Morroniside (BioDeep_00000000296)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate

化学式: C17H26O11 (406.1475046)
中文名称: 莫诺苷（α+β）, 莫诺苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 41.54%

分子结构信息

SMILES: CC1C2C(CC(O1)O)C(=COC2OC3C(C(C(C(O3)CO)O)O)O)C(=O)OC
InChI: InChI=1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3

描述信息

Morroniside is a glycoside.
Morroniside is a natural product found in Lonicera japonica, Tripterospermum japonicum, and other organisms with data available.
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

同义名列表

6 个代谢物同义名

Methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate; methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate; Methyl 8-(hexopyranosyloxy)-3-hydroxy-1-methyl-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate; (7Beta-Hydroxy)-Morroniside; Morroniside; CID 12312977



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cong Zhang, Qiao Tong, Kexin Liu, Tongyun Mao, Yingying Song, Yaqin Qu, Xin Chen, Zhenpeng Qiu. Morroniside delays the progression of non-alcoholic steatohepatitis by promoting AMPK-mediated lipophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155703. doi: 10.1016/j.phymed.2024.155703. [PMID: 38723527]
  • Md Shimul Bhuia, Raihan Chowdhury, Iffat Ara, Md Mamun, Razina Rouf, Muahmmad Ali Khan, Shaikh Jamal Uddin, Md Abdul Kader Shakil, Solomon Habtemariam, Jannatul Ferdous, Daniela Calina, Javad Sharifi-Rad, Muhammad Torequl Islam. Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms. Fitoterapia. 2024 Jun; 175(?):105896. doi: 10.1016/j.fitote.2024.105896. [PMID: 38471574]
  • Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang. Morroniside improves the symptoms of post-stroke depression in mice through the BDNF signaling pathway mediated by MiR-409-3p. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155224. doi: 10.1016/j.phymed.2023.155224. [PMID: 38006805]
  • Mao Li, Junli Zhang, Lianyan Jiang, Wujun Wang, Xianrong Feng, Meijun Liu, Dongdong Yang. Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis. BMC complementary medicine and therapies. 2023 Jul; 23(1):218. doi: 10.1186/s12906-023-03967-0. [PMID: 37393274]
  • Shifen Zhang, Qiaohua Lai, Liming Liu, Yajie Yang, Juan Wang. Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative stress in inflammatory bowel disease by inhibiting NLRP3 and NF-κB signaling pathways. Allergologia et immunopathologia. 2022; 50(6):93-99. doi: 10.15586/aei.v50i6.674. [PMID: 36335451]
  • Chang Gun Lee, Jeonghyun Kim, Seung Hee Yun, Seokjin Hwang, Hyoju Jeon, Eunkuk Park, Seon-Yong Jeong. Anti-Osteoporotic Effect of Morroniside on Osteoblast and Osteoclast Differentiation In Vitro and Ovariectomized Mice In Vivo. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910642. [PMID: 34638983]
  • Cheol Park, Hee-Jae Cha, Hyesook Lee, Gi-Young Kim, Yung Hyun Choi. The regulation of the TLR4/NF-κB and Nrf2/HO-1 signaling pathways is involved in the inhibition of lipopolysaccharide-induced inflammation and oxidative reactions by morroniside in RAW 264.7 macrophages. Archives of biochemistry and biophysics. 2021 07; 706(?):108926. doi: 10.1016/j.abb.2021.108926. [PMID: 34029560]
  • D Deng, J Yan, Y Wu, K Wu, W Li. Morroniside suppresses hydrogen peroxide-stimulated autophagy and apoptosis in rat ovarian granulosa cells through the PI3K/AKT/mTOR pathway. Human & experimental toxicology. 2021 Apr; 40(4):577-586. doi: 10.1177/0960327120960768. [PMID: 32954801]
  • Eunkuk Park, Chang Gun Lee, Seong Jae Han, Seung Hee Yun, Seokjin Hwang, Hyoju Jeon, Jeonghyun Kim, Chun Whan Choi, Siyoung Yang, Seon-Yong Jeong. Antiosteoarthritic Effect of Morroniside in Chondrocyte Inflammation and Destabilization of Medial Meniscus-Induced Mouse Model. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062987. [PMID: 33804203]
  • Huan Yu, Sai Yao, Chengchong Zhou, Fangda Fu, Huan Luo, Weibin Du, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Hongfeng Ruan. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. Journal of ethnopharmacology. 2021 Feb; 266(?):113447. doi: 10.1016/j.jep.2020.113447. [PMID: 33022338]
  • Junwei Gao, Peng Liu, Zhengri Shen, Ke Xu, Chenguang Wu, Feng Tian, Ming Chen, Lifan Wang, Ping Li. Morroniside Promotes PGC-1α-Mediated Cholesterol Efflux in Sodium Palmitate or High Glucose-Induced Mouse Renal Tubular Epithelial Cells. BioMed research international. 2021; 2021(?):9942152. doi: 10.1155/2021/9942152. [PMID: 34485530]
  • Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
  • Jiahui Yuan, Weipeng Cheng, Gongye Zhang, Qiujuan Ma, Xiaomei Li, Bing Zhang, Tianhui Hu, Gang Song. Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway. International immunopharmacology. 2020 Apr; 81(?):106240. doi: 10.1016/j.intimp.2020.106240. [PMID: 32044657]
  • Xian-Sheng Ye, Jun He, Jie-Kun Xu, Xiao-Li He, Cong-Yuan Xia, Yu Yan, Wen-Wen Lian, Wei-Ku Zhang. Undescribed morroniside-like secoiridoid diglycosides with α-glucosidase inhibitory activity from Corni Fructus. Phytochemistry. 2020 Mar; 171(?):112232. doi: 10.1016/j.phytochem.2019.112232. [PMID: 31911266]
  • Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):35-42. doi: 10.1016/j.jchromb.2018.12.031. [PMID: 30639948]
  • Jin-Hua Tao, Min Zhao, Shu Jiang, Wei Zhang, Bo-Hui Xu, Jin-Ao Duan. UPLC-Q-TOF/MS-based metabolic profiling comparison of four major bioactive components in normal and CKD rat plasma, urine and feces following oral administration of Cornus officinalis Sieb and Rehmannia glutinosa Libosch herb couple extract. Journal of pharmaceutical and biomedical analysis. 2018 Nov; 161(?):254-261. doi: 10.1016/j.jpba.2018.08.051. [PMID: 30172880]
  • Kang Chen, Yunwei Lu, Chenyang Liu, Limi Zhang, Zhuyuan Fang, Guran Yu. Morroniside prevents H2O2 or Aβ1-42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation. European journal of pharmacology. 2018 Sep; 834(?):295-304. doi: 10.1016/j.ejphar.2018.07.047. [PMID: 30059683]
  • Jin-Hua Tao, Min Zhao, Shu Jiang, Xue-Lian Pu, Xiao-Yan Wei. Comparative metabolism of two major compounds in Fructus Corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jan; 1073(?):170-176. doi: 10.1016/j.jchromb.2017.12.025. [PMID: 29276981]
  • Xian-Sheng Ye, Jun He, Yung-Chi Cheng, Lei Zhang, Hao-Yi Qiao, Xue-Ge Pan, Jia Zhang, Shu-Na Liu, Wei-Ku Zhang, Jie-Kun Xu. Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis. Journal of natural products. 2017 12; 80(12):3103-3111. doi: 10.1021/acs.jnatprod.6b01127. [PMID: 29140705]
  • Min Zhao, Jinhua Tao, Leyue Du, Shu Jiang, Dawei Qian, Jinao Duan. UPLC-Q-TOF/MS-Based Metabolic Profiling Comparison of Two Major Bioactive Components and Their Metabolites in Normal and CKD Rat Plasma, Urine and Feces Following Oral Administration of Fructus Corni Extract. Journal of chromatographic science. 2017 Sep; 55(8):857-865. doi: 10.1093/chromsci/bmx046. [PMID: 28541451]
  • Jing-Xing Zhang, Rui Wang, Jin Xi, Lin Shen, An-You Zhu, Qi Qi, Qi-Yi Wang, Lun-Jun Zhang, Feng-Chao Wang, He-Zuo Lü, Jian-Guo Hu. Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage. International journal of molecular medicine. 2017 Mar; 39(3):603-612. doi: 10.3892/ijmm.2017.2882. [PMID: 28204825]
  • Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai. Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis. Molecules (Basel, Switzerland). 2017 Jan; 22(1):. doi: 10.3390/molecules22010163. [PMID: 28106847]
  • Gaohong Lv, Xing Lv, Yuhan Tao, Huiqin Xu. Effect of morroniside on glomerular mesangial cells through AGE-RAGE pathway. Human cell. 2016 Oct; 29(4):148-54. doi: 10.1007/s13577-015-0128-0. [PMID: 27068830]
  • Shan Xiong, Jinglai Li, Zhenqing Zhang. Excretion of Morroniside in Rat Urine After Single Oral and Intravenous Administration. Journal of chromatographic science. 2016 Jul; 54(6):912-7. doi: 10.1093/chromsci/bmw017. [PMID: 26896349]
  • Kai He, Shanghua Song, Zongyao Zou, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli Ye. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytotherapy research : PTR. 2016 Feb; 30(2):283-91. doi: 10.1002/ptr.5529. [PMID: 26619955]
  • Min Zhao, Jinhua Tao, Dawei Qian, Pei Liu, Er-xin Shang, Shu Jiang, Jianming Guo, Shu-lan Su, Jin-ao Duan, Leyue Du. Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1009-1010(?):122-9. doi: 10.1016/j.jchromb.2015.12.020. [PMID: 26720701]
  • Cui-cui Yang, Xue-xian Kuai, Wen-bin Gao, Jian-chun Yu, Qi Wang, Lin Li, Lan Zhang. Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration. Journal of Alzheimer's disease : JAD. 2016; 51(1):33-44. doi: 10.3233/jad-150728. [PMID: 26836014]
  • Min Zhao, Dawei Qian, Er-xin Shang, Shu Jiang, Jianming Guo, Pei Liu, Shu-lan Su, Jin-ao Duan, Leyue Du, Jinhua Tao. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats. Journal of ethnopharmacology. 2015 Sep; 173(?):280-6. doi: 10.1016/j.jep.2015.07.037. [PMID: 26231452]
  • Min Zhao, Leyue Du, Jinhua Tao, Dawei Qian, Jianming Guo, Shu Jiang, Er-xin Shang, Jin-ao Duan, Chen Wu. Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for rapid analysis of the metabolites of morroniside produced by human intestinal bacteria. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Jan; 976-977(?):61-7. doi: 10.1016/j.jchromb.2014.11.014. [PMID: 25482010]
  • Carolina Cieniak, Charlotte McDonald, John Nash, Asim Muhammad, Alaa Badawi, Pierre S Haddad, Alain Cuerrier, Steffany A L Bennett, Brian C Foster, John T Arnason. Evaluation by microarray of the potential safety of Sarracenia purpurea L. (Sarraceniaceae) a traditional medicine used by the Cree of Eeyou Istchee. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2015; 18(4):562-77. doi: 10.18433/j3dc74. [PMID: 26626249]
  • Shan Xiong, Jinglai Li, Xiuqing Zhu, Xiaoying Wang, Guiyuan Lü, Zhenqing Zhang. [Determination of morroniside concentration in beagle plasma and its pharmacokinetics by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2014 Mar; 32(3):290-3. doi: 10.3724/sp.j.1123.2013.11027. [PMID: 24984470]
  • Shan Xiong, Jing-Lai Li, Xiu-Qing Zhu, Xiao-Ying Wang, Gui-Yuan Lv, Zhen-Qing Zhang. [Determination of morroniside concentration in rat plasma by high performance liquid chromatography-tandem mass spectrometry]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(19):3378-81. doi: NULL. [PMID: 24422412]
  • Ning Li, Lei Di, Wen-Chao Gao, Kai-Jin Wang, Ling-Bo Zu. Cytotoxic iridoids from the roots of Patrinia scabra. Journal of natural products. 2012 Oct; 75(10):1723-8. doi: 10.1021/np300286t. [PMID: 23002924]
  • Asim Muhammad, Jose A Guerrero-Analco, Louis C Martineau, Lina Musallam, Padma Madiraju, Abir Nachar, Ammar Saleem, Pierre S Haddad, John T Arnason. Antidiabetic compounds from Sarracenia purpurea used traditionally by the Eeyou Istchee Cree First Nation. Journal of natural products. 2012 Jul; 75(7):1284-8. doi: 10.1021/np3001317. [PMID: 22738356]
  • Eun Ju Jeong, Tae Bum Kim, Heejung Yang, So Young Kang, Sun Yeou Kim, Sang Hyun Sung, Young Choong Kim. Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):317-21. doi: 10.1016/j.phymed.2011.08.068. [PMID: 21982433]
  • Gang Cao, Qiyuan Shan, Chengrong Zhang, Yun Zhang, Hao Cai, Xiaodong Cong, Baochang Cai. Pharmacokinetic parameters of morroniside in iridoid glycosides of Fructus corni processing based on back-propagation neural network. Pharmaceutical biology. 2011 Sep; 49(9):989-93. doi: 10.3109/13880209.2010.551780. [PMID: 21591872]
  • Meng-ying Sun, Xu Feng, Xing-hun Lin, Min Yin, Xing-zeng Zhao, Yu Chen, Yu Shan. [Studies on the chemical constituents from stems and leaves of Lonicera macranthoides]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Feb; 34(2):218-20. doi: . [PMID: 21823476]
  • Chan Hum Park, Jeong Sook Noh, Ji Hyun Kim, Takashi Tanaka, Qi Zhao, Kinzo Matsumoto, Naotoshi Shibahara, Takako Yokozawa. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biological & pharmaceutical bulletin. 2011; 34(10):1559-65. doi: 10.1248/bpb.34.1559. [PMID: 21963495]
  • Bing Dai, Xing-Feng Li, Zi-Zeng Xiao, Ke-Jia Shen, Jing Zhao, Liu Peng. [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Dec; 33(12):1904-8. doi: . [PMID: 21548370]
  • Wen Wang, Jingdong Xu, Lei Li, Peichang Wang, Xunming Ji, Houxi Ai, Li Zhang, Lin Li. Neuroprotective effect of morroniside on focal cerebral ischemia in rats. Brain research bulletin. 2010 Oct; 83(5):196-201. doi: 10.1016/j.brainresbull.2010.07.003. [PMID: 20637265]
  • Manyu Li, Wei Wang, Ping Wang, Kun Yang, Hui Sun, Xijun Wang. The pharmacological effects of morroniside and loganin isolated from Liuweidihuang Wan, on MC3T3-E1 cells. Molecules (Basel, Switzerland). 2010 Oct; 15(10):7403-14. doi: 10.3390/molecules15107403. [PMID: 20966881]
  • Chan Hum Park, Jeong Sook Noh, Takashi Tanaka, Takako Yokozawa. Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice. The Journal of pharmacy and pharmacology. 2010 Mar; 62(3):374-80. doi: 10.1211/jpp.62.03.0013. [PMID: 20487222]
  • Chan Hum Park, Noriko Yamabe, Jeong Sook Noh, Ki Sung Kang, Takashi Tanaka, Takako Yokozawa. The beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice. Biological & pharmaceutical bulletin. 2009 Oct; 32(10):1734-40. doi: 10.1248/bpb.32.1734. [PMID: 19801836]
  • Liangpo Liu, Ailing Sun, Sujuan Wu, Renmin Liu. Preparative purification of morroniside and loganin from Fructus corni by combination of macroporous absorption resin and HSCCC. Journal of chromatographic science. 2009 May; 47(5):333-6. doi: . [PMID: 19476697]
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  • Takako Yokozawa, Noriko Yamabe, Hyun Young Kim, Ki Sung Kang, Jong Moon Hur, Chan Hum Park, Takashi Tanaka. Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats. Biological & pharmaceutical bulletin. 2008 Jul; 31(7):1422-8. doi: 10.1248/bpb.31.1422. [PMID: 18591786]
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  • Xiaona Li, Qiao Wang, Xiaowei Zhang, Xiaona Sheng, Yanan Zhou, Min Li, Xiujuan Jing, Deqiang Li, Lantong Zhang. HPLC study of pharmacokinetics and tissue distribution of morroniside in rats. Journal of pharmaceutical and biomedical analysis. 2007 Oct; 45(2):349-55. doi: 10.1016/j.jpba.2007.05.013. [PMID: 17596900]
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  • Huiqin Xu, Jian Shen, Hong Liu, Yan Shi, Lihua Li, Min Wei. Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress. Canadian journal of physiology and pharmacology. 2006 Dec; 84(12):1267-73. doi: 10.1139/y06-075. [PMID: 17487235]
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  • Hui-qin Xu, Hai-ping Hao, Xu Zhang, Yang Pan. Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose. Acta pharmacologica Sinica. 2004 Apr; 25(4):412-5. doi: . [PMID: 15066205]