p-Phenylenediamine (BioDeep_00000002885)
Secondary id: BioDeep_00001867638
human metabolite blood metabolite
代谢物信息卡片
4-Phenylenediamine monohydrochloride
化学式: C6H8N2 (108.0687)
中文名称: 对苯二胺
谱图信息:
最多检出来源 Homo sapiens(blood) 7.29%
分子结构信息
SMILES: C1=CC(=CC=C1N)N
InChI: InChI=1S/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2
描述信息
D004396 - Coloring Agents
同义名列表
30 个代谢物同义名
4-Phenylenediamine monohydrochloride; 4-Phenylenediamine bromide, ion(1+); 4-Phenylenediamine monohydrobromide; 4-Phenylenediamine dihydrochloride; 4-Phenylenediamine monoperchlorate; 4-Phenylenediamine monohydroiodide; 4-Phenylenediamine diperchlorate; 4-Phenylenediamine monosulfate; 4-Phenylenediamine monooxalate; 4-Phenylenediamine ion (1+); 4-Phenylenediamine sulfate; p-Phenylenediamine base; Para-phenylenediamine; Paraphenylene-diamine; Paraphenylenediamine; 1,4-Phenylenediamine; benzene-1,4-diamine; 1,4-Diaminobenzene; 1,4-Benzenediamine; 4-Phenylenediamine; p-Phenylenediamine; 1,4-Phenyldiamine; p-Diaminobenzene; 4-Aminoaniline; Black henna; Ursol-D; PPDA; PPD; para-Phenylenediamine; p-Phenylenediamine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:51403
- KEGG: C19499
- PubChem: 7814
- HMDB: HMDB0256055
- Metlin: METLIN73191
- DrugBank: DB14141
- ChEMBL: CHEMBL403741
- Wikipedia: P-Phenylenediamine
- KNApSAcK: C00014965
- chemspider: 13835179
- CAS: 106-50-3
- PMhub: MS000006775
- PubChem: 124490171
- KNApSAcK: 51403
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maryam Salami, Jalal Pourahmad, Mohammad Hadi Zarei. Toxicity of para-phenylenediamine (PPD;1, 4 diaminobenzene) on isolated human lymphocytes: The key role of intracellular calcium enhancement in PPD-induced apoptosis.
Toxicology and industrial health.
2023 May; ?(?):7482337231176594. doi:
10.1177/07482337231176594. [PMID: 37243687] - Pascal Houzé, Nouzha Djebrani Oussedik, Quentin Raimbourg, Dominique Vodovar, Joël Poupon, Laurence Labat. Title Not Available.
Annales de biologie clinique.
2022 Mar; 80(2):175-181. doi:
10.1684/abc.2022.1718. [PMID: 35766070] - Govindan Rajivgandhi, K Bhavya, B Vidhya, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Khalid F Alanzi, R Nandhakumar. Fabrication of graphene oxide-p-phenylenediamine nanocomposites as fluorescent chemosensors for detection of metal ions.
Environmental research.
2022 03; 204(Pt A):111914. doi:
10.1016/j.envres.2021.111914. [PMID: 34437851] - Francisca Cunha, Iolanda Alen Coutinho, Carmelita Ribeiro, Ana Todo Bom. Contact dermatitis from black henna tattoo in child due to paraphenylenediamine.
Allergologia et immunopathologia.
2022; 50(6):68-70. doi:
10.15586/aei.v50i6.597. [PMID: 36335447] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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2021; 22(3):423-432. doi:
10.2174/1389201021666200430115323. [PMID: 32351177] - Rubina Naqvi. Women beautify yourselves: Dye hair, apply henna but at the same time watch your kidneys.
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2019 Oct; 31(4):544-547. doi:
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2017 Oct; 59(1):66. doi:
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2017 Jul; 54(4):507-510. doi:
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Contact dermatitis.
2017 Jun; 76(6):350-356. doi:
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Analytical chemistry.
2017 05; 89(10):5484-5493. doi:
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Journal of forensic sciences.
2017 Mar; 62(2):483-487. doi:
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Contact dermatitis.
2017 Feb; 76(2):89-95. doi:
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2017 Jan; 68(1):48-54. doi:
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Toxicologic pathology.
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10.1177/0192623316673921. [PMID: 27770109] - Khaled M Mohamed, Vanessa Steenkamp. Application of a LC-MS/MS method developed for the determination of p-phenylenediamine, N-acetyl-p-phenylenediamine and N,N-diacetyl-p-phenylenediamine in human urine specimens.
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2016 Dec; 30(12):1922-1927. doi:
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2016 Aug; 57(3):219-21. doi:
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Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
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The Journal of the Association of Physicians of India.
2011 Jul; 59(?):415-9. doi:
NULL. [PMID: 22315744] - Saeed Nazifi, Ahmad Oryan, Fatemeh Namazi. Hematological and serum biochemical analyses in experimental caprine besnoitiosis.
The Korean journal of parasitology.
2011 Jun; 49(2):133-8. doi:
10.3347/kjp.2011.49.2.133. [PMID: 21738268] - Susanne Herter, Marlen Schmidt, Mark L Thompson, Annett Mikolasch, Frieder Schauer. A new phenol oxidase produced during melanogenesis and encystment stage in the nitrogen-fixing soil bacterium Azotobacter chroococcum.
Applied microbiology and biotechnology.
2011 May; 90(3):1037-49. doi:
10.1007/s00253-011-3093-x. [PMID: 21327414] - Syril K Que, Jeremy A Brauer, Nicholas A Soter, David E Cohen. Chronic actinic dermatitis: an analysis at a single institution over 25 years.
Dermatitis : contact, atopic, occupational, drug.
2011 May; 22(3):147-54. doi:
10.2310/6620.2011.10105. [PMID: 21569744] - M Gube, K Heinrich, P Dewes, P Brand, T Kraus, T Schettgen. Internal exposure of hairdressers to permanent hair dyes: a biomonitoring study using urinary aromatic diamines as biomarkers of exposure.
International archives of occupational and environmental health.
2011 Mar; 84(3):287-92. doi:
10.1007/s00420-010-0539-x. [PMID: 20443120] - Thomas Schettgen, K Heinrich, T Kraus, Monika Gube. Determination of 2,5-toluylenediamine (2,5-TDA) and aromatic amines in urine after personal application of hair dyes: kinetics and doses.
Archives of toxicology.
2011 Feb; 85(2):127-33. doi:
10.1007/s00204-010-0563-3. [PMID: 20549195] - Carsten Sauer Mikkelsen, Frederik Liljefred, Dorthe Bisgaard Mikkelsen. [Erythema multiforme-like reaction to para-phenylenediamine].
Ugeskrift for laeger.
2011 Jan; 173(1):51-2. doi:
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PloS one.
2011; 6(8):e22191. doi:
10.1371/journal.pone.0022191. [PMID: 21829608] - Helga Rothe, Katherine Sarlo, Heike Scheffler, Carsten Goebel. The hair dyes PPD and PTD fail to induce a T(H)2 immune response following repeated topical application in BALB/c mice.
Journal of immunotoxicology.
2011 Jan; 8(1):46-55. doi:
10.3109/1547691x.2010.543096. [PMID: 21299354] - Mohamed Hamdouk, Mohamed Abdelraheem, Ahbab Taha, David Cristina, Ionel Alexandru Checherita, Chechepita Ionel, Ciocãlteu Alexandru. The association between prolonged occupational exposure to paraphenylenediamine (hair-dye) and renal impairment.
Arab journal of nephrology and transplantation.
2011 Jan; 4(1):21-5. doi:
10.4314/ajnt.v4i1.63151. [PMID: 21469591] - Erin L Willis, David C Kersey, Barbara S Durrant, Andrew J Kouba. The acute phase protein ceruloplasmin as a non-invasive marker of pseudopregnancy, pregnancy, and pregnancy loss in the giant panda.
PloS one.
2011; 6(7):e21159. doi:
10.1371/journal.pone.0021159. [PMID: 21765892] - Gunjan Guha, V Rajkumar, R Ashok Kumar, Lazar Mathew. Antioxidant Activity of Lawsonia inermis Extracts Inhibits Chromium(VI)-Induced Cellular and DNA Toxicity.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):576456. doi:
10.1093/ecam/nep205. [PMID: 20008460] - Jürgen Hench, Ivana Bratić Hench, Claire Pujol, Sabine Ipsen, Susanne Brodesser, Arnaud Mourier, Markus Tolnay, Stephan Frank, Aleksandra Trifunović. A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans.
PloS one.
2011; 6(12):e28417. doi:
10.1371/journal.pone.0028417. [PMID: 22162770] - A V Sokolov, K V Ageeva, V A Kostevich, M N Berlov, O L Runova, E T Zakharova, V B Vasilyev. Study of interaction of ceruloplasmin with serprocidins.
Biochemistry. Biokhimiia.
2010 Nov; 75(11):1361-7. doi:
10.1134/s0006297910110076. [PMID: 21314603] - S C Chen, C H Chen, Y L Tioh, P Y Zhong, Y S Lin, S M Chye. Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin-Darby canine kidney cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2010 Jun; 24(4):1197-202. doi:
10.1016/j.tiv.2010.02.011. [PMID: 20156547] - Andrea Luna-Acosta, Eric Rosenfeld, Myriam Amari, Ingrid Fruitier-Arnaudin, Paco Bustamante, Hélène Thomas-Guyon. First evidence of laccase activity in the Pacific oyster Crassostrea gigas.
Fish & shellfish immunology.
2010 Apr; 28(4):719-26. doi:
10.1016/j.fsi.2010.01.008. [PMID: 20109560] - Sawsan A Shalaby, Mohy K Elmasry, Amany E Abd-Elrahman, Manal A Abd-Elkarim, Zeinab A Abd-Elhaleem. Clinical profile of acute paraphenylenediamine intoxication in Egypt.
Toxicology and industrial health.
2010 Mar; 26(2):81-7. doi:
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PLoS neglected tropical diseases.
2010 Feb; 4(2):e594. doi:
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The Journal of the Association of Physicians of India.
2009 Nov; 57(?):743-4. doi:
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The Journal of the Association of Physicians of India.
2009 Nov; 57(?):739. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2009 Oct; 25(10):1243-8. doi:
10.2116/analsci.25.1243. [PMID: 19822971] - M B Abdelraheem, M A A El-Tigani, E G Hassan, M A M Ali, I A Mohamed, A E Nazik. Acute renal failure owing to paraphenylene diamine hair dye poisoning in Sudanese children.
Annals of tropical paediatrics.
2009 Sep; 29(3):191-6. doi:
10.1179/027249309x12467994693815. [PMID: 19689860] - Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata. Identification of the toxic trigger in mushroom poisoning.
Nature chemical biology.
2009 Jul; 5(7):465-7. doi:
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Indian journal of pathology & microbiology.
2009 Jul; 52(3):444. doi:
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Journal of agricultural and food chemistry.
2009 Jun; 57(12):5173-7. doi:
10.1021/jf900696p. [PMID: 19456130] - Nevin Uzuner, Duygu Olmez, Arzu Babayigit, Ozlem Vayvada. Contact dermatitis with henna tattoo.
Indian pediatrics.
2009 May; 46(5):423-4. doi:
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Toxicology letters.
2009 Mar; 185(3):153-9. doi:
10.1016/j.toxlet.2008.12.008. [PMID: 19136049] - Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien, Chau-Fong Chen. Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling.
Journal of biomedical science.
2009 Mar; 16(?):35. doi:
10.1186/1423-0127-16-35. [PMID: 19317920] - Dragan L Jovanovic, Maja R Slavkovic-Jovanovic. Allergic contact dermatitis from temporary henna tattoo.
The Journal of dermatology.
2009 Jan; 36(1):63-5. doi:
10.1111/j.1346-8138.2008.00588.x. [PMID: 19207440] - Alexej V Sokolov, Kira V Ageeva, Maria O Pulina, Olga S Cherkalina, Valeria R Samygina, Irina I Vlasova, Oleg M Panasenko, Elena T Zakharova, Vadim B Vasilyev. Ceruloplasmin and myeloperoxidase in complex affect the enzymatic properties of each other.
Free radical research.
2008 Nov; 42(11-12):989-98. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 Apr; 33(4-5):371-9. doi:
10.1016/j.ejps.2008.01.006. [PMID: 18321686] - Eve Marie Coulter, Claire Jenkinson, Ying Wu, John Farrell, Brian Foster, Andrew Smith, Carolann McGuire, Camilla Pease, David Basketter, Clodagh King, Peter Simon Friedmann, Munir Pirmohamed, Brian Kevin Park, Dean J Naisbitt. Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base.
The Journal of investigative dermatology.
2008 Apr; 128(4):897-905. doi:
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Biological & pharmaceutical bulletin.
2008 Apr; 31(4):681-4. doi:
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Chemico-biological interactions.
2008 Mar; 172(1):39-47. doi:
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Pediatric dermatology.
2008 Mar; 25(2):201-4. doi:
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