4-Hydroxysphinganine (BioDeep_00000002939)
Secondary id: BioDeep_00000405994
human metabolite Endogenous PANOMIX_OTCML-2023
代谢物信息卡片
[2S-(2R*,3R*,4S*)]-2-amino-1,3,4-octadecanetriol
化学式: C18H39NO3 (317.293)
中文名称: N-[12-[(7-硝基-2-1,3-苯并恶二唑-4-基)氨基]十二烷酰基]-植物鞘氨醇, 植物鞘氨醇, 糖脂, 4-羟基鞘氨醇
谱图信息:
最多检出来源 Homo sapiens(plant) 11.81%
Reviewed
Last reviewed on 2024-09-13.
Cite this Page
4-Hydroxysphinganine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/phytosphingosine (retrieved
2024-12-21) (BioDeep RN: BioDeep_00000002939). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCCCCCCCCCCCCCC(C(C(CO)N)O)O
InChI: InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3
描述信息
Phytosphingosine is a phospholipid. Phospholipids are a class of lipids and a major component of all biological membranes; sphingolipid metabolites, such as sphingosine and ceramide, are highly bioactive compounds and are involved in diverse cell processes, including cell-cell interaction, cell proliferation, differentiation, and apoptosis. Phytosphingosine is also one of the most widely distributed natural sphingoid bases, which is abundant in fungi and plants, and also found in animals including humans. Phytosphingosine is structurally similar to sphingosine; phytosphingosine possesses a hydroxyl group at C-4 of the sphingoid long-chain base. The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities. (PMID: 12576463, 12531554, 8046331, 8048941,8706124) [HMDB]
Phytosphingosine is a phospholipid. Phospholipids are a class of lipids and a major component of all biological membranes; sphingolipid metabolites, such as sphingosine and ceramide, are highly bioactive compounds and are involved in diverse cell processes, including cell-cell interaction, cell proliferation, differentiation, and apoptosis. Phytosphingosine is also one of the most widely distributed natural sphingoid bases, which is abundant in fungi and plants, and also found in animals including humans. Phytosphingosine is structurally similar to sphingosine; phytosphingosine possesses a hydroxyl group at C-4 of the sphingoid long-chain base. The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities. (PMID: 12576463, 12531554, 8046331, 8048941,8706124).
Phytosphingosine is a?phospholipid and has anti-cancer activities. Phytosphingosine induces cell apoptosis via caspase 8 activation and Bax translocation in cancer cells[1].
同义名列表
23 个代谢物同义名
[2S-(2R*,3R*,4S*)]-2-amino-1,3,4-octadecanetriol; 4-hydroxysphinganine (SaccharoMyces Cerevisiae); (2S,3S,4R)-2-Amino-1,3,4-trihydroxyoctadecane; D-Ribo-1,3,4-trihydroxy-2-aminooctadecane; (2S,3S,4R)-2-Amino-1,3,4-octadecanetriol; (2S,3S,4R)-2-aminooctadecane-1,3,4-triol; D-Ribo-2-amino-1,3,4-octadecanetriol; 4-R-Hydroxyoctadecasphinganine; 2-Amino-1,3,4-octadecanetriol; 2-aminooctadecane-1,3,4-triol; 8-(Z-e)-C18-Phytosphingenine; (+)-D-Ribo-phytosphingosine; D-Ribo-phytosphingosine; 4-D-Hydroxy-sphinganine; 4-D-Hydroxysphinganine; 4R-hydroxysphinganine; 4D-Hydroxysphinganine; C18-Phytosphingosine; 4-Hydroxysphinganine; Phytosphingosine; SPB 18:0;O3; SP(t18:0); Phytosphingosine
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:191244
- ChEBI: CHEBI:177499
- ChEBI: CHEBI:46961
- KEGG: C12144
- PubChem: 122121
- PubChem: 248575
- HMDB: HMDB0004610
- Metlin: METLIN7066
- DrugBank: DB14119
- ChEMBL: CHEMBL236036
- Wikipedia: Phytosphingosine
- LipidMAPS: LMSP01030001
- MetaCyc: PHYTOSPINGOSINE
- KNApSAcK: C00007543
- foodb: FDB023381
- chemspider: 108921
- CAS: 554-62-1
- PMhub: MS000007247
- PubChem: 14291
- 3DMET: B04437
- NIKKAJI: J13.584D
- RefMet: Phytosphingosine
- medchemexpress: HY-W011303
- KNApSAcK: 46961
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
21 个相关的代谢反应过程信息。
Reactome(12)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Sphingolipid metabolism:
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN - Sphingolipid de novo biosynthesis:
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of lipids:
H+ + LTHSOL + Oxygen + TPNH ⟶ 7-dehydroCHOL + H2O + TPN - Sphingolipid metabolism:
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN - Sphingolipid de novo biosynthesis:
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Sphingolipid metabolism:
H2O + dehydroepiandrosterone sulfate ⟶ DHEA + SO4(2-) - Sphingolipid de novo biosynthesis:
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN
BioCyc(3)
- sphingolipid metabolism:
NADP+ + a sphinganine ⟶ 3-dehydrosphinganine + H+ + NADPH - sphingolipid metabolism:
H+ + palmitoyl-CoA + ser ⟶ 3-dehydrosphinganine + CO2 + coenzyme A - sphingolipid metabolism:
L-serine + palmitoyl CoA ⟶ 3-dehydrosphinganine + CO2 + coenzyme A
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(6)
- Biosynthesis of Unsaturated Fatty Acids (Tetracosanoyl-CoA):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate - Biosynthesis of Unsaturated Fatty Acids:
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate - Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate - Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate - Biosynthesis of Unsaturated Fatty Acids (Stearoyl-CoA):
Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate - Sphingolipid Metabolism:
L-Serine + Palmityl-CoA ⟶ 3-Dehydrosphinganine + Carbon dioxide
PharmGKB(0)
8 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 245205 - Averrhoa bilimbi: 10.3390/ANTIOX7100137
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 573 - Klebsiella pneumoniae: 10.3389/FMICB.2022.810403
- 183589 - Pseudo-nitzschia multistriata: 10.3390/MD18060313
- 29760 - Vitis vinifera: 10.1016/J.DIB.2020.106469
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Andreea Nădăban, Gerrit S Gooris, Charlotte M Beddoes, Robert M Dalgliesh, Marc Malfois, Bruno Demé, Joke A Bouwstra. The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures.
Biochimica et biophysica acta. Biomembranes.
2024 Jun; 1866(5):184324. doi:
10.1016/j.bbamem.2024.184324. [PMID: 38688405] - F J Bikker. [Phytosphingosine, a new ingredient for oral care products?].
Nederlands tijdschrift voor tandheelkunde.
2024 04; 131(4):163-166. doi:
10.5177/ntvt.2024.04.23102. [PMID: 38591120] - Andreea Nădăban, Jannik Rousel, Dounia El Yachioui, Gerrit S Gooris, Charlotte M Beddoes, Robert M Dalgliesh, Marc Malfois, Robert Rissmann, Joke A Bouwstra. Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models.
Journal of lipid research.
2023 Jun; ?(?):100400. doi:
10.1016/j.jlr.2023.100400. [PMID: 37301511] - Nina Hartrampf, Samuel M Leitao, Nils Winter, Henry Toombs-Ruane, James A Frank, Petra Schwille, Dirk Trauner, Henri G Franquelim. Structural Diversity of Photoswitchable Sphingolipids for Optodynamic Control of Lipid Microdomains.
Biophysical journal.
2023 Mar; ?(?):. doi:
10.1016/j.bpj.2023.02.029. [PMID: 36869591] - Andreea Nădăban, Gerrit S Gooris, Charlotte M Beddoes, Robert M Dalgliesh, Joke A Bouwstra. Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems.
Journal of lipid research.
2022 09; 63(9):100258. doi:
10.1016/j.jlr.2022.100258. [PMID: 35931203] - Keiko Nakashima, Yukie Hirahara, Taro Koike, Susumu Tanaka, Keizo Gamo, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yousuke Nakano, Chisato Ohe, Takashi Yoshida, Yosky Kataoka, Masayuki Tsuda, Tatsuyuki Yamashita, Koichi Honke, Masaaki Kitada. Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells.
Journal of lipid research.
2022 06; 63(6):100210. doi:
10.1016/j.jlr.2022.100210. [PMID: 35439525] - Jieying Luo, Junaid Ahmed Shaikh, Lei Huang, Lei Zhang, Shahid Iqbal, Yu Wang, Bojiang Liu, Quan Zhou, Aisha Ajmal, Maryam Rizvi, Maryam Ajmal, Yingwu Liu. Human Plasma Metabolomics Identify 9-cis-retinoic Acid and Dehydrophytosphingosine Levels as Novel biomarkers for Early Ventricular Fibrillation after ST-elevated Myocardial Infarction.
Bioengineered.
2022 02; 13(2):3334-3350. doi:
10.1080/21655979.2022.2027067. [PMID: 35094641] - René Glenz, Agnes Kaiping, Delia Göpfert, Hannah Weber, Benjamin Lambour, Marvin Sylvester, Christian Fröschel, Martin J Mueller, Mohamed Osman, Frank Waller. The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens.
Scientific reports.
2022 01; 12(1):1081. doi:
10.1038/s41598-022-05083-4. [PMID: 35058538] - Fabio Strati, Joana S L Oliveira, Lukas Opalka, Tetiana Mukhina, Bodo Dobner, Reinhard H H Neubert, Gerald Brezesinski. Two- and Three-Dimensional Physical-Chemical Characterization of CER[AP]: A Study of Stereochemistry and Chain Symmetry.
The journal of physical chemistry. B.
2021 09; 125(35):9960-9969. doi:
10.1021/acs.jpcb.1c05572. [PMID: 34463098] - Andrej Kováčik, Petra Pullmannová, Lukáš Opálka, Michaela Šilarová, Jaroslav Maixner, Kateřina Vávrová. Effects of (R)- and (S)-α-Hydroxylation of Acyl Chains in Sphingosine, Dihydrosphingosine, and Phytosphingosine Ceramides on Phase Behavior and Permeability of Skin Lipid Models.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147468. [PMID: 34299088] - Lucía Guevara, María Ángeles Domínguez-Anaya, Alba Ortigosa, Salvador González-Gordo, Caridad Díaz, Francisca Vicente, Francisco J Corpas, José Pérez Del Palacio, José M Palma. Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO).
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094476. [PMID: 33922964] - Li Wang, Xiaodong Suo, Yujie Liu, Chen Liu, Ming Luo. Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis.
Biomolecules.
2021 04; 11(4):. doi:
10.3390/biom11040525. [PMID: 33915924] - Nathaniel L Hepowit, Jessica K A Macedo, Lyndsay E A Young, Ke Liu, Ramon C Sun, Jason A MacGurn, Robert C Dickson. Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools.
Aging.
2021 03; 13(6):7846-7871. doi:
10.18632/aging.202849. [PMID: 33744865] - J A Davis, R B Pares, M Palmgren, R L López-Marqués, J F Harper. A potential pathway for flippase-facilitated glucosylceramide catabolism in plants.
Plant signaling & behavior.
2020 10; 15(10):1783486. doi:
10.1080/15592324.2020.1783486. [PMID: 32857675] - Xiaolei Ma, Lulu Lu, Zheng Zhao, Mingru Cai, Na Gao, Gangwen Han. Lipidomics profiling of skin surface lipids in senile pruritus.
Lipids in health and disease.
2020 Jul; 19(1):171. doi:
10.1186/s12944-020-01347-y. [PMID: 32677954] - Priya Gupta, Shweta Roy, Ashis Kumar Nandi. MEDEA-interacting protein LONG-CHAIN BASE KINASE 1 promotes pattern-triggered immunity in Arabidopsis thaliana.
Plant molecular biology.
2020 May; 103(1-2):173-184. doi:
10.1007/s11103-020-00982-4. [PMID: 32100164] - Ning-Jing Liu, Tao Zhang, Zhao-Hui Liu, Xin Chen, Hui-Shan Guo, Bai-Hang Ju, Yuan-Yuan Zhang, Guo-Zhu Li, Qiang-Hui Zhou, Yong-Mei Qin, Yu-Xian Zhu. Phytosphinganine Affects Plasmodesmata Permeability via Facilitating PDLP5-Stimulated Callose Accumulation in Arabidopsis.
Molecular plant.
2020 01; 13(1):128-143. doi:
10.1016/j.molp.2019.10.013. [PMID: 31698047] - L E Uche, G S Gooris, C M Beddoes, J A Bouwstra. New insight into phase behavior and permeability of skin lipid models based on sphingosine and phytosphingosine ceramides.
Biochimica et biophysica acta. Biomembranes.
2019 07; 1861(7):1317-1328. doi:
10.1016/j.bbamem.2019.04.005. [PMID: 30991016] - Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W Denning, Olaf Kniemeyer, Axel A Brakhage, David S Perlin. Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.
mBio.
2019 06; 10(3):. doi:
10.1128/mbio.00779-19. [PMID: 31164462] - Barbora Amélie Čuříková-Kindlová, Olivier Diat, František Štěpánek, Kateřina Vávrová, Jarmila Zbytovská. Probing the interactions among sphingosine and phytosphingosine ceramides with non- and alpha-hydroxylated acyl chains in skin lipid model membranes.
International journal of pharmaceutics.
2019 May; 563(?):384-394. doi:
10.1016/j.ijpharm.2019.04.010. [PMID: 30959237] - Renï Glenz, Dorette Schmalhaus, Markus Krischke, Martin J Mueller, Frank Waller. Elevated Levels of Phosphorylated Sphingobases Do Not Antagonize Sphingobase- or Fumonisin B1-Induced Plant Cell Death.
Plant & cell physiology.
2019 May; 60(5):1109-1119. doi:
10.1093/pcp/pcz033. [PMID: 30796453] - Mariko Takahashi, Kumi Izawa, Makoto Urai, Yoshinori Yamanishi, Akie Maehara, Masamichi Isobe, Toshihiro Matsukawa, Ayako Kaitani, Ayako Takamori, Shino Uchida, Hiromichi Yamada, Masakazu Nagamine, Tomoaki Ando, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Yuki Kinjo, Toshio Kitamura, Jiro Kitaura. The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
Science signaling.
2019 01; 12(564):. doi:
10.1126/scisignal.aar5514. [PMID: 30647146] - Lili Sun, Hongmei Jia, Liyan Ma, Meng Yu, Yong Yang, Yang Liu, Hongwu Zhang, Zhongmei Zou. Metabolic profiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulation of phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Oct; 49(?):83-94. doi:
10.1016/j.phymed.2018.06.026. [PMID: 30217265] - Tomotaka Nagasawa, Hikaru Nakamichi, Yoichiro Hama, Shigeki Higashiyama, Yasuyuki Igarashi, Susumu Mitsutake. Phytosphingosine is a novel activator of GPR120.
Journal of biochemistry.
2018 Jul; 164(1):27-32. doi:
10.1093/jb/mvy017. [PMID: 29373685] - Daiki Yanagawa, Toshiki Ishikawa, Hiroyuki Imai. Synthesis and degradation of long-chain base phosphates affect fumonisin B1-induced cell death in Arabidopsis thaliana.
Journal of plant research.
2017 May; 130(3):571-585. doi:
10.1007/s10265-017-0923-7. [PMID: 28303405] - Barbora Školová, Andrej Kováčik, Ondřej Tesař, Lukáš Opálka, Kateřina Vávrová. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics.
Biochimica et biophysica acta. Biomembranes.
2017 May; 1859(5):824-834. doi:
10.1016/j.bbamem.2017.01.019. [PMID: 28109750] - Nuria Cubells-Baeza, Cristina Gómez-Casado, Leticia Tordesillas, Carmen Ramírez-Castillejo, María Garrido-Arandia, Pablo González-Melendi, María Herrero, Luis F Pacios, Araceli Díaz-Perales. Identification of the ligand of Pru p 3, a peach LTP.
Plant molecular biology.
2017 May; 94(1-2):33-44. doi:
10.1007/s11103-017-0590-z. [PMID: 28299506] - Guangguo Tan, Haibo Wang, Jianlin Yuan, Weijun Qin, Xin Dong, Hong Wu, Ping Meng. Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer.
Scientific reports.
2017 04; 7(?):46176. doi:
10.1038/srep46176. [PMID: 28382976] - Christin Fischer, Sven Klockmann, Hauke Wessels, Tim Hünniger, Jil Schrader, Angelika Paschke-Kratzin, Markus Fischer. Aptamer-based trapping of phytosphingosine in urine samples.
Journal of biotechnology.
2016 Nov; 238(?):30-34. doi:
10.1016/j.jbiotec.2016.09.005. [PMID: 27637314] - Fernando Martínez-Montañés, Museer A Lone, Fong-Fu Hsu, Roger Schneiter. Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether.
Journal of lipid research.
2016 11; 57(11):2040-2050. doi:
10.1194/jlr.m070748. [PMID: 27561298] - Fong-Fu Hsu. Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry.
Biochimie.
2016 Nov; 130(?):63-75. doi:
10.1016/j.biochi.2016.07.012. [PMID: 27523779] - Huijuan Gao, Gaofu Qi, Rong Yin, Hongchun Zhang, Chenggang Li, Xiuyun Zhao. Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine.
Scientific reports.
2016 06; 6(?):28756. doi:
10.1038/srep28756. [PMID: 27338781] - Kyle D Luttgeharm, Edgar B Cahoon, Jonathan E Markham. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis.
The Biochemical journal.
2016 Mar; 473(5):593-603. doi:
10.1042/bj20150824. [PMID: 26635357] - Sören Stahlberg, Stefan Lange, Bodo Dobner, Daniel Huster. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy.
Langmuir : the ACS journal of surfaces and colloids.
2016 Mar; 32(8):2023-31. doi:
10.1021/acs.langmuir.5b04173. [PMID: 26828109] - María José Gómez-Torres, Eva María García, Jaime Guerrero, Sonia Medina, María José Izquierdo-Rico, Ángel Gil-Izquierdo, Jesús Orduna, María Savirón, Leopoldo González-Brusi, Jorge Ten, Rafael Bernabeu, Manuel Avilés. Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization.
Reproductive biology and endocrinology : RB&E.
2015 Nov; 13(?):123. doi:
10.1186/s12958-015-0118-9. [PMID: 26553294] - Joaquim T Marquês, André M Cordeiro, Ana S Viana, Andreas Herrmann, H Susana Marinho, Rodrigo F M de Almeida. Formation and Properties of Membrane-Ordered Domains by Phytoceramide: Role of Sphingoid Base Hydroxylation.
Langmuir : the ACS journal of surfaces and colloids.
2015 Sep; 31(34):9410-21. doi:
10.1021/acs.langmuir.5b02550. [PMID: 26262576] - Susanne Grether-Beck, Ingo Felsner, Tim Koehler, Mike Farwick, Peter Lersch, Anthony V Rawlings, Jean Krutmann. Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis.
Experimental dermatology.
2014 Nov; 23(11):853-5. doi:
10.1111/exd.12526. [PMID: 25078364] - D Pin, M Bekrich, O Fantini, G Noel, E Vidémont. An emulsion restores the skin barrier by decreasing the skin pH and inflammation in a canine experimental model.
Journal of comparative pathology.
2014 Aug; 151(2-3):244-54. doi:
10.1016/j.jcpa.2014.04.009. [PMID: 24975893] - Erwin Swinnen, Tobias Wilms, Jolanta Idkowiak-Baldys, Bart Smets, Pepijn De Snijder, Sabina Accardo, Ruben Ghillebert, Karin Thevissen, Bruno Cammue, Dirk De Vos, Jacek Bielawski, Yusuf A Hannun, Joris Winderickx. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.
Molecular biology of the cell.
2014 Jan; 25(1):196-211. doi:
10.1091/mbc.e13-06-0340. [PMID: 24196832] - Alexander Sigruener, Victoria Tarabin, György Paragh, Gerhard Liebisch, Tim Koehler, Mike Farwick, Gerd Schmitz. Effects of sphingoid bases on the sphingolipidome in early keratinocyte differentiation.
Experimental dermatology.
2013 Oct; 22(10):677-9. doi:
10.1111/exd.12231. [PMID: 24079743] - Sanjoy Paul, W Scott Moye-Rowley. Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae.
Fungal genetics and biology : FG & B.
2013 Aug; 57(?):85-91. doi:
10.1016/j.fgb.2013.06.004. [PMID: 23796749] - Ana Cristina Colabardini, Neil Andrew Brown, Marcela Savoldi, Maria Helena S Goldman, Gustavo Henrique Goldman. Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.
PloS one.
2013; 8(3):e57630. doi:
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Skin pharmacology and physiology.
2013; 26(1):36-44. doi:
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Analytical and bioanalytical chemistry.
2012 Jun; 403(7):1897-905. doi:
10.1007/s00216-012-6004-9. [PMID: 22538778] - Anna Kołaczkowska, Myriam Manente, Marcin Kołaczkowski, Justyna Laba, Michel Ghislain, Donata Wawrzycka. The regulatory inputs controlling pleiotropic drug resistance and hypoxic response in yeast converge at the promoter of the aminocholesterol resistance gene RTA1.
FEMS yeast research.
2012 May; 12(3):279-92. doi:
10.1111/j.1567-1364.2011.00768.x. [PMID: 22129104] - Sandra Frank, Irma van Die, Rudolf Geyer. Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae.
Glycobiology.
2012 May; 22(5):676-95. doi:
10.1093/glycob/cws004. [PMID: 22241826] - Ying-Yong Zhao, Jing Liu, Xian-Long Cheng, Xu Bai, Rui-Chao Lin. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS.
Clinica chimica acta; international journal of clinical chemistry.
2012 Mar; 413(5-6):642-9. doi:
10.1016/j.cca.2011.12.014. [PMID: 22227165] - Liang Guo, Girish Mishra, Jennifer E Markham, Maoyin Li, Amanda Tawfall, Ruth Welti, Xuemin Wang. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.
The Journal of biological chemistry.
2012 03; 287(11):8286-96. doi:
10.1074/jbc.m111.274274. [PMID: 22275366] - Carol L Fischer, David R Drake, Deborah V Dawson, Derek R Blanchette, Kim A Brogden, Philip W Wertz. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.
Antimicrobial agents and chemotherapy.
2012 Mar; 56(3):1157-61. doi:
10.1128/aac.05151-11. [PMID: 22155833] - Yuwei Chang, Chunxia Zhao, Zhen Zhu, Zeming Wu, Jia Zhou, Yanni Zhao, Xin Lu, Guowang Xu. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes.
Plant molecular biology.
2012 Mar; 78(4-5):477-87. doi:
10.1007/s11103-012-9876-3. [PMID: 22271304] - Hee Jin Byun, Kwang Hyun Cho, Hee Chul Eun, Min-Jung Lee, Youngae Lee, Serah Lee, Jin Ho Chung. Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.
Journal of dermatological science.
2012 Feb; 65(2):110-7. doi:
10.1016/j.jdermsci.2011.12.005. [PMID: 22209282] - Lin Wang, Yu Jia, Ren-Jie Tang, Zheng Xu, Yong-Bing Cao, Xin-Ming Jia, Yuan-Ying Jiang. Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans.
PloS one.
2012; 7(5):e37768. doi:
10.1371/journal.pone.0037768. [PMID: 22662216] - Ayşe Demirkan, Cornelia M van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P Pramstaller, Gerhard Liebisch, James F Wilson, Åsa Johansson, Igor Rudan, Yurii S Aulchenko, Anatoly V Kirichenko, A Cecile J W Janssens, Ritsert C Jansen, Carsten Gnewuch, Francisco S Domingues, Cristian Pattaro, Sarah H Wild, Inger Jonasson, Ozren Polasek, Irina V Zorkoltseva, Albert Hofman, Lennart C Karssen, Maksim Struchalin, James Floyd, Wilmar Igl, Zrinka Biloglav, Linda Broer, Arne Pfeufer, Irene Pichler, Susan Campbell, Ghazal Zaboli, Ivana Kolcic, Fernando Rivadeneira, Jennifer Huffman, Nicholas D Hastie, Andre Uitterlinden, Lude Franke, Christopher S Franklin, Veronique Vitart, Christopher P Nelson, Michael Preuss, Joshua C Bis, Christopher J O'Donnell, Nora Franceschini, Jacqueline C M Witteman, Tatiana Axenovich, Ben A Oostra, Thomas Meitinger, Andrew A Hicks, Caroline Hayward, Alan F Wright, Ulf Gyllensten, Harry Campbell, Gerd Schmitz. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
PLoS genetics.
2012; 8(2):e1002490. doi:
10.1371/journal.pgen.1002490. [PMID: 22359512] - Christian Klose, Michal A Surma, Mathias J Gerl, Felix Meyenhofer, Andrej Shevchenko, Kai Simons. Flexibility of a eukaryotic lipidome--insights from yeast lipidomics.
PloS one.
2012; 7(4):e35063. doi:
10.1371/journal.pone.0035063. [PMID: 22529973] - Liang Guo, Xuemin Wang. Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling.
Frontiers in plant science.
2012; 3(?):51. doi:
10.3389/fpls.2012.00051. [PMID: 22639650] - Robert Berkey, Dipti Bendigeri, Shunyuan Xiao. Sphingolipids and plant defense/disease: the 'death' connection and beyond.
Frontiers in plant science.
2012; 3(?):68. doi:
10.3389/fpls.2012.00068. [PMID: 22639658] - Shu-Fen Li, Li-Ying Song, Wei-Bo Yin, Yu-Hong Chen, Liang Chen, Ji-Lin Li, Richard R-C Wang, Zan-Min Hu. Isolation and functional characterisation of the genes encoding Δ(8)-sphingolipid desaturase from Brassica rapa.
Journal of genetics and genomics = Yi chuan xue bao.
2012 Jan; 39(1):47-59. doi:
10.1016/j.jgg.2011.12.002. [PMID: 22293117] - Won-Soo Lee. Integral hair lipid in human hair follicle.
Journal of dermatological science.
2011 Dec; 64(3):153-8. doi:
10.1016/j.jdermsci.2011.08.004. [PMID: 21906914] - Jae-Chul Jung, Yeonju Lee, Sohyeon Moon, Jong Hoon Ryu, Seikwan Oh. Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment.
Molecules (Basel, Switzerland).
2011 Oct; 16(11):9090-100. doi:
10.3390/molecules16119090. [PMID: 22037667] - Itsuo Murakami, Yukari Wakasa, Shinji Yamashita, Toshio Kurihara, Kota Zama, Naoyuki Kobayashi, Yukiko Mizutani, Susumu Mitsutake, Tatsuro Shigyo, Yasuyuki Igarashi. Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Lipids in health and disease.
2011 Aug; 10(?):150. doi:
10.1186/1476-511x-10-150. [PMID: 21861924] - Chunwang Fu, Tiejie Wang, Yang Wang, Xiaohui Chen, Jian Jiao, Feng Ma, Min Zhong, Kaishun Bi. Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose.
Journal of pharmaceutical and biomedical analysis.
2011 Jul; 55(5):1067-74. doi:
10.1016/j.jpba.2011.03.011. [PMID: 21444175] - Amin A Momin, Hyejung Park, Brent J Portz, Christopher A Haynes, Rebecca L Shaner, Samuel L Kelly, I King Jordan, Jr Alfred H Merrill. A method for visualization of 'omic' datasets for sphingolipid metabolism to predict potentially interesting differences.
Journal of lipid research.
2011 Jun; 52(6):1073-1083. doi:
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Carbohydrate research.
2011 May; 346(7):914-26. doi:
10.1016/j.carres.2011.02.014. [PMID: 21463856] - Bianca L Bozna, Paolo Polzella, Christian Rankl, Rong Zhu, Mariolina Salio, Dawn Shepherd, Memed Duman, Vincenzo Cerundolo, Peter Hinterdorfer. Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy.
The Journal of biological chemistry.
2011 May; 286(18):15973-9. doi:
10.1074/jbc.m110.192674. [PMID: 21454514] - Liang Guo, Girish Mishra, Kyle Taylor, Xuemin Wang. Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases.
The Journal of biological chemistry.
2011 Apr; 286(15):13336-45. doi:
10.1074/jbc.m110.190892. [PMID: 21330371] - Agnieszka Błachnio-Zabielska, Piotr Zabielski, Marcin Baranowski, Jan Gorski. Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity.
Lipids.
2011 Mar; 46(3):229-38. doi:
10.1007/s11745-010-3515-z. [PMID: 21181285] - Whitney P Bowe, Alan C Logan. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?.
Gut pathogens.
2011 Jan; 3(1):1. doi:
10.1186/1757-4749-3-1. [PMID: 21281494] - Yong Joo Lee, Shaoxiao Wang, Sunny R Slone, Talene A Yacoubian, Stephan N Witt. Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.
PloS one.
2011 Jan; 6(1):e15946. doi:
10.1371/journal.pone.0015946. [PMID: 21264320] - Griet Van Zeebroeck, Marlies Kimpe, Patrick Vandormael, Johan M Thevelein. A split-ubiquitin two-hybrid screen for proteins physically interacting with the yeast amino acid transceptor Gap1 and ammonium transceptor Mep2.
PloS one.
2011; 6(9):e24275. doi:
10.1371/journal.pone.0024275. [PMID: 21912684] - Leonardo Nimrichter, Marcio L Rodrigues. Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials.
Frontiers in microbiology.
2011; 2(?):212. doi:
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Skin pharmacology and physiology.
2011; 24(3):127-35. doi:
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Plant signaling & behavior.
2011 Jan; 6(1):140-2. doi:
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Methods in molecular biology (Clifton, N.J.).
2011; 739(?):171-85. doi:
10.1007/978-1-61779-102-4_15. [PMID: 21567327] - Gabriel Bricard, Manjunatha M Venkataswamy, Karl O A Yu, Jin S Im, Rachel M Ndonye, Amy R Howell, Natacha Veerapen, Petr A Illarionov, Gurdyal S Besra, Qian Li, Young-Tae Chang, Steven A Porcelli. Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.
PloS one.
2010 Dec; 5(12):e14374. doi:
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Neuromolecular medicine.
2010 Dec; 12(4):306-19. doi:
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Molecular systems biology.
2010 Nov; 6(?):430. doi:
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The Journal of biological chemistry.
2010 Nov; 285(46):35792-802. doi:
10.1074/jbc.m110.162883. [PMID: 20826817] - Iuliana Popa, Linh Hoang Thuy, Benoit Colsch, Didier Pin, Hugues Gatto, Marek Haftek, Jacques Portoukalian. Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs.
Archives of dermatological research.
2010 Nov; 302(9):639-44. doi:
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FEBS letters.
2010 Sep; 584(18):4053-6. doi:
10.1016/j.febslet.2010.08.027. [PMID: 20732322] - Patrick Garidel, Bettina Fölting, Ingrid Schaller, Andreas Kerth. The microstructure of the stratum corneum lipid barrier: mid-infrared spectroscopic studies of hydrated ceramide:palmitic acid:cholesterol model systems.
Biophysical chemistry.
2010 Aug; 150(1-3):144-56. doi:
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European journal of clinical nutrition.
2010 Apr; 64(4):419-23. doi:
10.1038/ejcn.2009.154. [PMID: 20179727] - Karin Thevissen, Wei-Lien Yen, Didac Carmona-Gutierrez, Jolanta Idkowiak-Baldys, An M Aerts, Isabelle E J A François, Frank Madeo, Daniel J Klionsky, Yusuf A Hannun, Bruno P A Cammue. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
FEMS microbiology letters.
2010 Feb; 303(2):163-8. doi:
10.1111/j.1574-6968.2009.01869.x. [PMID: 20030721] - Amra Hasanovic, Sonja Hoeller, Claudia Valenta. Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes.
International journal of pharmaceutics.
2010 Jan; 383(1-2):14-7. doi:
10.1016/j.ijpharm.2009.08.038. [PMID: 19732812] - Enno C I Veerman, Marianne Valentijn-Benz, Wim van't Hof, Kamran Nazmi, Jan van Marle, Arie V Nieuw Amerongen. Phytosphingosine kills Candida albicans by disrupting its cell membrane.
Biological chemistry.
2010 Jan; 391(1):65-71. doi:
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Molecular systems biology.
2010; 6(?):349. doi:
10.1038/msb.2010.3. [PMID: 20160710] - Bianca R Dias, Elaine G Rodrigues, Leonardo Nimrichter, Ernesto S Nakayasu, Igor C Almeida, Luiz R Travassos. Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3.
Molecular cancer.
2009 Dec; 8(?):116. doi:
10.1186/1476-4598-8-116. [PMID: 19968878] - Dayong Sun, Byron E Froman, Robert G Orth, Susan A MacIsaac, Thomas Larosa, Fenggao Dong, Henry E Valentin. Identification of plant sphingolipid desaturases using chromatography and mass spectrometry.
Journal of chromatographic science.
2009 Nov; 47(10):895-901. doi:
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PLoS genetics.
2009 Oct; 5(10):e1000672. doi:
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Analytica chimica acta.
2009 Sep; 650(1):16-22. doi:
10.1016/j.aca.2009.02.027. [PMID: 19720167] - Arnaldo Videira, Takao Kasuga, Chaoguang Tian, Catarina Lemos, Ana Castro, N Louise Glass. Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function.
Microbiology (Reading, England).
2009 Sep; 155(Pt 9):3134-3141. doi:
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PloS one.
2009 Aug; 4(8):e6813. doi:
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Immunity.
2009 Jun; 30(6):888-98. doi:
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Journal of biochemistry.
2009 Jun; 145(6):709-20. doi:
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International journal of pharmaceutics.
2009 Mar; 370(1-2):181-6. doi:
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Molecular microbiology.
2009 Mar; 71(6):1523-37. doi:
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Lipids.
2009 Mar; 44(3):291-5. doi:
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Chemical & pharmaceutical bulletin.
2009 Feb; 57(2):204-6. doi:
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Journal of lipid research.
2008 Aug; 49(8):1621-39. doi:
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Journal of biochemistry.
2008 Jul; 144(1):95-106. doi:
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