Orciprenaline (BioDeep_00000002733)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol

化学式: C11H17NO3 (211.1208372)
中文名称: 奥西那林
谱图信息: 最多检出来源 Viridiplantae(plant) 62.13%

分子结构信息

SMILES: CC(C)NCC(C1=CC(=CC(=C1)O)O)O
InChI: InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3

描述信息

Orciprenaline is only found in individuals that have used or taken this drug. It is a beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]Orciprenaline is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CB - Non-selective beta-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AB - Non-selective beta-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents

同义名列表

14 个代谢物同义名

5-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,3-diol; Boehringer ingelheim brand OF metaproterenol sulfate; Novartis brand OF metaproterenol sulfate; GSK Brand OF metaproterenol sulfate; Polistirex, metaproterenol; Metaproterenol polistirex; Metaproterenol sulfate; Orciprenaline sulfate; metaproterenol; orciprenaline; Astmopent; Metaprel; Alupent; Alotec

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:83329
ChEBI: CHEBI:6792
KEGG: C07144
KEGGdrug: D08300
PubChem: 4086
HMDB: HMDB0014954
Metlin: METLIN1176
DrugBank: DB00816
ChEMBL: CHEMBL776
Wikipedia: Orciprenaline
MeSH: Metaproterenol
chemspider: 3944
CAS: 586-06-1
PMhub: MS000004638
PubChem: 9353
NIKKAJI: J6.736I

分类词条

Resorcinols

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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F A Ibrahim, M E Fathy, H M Elmansi. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence : the journal of biological and chemical luminescence. 2019 Feb; 34(1):77-83. doi: 10.1002/bio.3579. [PMID: 30536899]
Jacqueline Calvano, William Achanzar, Bethanne Murphy, Janet DiPiero, Clifford Hixson, Cecilia Parrula, Holly Burr, Raja Mangipudy, Mark Tirmenstein. Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats. Toxicology and applied pharmacology. 2016 Dec; 312(?):53-60. doi: 10.1016/j.taap.2015.11.015. [PMID: 26627004]
Yoko Nishimura, Yuji Morikawa, Chiaki Kondo, Yutaka Tonomura, Ryou Fukushima, Mikinori Torii, Takeki Uehara. Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies. Journal of applied toxicology : JAT. 2013 Oct; 33(10):1120-30. doi: 10.1002/jat.2867. [PMID: 23558518]
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Harri Härmä, Anita Rozwandowicz-Jansen, Eija Martikkala, Heini Frang, Ilkka Hemmilä, Niko Sahlberg, Vidal Fey, Merja Perälä, Pekka Hänninen. A new simple cell-based homogeneous time-resolved fluorescence QRET technique for receptor-ligand interaction screening. Journal of biomolecular screening. 2009 Sep; 14(8):936-43. doi: 10.1177/1087057109341657. [PMID: 19684287]
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