID: 36817446]
  • Ningning Zhang, Hong Jiang, Huiqin Wang, Yating Wang, Ye Peng, Yangbo Liu, Congyuan Xia, Xu Yan, Shifeng Chu, Yi Zhang, Zhenzhen Wang, Naihong Chen. Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010575. [PMID: 36614017]
  • Jun Guo, Rong Wang, Fei Min. Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells. Journal of leukocyte biology. 2022 11; 112(5):1065-1077. doi: 10.1002/jlb.1a0422-211r. [PMID: 35774015]
  • Man Peng, Liming Wang, Hui Su, Lei Zhang, Yue Yang, Le Sun, Yi Wu, Lei Ran, Sida Liu, Min Yin, Shude Li, Weixun Chunyu. Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats. Journal of food biochemistry. 2022 10; 46(10):e14321. doi: 10.1111/jfbc.14321. [PMID: 35851705]
  • Qiong Li, Yu Zhan, Yonghua Xu, Lianxue Zhang, Peng Di, Baohui Lu, Changbao Chen. Deciphering the transcriptomic response of Ilyonectria robusta in relation to ginsenoside Rg1 treatment and the development of ginseng rusty root rot. FEMS microbiology letters. 2022 09; 369(1):. doi: 10.1093/femsle/fnac075. [PMID: 35945650]
  • Jiying Hou, Ruoxiang Ma, Shisheng Zhu, Yaping Wang. Revealing the Therapeutic Targets and Mechanism of Ginsenoside Rg1 for Liver Damage Related to Anti-Oxidative Stress Using Proteomic Analysis. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms231710045. [PMID: 36077440]
  • Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, Naihong Chen. New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases. Cells. 2022 08; 11(16):. doi: 10.3390/cells11162529. [PMID: 36010610]
  • Han Li, Yun-Hang Gao, Ling Song, Teng-Fei Chen, Guang-Ping Zhang, Zu-Guang Ye, Yue Gao, Wang Huo. Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor. Journal of ethnopharmacology. 2022 Aug; 294(?):115394. doi: 10.1016/j.jep.2022.115394. [PMID: 35595219]
  • Jiao-Jiao Wu, Yu Yang, Yan Wan, Jia Xia, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao, Cheng Peng. New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113207. doi: 10.1016/j.biopha.2022.113207. [PMID: 35667236]
  • Duoduo Zhang, Pengmin Ji, Ran Sun, Huimin Zhou, Lei Huang, Liangliang Kong, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112936. doi: 10.1016/j.biopha.2022.112936. [PMID: 35421784]
  • Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yuan. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022 Jun; 47(6):1721-1735. doi: 10.1007/s11064-022-03564-6. [PMID: 35229270]
  • Zhijie Chen, Yingbo Lin, Qichun Zhou, Shilin Xiao, Chan Li, Rukun Lin, Jing Li, Yifei Chen, Chaohua Luo, Zhixian Mo. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112935. doi: 10.1016/j.biopha.2022.112935. [PMID: 35447543]
  • Jingyi Mao, Xin Ma, Jiong Zhu, Huimin Zhang. Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes. Journal of food biochemistry. 2022 05; 46(5):e14053. doi: 10.1111/jfbc.14053. [PMID: 35218026]
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