Abacavir (BioDeep_00000002759)

 

Secondary id: BioDeep_00001868188

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


4R-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1S-methanol, monohydrochloride

化学式: C14H18N6O (286.1542018)
中文名称: 阿巴卡韦
谱图信息: 最多检出来源 Homo sapiens(blood) 0.95%

分子结构信息

SMILES: C1=C[C@@H](C[C@@H]1CO)n1cnc2c(NC3CC3)nc(N)nc12
InChI: InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)

描述信息

Abacavir is only found in individuals that have used or taken this drug. It is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. [Wikipedia]Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

12 个代谢物同义名

4R-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1S-methanol, monohydrochloride; {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol; [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol; (1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol; {4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol; Abacavir succinate; Abacavir Sulfate; Abacavir; 1592U89; Ziagen; ABC; Abacavir



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

53 个相关的代谢反应过程信息。

Reactome(52)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sandra Rotea-Salvo, Víctor Giménez-Arufe, Alejandro Martínez-Pradeda, Carla Fernández-Oliveira, Álvaro Mena-de-Cea, Luis Margusino-Framiñán, Isabel Martín-Herranz, Purificación Cid-Silva. Lipid profile changes associated with antiretroviral therapies in a real-world cohort. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2023 Sep; 47(5):T210-T217. doi: 10.1016/j.farma.2023.07.005. [PMID: 37673703]
  • Sandra Rotea-Salvo, Víctor Giménez-Arufe, Alejandro Martínez-Pradeda, Carla Fernández-Oliveira, Álvaro Mena-de-Cea, Luis Margusino-Framiñán, Isabel Martín-Herranz, Purificación Cid-Silva. Lipid profile changes associated with antiretroviral therapies in a real-world cohort. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2023 Jun; ?(?):. doi: 10.1016/j.farma.2023.04.007. [PMID: 37349200]
  • P N Kunene, P N Mahlambi. Case study on antiretroviral drugs uptake from soil irrigated with contaminated water: Bio-accumulation and bio-translocation to roots, stem, leaves, and fruits. Environmental pollution (Barking, Essex : 1987). 2023 Feb; 319(?):121004. doi: 10.1016/j.envpol.2023.121004. [PMID: 36608725]
  • Lucy Campbell, Fowzia Ibrahim, Birgit Barbini, Amanda Samarawickrama, Chloe Orkin, Julie Fox, Laura Waters, Yvonne Gilleece, Shema Tariq, Frank A Post. Bone mineral density, kidney function and participant-reported outcome measures in women who switch from tenofovir disoproxil emtricitabine and a nonnucleoside reverse transcriptase inhibitor to abacavir, lamivudine and dolutegravir. HIV medicine. 2022 04; 23(4):362-370. doi: 10.1111/hiv.13215. [PMID: 34866304]
  • Leonardo Calza, Giorgio Legnani, Ciro Fulgaro, Gabriella Verucchi, Isabella Bon, Tiziana Lazzarotto, Pierluigi Viale. Changes in Serum Inflammatory Markers in Antiretroviral Therapy-Naive HIV-Infected Patients Starting Dolutegravir/Lamivudine or Dolutegravir/Lamivudine/Abacavir. Journal of acquired immune deficiency syndromes (1999). 2022 03; 89(3):e30. doi: 10.1097/qai.0000000000002861. [PMID: 34743087]
  • E A Illarionova, N V Chmelevskaya, Yu A Gonchikova, A E Mitina. [Determination of abacavir in biological objects for the purpose of chemical and toxicological analysis]. Sudebno-meditsinskaia ekspertiza. 2022; 65(2):29-33. doi: 10.17116/sudmed20226502129. [PMID: 35416013]
  • Z C Lim, G S Hoo, J H Ang, C B Teng, L W Ang, C C Lee, Y S Leo, H L Law, O T Ng, C S Wong. Safety and effectiveness of switching to Abacavir/Lamivudine plus rilpivirine for maintenance therapy in virologically suppressed HIV-1 individuals in Singapore (SEALS). AIDS research and therapy. 2021 11; 18(1):80. doi: 10.1186/s12981-021-00402-7. [PMID: 34724931]
  • Rajendra P Singh, Kimberly Adkison, Allen Wolstenholme, Judy Hopking, Brian Wynne. Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Abacavir/Dolutegravir/Lamivudine Combination Tablets in Healthy Japanese Study Participants. Clinical pharmacology in drug development. 2021 09; 10(9):985-993. doi: 10.1002/cpdd.996. [PMID: 34265164]
  • Wouter A van der Heijden, Jun Wan, Lisa Van de Wijer, Martin Jaeger, Mihai G Netea, Andre J van der Ven, Philip G de Groot, Mark Roest, Quirijn de Mast. Plasmatic Coagulation Capacity Correlates With Inflammation and Abacavir Use During Chronic HIV Infection. Journal of acquired immune deficiency syndromes (1999). 2021 05; 87(1):711-719. doi: 10.1097/qai.0000000000002633. [PMID: 33492017]
  • Prashanth Chowdary, Shraddha Shetty, John Booth, Muhammad Arslan Khurram, Magdi Yaqoob, Ismail Heyder Mohamed. Experience of SARS-CoV-2 infection in two kidney transplant recipients living with HIV-1 infection. Transplant infectious disease : an official journal of the Transplantation Society. 2021 Apr; 23(2):e13500. doi: 10.1111/tid.13500. [PMID: 33174284]
  • Agnieszka Matuszewska, Beata Nowak, Wojciech Niżański, Maria Eberhardt, Kinga Domrazek, Anna Nikodem, Benita Wiatrak, Krzysztof Zduniak, Kamil Olejnik, Anna Merwid-Ląd, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Marzenna Podhorska-Okołów, Aleksandra Piotrowska, Izabela Jęśkowiak, Agata Heinrich, Maria Rutkowska, Wojciech Dziewiszek, Tomasz Sozański, Joanna Kwiatkowska, Paulina Jawień, Marek Bolanowski, Adam Szeląg. Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats. Oxidative medicine and cellular longevity. 2021; 2021(?):5596090. doi: 10.1155/2021/5596090. [PMID: 34373766]
  • Sanjeev Kumar, Himanshu Batra, Swarandeep Singh, Himanshi Chawla, Ravinder Singh, Sanket Katpara, Abdul Wahid Hussain, Bimal Kumar Das, Rakesh Lodha, Sushil Kumar Kabra, Kalpana Luthra. Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children. The Journal of general virology. 2020 12; 101(12):1289-1299. doi: 10.1099/jgv.0.001480. [PMID: 32915123]
  • Steffen Jockusch, Chuanjuan Tao, Xiaoxu Li, Thomas K Anderson, Minchen Chien, Shiv Kumar, James J Russo, Robert N Kirchdoerfer, Jingyue Ju. A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19. Antiviral research. 2020 08; 180(?):104857. doi: 10.1016/j.antiviral.2020.104857. [PMID: 32562705]
  • Eisuke Adachi, Makoto Saito, Kazuhiko Ikeuchi, Tokio Hoshina, Hiroshi Yotsuyanagi. Cases of coronavirus disease-2019 in HIV-infected transgender women. AIDS (London, England). 2020 07; 34(9):1435-1436. doi: 10.1097/qad.0000000000002573. [PMID: 32590441]
  • Chloe Orkin, Edwin DeJesus, Paul E Sax, Jose R Arribas, Samir K Gupta, Claudia Martorell, Jeffrey L Stephens, Hans-Jurgen Stellbrink, David Wohl, Franco Maggiolo, Melanie A Thompson, Daniel Podzamczer, Debbie Hagins, Jason A Flamm, Cynthia Brinson, Amanda Clarke, Hailin Huang, Rima Acosta, Diana M Brainard, Sean E Collins, Hal Martin. Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection: week 144 results from two randomised, double-blind, multicentre, phase 3, non-inferiority trials. The lancet. HIV. 2020 06; 7(6):e389-e400. doi: 10.1016/s2352-3018(20)30099-0. [PMID: 32504574]
  • Aude Jary, Anne-Geneviève Marcelin, Charlotte Charpentier, Marc Wirden, Minh P Lê, Gilles Peytavin, Diane Descamps, Vincent Calvez. M184V/I does not impact the efficacy of abacavir/lamivudine/dolutegravir use as switch therapy in virologically suppressed patients. The Journal of antimicrobial chemotherapy. 2020 05; 75(5):1290-1293. doi: 10.1093/jac/dkaa019. [PMID: 32065630]
  • Neha Agrawal, Jennifer Rowe, Jie Lan, Qigui Yu, Christine A Hrycyna, Jean Chmielewski. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity. Journal of medicinal chemistry. 2020 03; 63(5):2131-2138. doi: 10.1021/acs.jmedchem.9b00779. [PMID: 31505928]
  • Akiko Fukuda, Takako Nagao, Tomomi Kitaichi, Ichiro Koga, Akihiro Kobayashi, Toshiyuki Miura. Safety analysis of Lexiva tablets 700 (fosamprenavir calcium hydrate) in post-marketing surveillance in Japan. Current medical research and opinion. 2020 03; 36(3):455-464. doi: 10.1080/03007995.2019.1700495. [PMID: 31794279]
  • Marta Fernández-González, José A García, Sergio Padilla, Javier García-Abellán, Vanesa Agulló, Félix Gutiérrez, Mar Masiá. Rectal and seminal HIV-1 RNA decay towards virological suppression in infected MSM initiating dolutegravir/abacavir/lamivudine. The Journal of antimicrobial chemotherapy. 2020 03; 75(3):668-674. doi: 10.1093/jac/dkz482. [PMID: 31769846]
  • Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). 2020 01; 91(?):74-91. doi: 10.1016/j.reprotox.2019.10.004. [PMID: 31711903]
  • Leonardo Calza, Michele Sachs, Vincenzo Colangeli, Marco Borderi, Bianca Granozzi, Pietro Malosso, Giorgia Comai, Valeria Corradetti, Gaetano La Manna, Pierluigi Viale. Prevalence of chronic kidney disease among HIV-1-infected patients receiving a combination antiretroviral therapy. Clinical and experimental nephrology. 2019 Nov; 23(11):1272-1279. doi: 10.1007/s10157-019-01768-9. [PMID: 31327092]
  • Laurent Hocqueloux, François Raffi, Thierry Prazuck, Louis Bernard, Simon Sunder, Jean-Luc Esnault, David Rey, Gwenaël Le Moal, Mariam Roncato-Saberan, Marie André, Eric Billaud, Antoine Valéry, Véronique Avettand-Fènoël, Jean-Jacques Parienti, Clotilde Allavena. Dolutegravir Monotherapy Versus Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed People Living With Chronic Human Immunodeficiency Virus Infection: The Randomized Noninferiority MONotherapy of TiviCAY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019 10; 69(9):1498-1505. doi: 10.1093/cid/ciy1132. [PMID: 30601976]
  • Crystal R Leibrand, Jason J Paris, Austin M Jones, Quamrun N Masuda, Matthew S Halquist, Woong-Ki Kim, Pamela E Knapp, Angela D M Kashuba, Kurt F Hauser, MaryPeace McRae. HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood-brain barrier integrity. Journal of neurovirology. 2019 08; 25(4):560-577. doi: 10.1007/s13365-019-00757-8. [PMID: 31102185]
  • Lisa J Frigati, Karryn Brown, Sana Mahtab, Leah Githinji, Diane Gray, Liesl Zühlke, Peter Nourse, Dan J Stein, Jaqueline Hoare, Mark F Cotton, Landon Myer, Heather J Zar. Multisystem impairment in South African adolescents with Perinatally acquired HIV on antiretroviral therapy (ART). Journal of the International AIDS Society. 2019 08; 22(8):e25386. doi: 10.1002/jia2.25386. [PMID: 31441211]
  • David A Wohl, Yazdan Yazdanpanah, Axel Baumgarten, Amanda Clarke, Melanie A Thompson, Cynthia Brinson, Debbie Hagins, Moti N Ramgopal, Andrea Antinori, Xuelian Wei, Rima Acosta, Sean E Collins, Diana Brainard, Hal Martin. Bictegravir combined with emtricitabine and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial. The lancet. HIV. 2019 06; 6(6):e355-e363. doi: 10.1016/s2352-3018(19)30077-3. [PMID: 31068270]
  • Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC nephrology. 2019 05; 20(1):155. doi: 10.1186/s12882-019-1335-9. [PMID: 31064340]
  • Sebastiano Rizzardo, Massimiliano Lanzafame, Emanuela Lattuada, Damiano Bragantini, Stefano Nicolè, Leonardo Calza, Evelina Tacconelli. Efficacy and safety of abacavir/lamivudine with raltegravir in treatment-experienced and treatment-naïve patients with HIV-1 infection: an observational, retrospective, multi-centre study. International journal of STD & AIDS. 2019 04; 30(5):467-471. doi: 10.1177/0956462418817049. [PMID: 30999834]
  • Sarah M Michienzi, Christopher A Schriever, Melissa E Badowski. Abacavir/lamivudine/dolutegravir single tablet regimen in patients with human immunodeficiency virus and end-stage renal disease on hemodialysis. International journal of STD & AIDS. 2019 02; 30(2):181-187. doi: 10.1177/0956462418800865. [PMID: 30381029]
  • Edgar Dehesa Lopez, Carlos Córdova-Cázarez, Rafael Valdez-Ortiz, Carlie Michelle Cardona-Landeros, María Fernanda Gutiérrez-Rico. Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients. Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 2019 Jan; 41(1):48-54. doi: 10.1590/2175-8239-jbn-2018-0024. [PMID: 30010693]
  • Gordana Dragovic, Katarina Nikolic, Bozana Dimitrijevic, Djordje Jevtovic, Dubravka Salemovic, Nada Tomanovic, Ivan Boricic. Severe hepatotoxicity induced by efavirenz in a treatment-naïve, low body mass index HIV-infected, female patient with no hepatitis and other virus co-infections. Ultrastructural pathology. 2019; 43(4-5):220-223. doi: 10.1080/01913123.2019.1673862. [PMID: 31578116]
  • Aleš Chrdle, Zdeňka Jerhotová, Michal Vacík, Marek Linka, Václav Chmelík. Crushed dolutegravir/abacavir/lamivudine given via nasogastric tube in gastric outlet obstruction caused by cancer resulted in rapid viral load suppression. International journal of STD & AIDS. 2019 01; 30(1):94-98. doi: 10.1177/0956462418797847. [PMID: 30231834]
  • Rajendra P Singh, Jafar S B Shaik, Nancy Skoura, Shashidhar Joshi, Trevor Shreeves, Linda Casillas, Ann M Buchanan. Effects of Low- and High-Mineral Content Water on the Relative Bioavailability of a Coformulated Abacavir/Dolutegravir/Lamivudine Dispersible Tablet in Healthy Adults. Journal of acquired immune deficiency syndromes (1999). 2018 12; 79(5):631-638. doi: 10.1097/qai.0000000000001859. [PMID: 30239425]
  • Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L Greenwood, Jocelyn D Glazier, Frantisek Staud. Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta. Drug metabolism and disposition: the biological fate of chemicals. 2018 11; 46(11):1817-1826. doi: 10.1124/dmd.118.083329. [PMID: 30097436]
  • Jean-Michel Molina, Douglas Ward, Indira Brar, Anthony Mills, Hans-Jürgen Stellbrink, Luis López-Cortés, Peter Ruane, Daniel Podzamczer, Cynthia Brinson, Joseph Custodio, Hui Liu, Kristen Andreatta, Hal Martin, Andrew Cheng, Erin Quirk. Switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from dolutegravir plus abacavir and lamivudine in virologically suppressed adults with HIV-1: 48 week results of a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial. The lancet. HIV. 2018 07; 5(7):e357-e365. doi: 10.1016/s2352-3018(18)30092-4. [PMID: 29925489]
  • A Calcagno, C Pinnetti, A De Nicolò, E Scarvaglieri, M Gisslen, M Tempestilli, A D'Avolio, V Fedele, G Di Perri, A Antinori, S Bonora. Cerebrospinal fluid abacavir concentrations in HIV-positive patients following once-daily administration. British journal of clinical pharmacology. 2018 06; 84(6):1380-1383. doi: 10.1111/bcp.13552. [PMID: 29444348]
  • Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella. Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. Journal of acquired immune deficiency syndromes (1999). 2018 05; 78(1):62-72. doi: 10.1097/qai.0000000000001642. [PMID: 29419568]
  • Jane A O'Halloran, Eimear Dunne, Willard Tinago, Stephanie Denieffe, Dermot Kenny, Patrick W G Mallon. Switching from abacavir to tenofovir disoproxil fumarate is associated with rises in soluble glycoprotein VI, suggesting changes in platelet-collagen interactions. AIDS (London, England). 2018 04; 32(7):861-866. doi: 10.1097/qad.0000000000001783. [PMID: 29438200]
  • Catherine Orrell, Debbie P Hagins, Elena Belonosova, Norma Porteiro, Sharon Walmsley, Vicenç Falcó, Choy Y Man, Alicia Aylott, Ann M Buchanan, Brian Wynne, Cindy Vavro, Michael Aboud, Kimberly Y Smith. Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study. The lancet. HIV. 2017 12; 4(12):e536-e546. doi: 10.1016/s2352-3018(17)30095-4. [PMID: 28729158]
  • Roberta Gagliardini, Massimiliano Fabbiani, Manuela Colafigli, Alessandro D'Avino, Annalisa Mondi, Alberto Borghetti, Silvia Lamonica, Roberto Cauda, Andrea De Luca, Simona Di Giambenedetto. Lipid-lowering effect and changes in estimated cardiovascular risk after switching to a tenofovir-containing regimen for the treatment of HIV-infected patients. Journal of chemotherapy (Florence, Italy). 2017 Oct; 29(5):299-307. doi: 10.1080/1120009x.2016.1269040. [PMID: 28019192]
  • Josef Reznicek, Martina Ceckova, Zuzana Ptackova, Ondrej Martinec, Lenka Tupova, Lukas Cerveny, Frantisek Staud. MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption. Antimicrobial agents and chemotherapy. 2017 09; 61(9):. doi: 10.1128/aac.00837-17. [PMID: 28696229]
  • Samir K Gupta, Eunice Yeh, Douglas W Kitch, Todd T Brown, Charles S Venuto, Gene D Morse, Belinda Ha, Kathleen Melbourne, Grace A McComsey. Bone mineral density reductions after tenofovir disoproxil fumarate initiation and changes in phosphaturia: a secondary analysis of ACTG A5224s. The Journal of antimicrobial chemotherapy. 2017 07; 72(7):2042-2048. doi: 10.1093/jac/dkx076. [PMID: 28369419]
  • Eiko Yamada, Ritsuo Takagi, Yoshinari Tanabe, Hiroshi Fujiwara, Naoki Hasegawa, Shingo Kato. Plasma and saliva concentrations of abacavir, tenofovir, darunavir, and raltegravir in HIV-1-infected patients
. International journal of clinical pharmacology and therapeutics. 2017 Jul; 55(7):567-570. doi: 10.5414/cp202789. [PMID: 28427498]
  • Yacouba L Diallo, Véronique Ollivier, Véronique Joly, Dorothée Faille, Giovanna Catalano, Martine Jandrot-Perrus, Antoine Rauch, Patrick Yeni, Nadine Ajzenberg. Abacavir has no prothrombotic effect on platelets in vitro. The Journal of antimicrobial chemotherapy. 2016 12; 71(12):3506-3509. doi: 10.1093/jac/dkw303. [PMID: 27516475]
  • Suresh K A, Kadiam C Venkata Subbaiah, Rayapu Lavanya, Kuruva Chandrasekhar, Naga Raju Chamarti, M Suresh Kumar, Rajendra Wudayagiri, Lokanatha Valluru. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Applied biochemistry and biotechnology. 2016 Sep; 180(2):361-81. doi: 10.1007/s12010-016-2104-x. [PMID: 27142273]
  • Pasquale Pagliano, Tiziana Ascione, Maria Aurora Carleo, Giovanni Boccia, Francesco De Caro, Fabio Tortora. HIV positive patient with HSV-2 encephalitis: case report. Le infezioni in medicina. 2016 Sep; 24(3):245-9. doi: NULL. [PMID: 27668908]
  • Josep M Llibre, Andrew Hill. Abacavir and cardiovascular disease: A critical look at the data. Antiviral research. 2016 08; 132(?):116-21. doi: 10.1016/j.antiviral.2016.05.015. [PMID: 27260856]
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