Ephedrine (BioDeep_00000270888)

Main id: BioDeep_00000001464

Secondary id: BioDeep_00000174813, BioDeep_00000600469

natural product Volatile Flavor Compounds


代谢物信息卡片


2-(methylamino)-1-phenylpropan-1-ol

化学式: C10H15NO (165.115358)
中文名称: 麻黄碱, 2-(甲基氨基)-1-苯基-1-丙醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(C1=CC=CC=C1)O)NC
InChI: InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3

描述信息

R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AB - Sympathomimetics, combinations excl. corticosteroids
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CA - Alpha- and beta-adrenoreceptor agonists
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AA - Sympathomimetics, plain
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FB - Sympathomimetics excl. antiglaucoma preparations
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.064
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.062

同义名列表

6 个代谢物同义名

L-(-)-Ephedrine; Ephedrine; 2-(methylamino)-1-phenylpropan-1-ol; Racephedrine; Ephedrine; Racephedrine



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

143 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bryce Pardo, Alexandre Nobajas Ganau, Irmgard Zeiler. Modelling the amount of inputs needed for methamphetamine manufacture in Afghanistan. Addiction (Abingdon, England). 2024 Jun; 119(6):1013-1020. doi: 10.1111/add.16474. [PMID: 38509858]
  • Jiatai Yin, Yiheng Gou, Yiheng Wang, Qingyuan Ma, Rui Wang, Jing Yu, Yajun Zhang, Jing Wang, Qian Li, Xinfeng Zhao. Can the heptapeptide ASSIVSF of the β2-adrenoceptor recognize ephedrine and pseudoephedrine epimers in a complex system?. Journal of chromatography. A. 2024 May; 1722(?):464857. doi: 10.1016/j.chroma.2024.464857. [PMID: 38569445]
  • Masaki Kakimoto, Toshihito Nomura, Tanuza Nazmul, Akima Yamamoto, Hiroaki Sasaki, Akifumi Higashiura, Masanori Ito, Hiroki Ohge, Masayuki Mikage, Keiko Ochiai Ogawa, Takemasa Sakaguchi. In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract. Journal of ethnopharmacology. 2024 Jan; 319(Pt 3):117341. doi: 10.1016/j.jep.2023.117341. [PMID: 37879507]
  • Kengo Hayashi, Yuki Miyao, Hina Matsui, Takao Yamaura, Ken Tanaka, Mariko Baba, Hiroaki Hayashi. Comparison of Non-ephedrine Constituents from Ephedra Plants Cultivated in Japan. Chemical & pharmaceutical bulletin. 2024; 72(4):385-388. doi: 10.1248/cpb.c24-00043. [PMID: 38631893]
  • Hui Zhang, Ye Xia, Jin-Long Cui, Xin Ji, Shuang-Man Miao, Gang Zhang, Yi-Min Li. The composition characteristics of endophytic communities and their relationship with metabolites profile in Ephedra sinica under wild and cultivated conditions. Environmental science and pollution research international. 2023 Aug; ?(?):. doi: 10.1007/s11356-023-29145-w. [PMID: 37556062]
  • Yue-Chiun Li, Chia-Hung Wu, Thi Ha Le, Qingjun Yuan, Luqi Huang, Guo-Fen Chen, Mei-Lin Yang, Sio-Hong Lam, Hsin-Yi Hung, Handong Sun, Yi-Hung Wu, Ping-Chung Kuo, Tian-Shung Wu. A Modified 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedrae Herba Samples. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411272. [PMID: 37511036]
  • Mitsuhiko Nose, Risa Kobayashi, Momoka Tada, Shinsuke Hisaka, Sayaka Masada, Masato Homma, Takashi Hakamatsuka. Comparison of ephedrine and pseudoephedrine contents in 34 Kampo extracts containing Ephedrae Herba used clinically in Japan. Journal of natural medicines. 2023 Mar; ?(?):. doi: 10.1007/s11418-023-01687-w. [PMID: 36854954]
  • Yoshitomi Kudo, Hirokazu Ando, Ai Kaneda, Honoka Ito, Kazuki Umemoto, Si-Ran Ni, Masayuki Mikage, Yohei Sasaki. Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content. Journal of natural medicines. 2023 Mar; 77(2):327-342. doi: 10.1007/s11418-023-01680-3. [PMID: 36680565]
  • Yumin Cao, Ning Zhou, Tong Liu, Jinying Zhang, Yongxiang Wang, Bingxian Zhang, Zhenkai Zhang, Weisheng Feng, Xiaoke Zheng. Comparative pharmacokinetic studies of Ephedra herba in common cold and nephrotic syndrome rat models. Journal of separation science. 2023 Feb; ?(?):e2200895. doi: 10.1002/jssc.202200895. [PMID: 36823773]
  • Yongjing Liu, Suxia Zhang, Li Lou, Tang Yan, Wei Xu. Evaluating the behavior and principle of deep eutectic solvent on ephedrine-type alkaloid extraction from Ephedrae Herba. Biomedical chromatography : BMC. 2023 Feb; 37(2):e5541. doi: 10.1002/bmc.5541. [PMID: 36328792]
  • Xuedan Huang, Sumiko Hyuga, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi, Toshihiko Hanawa, Yoshinori Kobayashi. Overlooked switch from transient sedation to sustained excitement in the Biphasic effects of Ephedra Herb extract administered orally to mice. Journal of ethnopharmacology. 2023 Jan; 301(?):115827. doi: 10.1016/j.jep.2022.115827. [PMID: 36240977]
  • Hajime Hiyama, Yosuke Yoshioka, Ryo Ohsawa. Evaluation of the Influence of Genetic and Environmental Factors on the Ephedrine Alkaloids Content of Ephedra sinica. Biological & pharmaceutical bulletin. 2023; 46(12):1692-1698. doi: 10.1248/bpb.b23-00374. [PMID: 38044092]
  • Yoshitomi Kudo, Kazuki Umemoto, Toshihiro Obata, Ai Kaneda, Si-Ran Ni, Masayuki Mikage, Yohei Sasaki, Hirokazu Ando. Seasonal variation of alkaloids and polyphenol in Ephedra sinica cultivated in Japan and controlling factors. Journal of natural medicines. 2023 Jan; 77(1):137-151. doi: 10.1007/s11418-022-01656-9. [PMID: 36282406]
  • Longfei Guo, Ping He, Yuan He, Yu Gao, Xiaoting Zhang, Tongtong Huo, Cheng Peng, Fanyun Meng. Predicting the comprehensive geospatial pattern of two ephedrine-type alkaloids for Ephedra sinica in Inner Mongolia. PloS one. 2023; 18(4):e0283967. doi: 10.1371/journal.pone.0283967. [PMID: 37083689]
  • Mengnan Lu, Yongjuan Zhang, Shiyan Wang, Xiaona Wang, Shengnan Zhang, Ji De. Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China. PloS one. 2023; 18(8):e0290696. doi: 10.1371/journal.pone.0290696. [PMID: 37624827]
  • Hui Tian, Limei Wang, Taoli Fu. Ephedrine alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and restraining NF-κB signaling. The Journal of toxicological sciences. 2023; 48(10):547-556. doi: 10.2131/jts.48.547. [PMID: 37778983]
  • Mohd Imran, Shital Pradeep Patil, Mohammed A S Abourehab, Vidhu Aeri, Prashant Kesharwani. Quality by design-based optimization of Soxhlet extraction and identification of ephedrine by a HPTLC method for Sida rhombifolia and Sida Cordifolia. Biomedical chromatography : BMC. 2022 Dec; 36(12):e5479. doi: 10.1002/bmc.5479. [PMID: 35961325]
  • Chenchen Guo, Ying Chen, Dengyun Wu, Yu Du, Mengyue Wang, Cunqi Liu, Jianzhou Chu, Xiaoqin Yao. Transcriptome Analysis Reveals an Essential Role of Exogenous Brassinolide on the Alkaloid Biosynthesis Pathway in Pinellia Ternata. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810898. [PMID: 36142812]
  • Nan-Nan Tian, Xi-He Yang, Ya-Xuan Zhu, Xue-Shan Zeng, Jia-Ye Yuan, Jun-Ling Yang, Wei-Wei Jia, Chuan Li. [Mahuang (herbaceous stem of Ephedra spp.): chemistry, pharmacodynamics, and pharmacokinetics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(13):3409-3424. doi: 10.19540/j.cnki.cjcmm.20220425.601. [PMID: 35850791]
  • Heba Elmansi, Fathalla Belal, Galal Magdy. Determination of pholcodine alone or in combination with ephedrine in human plasma using fluorescence spectroscopy. Scientific reports. 2022 06; 12(1):9372. doi: 10.1038/s41598-022-13194-1. [PMID: 35672340]
  • Yang Fu, PeiPei Yuan, Yajuan Zheng, Liyuan Gao, Yaxin Wei, Yi Chen, Panying Li, Yuan Ruan, Xiaoke Zheng, Weisheng Feng. Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113061. doi: 10.1016/j.biopha.2022.113061. [PMID: 35658231]
  • Gang Wang, Xuanjiao Bai, Xiaochen Chen, Ying Ren, Jianping Han. Development of a Genus-Universal Nucleotide Signature for the Identification and Supervision of Ephedra-Containing Products. Molecules (Basel, Switzerland). 2022 Apr; 27(7):. doi: 10.3390/molecules27072342. [PMID: 35408741]
  • Chunying Song, Dongping Yu, Gaowa Jin, Junjie Ding, Han Zhou, Zhimou Guo, Xinmiao Liang. High-performance liquid chromatography quantitative analysis of ephedrine alkaloids in Ephedrae Herba on a perfluorooctyl stationary phase. Journal of separation science. 2022 Mar; 45(5):1051-1058. doi: 10.1002/jssc.202100645. [PMID: 34984820]
  • Shen Duan, Xue-Ying Cui, Xin-Yao Wang, Cheng-Bin Shan, Chao-Mei Ma. Combination of Ephedra sinica stems and Terminalia chebula fruits produces new ephedrine derivatives in vivo that diminish the permeability to BBB while retaining airway dilation and hepatoprotective effects. Journal of ethnopharmacology. 2022 Mar; 285(?):114837. doi: 10.1016/j.jep.2021.114837. [PMID: 34788644]
  • Ting Zhu, Yao Jin, Jingjing Zhao, Jing Jing, Tian Tian, Yuanhong Shan, Xin Xu, Yang Wang. Qualitative and quantitative analysis of ephedrine stimulants in urine by ultra-performance liquid chromatography-tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2022 Feb; 36(4):e9229. doi: 10.1002/rcm.9229. [PMID: 34854506]
  • Hong-Lei Wang, Fen-Qiao Chen, Li-Juan Wu. Ephedrine ameliorates chronic obstructive pulmonary disease (COPD) through restraining endoplasmic reticulum (ER) stress in vitro and in vivo. International immunopharmacology. 2022 Feb; 103(?):107842. doi: 10.1016/j.intimp.2021.107842. [PMID: 34953449]
  • Keisuke Ogura, Ayumi Kadota, Akiko Nakayama, Hitomi Kanno, Yoshio Tahara, Akinori Nishi. Maoto, a traditional Japanese medicine, controls acute systemic inflammation induced by polyI:C administration through noradrenergic function. Gene. 2022 Jan; 806(?):145921. doi: 10.1016/j.gene.2021.145921. [PMID: 34454033]
  • Meriem Hamoudi, Djouher Amroun, Sabrina Boutefnouchet, Chawki Bensouici, Samira Kaoula, Daoud Harzallah, Seddik Khennouf, Saliha Dahamna. Phytochemical Screening, In vitro Antioxidant and Enzyme Inhibitory Properties, and Acute Toxicity of Extracts from the Aerial Parts of Ephedra nebrodensis, a Source of Bioactive Compounds. Combinatorial chemistry & high throughput screening. 2022; 25(6):1058-1071. doi: 10.2174/1386207324666210303094339. [PMID: 33655855]
  • Lixian Huang, Bo Zhao, Qunxian Li, Jing Wu, Hui Jiang, Qingbin Li. Ephedrine alleviates middle cerebral artery occlusion-induced neurological deficits and hippocampal neuronal damage in rats by activating PI3K/AKT signaling pathway. Bioengineered. 2021 12; 12(1):4136-4149. doi: 10.1080/21655979.2021.1953218. [PMID: 34288825]
  • Sooyoung Lee, Wang-Seob Shim, Heejo Yoo, Sanghee Choi, Jiyoung Yoon, Kwang-Young Lee, Eun-Kyoung Chung, Byung-Cheol Lee, Sung-Vin Yim, Bo-Hyung Kim, Kyung-Tae Lee. A Pharmacokinetic Study of Ephedrine and Pseudoephedrine after Oral Administration of Ojeok-San by Validated LC-MS/MS Method in Human Plasma. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226991. [PMID: 34834083]
  • Fangfang Xu, Tao Hou, Aijin Shen, Hongli Jin, Yuansheng Xiao, Wenyi Yu, Xiaonong Li, Jixia Wang, Yanfang Liu, Xinmiao Liang. Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays. Journal of ethnopharmacology. 2021 Nov; 280(?):114488. doi: 10.1016/j.jep.2021.114488. [PMID: 34358653]
  • Mohamed Z Gad, Samar S Azab, Amira R Khattab, Mohamed A Farag. Over a century since ephedrine discovery: an updated revisit to its pharmacological aspects, functionality and toxicity in comparison to its herbal extracts. Food & function. 2021 Oct; 12(20):9563-9582. doi: 10.1039/d1fo02093e. [PMID: 34533553]
  • Yea-Jin Park, Divina C Cominguez, Hyo-Jung Kim, Jong-Sik Jin, Duck-Jae Koh, Seo-Young Kim, Young-Woo Lim, Young-Bae Park, Hyo-Jin An. Therapeutic effects of Gambi-jung for the treatment of obesity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111838. doi: 10.1016/j.biopha.2021.111838. [PMID: 34182414]
  • Haseeb Ahsan, Hafiz Muhammad Irfan, - Alamgeer, Mulazim Husain Asim, Muhammad Shafeeq Ur Rahman, Malik Zahid Imran, Sajid Bashir, Farwa Naqvi, Rizwan Hafeez. Therapeutic appraisal of ephedrine against rheumatoid arthritis: A new indication. Pakistan journal of pharmaceutical sciences. 2021 Jul; 34(4(Supplementary)):1549-1554. doi: . [PMID: 34799331]
  • Arthur Rocha-Gomes, Amanda Escobar Teixeira, Deiviany Santana Santos Lima, Luziane Dos Santos Rocha, Alexandre Alves da Silva, Mayara Rodrigues Lessa, Nísia Av Dessimoni Pinto, Sérgio R Stuckert-Seixas, Tania Regina Riul. Caloric restriction or cafeteria diet from birth to adulthood increases the sensitivity to ephedrine in anxiety and locomotion in Wistar rats. Physiology & behavior. 2021 07; 236(?):113430. doi: 10.1016/j.physbeh.2021.113430. [PMID: 33865851]
  • Hiroyuki Fuchino, Osamu Iida, Noriaki Kawano, Nobuo Kawahara, Kayo Yoshimatsu. One-pot discriminant LC/MS quantitative analysis of ephedrine and pseudoephedrine using Finger Masher and their distribution in the aerial stems of Ephedra plants. Journal of natural medicines. 2021 Jun; 75(3):707-716. doi: 10.1007/s11418-021-01494-1. [PMID: 33599897]
  • Tadahiro Yahagi, Toshiyuki Atsumi, Shuichirou Mano, Yuna Kikuchi, Yuka Hara, Megumi Furukawa, Zhigang Yang, Keiichi Matsuzaki. Quality evaluation of Pinellia tuber by LC-TOF/MS targeted to ephedrine. Journal of natural medicines. 2021 Jun; 75(3):692-698. doi: 10.1007/s11418-021-01485-2. [PMID: 33517509]
  • Yanni Lv, Saisai Wang, Peida Liang, Yamin Wang, Xin Zhang, Qianqian Jia, Jia Fu, Shengli Han, Langchong He. Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach. Analytical and bioanalytical chemistry. 2021 May; 413(11):2995-3004. doi: 10.1007/s00216-021-03233-7. [PMID: 33608752]
  • Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu. A Rapid and Feasible 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061599. [PMID: 33805790]
  • Nayoung Yun, Hye Jin Kim, Sang Cheol Park, Geonha Park, Min Kyung Kim, Young Hae Choi, Young Pyo Jang. Localization of Major Ephedra Alkaloids in Whole Aerial Parts of Ephedrae Herba Using Direct Analysis in Real Time-Time of Flight-Mass Spectrometry. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030580. [PMID: 33499348]
  • Lukasz Poltorak, Konrad Rudnicki, Viliam Kolivoška, Táňa Sebechlebská, Paweł Krzyczmonik, Sławomira Skrzypek. Electrochemical study of ephedrine at the polarized liquid-liquid interface supported with a 3D printed cell. Journal of hazardous materials. 2021 01; 402(?):123411. doi: 10.1016/j.jhazmat.2020.123411. [PMID: 32711385]
  • Hajime Hiyama, Aya Ozawa, Bunsho Makino, Yosuke Yoshioka, Ryo Ohsawa. Validity of Selection Breeding for High Ephedrine-Alkaloid Content in E. sinica under Different Environments in Japan. Biological & pharmaceutical bulletin. 2021; 44(2):287-291. doi: 10.1248/bpb.b20-00765. [PMID: 33518684]
  • Qiong Wang, Yubao Cui, Xufeng Wu, Junfang Wang. Riparin II potentials the effect of ephedrine on inflammation and remodelling in the airway of rats suffering from asthma by regulating transforming growth factor-β/Smad3 signalling pathway. International immunopharmacology. 2021 Jan; 90(?):107116. doi: 10.1016/j.intimp.2020.107116. [PMID: 33218943]
  • Hajime Hiyama, Aya Ozawa, Bunsho Makino, Yosuke Yoshioka, Ryo Ohsawa. Stability and Reproducibility of Ephedra sinica Ephedrine Alkaloid Content and Terrestrial Stem Dry Weight. Biological & pharmaceutical bulletin. 2021; 44(11):1781-1789. doi: 10.1248/bpb.b21-00599. [PMID: 34719654]
  • Fatma Ağın, Gökçe Öztürk, Dilek Kul. Voltammetric Analysis of Ephedrine in Pharmaceutical Dosage Forms and Urine Using poly(Nile Blue A) Modified Glassy Carbon Electrode. Combinatorial chemistry & high throughput screening. 2021; 24(3):366-375. doi: 10.2174/1386207323666200727100231. [PMID: 32718283]
  • Hannes M Schwelm, Christina Grumann, Volker Auwärter, Merja A Neukamm. Application of a chiral high-performance liquid chromatography-tandem mass spectrometry method for the determination of 13 related amphetamine-type stimulants to forensic samples: Interpretative hypotheses. Drug testing and analysis. 2020 Sep; 12(9):1354-1365. doi: 10.1002/dta.2886. [PMID: 32589765]
  • Pengcheng Huang, Yinghong Tang, Chang Li, Huifen Zhou, Li Yu, Haitong Wan, Yu He. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113144. doi: 10.1016/j.jpba.2020.113144. [PMID: 32070931]
  • Fatemeh Roodneshin, Mahtab Poor Zamany Nejat Kermany, Pooya Rostami, Narges Ahmadzadeh, Babak Gharaei, Mohammad Reza Kamranmanesh. Comparison of Hemodynamic Stability and Pain Control in Lateral and Prone Positions in Patients Undergoing Percutaneous Nephrolithotomy: A Randomized Controlled Trial. Urology journal. 2020 03; 17(2):124-128. doi: 10.22037/uj.v0i0.4915. [PMID: 31788775]
  • Luwei Fang, Jinfeng Xie, Liangwen Lin, Minglei Tian, Kyung Ho Row. Multi-phase extraction of ephedrine from Pinellia ternata and herbal medicine using molecular imprinted polymer coated ionic liquid-based silica. Phytochemical analysis : PCA. 2020 Mar; 31(2):242-251. doi: 10.1002/pca.2888. [PMID: 31435982]
  • Morio Yoshimura, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori, Takuro Maruyama, Naohiro Oshima, Nahoko Uchiyama, Jinwei Yang, Hideki Oka, Hideyuki Ito, Yoshinori Kobayashi, Hiroshi Odaguchi, Takashi Hakamatsuka, Toshihiko Hanawa, Yukihiro Goda. Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract. Chemical & pharmaceutical bulletin. 2020; 68(2):140-149. doi: 10.1248/cpb.c19-00761. [PMID: 32009081]
  • Zhi-Gang Liu, Cheng-Zhi Chai. [Drug syndrome of ephedra based on its property and pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Sep; 44(18):3883-3889. doi: 10.19540/j.cnki.cjcmm.20190314.003. [PMID: 31872719]
  • Huanmei Sun, Jiajun Liu, Yifei Li, Jing Wang, Yajun Zhang. Characterization of the heterogeneous adsorption of three drugs on immobilized bovine serum albumin by adsorption energy distribution. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Sep; 1125(?):121727. doi: 10.1016/j.jchromb.2019.121727. [PMID: 31352202]
  • Yusuke Tokuda, Mamoru Sakakibara, Keiichiro Yoshinaga, Shiro Yamada, Kiwamu Kamiya, Naoya Asakawa, Takashi Yoshitani, Keiji Noguchi, Osamu Manabe, Nagara Tamaki, Hiroyuki Tsutsui. Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2019 08; 26(4):1079-1089. doi: 10.1007/s12350-017-1132-4. [PMID: 29181786]
  • Albert Pérez-Alcaraz, Francesc Borrull, Carme Aguilar, Marta Calull. Enantioselective determination of cathinones in urine by high pressure in-line SPE-CE. Electrophoresis. 2019 07; 40(14):1762-1770. doi: 10.1002/elps.201900072. [PMID: 31093983]
  • Yukiko Makino, Yasuteru Urano, Kiyoko Kaneko. Trial analysis of drug profiling by liquid chromatography/mass spectrometry and inductively coupled plasma mass spectrometry to establish the origin of ephedrines used as precursors for illicit production of methamphetamine. Rapid communications in mass spectrometry : RCM. 2019 Jun; 33(11):995-1005. doi: 10.1002/rcm.8429. [PMID: 30849207]
  • Márcio Galindo Kiuchi, Janis Marc Nolde, Humberto Villacorta, Revathy Carnagarin, Justine Joy Su-Yin Chan, Leslie Marisol Lugo-Gavidia, Jan K Ho, Vance B Matthews, Girish Dwivedi, Markus P Schlaich. New Approaches in the Management of Sudden Cardiac Death in Patients with Heart Failure-Targeting the Sympathetic Nervous System. International journal of molecular sciences. 2019 May; 20(10):. doi: 10.3390/ijms20102430. [PMID: 31100908]
  • M Volpp, U Holzgrabe. Determination of plasma protein binding for sympathomimetic drugs by means of ultrafiltration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Jan; 127(?):175-184. doi: 10.1016/j.ejps.2018.10.027. [PMID: 30391401]
  • Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Jinwei Yang, Hiroaki Takemoto, Takuro Maruyama, Naohiro Oshima, Nahoko Uchiyama, Yoshiaki Amakura, Masashi Hyuga, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi, Toshihiko Hanawa, Yoshinori Kobayashi. Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain. Biological & pharmaceutical bulletin. 2019; 42(9):1538-1544. doi: 10.1248/bpb.b19-00260. [PMID: 31474713]
  • Pengfei Xu, Yonggui Song, Bingwei Feng, Qiang Zeng, Baixi Shan, Kuangyi Liu, Dan Su. Multi-component profiles through the blood-brain barrier in rat after oral administration of over-the-counter drug Keke capsule by ultra-performance liquid chromatography/quadrupole- time-of-flight MSE method. Biomedical chromatography : BMC. 2019 Jan; 33(1):e4380. doi: 10.1002/bmc.4380. [PMID: 30178888]
  • Xinlian Chen, Yingxian Cui, Liping Nie, Haoyu Hu, Zhichao Xu, Wei Sun, Ting Gao, Jingyuan Song, Hui Yao. Identification and Phylogenetic Analysis of the Complete Chloroplast Genomes of Three Ephedra Herbs Containing Ephedrine. BioMed research international. 2019; 2019(?):5921725. doi: 10.1155/2019/5921725. [PMID: 30941367]
  • Hiroaki Hayashi, Musavvara Shukurova, Shihoko Oikawa, Minami Ohta, Isao Fujii, Firuza Nasyrova, Kurbon Aliev, Hikmat Hisoriev, Inoyat Fattokhov, Madibron Saidov. Field Survey of Ephedra Plants in Central Asia (1). Characterization of Ephedra equisetina, Ephedra intermedia, and Their Putative Hybrids Collected in the Zaravshan Mountains of Tajikistan. Biological & pharmaceutical bulletin. 2019; 42(4):552-560. doi: 10.1248/bpb.b18-00289. [PMID: 30930415]
  • Cun-Yu Li, Xin Wu, Wen-Wen Zuo, Zi-Bo Shen, Hong-Yang Li, Guo-Ping Peng. [Enhanced separation behavior of ephedrine in organic solution by nanofiltration mass transfer model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Nov; 43(22):4433-4438. doi: 10.19540/j.cnki.cjcmm.20180807.007. [PMID: 30593235]
  • Seung-Hyun Jeong, Ji-Hun Jang, Seong-Ho Ham, Seung-Jeong Yang, Hea-Young Cho, Yong-Bok Lee. Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):214-225. doi: 10.1016/j.jchromb.2018.07.043. [PMID: 30081350]
  • Jeremy S Morris, Ryan A Groves, Jillian M Hagel, Peter J Facchini. An N-methyltransferase from Ephedra sinica catalyzing the formation of ephedrine and pseudoephedrine enables microbial phenylalkylamine production. The Journal of biological chemistry. 2018 08; 293(35):13364-13376. doi: 10.1074/jbc.ra118.004067. [PMID: 29929980]
  • Cuimei Liu, Peipei Liu, Wei Jia, Yingfeng Fan. Carbon and Nitrogen Stable Isotope Analyses of Ephedra Plant and Ephedrine Samples and Their Application For Methamphetamine Profiling. Journal of forensic sciences. 2018 Jul; 63(4):1053-1058. doi: 10.1111/1556-4029.13692. [PMID: 29193073]
  • Hiroaki Takemoto, Jun Takahashi, Sumiko Hyuga, Hiroshi Odaguchi, Nahoko Uchiyama, Takuro Maruyama, Tadatoshi Yamashita, Masashi Hyuga, Naohiro Oshima, Yoshiaki Amakura, Takashi Hakamatsuka, Yukihiro Goda, Toshihiko Hanawa, Yoshinori Kobayashi. Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias. Biological & pharmaceutical bulletin. 2018; 41(2):247-253. doi: 10.1248/bpb.b17-00803. [PMID: 29386484]
  • Maha Sellami, Olfa Slimeni, Andrzej Pokrywka, Goran Kuvačić, Lawrence D Hayes, Mirjana Milic, Johnny Padulo. Herbal medicine for sports: a review. Journal of the International Society of Sports Nutrition. 2018; 15(?):14. doi: 10.1186/s12970-018-0218-y. [PMID: 29568244]
  • María José Ojeda-Montes, Andrea Ardid-Ruiz, Sarah Tomás-Hernández, Aleix Gimeno, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Santiago Garcia-Vallvé, Gerard Pujadas, Cristina Valls. Ephedrine as a lead compound for the development of new DPP-IV inhibitors. Future medicinal chemistry. 2017 12; 9(18):2129-2146. doi: 10.4155/fmc-2017-0080. [PMID: 29172693]
  • Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Monireh Karami. Quantitative analysis of clonidine and ephedrine by a microfluidic system: On-chip electromembrane extraction followed by high performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Nov; 1068-1069(?):313-321. doi: 10.1016/j.jchromb.2017.10.062. [PMID: 29127057]
  • K Uerpairojkit, R Anusorntanawat, A Sirisabya, M Chaichalothorn, S Charuluxananan. Neonatal effects after vasopressor during spinal anesthesia for cesarean section: a multicenter, randomized controlled trial. International journal of obstetric anesthesia. 2017 Nov; 32(?):41-47. doi: 10.1016/j.ijoa.2017.05.009. [PMID: 28689624]
  • Zengyong Wang, Yu Cui, Guoyu Ding, Mengge Zhou, Xiaoyao Ma, Yuanyuan Hou, Min Jiang, Dailin Liu, Gang Bai. Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing β2-adrenoceptor/cAMP signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Jul; 30(?):18-27. doi: 10.1016/j.phymed.2017.03.002. [PMID: 28545666]
  • Takashi Matsumoto, Hirotaka Kushida, Shoko Matsushita, Yoshiyuki Oyama, Takafumi Suda, Junko Watanabe, Yoshio Kase, Mitsutoshi Setou. Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto. Scientific reports. 2017 03; 7(?):44098. doi: 10.1038/srep44098. [PMID: 28272490]
  • Jia-Yu Tong, Jung Chao, Yun-Tao Dai, Zi-Quan Fan, Dan-Dan Wang, Xue-Mei Qin, Shi-Lin Chen. [Establish quality evaluation system for standard Ephedrae Herba decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Mar; 42(5):823-829. doi: 10.19540/j.cnki.cjcmm.20170121.011. [PMID: 28994520]
  • Jie Xu, Rui Yan. Determination of the Metabolite of Ephedrine, 4-Hydroxyephedrine, by LC-MS-MS in Rat Urine and Its Application in Excretion Profiles After Oral Administration of Ephedra sinica Stapf and Processing Ephedra sinica Stapf. Journal of chromatographic science. 2017 02; 55(2):162-165. doi: 10.1093/chromsci/bmw165. [PMID: 27733484]
  • Arezou Taghvimi, Hamed Hamishehkar. Carbon coated magnetic nanoparticles as a novel magnetic solid phase extraction adsorbent for simultaneous extraction of methamphetamine and ephedrine from urine samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jan; 1041-1042(?):113-119. doi: 10.1016/j.jchromb.2016.11.039. [PMID: 28033585]
  • Yukihiro Goda. Our Approaches to the New Drug Application of Ephedrine Alkaloids-free Ephedra Herb Extract (EFE): Toward Breakthrough in Natural Medicines in Japan. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(2):161-162. doi: 10.1248/yakushi.16-00233-f. [PMID: 28154325]
  • Sumiko Hyuga. The Pharmacological Actions of Ephedrine Alkaloids-free Ephreda Herb Extract and Preparation for Clinical Application. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(2):179-186. doi: 10.1248/yakushi.16-00233-4. [PMID: 28154329]
  • Ah Young Lee, Yoonjeong Jang, Seong-Ho Hong, Seung-Hee Chang, Sungjin Park, Sanghwa Kim, Kyung-Sun Kang, Ji-Eun Kim, Myung-Haing Cho. Ephedrine-induced mitophagy via oxidative stress in human hepatic stellate cells. The Journal of toxicological sciences. 2017; 42(4):461-473. doi: 10.2131/jts.42.461. [PMID: 28717105]
  • Hiroshi Odaguchi. Clinical Research Testing the Usefulness of Ephedrine Alkaloids-free Ephedra Herb Extract. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(2):195-197. doi: 10.1248/yakushi.16-00233-6. [PMID: 28154331]
  • Yoshinori Kobayashi. Analgesic Effects and Side Effects of Ephedra Herb Extract and Ephedrine Alkaloids-free Ephedra Herb Extract. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(2):187-194. doi: 10.1248/yakushi.16-00233-5. [PMID: 28154330]
  • Naohiro Oshima. Efficient Preparation of Ephedrine Alkaloids-free Ephedra Herb Extract and Its Antitumor Effect and Putative Marker Compound. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(2):173-177. doi: 10.1248/yakushi.16-00233-3. [PMID: 28154328]
  • Hajime Hiyama, Aya Ozawa, Hiroaki Kumazawa, Osami Takeda. Stabilization of Ephedrine Alkaloid Content in Ephedra sinica by Selective Breeding and Stolon Propagation. Biological & pharmaceutical bulletin. 2017; 40(1):43-48. doi: 10.1248/bpb.b16-00531. [PMID: 28049947]
  • Nicola Mastroianni, Maria Jose Bleda, Miren López de Alda, Damià Barceló. Occurrence of drugs of abuse in surface water from four Spanish river basins: Spatial and temporal variations and environmental risk assessment. Journal of hazardous materials. 2016 10; 316(?):134-42. doi: 10.1016/j.jhazmat.2016.05.025. [PMID: 27232724]
  • Abdullah S Terkawi, Sarah K Larkin, Siny Tsang, Jessica S Sheeran, Mohamed Tiouririne. Effects of hydroxyethyl starch 6 \% (130/0.4) on blood loss during cesarean delivery: a propensity-matched analysis. Journal of anesthesia. 2016 10; 30(5):796-802. doi: 10.1007/s00540-016-2208-z. [PMID: 27364518]
  • Chuixiu Huang, Knut Fredrik Seip, Astrid Gjelstad, Stig Pedersen-Bjergaard. Electromembrane extraction of polar basic drugs from plasma with pure bis(2-ethylhexyl) phosphite as supported liquid membrane. Analytica chimica acta. 2016 Aug; 934(?):80-7. doi: 10.1016/j.aca.2016.06.002. [PMID: 27506347]
  • Eun Sook Jeong, Ki Hun Kim, Eunju Cha, Oh-Seung Kwon, Sangwon Cha, Jaeick Lee. Direct and rapid quantitation of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1028(?):237-241. doi: 10.1016/j.jchromb.2016.06.040. [PMID: 27393909]
  • Ju-Wen Wang, Meng-Hsuan Chiang, Chia-Ming Lu, Tung-Hu Tsai. Determination the active compounds of herbal preparation by UHPLC-MS/MS and its application on the preclinical pharmacokinetics of pure ephedrine, single herbal extract of Ephedra, and a multiple herbal preparation in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jul; 1026(?):152-161. doi: 10.1016/j.jchromb.2015.12.027. [PMID: 26724253]
  • Naohiro Oshima, Tadatoshi Yamashita, Sumiko Hyuga, Masashi Hyuga, Hiroyuki Kamakura, Morio Yoshimura, Takuro Maruyama, Takashi Hakamatsuka, Yoshiaki Amakura, Toshihiko Hanawa, Yukihiro Goda. Efficiently prepared ephedrine alkaloids-free Ephedra Herb extract: a putative marker and antiproliferative effects. Journal of natural medicines. 2016 Jul; 70(3):554-62. doi: 10.1007/s11418-016-0977-1. [PMID: 26976141]
  • Korey Kilpatrick, Agnieszka Pajak, Jillian M Hagel, Mark W Sumarah, Efraim Lewinsohn, Peter J Facchini, Frédéric Marsolais. Characterization of aromatic aminotransferases from Ephedra sinica Stapf. Amino acids. 2016 May; 48(5):1209-20. doi: 10.1007/s00726-015-2156-1. [PMID: 26832171]
  • Sidney J Stohs, Vladimir Badmaev. A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytotherapy research : PTR. 2016 May; 30(5):732-40. doi: 10.1002/ptr.5583. [PMID: 26856274]
  • Rosa Ventura, Xavier Matabosch, Jordi Segura. Bioanalytical techniques in discrimination between therapeutic and abusive use of drugs in sport. Bioanalysis. 2016 May; 8(9):965-80. doi: 10.4155/bio.15.253. [PMID: 26884281]
  • Ashton D Lesiak, Robert B Cody, Masaaki Ubukata, Rabi A Musah. Direct analysis in real time high resolution mass spectrometry as a tool for rapid characterization of mind-altering plant materials and revelation of supplement adulteration--The case of Kanna. Forensic science international. 2016 Mar; 260(?):66-73. doi: 10.1016/j.forsciint.2015.12.037. [PMID: 26821203]
  • Asami Kojima, Yasunori Nishitani, Mitsuhiko Sato, Shinji Kageyama, Michiko Dohi, Masato Okano. Comparison of urine analysis and dried blood spot analysis for the detection of ephedrine and methylephedrine in doping control. Drug testing and analysis. 2016 Feb; 8(2):189-98. doi: 10.1002/dta.1803. [PMID: 25869885]
  • M Aghdasi, M Mofid Bojnoordi, M Mianabadi, M Nadaf. Chemical components of the Ephedra major from Iran. Natural product research. 2016; 30(3):369-71. doi: 10.1080/14786419.2015.1058794. [PMID: 26211728]
  • David F Snipelisky, Andrew K Kurklinsky, Razvan Chirila. Transient Cardiomyopathy and Quadriplegia Induced by Ephedrine Decongestant. Texas Heart Institute journal. 2015 Dec; 42(6):575-8. doi: 10.14503/thij-14-4487. [PMID: 26664316]
  • Mengying Lv, Jianbo Sun, Min Wang, Wanqiu Huang, Hongyan Fan, Fengguo Xu, Zunjian Zhang. GC-MS based metabolomics study of stems and roots of Ephedra sinica. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):49-52. doi: 10.1016/j.jpba.2015.04.035. [PMID: 26004227]
  • Mengying Lv, Jiaqing Chen, Yiqiao Gao, Jianbo Sun, Qianqian Zhang, Mohan Zhang, Fengguo Xu, Zunjian Zhang. Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica. Journal of separation science. 2015 Oct; 38(19):3331-6. doi: 10.1002/jssc.201500529. [PMID: 26224607]
  • Tianhua Yan, Qiang Fu, Jing Wang, Shiping Ma. UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in Beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang. Drug testing and analysis. 2015 Feb; 7(2):158-63. doi: 10.1002/dta.1635. [PMID: 24824649]
  • Masashi Matsumoto, Manabu Hirayama, Norihiro Ohtomi, Takeshi Ohno, Yukihiro Nomura, Osamu Iida, Koji Sugimura, Nobuo Kawahara, Takashi Tsuchida, Masayuki Mikage. Influence of genetic factors on the ephedrine alkaloid composition ratio of Ephedra plants. Journal of natural medicines. 2015 Jan; 69(1):63-7. doi: 10.1007/s11418-014-0863-7. [PMID: 25115226]