Hydralazine (BioDeep_00000002898)
Secondary id: BioDeep_00001867821
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1Z)-1(2H)-Phthalazinone hydrazone
化学式: C8H8N4 (160.0748928)
中文名称: 1(2H)-酞嗪酮腙, 肼酞嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 5.29%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NN=C2NN
InChI: InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
描述信息
Hydralazine is only found in individuals that have used or taken this drug. It is a direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. It has also been suggested that cyclic 3,5-adenosine monophosphate (cyclic AMP) mediates, at least partly, the relaxation of arterial smooth muscle by altering cellular calcium metabolism, which interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. In hypertensive patients, the hydralazine-induced decrease in blood pressure is accompanied by increased heart rate, cardiac output, and stroke volume, probably because of a reflex response to decreased peripheral resistance. The drug has no direct effect on the heart. Hydralazine may increase pulmonary arterial pressure, as well as coronary, splanchnic, cerebral, and renal blood flow. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Tolerance to the antihypertensive effect of the drug develops during prolonged therapy, especially if a diuretic is not administered concurrently. In patients with CHF, hydralazine decreases systemic vascular resistance and increases cardiac output.
C - Cardiovascular system > C02 - Antihypertensives > C02D - Arteriolar smooth muscle, agents acting on > C02DB - Hydrazinophthalazine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
28 个代谢物同义名
(1Z)-1(2H)-Phthalazinone hydrazone; mono-Hydrochloride, hydralazine; Hydralazine mono hydrochloride; Hydralazine mono-hydrochloride; Hydrazone 1(2H)-phthalazinone; (2H)-Phthalazinone hydrazone; Hydrochloride, hydralazine; Hydralazine hydrochloride; Phthalazin-1-ylhydrazine; 1-Hydrazino-phthalazine; 1-Phthalazinylhydrazine; 1-hydrazinylphthalazine; 1-Hydrazinophthalazine; Hydrazinophthalazine; 6-Hydralazine; Hypophthalin; Hydrallazine; Hydralazinum; hydralazine; Hydrallazin; Apressoline; Hidralazina; Idralazina; Hydralazin; Apresoline; Apressin; Nepresol; Hidral
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:5775
- KEGG: C07040
- KEGGdrug: D08044
- PubChem: 3637
- HMDB: HMDB0015400
- Metlin: METLIN3163
- DrugBank: DB01275
- ChEMBL: CHEMBL276832
- Wikipedia: Hydralazine
- MeSH: Hydralazine
- chemspider: 3511
- CAS: 59275-69-3
- CAS: 86-54-4
- PMhub: MS000006842
- PubChem: 9252
- PDB-CCD: HLZ
- NIKKAJI: J4.262E
- RefMet: Hydralazine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 282760 Achillea pseudopectinata: 10.1080/14786410310001643849
- 282760 Achillea pseudopectinata: 10.1080/14786410310001643849
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xin Quan, Caiyong Yu, Zhongmin Fan, Tong Wu, Chuchu Qi, Haoying Zhang, Shengxi Wu, Xi Wang. Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury.
Experimental neurology.
2023 Feb; ?(?):114367. doi:
10.1016/j.expneurol.2023.114367. [PMID: 36858281] - Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen. Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113139. doi:
10.1016/j.biopha.2022.113139. [PMID: 35623171] - Seth A Herr, Spencer S Gardeen, Philip S Low, Riyi Shi. Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation.
Free radical biology & medicine.
2022 05; 184(?):66-73. doi:
10.1016/j.freeradbiomed.2022.04.003. [PMID: 35398493] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Jyh-Gang Leu, Wei-Hsiang Su, Yu-Cheng Chen, Yao-Jen Liang. Hydralazine attenuates renal inflammation in diabetic rats with ischemia/reperfusion acute kidney injury.
European journal of pharmacology.
2021 Nov; 910(?):174468. doi:
10.1016/j.ejphar.2021.174468. [PMID: 34478692] - Danillo Menezes Dos Santos, Eric Aian Pereira Da Silva, Jeferson Yuri Santos Oliveira, Yandra Yssa de Menezes Marinho, Izabel Rodrigues de Santana, Luana Heimfarth, Erik Willyame Menezes Pereira, Lucindo José Quintans Júnior, Jamil Assreuy, Igor Alexandre Cortes Menezes, Márcio Roberto Viana Dos Santos. The Therapeutic Value of Hydralazine in Reducing Inflammatory Response, Oxidative Stress, and Mortality in Animal Sepsis: Involvement of the PI3K/AKT Pathway.
Shock (Augusta, Ga.).
2021 11; 56(5):782-792. doi:
10.1097/shk.0000000000001746. [PMID: 33555842] - Mohamed Amar, Simon W Lam, Kathleen Faulkenberg, Antonio Perez, W H Wilson Tang, J Bradley Williams. Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside.
Journal of cardiac failure.
2021 10; 27(10):1053-1060. doi:
10.1016/j.cardfail.2021.05.007. [PMID: 34051349] - Dominick Santoriello, Andrew S Bomback, Satoru Kudose, Ibrahim Batal, M Barry Stokes, Pietro A Canetta, Jai Radhakrishnan, Gerald B Appel, Vivette D D'Agati, Glen S Markowitz. Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine.
Kidney international.
2021 08; 100(2):440-446. doi:
10.1016/j.kint.2021.03.029. [PMID: 33857570] - Weiwei Tang, Andrew Gordon, Fang Wang, Yanwen Chen, Bin Li. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.
Analytical chemistry.
2021 07; 93(26):9083-9093. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2021 Jun; 44(6):618-627. doi:
10.1038/s41440-021-00620-6. [PMID: 33558668] - Wan Tu, Barry Fayman, Stephen C Ward, Yusufal Mamoon, Sabiha S Bandagi. Hydralazine-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Asymptomatic and Renal-Restricted Presentation.
The American journal of case reports.
2021 May; 22(?):e931263. doi:
10.12659/ajcr.931263. [PMID: 33993184] - Mae Xintong Huo, Alzira Rocheteau M Avelino, Gurpreet Singh. Severe cutaneous presentation of hydralazine-induced ANCA vasculitis without renal or pulmonary involvement, complicated by DIC.
BMJ case reports.
2021 May; 14(5):. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
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Scientific reports.
2021 01; 11(1):982. doi:
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The Journal of toxicological sciences.
2021; 46(1):31-42. doi:
10.2131/jts.46.31. [PMID: 33408299] - Wei Xu, Lei Qian, Xiaoyan Yuan, Yong Lu. Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients.
Pakistan journal of pharmaceutical sciences.
2021 Jan; 34(1(Special)):381-386. doi:
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Journal of pharmacological sciences.
2021 Jan; 145(1):79-87. doi:
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PloS one.
2021; 16(3):e0248854. doi:
10.1371/journal.pone.0248854. [PMID: 33735324] - David M Charytan, Jesse Y Hsu, Finnian R Mc Causland, Sushrut S Waikar, T Alp Ikizler, Dominic S Raj, J Richard Landis, Rajnish Mehrotra, Mark Williams, Marcelo DiCarli, Hicham Skali, Paul L Kimmel, Alan S Kliger, Laura M Dember. Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial.
Kidney360.
2020 12; 1(12):1380-1389. doi:
10.34067/kid.0004342020. [PMID: 35372900] - Pattraporn Chera-Aree, Pimrapat Tengtrakulcharoen, Jarunee Leetheeragul, Urai Sampaojarean, Supitchaya Surasereewong, Tuangsit Wataganara. Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women.
Journal of clinical pharmacology.
2020 12; 60(12):1662-1670. doi:
10.1002/jcph.1685. [PMID: 32598488] - Hsieh-Chou Huang, Tsan-Seng Hsiao, Mei-Hui Liao, Cheng-Ming Tsao, Chih-Chin Shih, Chin-Chen Wu. Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties.
European journal of pharmacology.
2020 Sep; 882(?):173279. doi:
10.1016/j.ejphar.2020.173279. [PMID: 32561290] - Ahmad Al-Abdouh, Abdul Muhaymin Siyal, Hanan Seid, Ammer Bekele, Pablo Garcia. Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.
Journal of medical case reports.
2020 Apr; 14(1):47. doi:
10.1186/s13256-020-02378-w. [PMID: 32290867] - Qingjun Pan, Yun Guo, Linjie Guo, Shuzhen Liao, Chunfei Zhao, Sijie Wang, Hua-Feng Liu. Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.
Current medicinal chemistry.
2020; 27(31):5175-5188. doi:
10.2174/0929867326666190404140658. [PMID: 30947650] - Yuan Yuan, Hisao Naito, Kazuya Kitamori, Sayuki Hashimoto, Tomomi Asano, Tamie Nakajima. The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension.
PloS one.
2020; 15(12):e0243846. doi:
10.1371/journal.pone.0243846. [PMID: 33315911] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Lena R Thurner, Klaus Höcherl. Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 11; 392(11):1401-1410. doi:
10.1007/s00210-019-01677-4. [PMID: 31243492] - Amrita V Pai, Crystal A West, Aline M Arlindo de Souza, Parnika S Kadam, Emma J Pollner, David A West, Jia Li, Hong Ji, Xie Wu, Michelle J Zhu, Chris Baylis, Kathryn Sandberg. Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-Na+ diet.
American journal of physiology. Renal physiology.
2019 09; 317(3):F572-F583. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2019 05; 42(5):628-640. doi:
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Pediatric nephrology (Berlin, Germany).
2019 05; 34(5):787-799. doi:
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European journal of pharmacology.
2019 Jan; 843(?):199-209. doi:
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Jan; 30(1):226-230. doi:
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Biochemical and biophysical research communications.
2018 12; 507(1-4):203-210. doi:
10.1016/j.bbrc.2018.11.008. [PMID: 30446221] - Narothama Reddy Aeddula, Samata Pathireddy, Asif Ansari, Peter J Juran. Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome.
BMJ case reports.
2018 Nov; 2018(?):. doi:
10.1136/bcr-2018-227161. [PMID: 30413463] - Noor Ul-Ain Baloch, Adaeze N Ibeabuchi. Hydralazine-induced MPO-ANCA Renal-Limited Vasculitis Masquerading as Lupus Nephritis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2018 Nov; 28(11):896-897. doi:
10.29271/jcpsp.2018.11.896. [PMID: 30369391] - Bharat Kumar, Jennifer Strouse, Melissa Swee, Petar Lenert, Manish Suneja. Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis.
Seminars in arthritis and rheumatism.
2018 10; 48(2):283-287. doi:
10.1016/j.semarthrit.2018.01.005. [PMID: 29519741] - Kwadwo A Yeboah, Amy Allspaw, Akram Al-Makki, Brian M Shepler. Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature.
Clinical therapeutics.
2018 09; 40(9):1592-1595. doi:
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Biochemical pharmacology.
2018 08; 154(?):397-406. doi:
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American journal of therapeutics.
2018 Jul; 25(4):e514-e516. doi:
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Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
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Arthritis & rheumatology (Hoboken, N.J.).
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PloS one.
2018; 13(10):e0203823. doi:
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Anatomical record (Hoboken, N.J. : 2007).
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The Journal of comparative neurology.
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Clinical journal of the American Society of Nephrology : CJASN.
2017 05; 12(5):836-838. doi:
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Autonomic neuroscience : basic & clinical.
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Kidney international.
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Oxidative medicine and cellular longevity.
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Rhode Island medical journal (2013).
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CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
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BMC nephrology.
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Cellular and molecular gastroenterology and hepatology.
2016 Sep; 2(5):685-700. doi:
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Journal of neurochemistry.
2016 07; 138(2):328-38. doi:
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Journal of molecular recognition : JMR.
2016 07; 29(7):308-17. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2016 May; 39(5):312-20. doi:
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American journal of physiology. Renal physiology.
2016 Mar; 310(6):F456-65. doi:
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Advances in chronic kidney disease.
2016 Mar; 23(2):57-60. doi:
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PloS one.
2016; 11(2):e0150319. doi:
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Journal of neurochemistry.
2015 Dec; 135(5):987-97. doi:
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Plant physiology.
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Journal of the American Society of Nephrology : JASN.
2015 Jul; 26(7):1619-33. doi:
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American journal of hypertension.
2015 Apr; 28(4):444-51. doi:
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Clinical and experimental nephrology.
2015 Apr; 19(2):197-207. doi:
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Journal of the American Society of Nephrology : JASN.
2015 Mar; 26(3):597-610. doi:
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PloS one.
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Kidney & blood pressure research.
2015; 40(6):605-13. doi:
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Nephron.
2015; 129(3):223-32. doi:
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Atherosclerosis.
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The Journal of nutrition.
2014 Oct; 144(10):1571-8. doi:
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Hypertension (Dallas, Tex. : 1979).
2014 Oct; 64(4):801-7. doi:
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Clinical and experimental nephrology.
2014 Aug; 18(4):593-9. doi:
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Journal of clinical pharmacy and therapeutics.
2014 Jun; 39(3):322-4. doi:
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Seminars in liver disease.
2014 May; 34(2):194-204. doi:
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Cleveland Clinic journal of medicine.
2014 May; 81(5):301-11. doi:
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Hormone molecular biology and clinical investigation.
2014 May; 18(2):105-12. doi:
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Journal of neurochemistry.
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Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
2014 Mar; 20(2):99-102. doi:
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Planta medica.
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Journal of hypertension.
2014 Mar; 32(3):534-41. doi:
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Journal of neurochemistry.
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Current opinion in rheumatology.
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International urology and nephrology.
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Scientific reports.
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Clinical and experimental nephrology.
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Semergen.
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Toxicology and applied pharmacology.
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International journal of molecular sciences.
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American journal of physiology. Renal physiology.
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The Journal of pathology.
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Chemico-biological interactions.
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Hypertension (Dallas, Tex. : 1979).
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Free radical biology & medicine.
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Journal of pharmacological sciences.
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PloS one.
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Drug metabolism and disposition: the biological fate of chemicals.
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Free radical biology & medicine.
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