Classification Term: 493
2,4-disubstituted thiazoles (ontology term: CHEMONTID:0002634)
Compounds containing a thiazole ring substituted at the positions 2 and 3." [PMID:21084135]
found 29 associated metabolites at category metabolite taxonomy ontology rank level.
Ancestor: Thiazoles
Child Taxonomies: There is no child term of current ontology term.
Nizatidine
Nizatidine is only found in individuals that have used or taken this drug. It is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. [PubChem]Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin. A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].
Famotidine
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Merck under the trade names Pepcidine and Pepcid. [HMDB] Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Merck under the trade names Pepcidine and Pepcid. A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
2-Ethyl-4-methylthiazole
Organoleptic, occurring mainly in coffee aroma, also cooked uncured pork and fennel. Flavouring agent. 2-Ethyl-4-methylthiazole is found in coffee and coffee products, animal foods, and green vegetables. 2-Ethyl-4-methylthiazole is found in animal foods. Organoleptic, occurring mainly in coffee aroma, also cooked uncured pork and fennel. 2-Ethyl-4-methylthiazole is a flavouring agent
4-Ethyl-2-methylthiazole
Organoleptic, present mainly in coffee aroma and cooked meat. 4-Ethyl-2-methylthiazole is found in coffee and coffee products and animal foods. 4-Ethyl-2-methylthiazole is found in animal foods. Organoleptic, present mainly in coffee aroma and cooked mea
2,4-Dimethylthiazole
2,4-Dimethylthiazole is found in animal foods. 2,4-Dimethylthiazole is a constituent of beef aroma. Constituent of beef aroma. 2,4-Dimethylthiazole is found in tea and animal foods.
4-Methyl-2-(1-methylethyl)thiazole
4-Methyl-2-(1-methylethyl)thiazole, also known as fema 3555 or 2-isopropyl-4-methyl-thiazole, belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. 2,4-disubstituted thiazoles are compounds containing a thiazole ring substituted at the positions 2 and 3. A 1,3-thiazole that is substituted at positions 2 and 4 by isopropyl and methyl groups, respectively. 4-Methyl-2-(1-methylethyl)thiazole is an earthy, fruit, and green tasting compound. 4-Methyl-2-(1-methylethyl)thiazole has been detected, but not quantified, in several different foods, such as cocoa and cocoa products, fruits, garden tomato, herbs and spices, and mushrooms. This could make 4-methyl-2-(1-methylethyl)thiazole a potential biomarker for the consumption of these foods. A fruit flavour intensifier, it has a peach flavour with distinct vegetable and tropical notes. Present in Indonesian durian fruit (Durio zibethinus), red tomatoes, yeast extract, coriander seed oil, and roast meats. Also used in apricot, nectarine, durian, mango, pear and blackcurrant flavours. 4-Methyl-2-(1-methylethyl)thiazole is a fruit flavour intensifier. It is found in indonesian durian fruit (Durio zibethinus), cocoa butter/roasted beans, red tomatoes, yeast extract, coriander seed oil and roast meats. Off-flavour component in fortified juice-containing beverages. It is also found in mushrooms.
2-Methyl-4-(1-methylethyl)thiazole
2-Methyl-4-(1-methylethyl)thiazole is found in mushrooms. Aroma component of yeast extract. Aroma component of yeast extract. 2-Methyl-4-(1-methylethyl)thiazole is found in mushrooms.
2,4-Diethylthiazole
2,4-Diethylthiazole is found in coffee and coffee products. 2,4-Diethylthiazole is a volatile flavour component of coffee aroma and yeast extract. Volatile flavour component of coffee aroma and yeast extract. 2,4-Diethylthiazole is found in mushrooms and coffee and coffee products.
2-Butyl-4-methylthiazole
2-Butyl-4-methylthiazole is classified as a Natural Food Constituent (code WA) in the DFC. Classified as a Natural Food Constituent (code WA) in the DFC
4-Butyl-2-methylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
2-Ethyl-4-propylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
4-Ethyl-2-propylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
4-Methyl-2-pentylthiazole
4-Methyl-2-pentylthiazole is classified as a Natural Food Constituent (code WA) in the DFC. Classified as a Natural Food Constituent (code WA) in the DFC
2,4-Dipropylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
2-(1-Methylethyl)-4-propylthiazole
2-(1-Methylethyl)-4-propylthiazole is found in nuts. 2-(1-Methylethyl)-4-propylthiazole is a component of roast peanut flavour. Component of roast peanut flavour. 2-(1-Methylethyl)-4-propylthiazole is found in nuts.
4-Ethyl-2-pentylthiazole
4-Ethyl-2-pentylthiazole is classified as a Natural Food Constituent (code WA) in the DFC. Classified as a Natural Food Constituent (code WA) in the DFC
2-Butyl-4-propylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
4-Ethyl-2-hexylthiazole
4-Ethyl-2-hexylthiazole is classified as a Natural Food Constituent (code WA) in the DFC. Classified as a Natural Food Constituent (code WA) in the DFC
2-Pentyl-4-propylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
4-Ethyl-2-heptylthiazole
4-Ethyl-2-heptylthiazole is classified as a Natural Food Constituent (code WA) in the DFC. Classified as a Natural Food Constituent (code WA) in the DFC
2-Octyl-4-propylthiazole
Claimed food uses are not well documented. Claimed food uses are not well documented
4-Ethyl-2-octylthiazole
4-Ethyl-2-octylthiazole is a maillard product. Maillard product
N2-Monodes-methylnizatidine
N2-Monodes-methylnizatidine is a metabolite of nizatidine. Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the brand names Tazac and Axid. (Wikipedia)
