Dezocine (BioDeep_00000002716)

 

Secondary id: BioDeep_00001868456

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5,11-Methanobenzocyclodecen-3-ol, 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5alpha,11alpha,13S*)

化学式: C16H23NO (245.17795479999998)
中文名称: 地佐辛
谱图信息: 最多检出来源 Homo sapiens(urine) 8.22%

分子结构信息

SMILES: CC12CCCCCC(C1N)CC3=C2C=C(C=C3)O
InChI: InChI=1S/C16H23NO/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3/t12-,15-,16+/m0/s1

描述信息

Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics > N02A - Opioids

同义名列表

17 个代谢物同义名

5,11-Methanobenzocyclodecen-3-ol, 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5alpha,11alpha,13S*); (-5alpha, 11alpha,13S)-13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3-ol; (-)-13beta-Amino-5,6,7,8,9,10,11alpha,12-octahydro-5alpha-methyl-5,11-methanobenzocyclodecen-3-ol; (-)-13b-Amino-5,6,7,8,9,10,11a,12-octahydro-5a-methyl-5,11-methanobenzocyclodecen-3-ol; (-)-13Β-amino-5,6,7,8,9,10,11α,12-octahydro-5α-methyl-5,11-methanobenzocyclodecen-3-ol; 13-Amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecenol; (1R,9S,15S)-15-amino-1-methyltricyclo[7.5.1.0²,⁷]pentadeca-2,4,6-trien-4-ol; Dezocine hydrobromide, (5R-(5alpha,11alpha,13S*))-isomer; Dezocine hydrobromide, (5S-(5alpha,11alpha,13*))-isomer; Dezocine hydrobromide, (5alpha,11alpha,13S*)-isomer; Dezocine hydrobromide, (5alpha,11alpha,13*)-isomer; Dezocine, (5alpha,11alpha,13S*)-isomer; SCHEMBL7781933; Dezocinum; dezocine; Dezocina; Dalgan



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Boran Deng, Dingding Wang, Zifeng Xie, Yongqin Wang, Li Huang, Manlin Jiang, Tu Shen. Comparison of the analgesic effect of dezocine and esketamine in combination with sufentanil respectively after laparoscopic cholecystectomy: a prospective randomized controlled study. BMC anesthesiology. 2024 Feb; 24(1):51. doi: 10.1186/s12871-024-02430-y. [PMID: 38317099]
  • Yue-Xia Lu, Qin-Feng Cai. [Application value and safety of prostate peripheral nerve block combined with dezocine in transrectal prostate biopsy]. Zhonghua nan ke xue = National journal of andrology. 2022 Jun; 28(6):506-510. doi: . [PMID: 37477467]
  • Z-H Yang, R Shen, F-F Zhan, J-L Shao, Y-J Lu, L Wang. Effects of dezocine combined with dexmedetomidine on adverse reactions and inflammatory factors in patients undergoing HIPEC after intestinal surgery and its protective effect on the heart in the perioperative period. European review for medical and pharmacological sciences. 2022 05; 26(10):3437-3443. doi: 10.26355/eurrev_202205_28837. [PMID: 35647823]
  • Fang Zhu, Wei Duan, Chao Zhong, Bing Ji, Xinjun Liu. The protective effects of dezocine on interleukin-1β-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms. Bioengineered. 2022 01; 13(1):1399-1410. doi: 10.1080/21655979.2021.2017700. [PMID: 34974796]
  • Siqingaowa Han, Chen Zhang, Zhijie Chen, Xuanyu Sha, Wuliji Hasi. Rapid Detection of Dezocine in Biological Fluids Based on SERS Technology. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2021 Feb; 37(2):315-320. doi: 10.2116/analsci.20p259. [PMID: 32893251]
  • Jie Hu, Xin-Juan Su, Hui-Ling Si, Rui-Xiang Song, Fang Zhang, Xiang-Jun Qiu, Xing-Peng Chen. Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics. Drug design, development and therapy. 2021; 15(?):2529-2541. doi: 10.2147/dddt.s314562. [PMID: 34163139]
  • Yajing Dong, Zhi Liang, Zhe Xu, Wei Hao, Dandan Wang, Shuping Huo, Huayu Zhao. Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia. Annals of palliative medicine. 2020 Jul; 9(4):1556-1563. doi: 10.21037/apm-19-460. [PMID: 32762221]
  • Ronggang Zhu, Tingting Du, Hongzhu Gao. Effects of dezocine and ropivacaine infiltration anesthesia on cellular immune function indicators, anesthesia recovery time and pain factors in patients with open liver resection. Cellular and molecular biology (Noisy-le-Grand, France). 2020 Jun; 66(3):149-154. doi: . [PMID: 32538762]
  • Wei Zhou, Shuang-Long Li, Ti Zhao, Le Li, Wen-Bin Xing, Xiang-Jun Qiu, Wei Zhang. Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS. Drug design, development and therapy. 2020; 14(?):2595-2605. doi: 10.2147/dddt.s254055. [PMID: 32753841]
  • Qiang Jia, Fen Tian, Wei-Na Duan, Yi-Fan Jia, Hua-Xin Wang, Zhong-Yuan Xia. Effects of Dezocine-Remifentanil Intravenous Anaesthesia on Perioperative Signs, Serum TNF-&aipha; and IL-6 in Liver Cancer Patients undergoing Radiofrequency Ablation. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2019 Jan; 29(1):4-7. doi: 10.29271/jcpsp.2019.01.4. [PMID: 30630559]
  • Guang-Fen Zhang, Jie Guo, Li-Li Qiu, Shu-Ming Li, Man Zheng, Jiang-Yan Xia, Jian-Jun Yang. Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial. Drug design, development and therapy. 2019; 13(?):1281-1288. doi: 10.2147/dddt.s199897. [PMID: 31114164]
  • Li Zhou, Youchuan Zhang, Haotian Sun, Ruchun Hu, Jin Wang, Guoyong Xu. Effect of preemptive dezocine before general anesthesia on postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A prospective observational study. Medicine. 2018 Sep; 97(39):e12533. doi: 10.1097/md.0000000000012533. [PMID: 30278544]
  • Z-M Jia, H-N Hao, M-L Huang, D-F Ma, X-L Jia, B Ma. Influence of dexmedetomidine to cognitive function during recovery period for children with general anesthesia. European review for medical and pharmacological sciences. 2017 03; 21(5):1106-1111. doi: . [PMID: 28338180]
  • Shangkun Li, Su Min, Bin Wu, Wanbi Tang. [Application of patient-controlled intravenous analgesia of dezocine combined with sufentanil in burn patients after surgery]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2015 Feb; 31(1):48-51. doi: . [PMID: 25876640]
  • Renyu Liu, Xi-Ping Huang, Alexei Yeliseev, Jin Xi, Bryan L Roth. Novel molecular targets of dezocine and their clinical implications. Anesthesiology. 2014 Mar; 120(3):714-23. doi: 10.1097/aln.0000000000000076. [PMID: 24263237]
  • Parham Gharagozlou, Ezzat Hashemi, Timothy M DeLorey, J David Clark, Jelveh Lameh. Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC pharmacology. 2006 Jan; 6(?):3. doi: 10.1186/1471-2210-6-3. [PMID: 16433932]
  • Parham Gharagozlou, Hasan Demirci, J David Clark, Jelveh Lameh. Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors. BMC neuroscience. 2002 Nov; 3(?):19. doi: 10.1186/1471-2202-3-19. [PMID: 12437765]
  • J M Wilson, R I Cohen, E A Kezer, S J Schange, E R Smith. Single- and multiple-dose pharmacokinetics of dezocine in patients with acute or chronic pain. Journal of clinical pharmacology. 1995 Apr; 35(4):398-403. doi: 10.1002/j.1552-4604.1995.tb04080.x. [PMID: 7650230]
  • M M Warren, W H Boyce, J W Evans, P C Peters. A double-blind comparison of dezocine and morphine in patients with acute renal and ureteral colic. The Journal of urology. 1985 Sep; 134(3):457-9. doi: 10.1016/s0022-5347(17)47239-9. [PMID: 2863392]
  • S F Sisenwine, C O Tio, A L Liu, H W Ruelius. Pharmacokinetics of parenteral dezocine in rhesus monkeys and dogs. Drug metabolism and disposition: the biological fate of chemicals. 1982 Jul; 10(4):366-70. doi: NULL. [PMID: 6126336]
  • A J Lewis, T Kirchner. A comparison of the cardiorespiratory effects of ciramadol, dezocine, morphine and pentazocine in the anesthetized dog. Archives internationales de pharmacodynamie et de therapie. 1981 Mar; 250(1):73-83. doi: . [PMID: 6115623]
  • S F Sisenwine, C O Tio. The metabolic disposition of dezocine in rhesus monkeys and female rats given 14C-dezocine intragastrically. Drug metabolism and disposition: the biological fate of chemicals. 1981 Jan; 9(1):37-42. doi: NULL. [PMID: 6111429]
  • W Oosterlinck, A Verbaeys. Preliminary clinical experience with dezocine, a new potent analgesic. Current medical research and opinion. 1980; 6(7):472-4. doi: 10.1185/03007998009109470. [PMID: 7363647]