Nizatidine (BioDeep_00000002917)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


dimethyl[(4-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine

化学式: C12H21N5O2S2 (331.1136606)
中文名称: 尼扎替丁
谱图信息: 最多检出来源 Mentha canadensis(plant) 6.25%

分子结构信息

SMILES: CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(CN(C)C)n1
InChI: InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3

描述信息

Nizatidine is only found in individuals that have used or taken this drug. It is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. [PubChem]Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].

同义名列表

7 个代谢物同义名

dimethyl[(4-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine; N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-n-methyl-2-nitro-1,1-ethenediamine; UNII-P41PML4GHR; Nizatidine; Acinon; Nizax; Axid



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yusra Rahman, Shumaila Afrin, Mustafa Alhaji Isa, Shahbaz Ahmed, Mohammad Tabish. Elucidating the molecular interaction of serum albumin with nizatidine and the role of β-cyclodextrin: multi-spectroscopic and computational approach. Journal of biomolecular structure & dynamics. 2020 Mar; 38(5):1375-1387. doi: 10.1080/07391102.2019.1604265. [PMID: 30955446]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rania El-Shaheny, Mohamed Radwan, Koji Yamada, Mahmoud El-Maghrabey. Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking. Journal of food and drug analysis. 2019 10; 27(4):915-925. doi: 10.1016/j.jfda.2019.08.001. [PMID: 31590763]
  • Kari M Morrissey, Sophie L Stocker, Eugene C Chen, Richard A Castro, Claire M Brett, Kathleen M Giacomini. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clinical pharmacokinetics. 2016 Apr; 55(4):495-506. doi: 10.1007/s40262-015-0332-9. [PMID: 26507723]
  • Salwa R Elshaboury, Niveen A Mohamed, Sameh Ahmed, Shereen Farrag. An Efficient Ion-Pair Liquid Chromatographic Method for the Determination of Some H2 Receptor Antagonists. Journal of chromatographic science. 2016 Mar; 54(3):419-28. doi: 10.1093/chromsci/bmv159. [PMID: 26538490]
  • Zhenwei Qin, Qiuli Fu, Lifang Zhang, Houfa Yin, Xiuming Jin, Qiaomei Tang, Danni Lyu, Ke Yao. Proliferative Effects of Histamine on Primary Human Pterygium Fibroblasts. Mediators of inflammation. 2016; 2016(?):9862496. doi: 10.1155/2016/9862496. [PMID: 27872516]
  • Filip Zmuda, Gaurav Malviya, Adele Blair, Marie Boyd, Anthony J Chalmers, Andrew Sutherland, Sally L Pimlott. Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. Journal of medicinal chemistry. 2015 Nov; 58(21):8683-93. doi: 10.1021/acs.jmedchem.5b01324. [PMID: 26469301]
  • De-Wei Shang, Zhan-Zhang Wang, Xiao-Jia Ni, Ming Zhang, Jin-Qing Hu, Chang Qiu, Yu-Guan Wen. Development and validation of a sensitive LC-MS/MS assay for the quantification of nizatidine in human plasma and urine and its application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 998-999(?):80-7. doi: 10.1016/j.jchromb.2015.06.026. [PMID: 26197435]
  • Mahmut B Çakar, Sevgi T Ulu. HPLC fluorescence method for the determination of nizatidine in human plasma and its application to pharmacokinetic study. Luminescence : the journal of biological and chemical luminescence. 2014 Jun; 29(4):357-61. doi: 10.1002/bio.2552. [PMID: 23836529]
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  • Yin-Xia Chang, Yue-Qin Qiu, Li-Ming Du, Chang-Feng Li, Min Guo. Determination of ranitidine, nizatidine, and cimetidine by a sensitive fluorescent probe. The Analyst. 2011 Oct; 136(20):4168-73. doi: 10.1039/c1an15078b. [PMID: 21858296]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
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  • Sheila Seleri Marques Assunção, Sandra Inês Ruschel, Lucena de Cássia Rodrigues Rosa, João Alberto O Campos, Mercedes Jurema O Alves, Oswaldo Luis Bracco, Mauricio Silva de Lima. Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2006 Dec; 28(4):270-6. doi: . [PMID: 17242805]
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  • Marilyn Lockyer, Saleh Al-Dgither, Eman Al-Gaai, Ahmed Yousuf, Muhammad M Hammami. Bioequivalence of two oral formulations of nizatidine capsules in healthy male volunteers. Biopharmaceutics & drug disposition. 2005 Apr; 26(3):117-20. doi: 10.1002/bdd.438. [PMID: 15723428]
  • Takako Nakano, Takashi Kuroiwa, Yuki Tsumita, Yoriaki Kaneko, Keiju Hiromura, Kazue Ueki, Yoshihisa Nojima. Aplastic anemia associated with initiation of nizatidine therapy in a hemodialysis patient. Clinical and experimental nephrology. 2004 Jun; 8(2):160-2. doi: 10.1007/s10157-003-0274-7. [PMID: 15235935]
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  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Murad Atmaca, Murat Kuloglu, Ertan Tezcan, Bilal Ustundag, Nulufer Kilic. Nizatidine for the treatment of patients with quetiapine-induced weight gain. Human psychopharmacology. 2004 Jan; 19(1):37-40. doi: 10.1002/hup.477. [PMID: 14716710]
  • Murad Atmaca, Murat Kuloglu, Ertan Tezcan, Bilal Ustundag. Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain. Human psychopharmacology. 2003 Aug; 18(6):457-61. doi: 10.1002/hup.514. [PMID: 12923824]
  • Susan M Abdel-Rahman, Franklin K Johnson, Ginette Gauthier-Dubois, Irving E Weston, Gregory L Kearns. The bioequivalence of nizatidine (Axid) in two extemporaneously and one commercially prepared oral liquid formulations compared with capsule. Journal of clinical pharmacology. 2003 Feb; 43(2):148-53. doi: 10.1177/0091270002239823. [PMID: 12616667]
  • Kazunari Murakami, Ryugo Sato, Tadayoshi Okimoto, Koichiro Watanabe, Masaru Nasu, Toshio Fujioka, Masaaki Kodama, Jiro Kagawa. Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection. Journal of gastroenterology. 2003; 38(10):937-41. doi: 10.1007/s00535-003-1176-x. [PMID: 14614600]
  • Robert A Blum, Alan J Braverman, Patricia Rice, Franklin K Johnson. Pharmacokinetics and pharmacodynamics of a novel nizatidine controlled-release formulation in healthy subjects. Journal of clinical pharmacology. 2003 Jan; 43(1):74-83. doi: 10.1177/0091270002239709. [PMID: 12520631]
  • Hiroki Itoh, Takafumi Naito, Masaharu Takeyama. Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. The Journal of pharmacy and pharmacology. 2002 Nov; 54(11):1559-63. doi: 10.1211/002235702117. [PMID: 12495560]
  • Gail S Itokazu, James H Fischer, Prasarn Manitpisitkul, Radhika Hariharan, Larry H Danziger. Lack of effect of nizatidine-induced elevation of gastric pH on the oral bioavailability of dapsone in healthy volunteers. Pharmacotherapy. 2002 Nov; 22(11):1420-5. doi: 10.1592/phco.22.16.1420.33698. [PMID: 12432968]
  • Susan M Abdel-Rahman, Franklin K Johnson, Neil Manowitz, Gregory B Holmes, Gregory L Kearns. Single-dose pharmacokinetics of nizatidine (Axid) in children. Journal of clinical pharmacology. 2002 Oct; 42(10):1089-96. doi: 10.1177/009127002401382687. [PMID: 12362922]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry. 2002 Jun; 45(13):2867-76. doi: 10.1021/jm0200409. [PMID: 12061889]
  • Hiroki Itoh, Toshiaki Nagano, Masaharu Takeyama. Effect of nizatidine on paracetamol and its metabolites in human plasma. The Journal of pharmacy and pharmacology. 2002 Jun; 54(6):869-73. doi: 10.1211/0022357021779050. [PMID: 12079004]
  • S M Wu, Y H Ho, H L Wu, S H Chen, H S Ko. Head-column field-amplified sample stacking in capillary electrophoresis for the determination of cimetidine, famotidine, nizatidine, and ranitidine-HCl in plasma. Electrophoresis. 2001 Aug; 22(13):2717-22. doi: 10.1002/1522-2683(200108)22:13<2717::aid-elps2717>3.0.co;2-2. [PMID: 11545397]
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  • A B Thomson, V Mahachai, R J Bailey, P Kirdeikis, L Zuk, B Marriage, I Simpson, F Jamali. Twice daily nizatidine or ranitidine is superior to once daily dosing in elevating 24 h intragastric pH in patients with duodenal ulcer disease. Journal of gastroenterology and hepatology. 1996 Dec; 11(12):1171-6. doi: 10.1111/j.1440-1746.1996.tb01847.x. [PMID: 9034938]
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