sulfasalazine (BioDeep_00000275651)

Main id: BioDeep_00000002818

 

natural product


代谢物信息卡片


Sulfasalazine (Azulfidine)

化学式: C18H14N4O5S (398.0685)
中文名称: 柳氮磺胺吡啶
谱图信息: 最多检出来源 Mus musculus(general) 22.46%

分子结构信息

SMILES: C1(NS(C2=CC=C(C=C2)/N=N/C3=CC(=C(C=C3)O)C(=O)O)(=O)=O)=CC=CC=N1
InChI: InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)

描述信息

A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07E - Intestinal antiinflammatory agents > A07EC - Aminosalicylic acid and similar agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D005765 - Gastrointestinal Agents
D000890 - Anti-Infective Agents
D018501 - Antirheumatic Agents
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4230; ORIGINAL_PRECURSOR_SCAN_NO 4229
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4221; ORIGINAL_PRECURSOR_SCAN_NO 4220
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4107; ORIGINAL_PRECURSOR_SCAN_NO 4106
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4144; ORIGINAL_PRECURSOR_SCAN_NO 4143
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4237; ORIGINAL_PRECURSOR_SCAN_NO 4236
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4245; ORIGINAL_PRECURSOR_SCAN_NO 4244
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8819; ORIGINAL_PRECURSOR_SCAN_NO 8816
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8829; ORIGINAL_PRECURSOR_SCAN_NO 8824
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8833; ORIGINAL_PRECURSOR_SCAN_NO 8830
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8842; ORIGINAL_PRECURSOR_SCAN_NO 8838
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8867; ORIGINAL_PRECURSOR_SCAN_NO 8863
CONFIDENCE standard compound; INTERNAL_ID 1047; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8846; ORIGINAL_PRECURSOR_SCAN_NO 8844

同义名列表

3 个代谢物同义名

sulfasalazine; Sulfasalazine (Azulfidine); Sulfasalazine



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALOX5, BCL2, CASP3, CAT, NFKB1, PTGS2, RELA
Peripheral membrane protein 2 ALOX5, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CD4, PTGS2
Mitochondrion membrane 1 ABCG2
Nucleus 6 ACR, BCL2, CASP3, MPO, NFKB1, RELA
cytosol 7 ALOX5, BCL2, CASP3, CAT, CD44, NFKB1, RELA
mitochondrial membrane 1 ABCG2
nucleoplasm 6 ABCG2, ALOX5, CASP3, MPO, NFKB1, RELA
Cell membrane 4 ABCB1, ABCG2, CD4, CD44
Multi-pass membrane protein 2 ABCB1, ABCG2
cell surface 2 ABCB1, CD44
glutamatergic synapse 2 CASP3, RELA
Golgi apparatus 1 CD44
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 ALOX5
Lysosome 1 MPO
plasma membrane 5 ABCB1, ABCG2, CD4, CD44, IFNLR1
Membrane 6 ABCB1, ABCG2, BCL2, CAT, CD44, IFNLR1
apical plasma membrane 3 ABCB1, ABCG2, CD44
basolateral plasma membrane 1 CD44
caveola 1 PTGS2
extracellular exosome 4 ABCB1, CAT, CD44, MPO
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 8 ALOX5, CRP, CXCL8, IL10, IL2, IL4, IL6, MPO
perinuclear region of cytoplasm 1 ALOX5
mitochondrion 3 BCL2, CAT, NFKB1
protein-containing complex 4 ACR, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, CD44, IFNLR1
Secreted 7 CD44, CRP, CXCL8, IL10, IL2, IL4, IL6
extracellular region 12 ACR, ALOX5, CAT, CD44, CRP, CXCL8, IL10, IL2, IL4, IL6, MPO, NFKB1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CD44
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
transcription regulator complex 2 NFKB1, RELA
Nucleus membrane 2 ALOX5, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 ALOX5, BCL2
external side of plasma membrane 1 CD4
Early endosome 1 CD4
Golgi-associated vesicle 1 ACR
Apical cell membrane 2 ABCB1, ABCG2
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 2 ABCG2, CD4
pore complex 1 BCL2
focal adhesion 2 CAT, CD44
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 2 NFKB1, RELA
cell projection 1 CD44
brush border membrane 1 ABCG2
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
microvillus 1 CD44
Cell projection, microvillus 1 CD44
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 3 ALOX5, CAT, NFKB1
secretory granule membrane 1 CD44
endoplasmic reticulum lumen 3 CD4, IL6, PTGS2
nuclear matrix 1 ALOX5
specific granule lumen 1 NFKB1
azurophil granule lumen 1 MPO
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
clathrin-coated endocytic vesicle membrane 1 CD4
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 2 ABCB1, ABCG2
death-inducing signaling complex 1 CASP3
lamellipodium membrane 1 CD44
T cell receptor complex 1 CD4
catalase complex 1 CAT
macrophage migration inhibitory factor receptor complex 1 CD44
interleukin-6 receptor complex 1 IL6
acrosomal matrix 1 ACR
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 2 NFKB1, RELA
NF-kappaB complex 1 RELA
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Yuwen Tian, Tunyu Jian, Jin Li, Lushi Huang, Shen Li, Hao Lu, Guanting Niu, Xiuhua Meng, Bingru Ren, Huarong Liao, Xiaoqin Ding, Jian Chen. Phenolic acids from Chicory roots ameliorate dextran sulfate sodium-induced colitis in mice by targeting TRP signaling pathways and the gut microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155378. doi: 10.1016/j.phymed.2024.155378. [PMID: 38507851]
  • Wei Wu, Wenhao Bu, Yongxing Tan, Yongwang Wang. Effect of sulfasalazine on ferroptosis during intestinal injury in rats after liver transplantation. Scientific reports. 2024 03; 14(1):7349. doi: 10.1038/s41598-024-58057-z. [PMID: 38538748]
  • Begümhan Ömeroğlu Gülada, Muhammet Emin Cam, Meral Yüksel, Dilek Akakın, Turgut Taşkın, Gizem Emre, Göksel Şener, Berna Karakoyun. Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage. Journal of ethnopharmacology. 2024 Mar; 322(?):117624. doi: 10.1016/j.jep.2023.117624. [PMID: 38128893]
  • Dai Xiaoling, Zhang Anming, Lin Hui, Shi Bei, Ren Yi, Wen Hongzhu, Fei Xiaoyan, Lin Jiang. Qingchang suppositry induced remission in patients with mild-to-moderate ulcerative proctitis: a multicenter, prospective, randomized, parallel-controlled clinical trial. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):156-162. doi: 10.19852/j.cnki.jtcm.20231121.004. [PMID: 38213250]
  • Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa. The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia. Blood advances. 2023 Oct; ?(?):. doi: 10.1182/bloodadvances.2023010786. [PMID: 37906522]
  • Narandulam Usukhbayar, Shota Uesugi, Ken-Ichi Kimura. 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines. Bioscience, biotechnology, and biochemistry. 2023 Aug; ?(?):. doi: 10.1093/bbb/zbad117. [PMID: 37604790]
  • Urara Idei, Tsuyoshi Ohta, Hizuru Yamatani, Manabu Seino, Satoru Nagase. Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411781. [PMID: 37511540]
  • Hikaru Murakami, Masami Hayashi, Shinichi Terada, Masahide Ohmichi. Medroxyprogesterone acetate-resistant endometrial cancer cells are susceptible to ferroptosis inducers. Life sciences. 2023 Jul; 325(?):121753. doi: 10.1016/j.lfs.2023.121753. [PMID: 37160245]
  • Medhat Taha, Sara T Elazab, Omer Abdelbagi, Abdullah A Saati, Omar Babateen, Tourki A S Baokbah, Naeem F Qusty, Mohamed Ezzat Mahmoud, Mohie Mahmoud Ibrahim, Alaa M Badawy. Phytochemical analysis of Origanum majorana L. extract and investigation of its antioxidant, anti-inflammatory and immunomodulatory effects against experimentally induced colitis downregulating Th17 cells. Journal of ethnopharmacology. 2023 Jun; 317(?):116826. doi: 10.1016/j.jep.2023.116826. [PMID: 37348796]
  • Lai-Bo Yin, Zhi-Wei Li, Jing-Ling Wang, Lei Wang, Liang Hou, Si-Yuan Hu, Huan Chen, Pan Luo, Xiao-Bin Cui, Jia-Long Zhu. Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis. Chemical biology & drug design. 2023 Jun; ?(?):. doi: 10.1111/cbdd.14281. [PMID: 37291716]
  • Mustafa Cellat, İbrahim Ozan Tekeli, Erdinç Türk, Tuba Aydin, Ahmet Uyar, Cafer Tayer İşler, İshak Gökçek, Muhammed Etyemez, Mehmet Güvenç. Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 May; 98(4):255-266. doi: 10.1080/10520295.2023.2176923. [PMID: 37165766]
  • Abozar Nasiri-Jahrodi, Fatemeh-Maryam Sheikholeslami, Mehdi Barati. Cladosporium tenuissimum-induced sinusitis in a woman with immune-deficiency disorder. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2023 Apr; ?(?):. doi: 10.1007/s42770-023-00978-4. [PMID: 37101101]
  • Marta Szandruk-Bender, Beata Nowak, Anna Merwid-Ląd, Alicja Z Kucharska, Małgorzata Krzystek-Korpacka, Iwona Bednarz-Misa, Benita Wiatrak, Adam Szeląg, Narcyz Piórecki, Tomasz Sozański. Cornus mas L. Extract Targets the Specific Molecules of the Th17/Treg Developmental Pathway in TNBS-Induced Experimental Colitis in Rats. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073034. [PMID: 37049797]
  • Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications. European journal of medicinal chemistry. 2022 Dec; 244(?):114861. doi: 10.1016/j.ejmech.2022.114861. [PMID: 36332549]
  • Ritu Mishra, Neha Jain, Shreya Kaul, Upendra Nagaich. Central composite design-based optimization, fabrication, and pharmacodynamic assessment of sulfasalazine-loaded lipoidal nanoparticle-based hydrogel for the management of rheumatoid arthritis. Drug delivery and translational research. 2022 Dec; ?(?):. doi: 10.1007/s13346-022-01260-0. [PMID: 36515863]
  • Lixia Li, Yingjie Wang, Ling Zhao, Gang Ye, Fei Shi, Yinglun Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Xueyuan Wu, Wen Li, Huaqiao Tang. Sanhuang xiexin decoction ameliorates secondary liver injury in DSS-induced colitis involve regulating inflammation and bile acid metabolism. Journal of ethnopharmacology. 2022 Dec; 299(?):115682. doi: 10.1016/j.jep.2022.115682. [PMID: 36058478]
  • Hussam Murad, Osama Ahmed, Thamer Alqurashi, Mostafa Hussien. Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats. Drug delivery. 2022 Dec; 29(1):2017-2028. doi: 10.1080/10717544.2022.2086939. [PMID: 35766160]
  • Shaowei Huang, Jinrong He, Yanping Chen, Xiaojing Wang, Yanyang Li, Yulin Su, Ruyan Wen, Xiuling Li, Guanghua Yang, Shuang Luo, Lian Zhou, Xia Luo. Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway. Pharmaceutical biology. 2022 Dec; 60(1):108-118. doi: 10.1080/13880209.2021.2017981. [PMID: 34967696]
  • Qianwen Zhou, Xiaoqi Wang, Yingxue Zhang, Lie Wang, Zhijun Chen. Inhibition of AEBP1 predisposes cisplatin-resistant oral cancer cells to ferroptosis. BMC oral health. 2022 Nov; 22(1):478. doi: 10.1186/s12903-022-02503-9. [PMID: 36352396]
  • Anil Yilmaz, Fatih Uckaya, Nihan Bayindir, Eray Metin Guler, Ali Toprak, Abdurrahim Kocyigit, Mukaddes Esrefoglu, Gulacti Topcu. Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats. Journal of food biochemistry. 2022 11; 46(11):e14299. doi: 10.1111/jfbc.14299. [PMID: 35778816]
  • Saba Ahmed, Justin Konig, Lora J Kasselman, Heather A Renna, Joshua De Leon, Steven E Carsons, Allison B Reiss. Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial. Medicina (Kaunas, Lithuania). 2022 Sep; 58(9):. doi: 10.3390/medicina58091287. [PMID: 36143964]
  • Rania M Salama, Samar F Darwish, Ismail El Shaffei, Noura F Elmongy, Nouran M Fahmy, Manal S Afifi, Ghada A Abdel-Latif. Morus macroura Miq. Fruit extract protects against acetic acid-induced ulcerative colitis in rats: Novel mechanistic insights on its impact on miRNA-223 and on the TNFα/NFκB/NLRP3 inflammatory axis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Jul; 165(?):113146. doi: 10.1016/j.fct.2022.113146. [PMID: 35595039]
  • Junyu Liu, Chenge Lou, Chenxiao Zhen, Yijia Wang, Peng Shang, Huanhuan Lv. Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blockage in K7M2 osteosarcoma cells. Metallomics : integrated biometal science. 2022 05; 14(5):. doi: 10.1093/mtomcs/mfac027. [PMID: 35441682]
  • Vasileios Tsamis, Eleni Tsanaktsidou, Christina Karavasili, Constantinos K Zacharis, Nikolaos Bouropoulos, Dimitrios G Fatouros, Catherine K Markopoulou. Development and validation of HPLC-DAD and LC-(ESI)/MS methods for the determination of sulfasalazine, mesalazine and hydrocortisone 21-acetate in tablets and rectal suppositories: In vitro and ex vivo permeability studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 May; 1198(?):123246. doi: 10.1016/j.jchromb.2022.123246. [PMID: 35405570]
  • Bassem Refaat, Mohamed El-Boshy. Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat. Experimental biology and medicine (Maywood, N.J.). 2022 04; 247(8):691-699. doi: 10.1177/15353702211073804. [PMID: 35068213]
  • Simone Forcato, Ana Beatriz de Oliveira Aquino, Nathaly de Moura Camparoto, Hannah Hamada Mendonça Lens, Flávia Alessandra Guarnier, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin. Sulfasalazine exposure during pregnancy and lactation induces alterations in reproductive behavior in adult female rat offspring. Life sciences. 2022 Mar; 293(?):120303. doi: 10.1016/j.lfs.2022.120303. [PMID: 35051419]
  • Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan. Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia. American journal of obstetrics and gynecology. 2022 02; 226(2S):S1157-S1170. doi: 10.1016/j.ajog.2020.09.014. [PMID: 32946849]
  • Napapan Kangwan, Sarawut Kongkarnka, Nitsara Boonkerd, Kridsada Unban, Kalidas Shetty, Chartchai Khanongnuch. Protective Effect of Probiotics Isolated from Traditional Fermented Tea Leaves (Miang) from Northern Thailand and Role of Synbiotics in Ameliorating Experimental Ulcerative Colitis in Mice. Nutrients. 2022 Jan; 14(1):. doi: 10.3390/nu14010227. [PMID: 35011101]
  • You Kyoung Shin, Soonho Kwon, Yu Shan Hsieh, A Young Han, Geun Hee Seol. Linalyl acetate restores colon contractility and blood pressure in repeatedly stressed-ulcerative colitis rats. Environmental health and preventive medicine. 2022; 27(0):27. doi: 10.1265/ehpm.22-00041. [PMID: 35753805]
  • Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. Human & experimental toxicology. 2022 Jan; 41(?):9603271221078866. doi: 10.1177/09603271221078866. [PMID: 35290143]
  • Ryan C Ungaro, Erica J Brenner, Manasi Agrawal, Xian Zhang, Michael D Kappelman, Jean-Frederic Colombel. Impact of Medications on COVID-19 Outcomes in Inflammatory Bowel Disease: Analysis of More Than 6000 Patients From an International Registry. Gastroenterology. 2022 Jan; 162(1):316-319.e5. doi: 10.1053/j.gastro.2021.09.011. [PMID: 34529987]
  • Shicheng Sun, Changfa Guo, Taihong Gao, Dengzhen Ma, Xiangsheng Su, Qi Pang, Rui Zhang. Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1α Axis. Oxidative medicine and cellular longevity. 2022; 2022(?):7862430. doi: 10.1155/2022/7862430. [PMID: 36439690]
  • Ruonan Ma, Ling Fang, Lei Chen, Xiaonan Wang, Jing Jiang, Lizeng Gao. Ferroptotic stress promotes macrophages against intracellular bacteria. Theranostics. 2022; 12(5):2266-2289. doi: 10.7150/thno.66663. [PMID: 35265210]
  • Morteza Ghasemnejad-Berenji. Can sulfasalazine as an old drug with immunomodulatory and anti-inflammatory effects be effective in COVID-19?. Journal of basic and clinical physiology and pharmacology. 2021 Dec; 33(1):113-115. doi: 10.1515/jbcpp-2021-0349. [PMID: 34855313]
  • González-Ramírez Adriana Estrella, González-Trujano María Eva, Hernandez-Leon Alberto, Valle-Dorado María Guadalupe, Carballo-Villalobos Azucena, Orozco-Suárez Sandra, Alvarado-Vásquez Noé, López-Muñoz Francisco Javier. Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis. Journal of ethnopharmacology. 2021 Nov; 280(?):114462. doi: 10.1016/j.jep.2021.114462. [PMID: 34324951]
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