Flurbiprofen (BioDeep_00000002723)
Secondary id: BioDeep_00000398947
human metabolite blood metabolite
代谢物信息卡片
(±)-2-fluoro-α-methyl-[1,1-biphenyl]-4-acetic acid
化学式: C15H13FO2 (244.09)
中文名称: 氟比洛芬, 2-氟-α-甲基-4-联苯甲酸
谱图信息:
最多检出来源 Homo sapiens(blood) 14.11%
分子结构信息
SMILES: CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1
InChI: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
描述信息
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
62 个代谢物同义名
(±)-2-fluoro-α-methyl-[1,1-biphenyl]-4-acetic acid; 2-Fluoro-alpha-methyl-(1,1-biphenyl)-4-acetic acid; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; 2-{2-fluoro-[1,1-biphenyl]-4-yl}propanoic acid; 2-Fluoro-α-methyl-(1,1-biphenyl)-4-acetic acid; 2-Fluoro-a-methyl-(1,1-biphenyl)-4-acetic acid; 2-Fluoro-alpha-methyl-(1,1-biphenyl)-4-acetate; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetate; (+-)-2-Fluoro-α-methyl-4-biphenylacetic acid; (+-)-2-Fluoro-a-methyl-4-biphenylacetic acid; Pharm allergan brand OF flurbiprofen sodium; Pharm-allergan brand OF flurbiprofen sodium; 2-Fluoro-a-methyl-(1,1-biphenyl)-4-acetate; 2-Fluoro-α-methyl-(1,1-biphenyl)-4-acetate; (+-)-2-Fluoro-α-methyl-4-biphenylacetate; (+-)-2-Fluoro-a-methyl-4-biphenylacetate; 2-Fluoro-α-methyl-4-biphenylacetic Acid; 2-(2-Fluorobiphenyl-4-yl)propanoic acid; Allergan brand OF flurbiprofen sodium; 2-(2-Fluorobiphenyl-4-yl)propanoate; Klosterfrau brand OF flurbiprofen; 3-Fluoro-4-phenylhydratropic acid; Ratiopharm brand OF flurbiprofen; Novopharm brand OF flurbiprofen; Recordati brand OF flurbiprofen; Cantabria brand OF flurbiprofen; Nu-pharm brand OF flurbiprofen; Nu pharm brand OF flurbiprofen; Crookes brand OF flurbiprofen; 3-Fluoro-4-phenylhydratropate; Apotex brand OF flurbiprofen; Pfizer brand OF flurbiprofen; Abbott brand OF flurbiprofen; Shire brand OF flurbiprofen; Knoll brand OF flurbiprofen; Flurbiprofen pfizer brand; (±)-Flurbiprofen; Sodium, flurbiprofen; Flurbiprofen sodium; ratio Flurbiprofen; ratio-Flurbiprofen; apo Flurbiprofen; apo-Flurbiprofen; Nu flurbiprofen; novo Flurprofen; novo-Flurprofen; Nu-flurbiprofen; flurbiprofen; Fluriproben; Flubiprofen; neo Artrol; Froben SR; Dobrofen; Flugalin; Strefen; Ocuflur; Cebutid; Froben; Ansaid; Ocufen; FLP; Flurbiprofen
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:5130
- KEGG: C07013
- KEGGdrug: D00330
- PubChem: 3394
- HMDB: HMDB0014850
- Metlin: METLIN2922
- DrugBank: DB00712
- ChEMBL: CHEMBL563
- Wikipedia: Flurbiprofen
- MeSH: Flurbiprofen
- chemspider: 3277
- CAS: 51543-38-5
- CAS: 5104-49-4
- PMhub: MS000004611
- PubChem: 9226
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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2023 Mar; 13(4):. doi:
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2017 Mar; 24(1):42-51. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2017 02; 248(?):33-44. doi:
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Chimia.
2017 Feb; 71(1-2):18-25. doi:
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Pharmacology.
2017; 99(5-6):236-239. doi:
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International journal of molecular sciences.
2016 Dec; 18(1):. doi:
10.3390/ijms18010068. [PMID: 28042832] - Eameema Muntimadugu, Raju Dhommati, Anjali Jain, Venu Gopala Swami Challa, M Shaheen, Wahid Khan. Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Sep; 92(?):224-34. doi:
10.1016/j.ejps.2016.05.012. [PMID: 27185298] - Aihua Song, Xiaoshu Zhang, Yanting Li, Xinjuan Mao, Fei Han. Effect of liquid-to-solid lipid ratio on characterizations of flurbiprofen-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for transdermal administration.
Drug development and industrial pharmacy.
2016 Aug; 42(8):1308-14. doi:
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Veterinary ophthalmology.
2016 07; 19 Suppl 1(?):24-9. doi:
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Basic & clinical pharmacology & toxicology.
2016 Jun; 118(6):496-8. doi:
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Drug design, development and therapy.
2016; 10(?):2401-19. doi:
10.2147/dddt.s109318. [PMID: 27555750] - Lindi van Zyl, Jan du Preez, Minja Gerber, Jeanetta du Plessis, Joe Viljoen. Essential Fatty Acids as Transdermal Penetration Enhancers.
Journal of pharmaceutical sciences.
2016 Jan; 105(1):188-93. doi:
10.1016/j.xphs.2015.11.032. [PMID: 26852854] - Ikuko Yataba, Noboru Otsuka, Isao Matsushita, Miho Kamezawa, Ichimaro Yamada, Sigeru Sasaki, Kazuo Uebaba, Hideo Matsumoto, Yuichi Hoshino. Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans.
European journal of clinical pharmacology.
2016 Jan; 72(1):53-9. doi:
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Genetics and molecular research : GMR.
2015 Dec; 14(4):16469-75. doi:
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AAPS PharmSciTech.
2015 Dec; 16(6):1465-73. doi:
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Journal of anesthesia.
2015 Dec; 29(6):881-6. doi:
10.1007/s00540-015-2060-6. [PMID: 26272250] - Tong-yu Chen, Jia Zhou, Ke Wang, Jian-jun Xu, Wen Ma, Yong-yong Wu. [Electroacupuncture Intervention Combined with Anesthetics for Analgesia and Post-surgical Gastrointestinal Recovery in Pneumectomy Patients].
Zhen ci yan jiu = Acupuncture research.
2015 Dec; 40(6):461-4. doi:
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Journal of chromatographic science.
2015 Oct; 53(9):1443-8. doi:
10.1093/chromsci/bmv032. [PMID: 25820260] - Lina Zhang, Qi Zhang, Xin Wang, Wenji Zhang, Congcong Lin, Fen Chen, Xinggang Yang, Weisan Pan. Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen.
International journal of pharmaceutics.
2015 Aug; 492(1-2):40-5. doi:
10.1016/j.ijpharm.2015.07.011. [PMID: 26162980] - Fakhar Ud Din, Omer Mustapha, Dong Wuk Kim, Rehmana Rashid, Jong Hyuck Park, Ju Yeon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi. Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Aug; 94(?):64-72. doi:
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Pain practice : the official journal of World Institute of Pain.
2015 Jul; 15(6):530-7. doi:
10.1111/papr.12206. [PMID: 24807396] - Chenghan Mei, Bin Li, Qiangfeng Yin, Jing Jin, Ting Xiong, Wenjuan He, Xiujuan Gao, Rong Xu, Piqi Zhou, Heng Zheng, Hui Chen. Liquid chromatography-tandem mass spectrometry for the quantification of flurbiprofen in human plasma and its application in a study of bioequivalence.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jul; 993-994(?):69-74. doi:
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Archives of pharmacal research.
2015 Jun; 38(6):1232-7. doi:
10.1007/s12272-015-0580-0. [PMID: 25712887] - Mercedes Roldán-Pijuán, Stig Pedersen-Bjergaard, Astrid Gjelstad. Parallel artificial liquid membrane extraction of acidic drugs from human plasma.
Analytical and bioanalytical chemistry.
2015 Apr; 407(10):2811-9. doi:
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FEBS letters.
2015 Mar; 589(7):849-56. doi:
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Acta poloniae pharmaceutica.
2015 Mar; 72(2):403-6. doi:
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Chemical & pharmaceutical bulletin.
2015; 63(5):334-40. doi:
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Drug development and industrial pharmacy.
2015; 41(9):1488-92. doi:
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Drug development and industrial pharmacy.
2015; 41(8):1254-62. doi:
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Drug development and industrial pharmacy.
2015; 41(12):2089-99. doi:
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PloS one.
2015; 10(9):e0139212. doi:
10.1371/journal.pone.0139212. [PMID: 26406890] - Hye-In Lee, Chang-Ik Choi, Ji-Yeong Byeon, Jung-Eun Lee, So-Young Park, Young-Hoon Kim, Se-Hyung Kim, Yun-Jeong Lee, Choon-Gon Jang, Seok-Yong Lee. Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):58-63. doi:
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EMBO molecular medicine.
2014 Nov; 6(11):1398-422. doi:
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Clinical pharmacology and therapeutics.
2014 Sep; 96(3):349-59. doi:
10.1038/clpt.2014.83. [PMID: 24722393] - Steven Lehrer. Nasal NSAIDs for Alzheimer's Disease.
American journal of Alzheimer's disease and other dementias.
2014 Aug; 29(5):401-3. doi:
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Journal of AOAC International.
2014 Jul; 97(4):1061-6. doi:
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Biopharmaceutics & drug disposition.
2014 May; 35(4):218-27. doi:
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Pharmacotherapy.
2014 Feb; 34(2):114-22. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
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Pharmacology.
2014; 94(3-4):143-7. doi:
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Current topics in medicinal chemistry.
2014; 14(23):2734-42. doi:
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Bioanalysis.
2014 Jan; 6(2):151-64. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2014; 15(24):10855-60. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2013 Dec; 60(12):1204-11. doi:
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Pakistan journal of pharmaceutical sciences.
2013 Nov; 26(6):1221-7. doi:
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Journal of anesthesia.
2013 Oct; 27(5):676-83. doi:
10.1007/s00540-013-1597-5. [PMID: 23543346] - Joel Ross, Sanjiv Sharma, Jaron Winston, Margarita Nunez, Gabriella Bottini, Massimo Franceschi, Elio Scarpini, Enrico Frigerio, Francesco Fiorentini, Mercedes Fernandez, Sandra Sivilia, Luciana Giardino, Laura Calza, Dottie Norris, Helen Cicirello, Daniela Casula, Bruno P Imbimbo. CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.
Current Alzheimer research.
2013 Sep; 10(7):742-53. doi:
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2013 Jul; 38(7):653-60. doi:
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Alzheimer disease and associated disorders.
2013 Jul; 27(3):278-86. doi:
10.1097/wad.0b013e3182622ace. [PMID: 22922591] - Sujash Halder, Kanchan Kumar Mondal, Supreeti Biswas, Tapan Kumar Mandal, Bakul Kumar Dutta, Mithilesh Haldar. Comparative evaluation of aqueous and plasma concentration of topical moxifloxacin alone and with flurbiprofen in patients of cataract surgery.
Indian journal of pharmacology.
2013 May; 45(3):223-6. doi:
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