Levallorphan (BioDeep_00000002728)

 

Secondary id: BioDeep_00001867912

human metabolite blood metabolite natural product


代谢物信息卡片


(1R,9R,10R)-17-(prop-2-en-1-yl)-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-trien-4-ol

化学式: C19H25NO (283.1936)
中文名称: 左洛啡烷
谱图信息: 最多检出来源 Mus musculus(blood) 10.64%

分子结构信息

SMILES: C=CCN1CCC23CCCCC2C1Cc1ccc(O)cc13
InChI: InChI=1S/C19H25NO/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19/h2,6-7,13,16,18,21H,1,3-5,8-12H2/t16-,18+,19+/m0/s1

描述信息

An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist

同义名列表

6 个代谢物同义名

(1R,9R,10R)-17-(prop-2-en-1-yl)-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2(7),3,5-trien-4-ol; Dextrallorphan; levallorphan; Naloxiphan; Lorfan; Levallorphan



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, CALCA, CYP2D6, CYP3A4, POMC, PRKX, SDF4
Peripheral membrane protein 2 AP2S1, FLOT2
Endoplasmic reticulum membrane 2 CYP2D6, CYP3A4
Nucleus 1 PRKX
cytosol 3 AP2S1, GYPA, PRKCQ
dendrite 3 OPRM1, PDYN, PENK
nucleoplasm 2 GYPA, PRKX
Cell membrane 7 ACE, AP2S1, FLOT2, GYPA, OPRD1, OPRM1, SDF4
Lipid-anchor 1 FLOT2
Cytoplasmic side 1 AP2S1
lamellipodium 1 FLOT2
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 2 OPRD1, OPRM1
Synapse 3 OPRM1, PDYN, TAC1
glutamatergic synapse 1 FLOT2
Golgi apparatus 2 OPRM1, SDF4
neuronal cell body 4 CALCA, PDYN, PENK, TAC1
postsynapse 1 AP2S1
presynaptic membrane 1 OPRD1
Lysosome 1 ACE
Presynapse 1 AP2S1
endosome 3 ACE, FLOT2, OPRM1
plasma membrane 12 ACE, AP2S1, BCHE, FLOT2, GYPA, KNG1, OPRD1, OPRM1, PDYN, PENK, PRKCQ, SDF4
synaptic vesicle membrane 1 OPRD1
terminal bouton 1 CALCA
Membrane 8 ACE, CYP2D6, CYP3A4, FLOT2, GYPA, OPRD1, OPRM1, SDF4
axon 3 CCK, OPRM1, TAC1
basolateral plasma membrane 1 FLOT2
caveola 1 FLOT2
extracellular exosome 4 ACE, FLOT2, KNG1, SDF4
endoplasmic reticulum 3 CYP2D6, OPRM1, SDF4
extracellular space 7 ACE, BCHE, CALCA, CCK, KNG1, POMC, TAC1
perinuclear region of cytoplasm 1 FLOT2
adherens junction 1 FLOT2
mitochondrion 1 CYP2D6
intracellular membrane-bounded organelle 4 AP2S1, CYP2D6, CYP3A4, FLOT2
Microsome membrane 2 CYP2D6, CYP3A4
Single-pass type I membrane protein 2 ACE, GYPA
Secreted 8 ACE, BCHE, CALCA, CCK, PDYN, PENK, POMC, TRH
extracellular region 10 ACE, BCHE, CALCA, CCK, KNG1, PDYN, PENK, POMC, TAC1, TRH
cytoplasmic side of plasma membrane 1 AP2S1
Single-pass membrane protein 2 CYP2D6, GYPA
hippocampal mossy fiber to CA3 synapse 2 CALCA, PDYN
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 ACE
neuronal dense core vesicle lumen 1 PENK
perikaryon 2 OPRM1, PENK
cytoplasmic vesicle 1 FLOT2
vesicle 1 FLOT2
focal adhesion 1 FLOT2
flotillin complex 1 FLOT2
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 POMC, TRH
dendrite cytoplasm 1 FLOT2
Late endosome 1 SDF4
neuron projection 2 OPRD1, OPRM1
cell periphery 1 AP2S1
[Isoform 5]: Cytoplasm 1 SDF4
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
blood microparticle 2 BCHE, KNG1
sperm midpiece 1 ACE
Membrane, caveola 1 FLOT2
cell body fiber 1 PENK
Cell projection, dendrite 1 OPRM1
basal plasma membrane 1 ACE
secretory granule lumen 1 POMC
Golgi apparatus lumen 1 SDF4
Golgi lumen 1 SDF4
endoplasmic reticulum lumen 3 BCHE, KNG1, PENK
platelet alpha granule lumen 1 KNG1
axon terminus 3 OPRD1, PDYN, PENK
endocytic vesicle membrane 1 AP2S1
endocytic vesicle 1 FLOT2
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 3 CALCA, OPRD1, PDYN
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle 1 AP2S1
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 AP2S1
uropod 1 FLOT2
endolysosome membrane 1 AP2S1
membrane coat 1 AP2S1
dendrite membrane 1 OPRD1
acrosomal membrane 1 FLOT2
Membrane, coated pit 1 AP2S1
cell-cell contact zone 1 FLOT2
AP-2 adaptor complex 1 AP2S1
bleb 1 SDF4
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 PENK
chromaffin granule lumen 1 PENK
symmetric synapse 1 PENK
synaptic vesicle lumen 1 PENK
ankyrin-1 complex 1 GYPA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
[Isoform 1]: Golgi apparatus lumen 1 SDF4


文献列表

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