S-Carboxymethyl-L-cysteine (BioDeep_00000002760)

 

Secondary id: BioDeep_00000399971, BioDeep_00000405775

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


2-Amino-3-[(carboxymethyl)sulfanyl]propanoic acid

化学式: C5H9NO4S (179.0252)
中文名称: S-(羧甲基)-L-半胱氨酸, S-(羧甲基)半胱氨酸, S-羧甲基-L-半胱氨酸, 羧甲基半胱氨酸, 羧甲司坦
谱图信息: 最多检出来源 Homo sapiens(feces) 13.46%

分子结构信息

SMILES: C(C(C(=O)O)N)SCC(=O)O
InChI: InChI=1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)

描述信息

S-carboxymethylcysteine (carbocisteine) is the most frequently prescribed mucoactive agent for long-term COPD (chronic obstructive pulmonary disease) use in a number of countries. In addition to its mucoregulatory activity, carbocisteine exhibits free-radical scavenging and anti-inflammatory properties. S-Carboxymethyl-L-cysteine can be found in root vegetables and has been isolated from radish seedlings. S-carboxymethyl-L-cysteine can be detectable in urine especially after the processing of chlorinated compounds by gut microlfora.
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CB - Mucolytics
Acquisition and generation of the data is financially supported in part by CREST/JST.
C78273 - Agent Affecting Respiratory System > C74536 - Mucolytic Agent
D019141 - Respiratory System Agents > D005100 - Expectorants
D000890 - Anti-Infective Agents
KEIO_ID A059

同义名列表

44 个代谢物同义名

2-Amino-3-[(carboxymethyl)sulfanyl]propanoic acid; (L)-2-Amino-3-(carboxymethylthio)propionic acid; 2-Amino-3-(carboxymethylthio)propionic acid; 3-[(Carboxymethyl)thio]-L-alanine; L-3-((Carboxymethyl)thio)alanine; 3-(Carboxymethylthio)-L-alanine; 3-[(Carboxymethyl)thio]alanine; 3-((Carboxymethyl)thio)alanine; S-(Carboxymethyl)-(R)-cysteine; 5-Amino-3-thiadihexanoic acid; (R)-S-(Carboxymethyl)cysteine; S-(Carboxymethyl)-L-cysteine; 3-(Carboxymethylthio)alanine; S-Carboxylmethyl-L-cysteine; s-carboxymethyl-l-cysteine; Carboxymethylated cysteine; S-(Carboxymethyl)cysteine; Carboxymethylenecysteine; S Carboxymethylcysteine; 1-Carboxymethylcysteine; Carbocysteine, L isomer; Carbocysteine, L-isomer; S-Carboxymethylcysteine; L-Carboxymethylcysteine; L-Isomer carbocysteine; Carboxymethylcysteine; Carbocisteine-13C3; Carbocysteine; Carbocisteine; carbocystein; Rhinathiol; carbofuran; Thiodril; Mucodyne; Reomucil; Mucodine; Loviscol; Muciclar; Mucofan; Mucocis; Mukodin; S-Carboxymethyl-cysteine; S-Carboxymethyl-L-cysteine; S-Carboxymethyl-L-cysteine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, BCL2, CASP3, CFTR, HDAC2, NFKB1, TLR4, VEGFA
Peripheral membrane protein 1 GORASP1
Endosome membrane 2 CFTR, TLR4
Endoplasmic reticulum membrane 3 BCL2, CFTR, HMOX1
Nucleus 12 AFF1, ALB, BCL2, CASP3, CFTR, GABPA, HDAC2, HMOX1, JUND, MPO, NFKB1, VEGFA
cytosol 6 ALB, BCL2, CASP3, CFTR, HMOX1, NFKB1
centrosome 1 ALB
nucleoplasm 7 CASP3, GABPA, HDAC2, HMOX1, JUND, MPO, NFKB1
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 4 CD8A, CFTR, TLR4, TNF
Cytoplasmic side 2 GORASP1, HMOX1
Early endosome membrane 1 CFTR
Multi-pass membrane protein 1 CFTR
Golgi apparatus membrane 1 GORASP1
cell surface 5 CFTR, ICAM1, TLR4, TNF, VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 3 ALB, GORASP1, VEGFA
Golgi membrane 1 GORASP1
lysosomal membrane 1 CFTR
neuronal cell body 2 CASP3, TNF
Lysosome 1 MPO
plasma membrane 6 CD8A, CFTR, ICAM1, IFNLR1, TLR4, TNF
Membrane 8 BCL2, CFTR, HDAC2, HMOX1, ICAM1, IFNLR1, TLR4, VEGFA
apical plasma membrane 1 CFTR
extracellular exosome 3 ALB, ICAM1, MPO
endoplasmic reticulum 4 ALB, BCL2, HMOX1, VEGFA
extracellular space 8 ALB, CXCL8, HMOX1, ICAM1, IL6, MPO, TNF, VEGFA
perinuclear region of cytoplasm 2 HMOX1, TLR4
adherens junction 1 VEGFA
mitochondrion 2 BCL2, NFKB1
protein-containing complex 4 ALB, BCL2, CFTR, HDAC2
intracellular membrane-bounded organelle 1 MPO
postsynaptic density 1 CASP3
ESC/E(Z) complex 1 HDAC2
Single-pass type I membrane protein 4 CD8A, ICAM1, IFNLR1, TLR4
Secreted 4 ALB, CXCL8, IL6, VEGFA
extracellular region 8 ALB, CD8A, CXCL8, IL6, MPO, NFKB1, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
transcription regulator complex 2 JUND, NFKB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 CD8A, ICAM1, TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Early endosome 2 CFTR, TLR4
recycling endosome 2 CFTR, TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 CFTR
Membrane raft 2 ICAM1, TNF
pore complex 1 BCL2
focal adhesion 1 ICAM1
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
collagen-containing extracellular matrix 1 ICAM1
secretory granule 2 MPO, VEGFA
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 CD8A, TLR4
ciliary basal body 1 ALB
chromatin 4 GABPA, HDAC2, JUND, NFKB1
phagocytic cup 2 TLR4, TNF
centriole 1 ALB
spindle pole 1 ALB
chromosome, telomeric region 1 HDAC2
blood microparticle 1 ALB
Recycling endosome membrane 1 CFTR
chloride channel complex 1 CFTR
Golgi-associated vesicle membrane 1 CFTR
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 CD8A
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 JUND
platelet alpha granule lumen 2 ALB, VEGFA
specific granule lumen 1 NFKB1
histone deacetylase complex 1 HDAC2
transcription elongation factor complex 1 AFF1
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
NuRD complex 1 HDAC2
immunological synapse 1 ICAM1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 CFTR
phagocytic vesicle lumen 1 MPO
Sin3-type complex 1 HDAC2
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
ciliary transition fiber 1 ALB
super elongation complex 1 AFF1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


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