Orciprenaline (BioDeep_00000002733)

 

Secondary id: BioDeep_00001868241

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol

化学式: C11H17NO3 (211.1208)
中文名称: 奥西那林
谱图信息: 最多检出来源 Homo sapiens(plant) 9.51%

分子结构信息

SMILES: CC(C)NCC(C1=CC(=CC(=C1)O)O)O
InChI: InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3

描述信息

Orciprenaline is only found in individuals that have used or taken this drug. It is a beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]Orciprenaline is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CB - Non-selective beta-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AB - Non-selective beta-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents

同义名列表

16 个代谢物同义名

5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol; Boehringer ingelheim brand OF metaproterenol sulfate; Novartis brand OF metaproterenol sulfate; GSK Brand OF metaproterenol sulfate; Polistirex, metaproterenol; Metaproterenol polistirex; Metaproterenol sulfate; Orciprenaline sulfate; metaproterenol; orciprenaline; Astmopent; Metaprel; Alupent; Alotec; Metaproterenol; Metaproterenol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADA, ANXA6, AXIN2, MEFV, PIK3C2A, PIK3C3, RPS6KA2, TNK1
Peripheral membrane protein 4 ADA, ANXA6, AP1S2, TNK1
Endosome membrane 1 ADRB2
Cytoplasmic vesicle, autophagosome 2 MEFV, PIK3C3
Nucleus 6 ADRB2, AXIN2, MEFV, PIK3C2A, PLCZ1, RPS6KA2
autophagosome 2 MEFV, PIK3C3
cytosol 9 ADA, AP1S2, AXIN2, MEFV, PIK3C2A, PIK3C3, PLCZ1, PRKCQ, RPS6KA2
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 PIK3C2A
centrosome 1 AXIN2
nucleoplasm 4 MEFV, PIK3C2A, PLCZ1, RPS6KA2
Cell membrane 5 ADA, ADRB1, ADRB2, ADRB3, PIK3C2A
Cytoplasmic side 1 AP1S2
lamellipodium 1 MEFV
Multi-pass membrane protein 3 ADRB1, ADRB2, ADRB3
Synapse 1 RPS6KA2
cell junction 1 ADA
cell surface 1 ADA
glutamatergic synapse 1 PIK3C3
Golgi apparatus 2 ADRB2, AP1S2
Golgi membrane 2 AP1S2, INS
lysosomal membrane 3 ANXA6, AP1S2, EGF
sarcolemma 1 ANXA6
Lysosome 2 ADA, ADRB2
endosome 2 ADRB2, PIK3C3
plasma membrane 12 ADA, ADRB1, ADRB2, ADRB3, AXIN2, EDNRA, EGF, GCG, PIK3C2A, PRKCQ, REN, TNK1
Membrane 9 ADA, ADRB2, ANXA6, EGF, HGF, PIK3C2A, PIK3C3, REN, TNK1
apical plasma membrane 1 ADRB2
extracellular exosome 3 ANXA6, EGF, PIK3C2A
extracellular space 5 EGF, GCG, HGF, INS, REN
perinuclear region of cytoplasm 2 ANXA6, PLCZ1
Schaffer collateral - CA1 synapse 1 ADRB1
mitochondrion 1 ANXA6
intracellular membrane-bounded organelle 2 AP1S2, PIK3C2A
pronucleus 1 PLCZ1
Secreted 3 GCG, INS, REN
extracellular region 5 EGF, GCG, HGF, INS, REN
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 ADA
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 MEFV
nucleolus 1 PLCZ1
midbody 1 PIK3C3
Early endosome 3 ADRB1, ADRB2, AP1S2
Membrane, clathrin-coated pit 1 AP1S2
apical part of cell 1 REN
clathrin-coated pit 1 AP1S2
vesicle 1 PIK3C2A
Cell projection, lamellipodium 1 MEFV
Cytoplasm, perinuclear region 1 PLCZ1
focal adhesion 1 ANXA6
microtubule 1 MEFV
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
collagen-containing extracellular matrix 1 ANXA6
axoneme 1 PIK3C3
Cell projection, ruffle 1 MEFV
Late endosome 1 PIK3C3
ruffle 1 MEFV
receptor complex 2 ADRB2, ADRB3
Zymogen granule membrane 1 ANXA6
microtubule associated complex 1 MEFV
Late endosome membrane 1 ANXA6
phagocytic vesicle membrane 1 PIK3C3
Golgi apparatus, trans-Golgi network 1 PIK3C2A
Endomembrane system 1 AP1S2
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasmic vesicle membrane 1 AP1S2
Melanosome 1 ANXA6
clathrin-coated vesicle 1 PIK3C2A
trans-Golgi network membrane 1 AP1S2
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
platelet alpha granule lumen 2 EGF, HGF
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
neuronal dense core vesicle 2 ADRB1, ADRB2
aggresome 1 PRKCQ
vesicle membrane 1 ANXA6
clathrin-coated endocytic vesicle membrane 2 ADRB2, EGF
[Isoform 2]: Nucleus 1 MEFV
[Isoform 1]: Cytoplasm, cytoskeleton 1 MEFV
canonical inflammasome complex 1 MEFV
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
postsynaptic endosome 1 PIK3C3
ribosome 1 RPS6KA2
[Glucagon-like peptide 1]: Secreted 1 GCG
Autolysosome 1 PIK3C3
sperm head 1 PLCZ1


文献列表

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