Ascorbic acid 2-sulfate (BioDeep_00000002944)

 

Secondary id: BioDeep_00001870513

human metabolite Endogenous blood metabolite


代谢物信息卡片


[(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl]oxidanesulfonic acid

化学式: C6H8O9S (255.9889038)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 26.49%

分子结构信息

SMILES: C(C(C1C(=C(C(=O)O1)OS(=O)(=O)O)O)O)O
InChI: InChI=1S/C6H8O9S/c7-1-2(8)4-3(9)5(6(10)14-4)15-16(11,12)13/h2,4,7-9H,1H2,(H,11,12,13)/t2-,4+/m0/s1

描述信息

Ascorbic acid 2-sulfate belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom. Ascorbic acid 2-sulfate is an extremely weak basic (essentially neutral) compound (based on its pKa). Ascorbic acid 2-sulfate is a metabolite of vitamin C. Vitamin C, also known as L-ascorbic acid or L-ascorbate, is an essential nutrient for humans and certain other animal species. In living organisms, ascorbate acts as an antioxidant by protecting the body against oxidative stress. It is also a cofactor in at least eight enzymatic reactions including several collagen synthesis reactions that, when dysfunctional, cause the most severe symptoms of scurvy (Wikipedia).
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites

同义名列表

13 个代谢物同义名

[(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl]oxidanesulfonic acid; L-Ascorbic acid-2-sulphuric acid ester; L-Ascorbic acid-2-sulfuric acid ester; Ascorbic acid 2-sulphuric acid; Ascorbic acid 2-sulfuric acid; L-Ascorbic acid 2-sulphate; L-Ascorbic acid 2-sulfate; Ascorbic acid 2-sulphate; Ascorbic acid 2-sulfate; Ascorbic acid-2-sulfate; L-Ascorbyl-2-sulfate; Ascorbate 2-sulphate; ascorbate 2-sulfate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Bérczi, R J Caubergs, H Asard. Partial purification and characterization of an ascorbate-reducible b-type cytochrome from the plasma membrane of Arabidopsis thaliana leaves. Protoplasma. 2003 May; 221(1-2):47-56. doi: 10.1007/s00709-002-0060-5. [PMID: 12768341]
  • Itaru Yamamoto, Akihiro Tai, Yoshihito Fujinami, Kenji Sasaki, Shino Okazaki. Synthesis and characterization of a series of novel monoacylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as skin antioxidants. Journal of medicinal chemistry. 2002 Jan; 45(2):462-8. doi: 10.1021/jm010379f. [PMID: 11784150]
  • A L Boskey, R D Blank, S B Doty. Vitamin C-sulfate inhibits mineralization in chondrocyte cultures: a caveat. Matrix biology : journal of the International Society for Matrix Biology. 2001 Apr; 20(2):99-106. doi: 10.1016/s0945-053x(01)00116-0. [PMID: 11334711]
  • T Fukuda, H Komatsubara, T Kasai, M Tsujimura. Studies on the ascorbic acid 2-sulfate biosynthesis in rat. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1991; 61(4):325-7. doi: NULL. [PMID: 1806537]
  • K Dabrowski. Absorption of ascorbic acid and ascorbic sulfate and ascorbate metabolism in common carp (Cyprinus carpio L.). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 1990; 160(5):549-61. doi: 10.1007/bf00258983. [PMID: 2097301]
  • H Senoo, Y Tsukada, T Sato, R Hata. Co-culture of fibroblasts and hepatic parenchymal cells induces metabolic changes and formation of a three-dimensional structure. Cell biology international reports. 1989 Feb; 13(2):197-206. doi: 10.1016/0309-1651(89)90066-0. [PMID: 2720794]
  • C S Tsao, M Young, S M Rose. Quantitative analysis of ascorbic acid-2-sulfate by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1984 Jun; 308(?):306-9. doi: 10.1016/s0021-9673(01)87558-0. [PMID: 6746823]
  • B W Tucker, J E Halver. Distribution of ascorbate-2-sulfate and distribution, half-life and turnover rates of [1-14C]ascorbic acid in rainbow trout. The Journal of nutrition. 1984 Jun; 114(6):991-1000. doi: 10.1093/jn/114.6.991. [PMID: 6726482]
  • M Tsujimura, T Fukuda, T Kasai. Studies on the excretion of ascorbic acid 2-sulfate and total vitamin C into human urine after oral administration of ascorbic acid 2-sulfate. Journal of nutritional science and vitaminology. 1982 Oct; 28(5):467-76. doi: 10.3177/jnsv.28.467. [PMID: 7161646]
  • M Terada, S Wakusawa, Y Watanabe, M Kato, M Hayashi, E Hayashi. Effect of l-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs. Journal of nutritional science and vitaminology. 1980; 26(6):521-34. doi: 10.3177/jnsv.26.521. [PMID: 7241235]