Lomefloxacin (BioDeep_00000002814)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

化学式: C17H19F2N3O3 (351.1394408)
中文名称: 洛美沙星
谱图信息: 最多检出来源 Mentha canadensis(plant) 30.77%

分子结构信息

SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
InChI: InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)

描述信息

Lomefloxacin is only found in individuals that have used or taken this drug. It is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

21 个代谢物同义名

(+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate; Pharmacia brand 2 OF lomefloxacin hydrochloride; Pharmacia brand 1 OF lomefloxacin hydrochloride; Lomefloxacin hydrochloride; Lomefloxacinum; Lomenfloxacin; Lomefloxacine; Lomefloxacino; lomefloxacin; Décalogiflox; Maxaquin; Logiflox; Ocacin; Okacin; Okacyn; LFLX

数据库引用编号

14 个数据库交叉引用编号

ChEBI: CHEBI:116278
KEGG: C07078
KEGGdrug: D02318
PubChem: 3948
HMDB: HMDB0015113
Metlin: METLIN1015
DrugBank: DB00978
ChEMBL: CHEMBL561
Wikipedia: Lomefloxacin
chemspider: 3811
CAS: 98079-51-7
PMhub: MS000005943
PubChem: 9289
NIKKAJI: J135.046C

分类词条

Monobactams

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Tamer Z Attia, Mahmoud A Omar, Deena A M Nour El-Deen, Asmaa Mohamed Abbas, Abobakr A Mohamed. A novel spectrofluorimetric method for determination of lomefloxacin adopting on zinc(II) chelation strategy: Application in human plasma. Luminescence : the journal of biological and chemical luminescence. 2022 Feb; 37(2):255-262. doi: 10.1002/bio.4168. [PMID: 34806313]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Kamal Ahmed El-Shazly, Amera Abd El-Latif, Walied Abdo, Ahmed El-Morsey, Magdy Ibrahim Abd El-Aziz, Heba El-Mogazy. The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens. Parasitology research. 2020 Jun; 119(6):1955-1968. doi: 10.1007/s00436-020-06692-6. [PMID: 32399722]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Sima Beigoli, Atena Sharifi Rad, Azam Askari, Reza Assaran Darban, Jamshidkhan Chamani. Isothermal titration calorimetry and stopped flow circular dichroism investigations of the interaction between lomefloxacin and human serum albumin in the presence of amino acids. Journal of biomolecular structure & dynamics. 2019 Jun; 37(9):2265-2282. doi: 10.1080/07391102.2018.1491421. [PMID: 30047851]
Shereen A Boltia, Aya T Soudi, Eman S Elzanfaly, Hala E Zaazaa. Analytical Eco-Scale for Assessing the Greenness of a Developed Potentiometric Method for Lomefloxacin Hydrochloride Determination in its Different Dosage Forms, Plasma, and Dissolution Medium. Journal of AOAC International. 2019 May; 102(3):794-800. doi: 10.5740/jaoacint.18-0217. [PMID: 30446018]
Ren San, Weidong Yue, Surong Hasi. Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel. Journal of veterinary science. 2019 May; 20(3):e12. doi: 10.4142/jvs.2019.20.e12. [PMID: 31161735]
Tianlie Luo, Jingwen Chen, Xuehua Li, Shuying Zhang, Hongye Yao, Willie J G M Peijnenburg. Effects of lomefloxacin on survival, growth and reproduction of Daphnia magna under simulated sunlight radiation. Ecotoxicology and environmental safety. 2018 Dec; 166(?):63-70. doi: 10.1016/j.ecoenv.2018.09.067. [PMID: 30248562]
Mengmeng Gao, Lili Li, Suxiang Lu, Qiang Liu, Hua He. Silver nanoparticles for the visual detection of lomefloxacin in the presence of cystine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Dec; 205(?):72-78. doi: 10.1016/j.saa.2018.05.072. [PMID: 30007902]
Lei Sha, Xiaoyan Tang, Dengyong Liu, Yongping Xu, Y U Ding, Feng Ding. Detection and Quantitation of Lomefloxacin and Pefloxacin Residues in the Organ Tissues and Eggs of Laying Hens. Journal of food protection. 2018 05; 81(5):810-814. doi: 10.4315/0362-028x.jfp-17-422. [PMID: 29637810]
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Mitra Amoli-Diva, Kamyar Pourghazi, Somayeh Hajjaran. Dispersive micro-solid phase extraction using magnetic nanoparticle modified multi-walled carbon nanotubes coupled with surfactant-enhanced spectrofluorimetry for sensitive determination of lomefloxacin and ofloxacin from biological samples. Materials science & engineering. C, Materials for biological applications. 2016 Mar; 60(?):30-36. doi: 10.1016/j.msec.2015.11.013. [PMID: 26706503]
Sonia Soldevila, M Consuelo Cuquerella, Francisco Bosca. Understanding of the photoallergic properties of fluoroquinolones: photoreactivity of lomefloxacin with amino acids and albumin. Chemical research in toxicology. 2014 Apr; 27(4):514-23. doi: 10.1021/tx400377s. [PMID: 24528107]
Ornella Di Pietro, Elisabet Viayna, Esther Vicente-García, Manuela Bartolini, Rosario Ramón, Jordi Juárez-Jiménez, M Victòria Clos, Belén Pérez, Vincenza Andrisano, F Javier Luque, Rodolfo Lavilla, Diego Muñoz-Torrero. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. European journal of medicinal chemistry. 2014 Feb; 73(?):141-52. doi: 10.1016/j.ejmech.2013.12.008. [PMID: 24389509]
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Zohreh Sattar, Hediye Iranfar, Ahmad Asoodeh, Mohammad Reza Saberi, Mahboobeh Mazhari, Jamshidkhan Chamani. Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin: an evaluation of PPIX aggregation in protein-protein interactions. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Nov; 97(?):1089-100. doi: 10.1016/j.saa.2012.07.034. [PMID: 22925987]
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Joana Sousa, Gilberto Alves, Ana Fortuna, Angelina Pena, Celeste Lino, Amílcar Falcão. Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma. Biomedical chromatography : BMC. 2011 May; 25(5):535-41. doi: 10.1002/bmc.1480. [PMID: 20641047]
JamshidKhan Chamani, Hanif Vahedian-Movahed, Mohammad Reza Saberi. Lomefloxacin promotes the interaction between human serum albumin and transferrin: a mechanistic insight into the emergence of antibiotic's side effects. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 55(1):114-24. doi: 10.1016/j.jpba.2010.12.029. [PMID: 21273024]
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